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Serine/threonine kinase 3

MST2, Krs1
This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] (from NCBI)
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Top mentioned proteins: MSP, MST, PAK1, CAN, Raf
Papers on MST2
Comparative Modeling, Molecular Docking, and Revealing of Potential Binding Pockets of RASSF2; a Candidate Cancer Gene.
New
Sehgal et al., Sāhīwāl, Pakistan. In Interdiscip Sci, Feb 2016
It stabilizes STK3/MST2 by protecting it from proteasomal degradation.
A-Raf: A new star of the family of raf kinases.
New
Xu et al., Glasgow, United Kingdom. In Crit Rev Biochem Mol Biol, Nov 2015
These include the inhibition of apoptosis by binding to MST2, acting as safeguard against oncogenic transformation by suppressing extracellular signal-regulated kinases (ERK) activation and playing a role in resistance to Raf inhibitors.
MST2-RASSF protein-protein interactions through SARAH domains.
New
Buchete et al., In Brief Bioinform, Nov 2015
Here, we focus on recent studies highlighting the special role being played by the specific interactions between the helical Salvador/RASSF/Hippo (SARAH) domains of MST2 and RASSF1a or RASSF5 enzymes.
Germline polymorphisms in genes involved in the Hippo pathway as recurrence biomarkers in stages II/III colon cancer.
New
Lenz et al., Los Angeles, United States. In Pharmacogenomics J, Oct 2015
In this study, 14 polymorphisms in 8 genes involved in the Hippo pathway (MST1, MST2, LATS1, LATS2, YAP, TAZ, FAT4 and RASSF1A) were evaluated as recurrence predictors in 194 patients with stages II/III colon cancer treated with 5-Fu-based adjuvant chemotherapy.
MST kinases in development and disease.
Review
New
Sahai et al., London, United Kingdom. In J Cell Biol, Oct 2015
The mammalian MST kinase family, which is related to the Hippo kinase in Drosophila melanogaster, includes five related proteins: MST1 (also called STK4), MST2 (also called STK3), MST3 (also called STK24), MST4, and YSK1 (also called STK25 or SOK1).
miR-155-dependent regulation of mammalian sterile 20-like kinase 2 (MST2) coordinates inflammation, oxidative stress and proliferation in vascular smooth muscle cells.
New
Wen et al., Shijiazhuang, China. In Biochim Biophys Acta, Jul 2015
Notably, expression of the miR-155-target protein mammalian sterile 20-like kinase 2 (MST2) was increased in the injured arteries of miR-155-/- mice.
Safeguarding genome stability: RASSF1A tumor suppressor regulates BRCA2 at stalled forks.
O'Neill et al., Oxford, United Kingdom. In Cell Cycle, 2014
Recently we uncovered how the core Hippo pathway components RASSF1A, MST2 and LATS1 regulate CDK2 activity towards BRCA2, in response to fork stalling.
One Hippo and many masters: differential regulation of the Hippo pathway in cancer.
Review
Kolch et al., Dublin, Ireland. In Biochem Soc Trans, 2014
The Hippo/MST2 (mammalian sterile 20-like kinase 2) pathway is a signalling cascade evolutionarily conserved in its structure.
Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling.
Impact
Kolch et al., Dublin, Ireland. In Nat Cell Biol, 2014
These include Akt phosphorylation of MST2 and a feedback phosphorylation of Raf-1 Ser 259 by LATS1, which enables Raf-1 to suppress both MST2 and MEK signalling.
Okadaic Acid: a tool to study the hippo pathway.
Review
Maimaiti et al., Tokyo, Japan. In Mar Drugs, 2013
MST1 and MST2 work as core kinases of the Hippo pathway and their activities depend on the autophosphorylation, which is negatively regulated by protein phosphatase 2A (PP2A).
Akt is negatively regulated by Hippo signaling for growth inhibition in Drosophila.
GeneRIF
Lai et al., United States. In Dev Biol, 2012
Hippo signaling not only blocks cell division and promotes apoptosis, but also regulates cellular growth by inhibiting the Akt pathway activity.
Separating planar cell polarity and Hippo pathway activities of the protocadherins Fat and Dachsous.
GeneRIF
Blair et al., Madison, United States. In Development, 2012
analysis of planar cell polarity and Hippo pathway activities of the protocadherins Fat and Dachsous
Dimerization and cytoplasmic localization regulate Hippo kinase signaling activity in organ size control.
GeneRIF
Zhang et al., Shanghai, China. In J Biol Chem, 2012
dimerization and nucleocytoplasmic translocation of Hpo are crucial for its biological function
Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras.
GeneRIF
Kolch et al., Dublin, Ireland. In Mol Cell, 2012
The small number of tumors with co-expression of mutant K-Ras and MST2 has elevated apoptosis rates.
Regulation of neuronal cell death by c-Abl-Hippo/MST2 signaling pathway.
GeneRIF
Yuan et al., Dalian, China. In Plos One, 2011
The identification of the c-Abl tyrosine kinase as a novel upstream activator of MST2 suggests that the conserved c-Abl-MST signaling cascade plays an important role in oxidative stress-induced neuronal cell death.
Downstream of human NDR kinases: impacting on c-myc and p21 protein stability to control cell cycle progression.
Review
Hemmings et al., Basel, Switzerland. In Cell Cycle, 2011
Apart from functions in apoptosis signaling and tumor suppression, NDR1/2 have been implicated in controlling centrosome duplication and mitotic chromosome alignment downstream of the HIPPO kinase homologs MST1 and MST2.
Cell biological manifestations of bisdioxopiperazines treatment of human tumor cell lines in culture.
Review
Ding et al., Shanghai, China. In Anticancer Agents Med Chem, 2010
Since 1980, two new Biz compounds {probimane (Pro, AT-2153, MST-2) and MST-16} have been synthesized at the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, PR China, based on structural modifications from British developed Biz compounds.
Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1.
Impact
GeneRIF
Kolch et al., Glasgow, United Kingdom. In Science, 2005
proteomic analysis of Raf-1 signaling complexes was used to show that Raf-1 counteracts apoptosis by suppressing the activation of mammalian sterile 20-like kinase (MST2)
The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila.
Impact
GeneRIF
Léopold et al., Nice, France. In Nat Cell Biol, 2003
data identify Hippo (Hpo) as a partner of Salvador (Sav), and suggest that Hpo and Sav function together to restrict tissue growth in vivo
Autoregulation of the yeast lysyl-tRNA synthetase gene GCD5/KRS1 by translational and transcriptional control mechanisms.
Impact
Mueller et al., Bern, Switzerland. In Cell, 1992
We cloned the GCD5 gene of S. cerevisiae and found it to be identical to KRS1, which encodes lysyl-tRNA synthetase (LysRS).
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