Matrix metalloproteinases as therapeutic targets for stroke.
Albuquerque, United States. In Brain Res, Nov 2015
Normally the constitutive enzymes, MMP-2 and membrane type MMP (MMP-14), are activated in a spatially specific manner and act close to the site of activation, while the inducible enzymes, MMP-3 and MMP-9, become active through the action of free radicals and other enzymes during neuroinflammation.
MMP-14 in skeletal muscle repair.
Pietermaritzburg, South Africa. In J Muscle Res Cell Motil, Jun 2015
MMP-14 (also known as MT1-MMP) is a membrane-bound collagenase and member of the Matrix Metalloprotease (MMP) family known to target a broad range of extracellular matrix (ECM) proteins.
Forcing the third dimension.
San Francisco, United States. In Cell, 2006
The authors show that remodeling of the extracellular matrix by the matrix metalloproteinase MT1-MMP contributes to the three-dimensional development of white adipose tissue in mice.
MT1-mmp: a collagenase essential for tumor cell invasive growth.
Bethesda, United States. In Cancer Cell, 2003
The authors show that tumor cells are able to escape the matrix-enforced growth control effect (entrapment) by pericellular proteolysis mediated by MT1-MMP, a membrane bound matrix metalloproteinase capable of directly cleaving both type I collagen and fibrin but not by other, soluble matrix metalloprotinases.