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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Branched chain keto acid dehydrogenase E1, alpha polypeptide

MSU, BCKDHA, Darkener of apricot
The branched-chain alpha-keto acid (BCAA) dehydrogenase (BCKD) complex is an innter mitochondrial enzyme complex that catalyzes the second major step in the catabolism of the branched-chain amino acids leucine, isoleucine, and valine. The BCKD complex consists of three catalytic components: a heterotetrameric (alpha2-beta2) branched-chain alpha-keto acid decarboxylase (E1), a dihydrolipoyl transacylase (E2), and a dihydrolipoamide dehydrogenase (E3). This gene encodes the alpha subunit of the decarboxylase (E1) component. Mutations in this gene result in maple syrup urine disease, type IA. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: ACID, CAN, IL-1beta, HAD, V1a
Papers using MSU antibodies
Latent TGF-beta structure and activation
Parkinson John, In PLoS ONE, 2010
... The human fibroblast cell line, MSU 1.1, was cultured under identical conditions and was used in some cell signaling assays as indicated in ...
Papers on MSU
Effects of Pimenta pseudocaryophyllus extracts on gout: Anti-inflammatory activity and anti-hyperuricemic effect through xantine oxidase and uricosuric action.
Saúde-Guimarães et al., Ouro Preto, Brazil. In J Ethnopharmacol, Feb 2016
Anti-inflammatory activity was investigated on MSU crystal-induced paw edema model.
Suppressive effect of Sanmiao formula on experimental gouty arthritis by inhibiting cartilage matrix degradation: An in vivo and in vitro study.
Xu et al., Nanjing, China. In Int Immunopharmacol, Jan 2016
Moreover, histological analysis of the joints and SM-serum substantially interfered with the MSU-induced expression of glycosaminoglycans (GAG), up-regulated the content of proteoglycan.
Anti-inflammatory properties of Morus bombycis Koidzumi via inhibiting IFN-β signaling and NLRP3 inflammasome activation.
Lee et al., Ch'ŏngju, South Korea. In J Ethnopharmacol, Jan 2016
A monosodium urate crystal (MSU)-induced peritonitis murine model was used to study the in vivo effects.
Curcumin loaded mesoporous silica: an effective drug delivery system for cancer treatment.
Gómez-Ruiz et al., Hyderābād, India. In Biomater Sci, Jan 2016
A series of mesoporous silica material based drug delivery systems (S2, S4 and S6) were first designed and developed through the amine functionalization of KIT-6, MSU-2 and MCM-41 followed by the loading of curcumin.
Innate immune perturbations, accumulating DAMPs and inflammasome dysregulation: A ticking time bomb in ageing.
Sweet et al., Australia. In Ageing Res Rev, Nov 2015
These include reactive oxygen species (ROS) released from damaged mitochondria, extracellular nucleotides like ATP, high mobility group box (HMGB) 1 protein, oxidized low density lipoprotein, amyloid-beta (Aβ), islet amyloid polypeptide and particulates like monosodium urate (MSU) crystals and cholesterol crystals.
How neutrophil extracellular traps orchestrate the local immune response in gout.
Hoffmann et al., Erlangen, Germany. In J Mol Med (berl), Jul 2015
At the very high neutrophil densities that occur at the site of inflammation, NETs build aggregates that densely pack the monosodium urate (MSU) crystals and trap and degrade pro-inflammatory mediators by inherent proteases.
Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome.
Zhou et al., Hefei, China. In Cell, Feb 2015
Importantly, in vivo data show that DA and DRD1 signaling prevent NLRP3 inflammasome-dependent inflammation, including neurotoxin-induced neuroinflammation, LPS-induced systemic inflammation, and monosodium urate crystal (MSU)-induced peritoneal inflammation.
Factors influencing the crystallization of monosodium urate: a systematic literature review.
Dalbeth et al., Auckland, New Zealand. In Bmc Musculoskelet Disord, 2014
BACKGROUND: Gout is a chronic disease of monosodium urate (MSU) crystal deposition.
Branched-chain amino acids in metabolic signalling and insulin resistance.
Adams et al., United States. In Nat Rev Endocrinol, 2014
Research on the role of individual and model-dependent differences in BCAA metabolism is needed, as several genes (BCKDHA, PPM1K, IVD and KLF15) have been designated as candidate genes for obesity and/or T2DM in humans, and distinct phenotypes of tissue-specific branched chain ketoacid dehydrogenase complex activity have been detected in animal models of obesity and T2DM.
Why does the gout attack stop? A roadmap for the immune pathogenesis of gout.
Herrmann et al., Erlangen, Germany. In Rmd Open, 2014
At high concentrations of uric acid in the body (hyperuricaemia), needle-shaped monosodium urate (MSU) crystals are formed.
Morin, a Bioflavonoid Suppresses Monosodium Urate Crystal-Induced Inflammatory Immune Response in RAW 264.7 Macrophages through the Inhibition of Inflammatory Mediators, Intracellular ROS Levels and NF-κB Activation.
Rasool et al., Vellore, India. In Plos One, 2014
In this current study, we investigated the anti-inflammatory mechanism of morin against monosodium urate crystal (MSU)-induced inflammation in RAW 264.7 macrophage cells, an in vitro model for acute gouty arthritis.
Monosodium Urate Crystal-Induced Chondrocyte Death via Autophagic Process.
Kim et al., Anyang, South Korea. In Int J Mol Sci, 2014
Monosodium urate (MSU) crystals, which are highly precipitated in the joint cartilage, increase the production of cartilage-degrading enzymes and pro-inflammatory mediators in cartilage, thereby leading to gouty inflammation and joint damage.
Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines.
Herrmann et al., Erlangen, Germany. In Nat Med, 2014
Gout is characterized by an acute inflammatory reaction and the accumulation of neutrophils in response to monosodium urate (MSU) crystals.
Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death.
Ruland et al., München, Germany. In Immunity, 2014
Both human and mouse Clec12a could physically sense uric acid crystals (monosodium urate, MSU), which are key danger signals for cell-death-induced immunity.
Mutations in BCKD-kinase lead to a potentially treatable form of autism with epilepsy.
Gleeson et al., San Diego, United States. In Science, 2012
autism presenting with intellectual disability and epilepsy caused by BCKDK mutations represents a potentially treatable syndrome.
Three Korean patients with maple syrup urine disease: four novel mutations in the BCKDHA gene.
Lee et al., Seoul, South Korea. In Ann Clin Lab Sci, 2010
identified 4 novel mutations of the BCKDHA gene in 3 Korean newborns; to the best of knowledge, this is the first report of maple syrup urine disease confirmed by genetic analysis in Korea
The role of the Drosophila LAMMER protein kinase DOA in somatic sex determination.
Samson et al., Orsay, France. In J Genet, 2010
The Doa locus encodes six different kinases, of which a 69-kDa isoform is expressed solely in females.
Maple syrup urine disease in Cypriot families: identification of three novel mutations and biochemical characterization of the p.Thr211Met mutation in the E1alpha subunit.
Drousiotou et al., Nicosia, Cyprus. In Genet Test Mol Biomarkers, 2009
five mutations, three of them novel, responsible for maple syrup urine disease
Molecular genetics of maple syrup urine disease in the Turkish population.
Wendel et al., Düsseldorf, Germany. In Turk J Pediatr, 2009
In 37% (12 patients) of a total of 64 alleles, the supposed maple syrup urine disease-causing mutations in Turkish patients were located in the BCKDHA gene, in 44% (14 patients) in the BCKDHB gene and in 19% (6 patients) in the DBT gene.
Gout-associated uric acid crystals activate the NALP3 inflammasome.
Tschopp et al., Lausanne, Switzerland. In Nature, 2006
Development of the acute and chronic inflammatory responses known as gout and pseudogout are associated with the deposition of monosodium urate (MSU) or calcium pyrophosphate dihydrate (CPPD) crystals, respectively, in joints and periarticular tissues.
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