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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Salt-inducible kinase 1

MSK, Brk, SIK, PTK6, muskelin
inhibits CREB binding and transcription of cAMP-responsive element (CRE)-dependent genes Cyp11A and Star [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, MSK1, V1a, CREB, HAD
Papers using MSK antibodies
In vivo identification of lymphocyte subsets exhibiting transcriptionally active NF-kappaB/Rel complexes.
Supplier
Blanke Steven R., In PLoS Pathogens, 1999
... histone H3 (ab1791), acetyl-histone H3 (H3AcK9, ab4441), methyl-histone H3 (H3me3K4, ab8580) and (H3me3K9, ab8898) and MSK-2 (ab42101) were from Abcam (Cambridge, USA) ...
Papers on MSK
The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer.
New
Impact
Yang et al., Houston, United States. In Nat Cell Biol, Feb 2016
Here, we identify a cytoplasmic lncRNA, LINK-A (long intergenic non-coding RNA for kinase activation), which mediates HB-EGF-triggered, EGFR:GPNMB heterodimer-dependent HIF1α phosphorylation at Tyr 565 and Ser 797 by BRK and LRRK2, respectively.
Identification of Targetable Kinase Alterations in Patients with Colorectal Carcinoma that are Preferentially Associated with Wild Type RAS/RAF.
New
Ladanyi et al., Kettering, United States. In Mol Cancer Res, Jan 2016
We investigated receptor tyrosine kinase (RTK) alterations and MAP2K1 (MEK1) mutations in a large cohort of CRC patients studied by MSK-IMPACT and TCGA, focusing on amplifications, fusions, and hotspot mutations in RTK genes and MAP2K1.
SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype.
New
Gabay et al., Genève, Switzerland. In J Leukoc Biol, Dec 2015
The expression and function of salt-inducible kinase in primary human myeloid cells are poorly characterized.
The critical role of Akt in cardiovascular function.
Review
New
Su et al., Augusta, United States. In Vascul Pharmacol, Nov 2015
Ack1, Src, PTK6, TBK1, IKBKE and IKKε are some of the non-canonical pathways which affect the Akt activity.
Angiotensin Converting Enzyme Inhibitor-related Angioedema: A Case of an Unexpected Death.
New
Gey et al., Kars, Turkey. In Iran J Allergy Asthma Immunol, Nov 2015
The treatment of choice in angioedema including fresh frozen plasma, C1 inhibitor concentrations and BRK-2 antagonists (bradykinin B2 receptor antagonists) were used.
Tracing the footprints of the breast cancer oncogene BRK - Past till present.
Review
New
Lukong et al., Saskatoon, Canada. In Biochim Biophys Acta, Aug 2015
Twenty years have passed since the non-receptor tyrosine kinase, Breast tumor kinase (BRK) was cloned.
Botlhoko, botlhoko! How people talk about their musculoskeletal complaints in rural Botswana: a focused ethnography.
Johannessen et al., Odense, Denmark. In Glob Health Action, 2014
Understanding musculoskeletal (MSK) complaints presents additional complexities when discussed in more than one language or in cross-cultural settings.
Evolution of breast cancer therapeutics: Breast tumour kinase's role in breast cancer and hope for breast tumour kinase targeted therapy.
Review
Harvey et al., London, United Kingdom. In World J Clin Oncol, 2014
Over a number of years interest has risen in breast tumour kinase (Brk) also known as protein tyrosine kinase 6; the research field has grown and Brk has been described as a desirable therapeutic target in relation to tyrosine kinase inhibition as well as disruption of its kinase independent activity.
Recent progress on liver kinase B1 (LKB1): expression, regulation, downstream signaling and cancer suppressive function.
Review
Li et al., Hong Kong, Hong Kong. In Int J Mol Sci, 2013
LKB1 dowcnstream pathways mainly include AMPK, microtubule affinity regulating kinase (MARK), salt-inducible kinase (SIK), sucrose non-fermenting protein-related kinase (SNRK) and brain selective kinase (BRSK) signalings, etc.
The regulation and function of the NUAK family.
Review
Zhao et al., Taipei, Taiwan. In J Mol Endocrinol, 2013
Twelve AMPK-related kinases (ARKs; BRSK1, BRSK2, NUAK1, NUAK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4, and MELK) have been identified recently.
Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila.
Impact
Tapon et al., London, United Kingdom. In Nat Cell Biol, 2013
Activated Sik kinases increase Yki target expression and promote tissue overgrowth through phosphorylation of Sav at Ser 413.
Identification of PTK6, via RNA sequencing analysis, as a suppressor of esophageal squamous cell carcinoma.
GeneRIF
Guan et al., Hong Kong, Hong Kong. In Gastroenterology, 2012
PTK6 was identified as a transcript that is down-regulated in human esophageal squamous cell carcinoma via epigenetic modification at the PTK6 locus.
Integration of global spectral karyotyping, CGH arrays, and expression arrays reveals important genes in the pathogenesis of glioblastoma multiforme.
GeneRIF
García et al., Salamanca, Spain. In Ann Surg Oncol, 2012
High SIK gene expression is assiciated with glioblastoma multiforme.
Suppressor of cytokine signaling 3 inhibits breast tumor kinase activation of STAT3.
GeneRIF
Reich et al., Stony Brook, United States. In J Biol Chem, 2012
Suppressor of cytokine signaling 3 inhibits breast tumor kinase activation of STAT3.
Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase.
GeneRIF
Moustakas et al., Uppsala, Sweden. In J Biol Chem, 2012
We now demonstrate that TGFbeta induces SIK1 levels via a direct transcriptional mechanism that implicates the Smad proteins, and we have mapped a putative enhancer element on the SIK1 gene.
Salt-inducible kinase is involved in the regulation of corticotropin-releasing hormone transcription in hypothalamic neurons in rats.
GeneRIF
Aguilera et al., Bethesda, United States. In Endocrinology, 2012
SIK2 mediates TORC2 inactivation in basal conditions, whereas induction of SIK1 limits transcriptional activation in the hypothalamic paraventricular nucleus
The nuts and bolts of AGC protein kinases.
Review
Impact
Alessi et al., Dundee, United Kingdom. In Nat Rev Mol Cell Biol, 2010
The family comprises some intensely examined protein kinases (such as Akt, S6K, RSK, MSK, PDK1 and GRK) as well as many less well-studied enzymes (such as SGK, NDR, LATS, CRIK, SGK494, PRKX, PRKY and MAST).
Estimation of Absolute Free Energies of Hydration Using Continuum Methods:  Accuracy of Partial Charge Models and Optimization of Nonpolar Contributions.
Kuntz et al., San Francisco, United States. In J Chem Theory Comput, 2006
The best overall PBSA and GBSA results, in comparison with experimental ΔGhyd values for small molecules, were obtained using MSK, RESP, or ChelpG charges obtained from ab initio calculations using 6-31G* wave functions.
Conversion of an extracellular Dpp/BMP morphogen gradient into an inverse transcriptional gradient.
Impact
Basler et al., Zürich, Switzerland. In Cell, 2003
Throughout development, Dpp transduction causes the graded transcriptional downregulation of the brinker (brk) gene.
Cells compete for decapentaplegic survival factor to prevent apoptosis in Drosophila wing development.
Impact
GeneRIF
Morata et al., Zürich, Switzerland. In Nature, 2002
Cells compete for decapentaplegic survival factor to prevent apoptosis in Drosophila wing development
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