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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Methionine sulfoxide reductase A

MsrA, methionine sulfoxide reductase A
This protein is ubiquitous and highly conserved. It carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. Its proposed function is the repair of oxidative damage to proteins to restore biological activity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: MsrB, CAN, ACID, Thioredoxin, HAD
Papers on MsrA
Methionine sulfoxide reductase A (MsrA) affects beta-amyloid solubility and mitochondrial function in a mouse model of Alzheimer's disease.
New
Yan et al., United States. In Am J Physiol Endocrinol Metab, Feb 2016
The current studies determine the effect of an in vivo methionine sulfoxidation of Aβ through ablation of the methionine sulfoxide reductase A (MsrA) in a mouse model of AD, a mouse that overexpresses amyloid precursor protein (APP) and Aβ in neurons.
The N-terminal acetyltransferase Naa10/ARD1 does not acetylate lysine residues.
New
Marmorstein et al., United States. In J Biol Chem, Feb 2016
Surprisingly, recent reports claim that Naa10 may also acetylate lysine residues of diverse targets, including methionine sulfoxide reductase A (MSRA), myosin light chain kinase (MLCK), and Runt-related transcription factor 2 (Runx2).
Identification of activators of methionine sulfoxide reductases A and B.
New
Weissbach et al., Port Saint Lucie, United States. In Biochem Biophys Res Commun, Jan 2016
UNASSIGNED: The methionine sulfoxide reductase (Msr) family of enzymes has been shown to protect cells against oxidative damage.
Targeting Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer by Inducing Epidermal Growth Factor Receptor Degradation via Methionine 790 Oxidation.
New
Liu et al., Aomen, Macao. In Antioxid Redox Signal, Jan 2016
Selective EGFR(T790M) degradation was manipulated by redox imbalance between NOX3 and methionine reductase A (MsrA).
Deletion of Methionine Sulfoxide Reductase A Does Not Affect Atherothrombosis but Promotes Neointimal Hyperplasia and Extracellular Signal-Regulated Kinase 1/2 Signaling.
New
Grumbach et al., Iowa City, United States. In Arterioscler Thromb Vasc Biol, Dec 2015
The objective of this study was to define the role of the methionine sulfoxide reductase A (MsrA) in models of vascular disease and identify its signaling pathways.
Hepatic overexpression of methionine sulfoxide reductase A reduces atherosclerosis in apolipoprotein E-deficient mice.
New
Yu et al., Wuhan, China. In J Lipid Res, Oct 2015
Methionine sulfoxide reductase A (MsrA), a specific enzyme that converts methionine-S-sulfoxide to methionine, plays an important role in the regulation of protein function and the maintenance of redox homeostasis.
The discovery of methionine sulfoxide reductase enzymes: An historical account and future perspectives.
Review
New
Minetti et al., Pavia, Italy. In Biofactors, Jun 2015
A fundamental discovery revealed the existence of two unrelated families of enzymes, MsrA and MsrB, whose members display opposite stereospecificity of reduction for the two sulfoxides.
PEP-1-MsrA ameliorates inflammation and reduces atherosclerosis in apolipoprotein E deficient mice.
Yu et al., Wuhan, China. In J Transl Med, 2014
BACKGROUND: Methionine sulfoxide reductase A (MsrA) is a potent intracellular oxidoreductase and serves as an essential factor that protects cells against oxidative damage.
Methionine sulfoxide reductase: chemistry, substrate binding, recycling process and oxidase activity.
Review
Branlant et al., Vandœuvre-lès-Nancy, France. In Bioorg Chem, 2014
Three classes of methionine sulfoxide reductases are known: MsrA and MsrB which are implicated stereo-selectively in the repair of protein oxidized on their methionine residues; and fRMsr, discovered more recently, which binds and reduces selectively free L-Met-R-O.
MsrA Overexpression Targeted to the Mitochondria, but Not Cytosol, Preserves Insulin Sensitivity in Diet-Induced Obese Mice.
Salmon et al., San Antonio, United States. In Plos One, 2014
We previously identified that mice lacking the protein oxidation repair enzyme methionine sulfoxide reductase A (MsrA) are particularly prone to obesity-induced insulin resistance suggesting an unrecognized role for this protein in metabolic regulation.
Regulation of the human thioredoxin gene promoter and its key substrates: a study of functional and putative regulatory elements.
Review
Tonissen et al., Griffith, Australia. In Biochim Biophys Acta, 2014
These include the peroxiredoxins, methionine sulfoxide reductase A and specific transcription factors.
Multi-scale computational enzymology: enhancing our understanding of enzymatic catalysis.
Review
Gauld et al., Windsor, Canada. In Int J Mol Sci, 2013
Using previous studies done within our group, on OvoA, EgtB, ThrRS, LuxS and MsrA enzymatic systems, we will review how these methods can be used either independently or cooperatively to get insights into enzymatic catalysis.
The methionine sulfoxide reduction system: selenium utilization and methionine sulfoxide reductase enzymes and their functions.
Review
Kim, Taegu, South Korea. In Antioxid Redox Signal, 2013
Methionine sulfoxide reductases (Msrs), MsrA and MsrB, are the enzymes responsible for this system.
Characterization and solution structure of mouse myristoylated methionine sulfoxide reductase A.
GeneRIF
Levine et al., Bethesda, United States. In J Biol Chem, 2012
Characterization and solution structure of mouse myristoylated methionine sulfoxide reductase A.
A low pKa cysteine at the active site of mouse methionine sulfoxide reductase A.
GeneRIF
Levine et al., Bethesda, United States. In J Biol Chem, 2012
A low pKa cysteine at the active site of mouse methionine sulfoxide reductase A.
Glutaredoxin serves as a reductant for methionine sulfoxide reductases with or without resolving cysteine.
GeneRIF
Kim, Taegu, South Korea. In Acta Biochim Biophys Sin (shanghai), 2012
Data show that glutaredoxin acts as a reductant for methionine sulfoxide reductases A and B (MsrA and MsrB) with or without resolving cysteine.
Methionine sulfoxide reductase A regulates cell growth through the p53-p21 pathway.
GeneRIF
Kim et al., Taegu, South Korea. In Biochem Biophys Res Commun, 2012
The data suggest that MsrA is a regulator of cell growth that mediates the p53-p21 pathway.
Variation in MSRA modifies risk of neonatal intestinal obstruction in cystic fibrosis.
GeneRIF
Cutting et al., Baltimore, United States. In Plos Genet, 2011
The haplotype with the lowest P value showed association with Meconium ileus in an independent sample of 1,335 unrelated cystic fibrosis patients
Oxidation of CaMKII determines the cardiotoxic effects of aldosterone.
Impact
Anderson et al., Iowa City, United States. In Nat Med, 2011
Myocardial CaMKII inhibition, overexpression of methionine sulfoxide reductase A (an enzyme that reduces oxidized CaMKII) or NADPH oxidase deficiency prevented aldosterone-enhanced cardiac rupture after myocardial infarction.
A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation.
Impact
Anderson et al., Iowa City, United States. In Cell, 2008
CaMKII oxidation is reversed by methionine sulfoxide reductase A (MsrA), and MsrA-/- mice show exaggerated CaMKII oxidation and myocardial apoptosis, impaired cardiac function, and increased mortality after myocardial infarction.
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