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Matrix metallopeptidase 14

MT1-MMP, MMP-14, Matrix Metalloproteinase 14, membrane-type 1 matrix metalloproteinase
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MT1, MMP-2, MMP-9, CAN, V1a
Papers using MT1-MMP antibodies
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells.
Zhou Zhongjun, In PLoS ONE, 2002
... Primary antibodies were purchased from Abcam (Cambridge, MA; anti-MT1-MMP hinge polyclonal antibody), Cell Signaling Technology (Beverly, MA, anti-β-actin ...
The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1
Nishimura Stephen L. et al., In The Journal of Cell Biology, 1999
... used were: anti-α5 (P5D10; Chemicon), anti-β1 (P5D2; Chemicon), pan-anti–TGF-β (1D11; R&D Systems), mouse or rabbit anti–MT1-MMP (Calbiochem and Chemicon), mouse anti-BrdU (Dako), phycoerythrin goat anti–mouse, rhodamine ...
Papers on MT1-MMP
Multiple essential MT1-MMP functions in tooth root formation, dentinogenesis, and tooth eruption.
Foster et al., Beijing, China. In Matrix Biol, Feb 2016
UNASSIGNED: Membrane-type matrix metalloproteinase 1 (MT1-MMP) is a transmembrane zinc-endopeptidase that breaks down extracellular matrix components, including several collagens, during tissue development and physiological remodeling.
Hic-5 mediates endothelial sprout initiation by regulating a key surface metalloproteinase.
Bayless et al., College Station, United States. In J Cell Sci, Feb 2016
Pro-angiogenic factors enhanced co-localization and complex formation between membrane type-1 matrix metalloproteinase (MT1-MMP) and Hic-5, but not paxillin, and the LIM2 and LIM3 domains of Hic-5 were necessary and sufficient for MT1-MMP complex formation.
Soft matrices inhibit cell proliferation and inactivate the fibrotic phenotype of deep endometriotic stromal cells in vitro†.
Darcha et al., Clermont-Ferrand, France. In Hum Reprod, Feb 2016
mRNA level of type I collagen, matrix metalloproteinase-1 (MMP-1), MMP-14 and cyclin D1 was measured by real-time PCR.
Downregulation of human intercellular adhesion molecule-1 attenuates the metastatic ability in human breast cancer cell lines.
Ju et al., Weifang, China. In Oncol Rep, Feb 2016
Our results showed that silencing of ICAM-1 can inhibit the metastatic ability of MCF-7 cell lines in vitro significantly, and the decreased migration and invasion was accompanied by a reduction of MMP-14.
Synergistic effect of blocking cancer cell invasion revealed by computer simulations.
Ichikawa, Tokyo, Japan. In Math Biosci Eng, Jan 2016
Membranous metalloproteinase MT1-MMP and soluble metalloproteinase MMP-2 are thought to play an important role in the degradation of ECM.
Matrix metalloproteinase 14 modulates signal transduction and angiogenesis in the cornea.
Azar et al., Tokyo, Japan. In Surv Ophthalmol, Dec 2015
Here, we elaborate on the facilitative role of MMPs, specifically MMP-14, in corneal NV.
Matrix metalloproteinases as therapeutic targets for stroke.
Rosenberg et al., Albuquerque, United States. In Brain Res, Nov 2015
Normally the constitutive enzymes, MMP-2 and membrane type MMP (MMP-14), are activated in a spatially specific manner and act close to the site of activation, while the inducible enzymes, MMP-3 and MMP-9, become active through the action of free radicals and other enzymes during neuroinflammation.
MMP-14 in skeletal muscle repair.
Niesler et al., Pietermaritzburg, South Africa. In J Muscle Res Cell Motil, Jun 2015
MMP-14 (also known as MT1-MMP) is a membrane-bound collagenase and member of the Matrix Metalloprotease (MMP) family known to target a broad range of extracellular matrix (ECM) proteins.
Membrane-type matrix metalloproteinases: Their functions and regulations.
Itoh, Oxford, United Kingdom. In Matrix Biol, May 2015
Among the 6 MT-MMPs, MT1-MMP is the most investigated enzyme and many of its roles and regulations have been revealed to date, but the potential roles and regulatory mechanisms of other MT-MMPs are gradually getting clearer as well.
Cellular protrusions--lamellipodia, filopodia, invadopodia and podosomes--and their roles in progression of orofacial tumours: current understanding.
Siar et al., Kuala Lumpur, Malaysia. In Asian Pac J Cancer Prev, 2014
Invadopodia-associated protein markers consisted of 129 proteins belonging to different functional classes including WASP, NWASP, cortactin, Src kinase, Arp 2/3 complex, MT1-MMP and F-actin.
microRNA-9 targets matrix metalloproteinase 14 to inhibit invasion, metastasis, and angiogenesis of neuroblastoma cells.
Tong et al., Wuhan, China. In Mol Cancer Ther, 2012
miR-9 suppresses MMP-14 expression via the binding site in the 3'-UTR, thus inhibiting the invasion, metastasis, and angiogenesis of neuroblastoma.
MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling and calvarial osteogenesis.
Zhou et al., Shenzhen, China. In Dev Cell, 2012
The data revealed a regulatory paradigm for FGRF2 signaling and identified MT1-MMP as a critical negative modulator of ADAM9 activity to maintain FGFR2 signaling in calvarial osteogenesis.
MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells.
Hattori et al., Tokyo, Japan. In Blood, 2012
MT1-MMP in niche cells regulates postnatal hematopoiesis, by modulating hematopoietic hypoxia-inducible factor-1 - dependent niche factors that are critical for terminal differentiation and migration.
[Association of MMP14 gene polymorphisms and osteoporosis in Zhuang men from Baise region of Guangxi].
Wu et al., China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2012
A significant higher risk of osteoporosis was found in individuals with MMP14 rs1003349 GT genotype.
Conversion of stationary to invasive tumor initiating cells (TICs): role of hypoxia in membrane type 1-matrix metalloproteinase (MT1-MMP) trafficking.
Cao et al., Stony Brook, United States. In Plos One, 2011
The observations suggest that MT1-MMP is a key molecule capable of executing conversion of stationary TICs to invasive tumor initiating cells under hypoxic conditions and thereby controlling metastasis.
Catecholaminergic neurotransmitters regulate migration and repopulation of immature human CD34+ cells through Wnt signaling.
Lapidot et al., Israel. In Nat Immunol, 2007
Treatment with neurotransmitters increased the motility, proliferation and colony formation of human progenitor cells, correlating with increased polarity, expression of the metalloproteinase MT1-MMP and activity of the metalloproteinase MMP-2.
Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion.
Friedl et al., Würzburg, Germany. In Nat Cell Biol, 2007
Data show how invasive tumor cells coordinate mechanotransduction and collagen remodelling by segregating the force-generating leading edge containing beta1 integrin, MT1-MMP and F-actin from a posterior proteolytic zone executing fibre breakdown.
A pericellular collagenase directs the 3-dimensional development of white adipose tissue.
Weiss et al., Ann Arbor, United States. In Cell, 2006
Hence, MT1-MMP acts as a 3-D-specific adipogenic factor that directs the dynamic adipocyte-ECM interactions critical to WAT development.
Forcing the third dimension.
Weaver et al., San Francisco, United States. In Cell, 2006
The authors show that remodeling of the extracellular matrix by the matrix metalloproteinase MT1-MMP contributes to the three-dimensional development of white adipose tissue in mice.
MT1-mmp: a collagenase essential for tumor cell invasive growth.
Birkedal-Hansen et al., Bethesda, United States. In Cancer Cell, 2003
The authors show that tumor cells are able to escape the matrix-enforced growth control effect (entrapment) by pericellular proteolysis mediated by MT1-MMP, a membrane bound matrix metalloproteinase capable of directly cleaving both type I collagen and fibrin but not by other, soluble matrix metalloprotinases.
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