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Cytoskeleton associated protein 5

Msps, TOGp, ch-TOG, TOG
This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: TACC3, Aurora, CAN, POLYMERASE, EB1
Papers on Msps
Affinity purification and characterization of functional tubulin from cell suspension cultures of Arabidopsis and tobacco.
New
Hashimoto et al., Ikoma, Japan. In Plant Physiol, Feb 2016
Here, we used a Tumor Overexpressed Gene (TOG) column, in which the tubulin-binding domains of a yeast TOG homologue are immobilized on resin, to isolate functional plant tubulin.
Eribulin targets a ch-TOG-dependent directed migration of cancer cells.
New
Verdier-Pinard et al., Marseille, France. In Oncotarget, Jan 2016
Actually, eribulin induced a dose-dependent depletion of EB1, CLIP-170 and the tubulin polymerase ch-TOG from microtubule +ends.
Crescerin uses a TOG domain array to regulate microtubules in the primary cilium.
New
Slep et al., Chapel Hill, United States. In Mol Biol Cell, Dec 2015
TOG domain array-containing proteins ch-TOG and CLASP are key regulators of cytoplasmic MTs.
Differentiating the roles of microtubule-associated proteins at meiotic kinetochores during chromosome segregation.
Review
New
Sato et al., Tokyo, Japan. In Chromosoma, Oct 2015
Recent studies have shown that microtubule-associated proteins (MAPs), including tumour overexpressed gene (TOG), play unique roles during meiosis.
Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly.
New
Bayliss et al., Leicester, United Kingdom. In Plos Genet, Jul 2015
In particular, phosphorylation on S558 by the mitotic kinase, Aurora-A, promotes spindle recruitment of TACC3 and triggers the formation of a complex with ch-TOG-clathrin that crosslinks and stabilises kinetochore microtubules.
MAPping the Ndc80 loop in cancer: A possible link between Ndc80/Hec1 overproduction and cancer formation.
Review
New
Toda et al., London, United Kingdom. In Bioessays, Mar 2015
Binding partners include the Ska complex, the replication licensing factor Cdt1, the Dam1 complex, TACC-TOG microtubule-associated proteins (MAPs) and kinesin motors.
AIBp regulates mitotic entry and mitotic spindle assembly by controlling activation of both Aurora-A and Plk1.
Hong et al., Kao-hsiung, Taiwan. In Cell Cycle, 2014
Our data show that depletion of AIBp results in the mis-localization of TACC3 and ch-TOG, but not CEP192 and CEP215, suggesting that loss of AIBp dominantly affects the Aurora-A substrate to cause mitotic aberrations.
Encoding the microtubule structure: Allosteric interactions between the microtubule +TIP complex master regulators and TOG-domain proteins.
Review
Kaverina et al., Nashville, United States. In Cell Cycle, 2014
Importantly, recent studies involving EBs, the master regulators of the +TIP complex, and several TOG-domain proteins have uncovered a novel mechanism of mutual +TIP regulation: allosteric interactions through changes in microtubule structure.
TOG Proteins Are Spatially Regulated by Rac-GSK3β to Control Interphase Microtubule Dynamics.
Rogers et al., Chapel Hill, United States. In Plos One, 2014
In this study, we have identified a novel protein-protein interaction between the XMAP215 homologue in Drosophila, Mini spindles (Msps), and the CLASP homologue, Orbit.
Role of centrosomal adaptor proteins of the TACC family in the regulation of microtubule dynamics during mitotic cell division.
Review
Piekorz et al., In Biol Chem, 2013
At the effector level, several TACC-binding partners have been identified and characterized in greater detail, in particular, the microtubule polymerase XMAP215/ch-TOG/CKAP5 and clathrin heavy chain (CHC).
Microtubules and Alp7-Alp14 (TACC-TOG) reposition chromosomes before meiotic segregation.
Impact
Yamamoto et al., Tokyo, Japan. In Nat Cell Biol, 2013
Although TOG was recently characterized as a microtubule polymerase, Dis1 (the other TOG orthologue in fission yeast), together with the Dam1 complex, plays a role in microtubule shortening to pull kinetochores polewards.
Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG.
GeneRIF
Brodsky et al., San Francisco, United States. In J Cell Biol, 2012
Clathrin promotes centrosome maturation by stabilizing the microtubule-binding protein ch-TOG, defining a novel role for the clathrin-ch-TOG complex.
A TOG:αβ-tubulin complex structure reveals conformation-based mechanisms for a microtubule polymerase.
Impact
Rice et al., Dallas, United States. In Science, 2012
Stu2p/XMAP215/Dis1 family proteins are evolutionarily conserved regulatory factors that use αβ-tubulin-interacting tumor overexpressed gene (TOG) domains to catalyze fast microtubule growth.
The role of clathrin in mitotic spindle organisation.
Review
Royle, Liverpool, United Kingdom. In J Cell Sci, 2012
This mitotic function is unrelated to the role of clathrin in membrane trafficking and occurs in partnership with two other spindle proteins: transforming acidic coiled-coil protein 3 (TACC3) and colonic hepatic tumour overexpressed gene (ch-TOG; also known as cytoskeleton-associated protein 5, CKAP5).
The microtubule lattice and plus-end association of Drosophila Mini spindles is spatially regulated to fine-tune microtubule dynamics.
GeneRIF
Rogers et al., Chapel Hill, United States. In Mol Biol Cell, 2011
Msps exhibits EB1-dependent and spatially regulated microtubule localization, targeting to microtubule plus ends in the cell interior and decorating the lattice of growing and shrinking microtubules in the cell periphery
A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells.
GeneRIF
Dedhar et al., Vancouver, Canada. In Oncogene, 2011
Data show that ILK performs its centrosome clustering activity in a centrosome-dependent, manner through the microtubule regulating proteins TACC3 and ch-TOG.
Parallel genetic and proteomic screens identify Msps as a CLASP-Abl pathway interactor in Drosophila.
GeneRIF
Zhan et al., Boston, United States. In Genetics, 2010
Data suggest a model in which CLASP and Msps converge in an antagonistic balance in the Abl signaling pathway.
Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability.
GeneRIF
Shih et al., Taipei, Taiwan. In J Cell Biol, 2010
the association between aurora A phosphorylation and spindle apparatus; regulation from aurora A is mediated by CHC in recruiting phospho-TACC3 and subsequently ch-TOG to mitotic spindles.
Msps/XMAP215 interacts with the centrosomal protein D-TACC to regulate microtubule behaviour.
Impact
Raff et al., Cambridge, United Kingdom. In Nat Cell Biol, 2001
The XMAP215/ch-TOG/Msps family of microtubule-associated proteins (MAPs) promote microtubule growth in vitro and are concentrated at centrosomes in vivo.
Msps protein is localized to acentrosomal poles to ensure bipolarity of Drosophila meiotic spindles.
Impact
Ohkura et al., Edinburgh, United Kingdom. In Nat Cell Biol, 2001
The acentrosomal poles contain at least two proteins, Mini-spindles (Msps) and D-TACC, which are also associated with mitotic centrosomes.
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