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MSS4 Mss4p

Mss4, Mss4p, STM7
This gene encodes a member of the SCE4/YPT1/RAB family of small GTP-binding proteins that are involved in the regulation of intracellular vesicular transport. This protein stimulates GTP-GDP exchange in SEC4, and to a lesser extent in YPT1 and RAB3A, and may play a general role in vesicular transport. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: ACID, Actin, Rab5, Fab1, Farr
Papers on Mss4
Role of phosphatidylinositol phosphate signaling in the regulation of the filamentous-growth mitogen-activated protein kinase pathway.
New
Cullen et al., Buffalo, United States. In Eukaryot Cell, Apr 2015
Lipid kinases that generate phosphatidylinositol 4-phosphate [PI(4)P] at the Golgi (Pik1p) or PI(4,5)P2 at the plasma membrane (PM) (Mss4p and Stt4p) were required for filamentous-growth MAPK pathway signaling.
Rab8a-AS160-MSS4 regulatory circuit controls lipid droplet fusion and growth.
Li et al., Beijing, China. In Dev Cell, 2014
MSS4 antagonizes Fsp27-mediated LD fusion activity through Rab8a.
Phosphatidylinositol 4,5-bisphosphate is required for invasive growth in Saccharomyces cerevisiae.
Arkowitz et al., Nice, France. In J Cell Sci, 2013
In the yeast Saccharomyces cerevisiae, the sole phosphatidylinositol-4-phosphate 5-kinase (PI4P5K) Mss4p is essential for generating plasma membrane PtdIns(4,5)P2.
TPT1/ TCTP-regulated pathways in phenotypic reprogramming.
Review
Telerman et al., Cachan, France. In Trends Cell Biol, 2013
The TPT1/TCTP protein is structurally similar to mRNA-helicases and MSS4.
The functions of anionic phospholipids during clathrin-mediated endocytosis site initiation and vesicle formation.
Drubin et al., Berkeley, United States. In J Cell Sci, 2013
Live-cell imaging of endocytic protein dynamics in an mss4(ts) mutant, which has severely reduced PI(4,5)P2 levels, revealed that PI(4,5)P2 is required for endocytic membrane invagination but is less important for endocytic site initiation.
Mss4 protein is a regulator of stress response and apoptosis.
GeneRIF
Wixler et al., Münster, Germany. In Cell Death Dis, 2011
The expression levels of cellular Mss4 mRNA and protein are rapidly changed in response to a broad range of extracellular stress stimuli.
The Saccharomyces cerevisiae flavodoxin-like proteins Ycp4 and Rfs1 play a role in stress response and in the regulation of genes related to metabolism.
del Olmo et al., Paterna, Spain. In Arch Microbiol, 2011
The phosphatidylinositol-4-phosphate 5-kinase gene MSS4 was identified as a positive activator of SPI1.
Sex-biased suppression of chemically induced neural carcinogenesis in congenic BDIX.BDIV-Mss4a rats.
GeneRIF
Kindler-Röhrborn et al., Essen, Germany. In Physiol Genomics, 2011
Transcription profiling using trigeminal nerve tissue of BDIX, BDIV, and BDIX.BDIV-Mss4a congenics of both sexes revealed 61 genes located in the Mss4a fragment differentially expressed between BDIV and BDIX rats.
Interruption of inositol sphingolipid synthesis triggers Stt4p-dependent protein kinase C signaling.
Henry et al., Ithaca, United States. In J Biol Chem, 2011
Like other mutations in the PKC-MAPK pathway, mutants defective in Stt4p and the PI4P 5-kinase Mss4p, which generates phosphatidylinositol 4,5-bisphosphate, exhibit inositol auxotrophy, yet fully derepress INO1, encoding inositol-3-phosphate synthase.
An isoform-specific PDZ-binding motif targets type I PIP5 kinase beta to the uropod and controls polarization of neutrophil-like HL60 cells.
GeneRIF
Lacalle et al., Madrid, Spain. In Faseb J, 2010
Results identify an isoform-specific PDZ-binding motif in PIP5KIbeta, which confers specificity for PIP5KIbeta signaling at the uropod during leukocyte chemotaxis.
Type I phosphatidylinositol phosphate kinase beta regulates focal adhesion disassembly by promoting beta1 integrin endocytosis.
GeneRIF
Kunz et al., Houston, United States. In Mol Cell Biol, 2010
Results identify PIPKIbeta as a novel regulator of focal adhesion disassembly and suggest that PIPKIbeta spatially regulates beta1 integrin endocytosis at adhesion sites to control cell migration.
A winged-helix transcription factor foxg1 induces expression of mss4 gene in rat hippocampal progenitor cells.
Huh et al., South Korea. In Exp Neurobiol, 2010
Foxg1 (previously named BF1) is a winged-helix transcription factor with restricted expression pattern in the telencephalic neuroepithelium of the neural tube and in the anterior half of the developing optic vesicle.
Bacillus halochares sp. nov., a halophilic bacterium isolated from a solar saltern.
Koukkou et al., Ioánnina, Greece. In Int J Syst Evol Microbiol, 2010
A novel halophilic bacterium, designated strain MSS4(T), was isolated from the solar salterns of Mesolongi, Greece.
Activation of the mitogen-activated protein kinase, Slt2p, at bud tips blocks a late stage of endoplasmic reticulum inheritance in Saccharomyces cerevisiae.
Novick et al., New Haven, United States. In Mol Biol Cell, 2010
The PI4P5-kinase, Mss4p, is an upstream activator of this pool of Slt2p.
Oxidative stress decreases phosphatidylinositol 4,5-bisphosphate levels by deactivating phosphatidylinositol- 4-phosphate 5-kinase beta in a Syk-dependent manner.
GeneRIF
Yin et al., Dallas, United States. In J Biol Chem, 2009
Syk-dependent phosphorylation of PIP5K1B is the dominant modification responsible for the decrease in cellular phosphatidylinositol 4,5-bisphosphate.
Phosphatidylinositol-4,5-bisphosphate and phospholipase D-generated phosphatidic acid specify SNARE-mediated vesicle fusion for prospore membrane formation.
Engebrecht et al., Davis, United States. In Eukaryot Cell, 2009
Overexpression of the phosphatidylinositol-4-phosphate 5-kinase MSS4 in sso1Delta cells induced to sporulate stimulates PSM production; PLD activity is not increased under these conditions, indicating that PI(4,5)P(2) has roles in addition to stimulating PLD in PSM formation.
The Friedreich's ataxia gene encodes a novel phosphatidylinositol-4- phosphate 5-kinase.
Impact
Chamberlain et al., London, United Kingdom. In Nat Genet, 1996
The STM7 gene on chromosome 9 was recently 'excluded' as a candidate for Friedreich's ataxia following the identification of an expanded intronic GAA triplet repeat in the adjacent gene, X25, in patients with the disease.
The phosphatidylinositol 4-phosphate 5-kinase family.
Review
Anderson et al., Madison, United States. In Adv Enzyme Regul, 1995
The identification of two S. cerevisiae homologues, Mss4p and Fab1p, confirms that this family of kinases is widely distributed in eukaryotes.
A mammalian guanine-nucleotide-releasing protein enhances function of yeast secretory protein Sec4.
Impact
De Camilli et al., New Haven, United States. In Nature, 1993
Here we report the isolation of a mammalian complementary DNA, mss4, encoding a GDP-releasing protein that enhances Sec4 function.
Calibration comparison for the Landsat 4 and 5 multispectral scanners and thematic mappers.
Price, In Appl Opt, 1989
A formulation is developed for comparing the calibration of matched instruments (MSS4, MSS5 and TM4, TM5), and spectral interpolation is used to compare the calibration of the nearly equivalent shortwave channels of all four instruments.
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