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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Microseminoprotein, beta-

MSP, E2F2, MST1, gp63
The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: POLYMERASE, CAN, HAD, AGE, OUT
Papers using MSP antibodies
Epithelial Hic-5/ARA55 expression contributes to prostate tumorigenesis and castrate responsiveness
Supplier
Moreno Carlos S et al., In BMC Cancer, 2010
... Methylation specific PCR (MSP)DNA was extracted using the DNeasy Blood and Tissue Kit (Qiagen, Valencia, CA) ...
Bacterial community structure along moisture gradients in the parafluvial sediments of two ephemeral desert streams
Supplier
Crump Byron C. et al., In Frontiers in Microbiology, 2010
... MspI, AluI, and HinP1I (New England BioLabs, Beverly, MA, USA) ...
Nematodes from an English chalk grassland - species distributions.
Supplier
Bell Thomas, In PLoS ONE, 2006
... MspI (New England Biolabs, Ipswich, MA, USA) at ...
Assay for redox-sensitive transcription factor.
Supplier
Hartl Dominik, In PLoS ONE, 1999
... Antibodies against COX-2, iNOS, Bcl-XL, Bax, GAPDH, cyclin-D1 and E2F2 were from Santa Cruz Biotechnology Inc ...
Papers on MSP
Severe Plasmodium falciparum malaria: targets and mechanisms associated with protection in Kenyan children.
New
Osier et al., Kilifi, Kenya. In Infect Immun, Feb 2016
We quantified immunological parameters in serum collected before the SM event in cases and their individually matched controls to evaluate the prospective odds of developing SM in the first two years of life.Anti-AMA1 antibodies were associated with a significant reduction in the odds of developing SM (OR 0.37, 95% CI 0.15 - 0.90, P=0.029) after adjustment for responses to all other merozoite antigens tested, whilst those against MSP-2, MSP-3, PfRh2, MSP-119 and the infected red blood cell surface were not.
Glycolic Acid Silences Inflammasome Complex Genes, NLRC4 and ASC, by Inducing DNA Methylation in HaCaT Cells.
New
Yang et al., Taiwan. In Dna Cell Biol, Feb 2016
Methylation changes were detected in these genes following treatment with DNA methyltransferase (DNMT) inhibitor 5-aza-2'-deoxycytidine (5-Aza) with or without the addition of GA using methylation-specific PCR (MSP).
Structural Aspects of Multistep Phosphorelay-Mediated Signaling in Plants.
Review
New
Hejátko et al., České Budějovice, Czech Republic. In Mol Plant, Feb 2016
The multistep phosphorelay (MSP) is a central signaling pathway in plants integrating a wide spectrum of hormonal and environmental inputs and controlling numerous developmental adaptations.
Integrated genomic characterization of IDH1-mutant glioma malignant progression.
New
Impact
Günel et al., New Haven, United States. In Nat Genet, Jan 2016
These include activation of the MYC and RTK-RAS-PI3K pathways and upregulation of the FOXM1- and E2F2-mediated cell cycle transitions, as well as epigenetic silencing of developmental transcription factor genes bound by Polycomb repressive complex 2 in human embryonic stem cells.
C-Terminal Auto-Regulatory Motif of Hepatitis C Virus NS5B Interacts with Human VAPB-MSP to Form a Dynamic Replication Complex.
New
Song et al., Singapore, Singapore. In Plos One, Dec 2015
Here by an integrated use of domain dissection and NMR spectroscopy, for the first time we have successfully deciphered that the HCV NS5B utilizes its auto-regulatory C-linker to bind the VAPB-MSP domain to form a dynamic complex.
Prognostic Significance of Promoter DNA Hypermethylation of cysteine dioxygenase 1 (CDO1) Gene in Primary Breast Cancer.
New
Watanabe et al., Sagamihara, Japan. In Plos One, Dec 2015
The CDO1 DNA methylation was quantified by TaqMan methylation specific PCR (Q-MSP) in 7 BC cell lines and 172 primary BC patients with no prior chemotherapy.
YAP and TAZ Take Center Stage in Cancer.
Review
New
Hong et al., Tianjin, China. In Biochemistry, Dec 2015
In the Hippo pathway, MST1/2 and LATS1/2 regulate downstream transcription coactivators YAP and TAZ, which mainly interact with TEAD family transcription factors to promote tissue proliferation, self-renewal of normal and cancer stem cells, migration, and carcinogenesis.
Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study.
New
Impact
Lees et al., Cambridge, United Kingdom. In Lancet, Nov 2015
Three loci (NOD2, MHC, and MST1 3p21) were associated with subphenotypes of inflammatory bowel disease, mainly disease location (essentially fixed over time; median follow-up of 10·5 years).
Hippo and TGF-β interplay in the lung field.
Review
New
Nagase et al., Tokyo, Japan. In Am J Physiol Lung Cell Mol Physiol, Nov 2015
The Hippo pathway is comprised of a kinase cascade that involves mammalian Ste20-like serine/threonine kinases (MST1/2) and large tumor suppressor kinases (LATS1/2) and leads to inactivation of transcriptional coactivator with PDZ-binding motif (TAZ) and yes-associated protein (YAP).
MST kinases in development and disease.
Review
New
Sahai et al., London, United Kingdom. In J Cell Biol, Oct 2015
The mammalian MST kinase family, which is related to the Hippo kinase in Drosophila melanogaster, includes five related proteins: MST1 (also called STK4), MST2 (also called STK3), MST3 (also called STK24), MST4, and YSK1 (also called STK25 or SOK1).
Leishmania survival in the macrophage: where the ends justify the means.
Review
New
Descoteaux et al., Canada. In Curr Opin Microbiol, Aug 2015
The GP63 metalloprotease, which disables key microbicidal pathways, has recently been found to disrupt processes ranging from antigen cross-presentation to nuclear pore dynamics.
Dual role of YAP and TAZ in renewal of the intestinal epithelium.
Impact
Nishida et al., Kyoto, Japan. In Nat Cell Biol, 2015
These functions of YAP/TAZ are regulated by the upstream Hippo pathway kinases MST1/2 and LATS1/2.
MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes.
Impact
Maedler et al., Bremen, Germany. In Nat Med, 2014
Here, we identified mammalian sterile 20-like kinase-1 (MST1) as a critical regulator of apoptotic beta cell death and function.
Extent and Mode of Action of Cationic Legume Proteins against Listeria monocytogenes and Salmonella Enteritidis.
Al-Gaby et al., Az Zaqāzīq, Egypt. In Probiotics Antimicrob Proteins, 2013
The methylated soybean protein and methylated chickpea protein (MSP and MCP) with isoelectric points around pI 8 were prepared by esterifying 83 % of their free carboxyl groups and tested for their interactions with Listeria monocytogenes and Salmonella Enteritidis.
MSP-RON signalling in cancer: pathogenesis and therapeutic potential.
Review
Impact
Wang et al., Hangzhou, China. In Nat Rev Cancer, 2013
Since the discovery of MSP (macrophage-stimulating protein; also known as MST1 and hepatocyte growth factor-like (HGFL)) as the ligand for the receptor tyrosine kinase RON (also known as MST1R) in the early 1990s, the roles of this signalling axis in cancer pathogenesis has been extensively studied in various model systems.
Promoter variants in the MSMB gene associated with prostate cancer regulate MSMB/NCOA4 fusion transcripts.
GeneRIF
Dean et al., Frederick, United States. In Hum Genet, 2012
Computational network analysis reveals that the MSMB gene is functionally connected to NCOA4 and the androgen receptor signaling pathway. The data provide an example of how GWAS-associated variants may have multiple genetic and epigenetic effects
The mechanism of pre-transfer editing in yeast mitochondrial threonyl-tRNA synthetase.
GeneRIF
Simonovic et al., New Haven, United States. In J Biol Chem, 2012
the plasticity of the aminoacylation site in MST1 allows binding of Ser-AMP and the appropriate positioning of the hydrolytic water molecule.
Threonine-120 phosphorylation regulated by phosphoinositide-3-kinase/Akt and mammalian target of rapamycin pathway signaling limits the antitumor activity of mammalian sterile 20-like kinase 1.
GeneRIF
Cinar et al., Los Angeles, United States. In J Biol Chem, 2012
Data suggest that phosphoinositide-3-kinase/Akt and mammalian target of rapamycin (mTOR) pathway signaling differentially regulate phospho-Mst1-Thr-120/Thr-183.
Fine mapping and replication of genetic risk loci in primary sclerosing cholangitis.
GeneRIF
Melum et al., Cambridge, United Kingdom. In Scand J Gastroenterol, 2012
The present results refine the known genetic architecture in primary sclerosing cholangitis by confirming MST1 locus association.
Molecular markers associated with nonepithelial ovarian cancer in formalin-fixed, paraffin-embedded specimens by genome wide expression profiling.
GeneRIF
Mokhtar et al., Kuala Lumpur, Malaysia. In Kaohsiung J Med Sci, 2012
Overexpression of E2F transcription factor 2 is associated with nonepithelial ovarian cancer.
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