Severe Plasmodium falciparum malaria: targets and mechanisms associated with protection in Kenyan children.
Kilifi, Kenya. In Infect Immun, Feb 2016
We quantified immunological parameters in serum collected before the SM event in cases and their individually matched controls to evaluate the prospective odds of developing SM in the first two years of life.Anti-AMA1 antibodies were associated with a significant reduction in the odds of developing SM (OR 0.37, 95% CI 0.15 - 0.90, P=0.029) after adjustment for responses to all other merozoite antigens tested, whilst those against MSP-2, MSP-3, PfRh2, MSP-119 and the infected red blood cell surface were not.
Integrated genomic characterization of IDH1-mutant glioma malignant progression.
New Haven, United States. In Nat Genet, Jan 2016
These include activation of the MYC and RTK-RAS-PI3K pathways and upregulation of the FOXM1- and E2F2-mediated cell cycle transitions, as well as epigenetic silencing of developmental transcription factor genes bound by Polycomb repressive complex 2 in human embryonic stem cells.
YAP and TAZ Take Center Stage in Cancer.
Tianjin, China. In Biochemistry, Dec 2015
In the Hippo pathway, MST1/2 and LATS1/2 regulate downstream transcription coactivators YAP and TAZ, which mainly interact with TEAD family transcription factors to promote tissue proliferation, self-renewal of normal and cancer stem cells, migration, and carcinogenesis.
Hippo and TGF-β interplay in the lung field.
Tokyo, Japan. In Am J Physiol Lung Cell Mol Physiol, Nov 2015
The Hippo pathway is comprised of a kinase cascade that involves mammalian Ste20-like serine/threonine kinases (MST1/2) and large tumor suppressor kinases (LATS1/2) and leads to inactivation of transcriptional coactivator with PDZ-binding motif (TAZ) and yes-associated protein (YAP).
MST kinases in development and disease.
London, United Kingdom. In J Cell Biol, Oct 2015
The mammalian MST kinase family, which is related to the Hippo kinase in Drosophila melanogaster, includes five related proteins: MST1 (also called STK4), MST2 (also called STK3), MST3 (also called STK24), MST4, and YSK1 (also called STK25 or SOK1).
MSP-RON signalling in cancer: pathogenesis and therapeutic potential.
Hangzhou, China. In Nat Rev Cancer, 2013
Since the discovery of MSP (macrophage-stimulating protein; also known as MST1 and hepatocyte growth factor-like (HGFL)) as the ligand for the receptor tyrosine kinase RON (also known as MST1R) in the early 1990s, the roles of this signalling axis in cancer pathogenesis has been extensively studied in various model systems.