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Musashi homolog 2

Msi2, Musashi2
This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Musashi-1, Numb, HAD, FATE, CAN
Papers using Msi2 antibodies
Assessing differentiation status of human embryonic stem cells noninvasively using Raman microspectroscopy
Supplier
Johnson J D et al., In Cell Death & Disease, 2009
... Msi2 were purchased from OriGene (Rockville, MD, USA) ...
Papers on Msi2
Musashi2 as a novel predictive biomarker for liver metastasis and poor prognosis in colorectal cancer.
New
Chen et al., Guangzhou, China. In Cancer Med, Feb 2016
UNASSIGNED: Aberrant expression of musashi2 (MSI-2) has been detected in several malignancies.
The Msi Family of RNA-Binding Proteins Function Redundantly as Intestinal Oncoproteins.
New
Lengner et al., Beijing, China. In Cell Rep, Jan 2016
MSI2 is highly expressed in hematopoietic cancers, where it is required for disease maintenance.
Prognostic significance of the Musashi-2 (MSI2) gene in childhood acute lymphoblastic leukemia.
New
Tang et al., In Neoplasma, Dec 2015
The prognostic value of the Musashi-2 (MSI2) gene has not yet been studied in childhood acute lymphoblastic leukemia (ALL).
RNA binding proteins in spermatogenesis: an in depth focus on the Musashi family.
Review
New
McLaughlin et al., Newcastle, Australia. In Asian J Androl, Jul 2015
We emphasize the historical role of the Musashi family of RBPs in stem cell function and cell fate determination, as originally characterized in Drosophila and Xenopus, and conclude with our current understanding of the differential roles and functions of the mammalian Musashi proteins, Musashi-1 and Musashi-2, with a primary focus on our findings in spermatogenesis.
Identify the signature genes for diagnose of uveal melanoma by weight gene co-expression network analysis.
Zhang et al., China. In Int J Ophthalmol, 2014
The hub gene RPS15A, PTGDS, CD53 and MSI2 might play a vital role in progress of uveal melanoma.
[Estimation of vegetation water content from Landsat 8 OLI data].
Zhang et al., In Guang Pu Xue Yu Guang Pu Fen Xi, 2014
The results show that: (1) red, near infrared and two shortwave infrared bands of OLI sensor are sensitive to the change in vegetation water content, and near infrared band is the most sensitive one; (2) At low vegetation coverage, solar radiation reflected by soil background will reach to spectral sensor and influence the relationship between vegetation water index and vegetation water content, and simulation results from ProSail model also show that soil background reflectance has a significant impact on vegetation canopy reflectance in both wet and dry soil conditions, so the optimized soil adjusted vegetation index (OSAVI) was used in this paper to remove the effect of soil background on vegetation water index and improve its relationship with vegetation water content; (3) for the 12 vegetation water indices, the relationship between MSI2 and vegetation water content is the best with the R-square of 0.948 and the average error of vegetation water content is 0.52 kg · m(-2); (4) it is difficult to estimate vegetation water content from vegetation water indices when vegetation water content is larger than 2 kg · m(-2) due to spectral saturation of these indices.
Musashi-2 Silencing Exerts Potent Activity against Acute Myeloid Leukemia and Enhances Chemosensitivity to Daunorubicin.
Zhang et al., Wenzhou, China. In Plos One, 2014
RNA-binding protein Musashi-2 (Msi2) is known to play a critical role in leukemogenesis and contributes to poor clinical prognosis in acute myeloid leukemia (AML).
Knockout of RNA Binding Protein MSI2 Impairs Follicle Development in the Mouse Ovary: Characterization of MSI1 and MSI2 during Folliculogenesis.
McLaughlin et al., Newcastle, Australia. In Biomolecules, 2014
In this study we determined the expression of mammalian Musashi proteins MSI1 and MSI2 during mouse folliculogenesis, and through the use of a MSI2-specific knockout mouse model we identified that MSI2 is essential for normal follicle development.
Musashi-2 promotes hepatitis Bvirus related hepatocellular carcinoma progression via the Wnt/β-catenin pathway.
Peng et al., Jinan, China. In Am J Cancer Res, 2014
Our recent study observed that the expression of Musashi-2 (MSI2), a member of the Musashi family, was up-regulated in hepatitis B virus (HBV) related hepatocellular carcinoma parenchymal cells.
Specificity factors in cytoplasmic polyadenylation.
Review
de Moor et al., Denver, United States. In Wiley Interdiscip Rev Rna, 2013
In addition to describing the role of general polyadenylation factors, we discuss the specific RNA binding protein families associated with cytoplasmic polyadenylation elements, including CPEB (CPEB1, CPEB2, CPEB3, and CPEB4), Pumilio (PUM2), Musashi (MSI1, MSI2), zygote arrest (ZAR2), ELAV like proteins (ELAVL1, HuR), poly(C) binding proteins (PCBP2, αCP2, hnRNP-E2), and Bicaudal C (BICC1).
Distinct expression profiles of MSI2 and NUMB genes in myelodysplastic syndromes and acute myeloid leukemia patients.
GeneRIF
Favaro et al., Campinas, Brazil. In Leuk Res, 2012
Down-modulation of MSI2 is associated with myelodysplastic syndromes and acute myeloid leukemia.
Musashi2 is required for the self-renewal and pluripotency of embryonic stem cells.
GeneRIF
Rizzino et al., Omaha, United States. In Plos One, 2011
Ectopic expression of Musashi 2 isoform 1, but not isoform 2, enhanced the cloning efficiency of embryonic stem cells, but both isoforms were required for the self-renewal of embryonic stem cells.
A de novo 3.54 Mb deletion of 17q22-q23.1 associated with hydrocephalus: a case report and review of literature.
Review
Bhandari et al., New Haven, United States. In Am J Med Genet A, 2011
We describe a female newborn with a de novo 3.54 megabase (Mb) deletion of 17q22-q23.1 (chr17:53,072,536-56,612,662, hg18) including genes from MSI2 to BCAS3 detected by oligonucleotide array comparative genomic hybridization (aCGH).
MSI2 protein expression predicts unfavorable outcome in acute myeloid leukemia.
GeneRIF
Kutok et al., Manchester, United Kingdom. In Blood, 2011
High MSI2 is associated with acute myeloid leukemia.
Translational control in germ cell development: A role for the RNA-binding proteins Musashi-1 and Musashi-2.
Review
McLaughlin et al., Newcastle, Australia. In Iubmb Life, 2011
Mammalian gametogenesis is a complex process involving specialised cell cycle progression and differentiation.
Musashi 2 is a regulator of the HSC compartment identified by a retroviral insertion screen and knockout mice.
GeneRIF
Graf et al., Barcelona, Spain. In Blood, 2011
Our data indicate that Msi2 maintains the stem cell compartment mainly by regulating the proliferation of primitive progenitors downstream of long term hematopoietic stem cells
Roles for MSI2 and PROX1 in hematopoietic stem cell activity.
Review
Sauvageau et al., Montréal, Canada. In Curr Opin Hematol, 2011
PURPOSE OF REVIEW: The MSI2 and PROX1 proteins are increasingly recognized for their critical roles in the biology of primitive hematopoietic cells and for their potential contributions to leukemic pathogenesis.
Musashi expression in β-cells coordinates insulin expression, apoptosis and proliferation in response to endoplasmic reticulum stress in diabetes.
GeneRIF
Johnson et al., Vancouver, Canada. In Cell Death Dis, 2010
Overexpression of MSI2 resulted in a decrease in MSI1 expression.
Regulation of myeloid leukaemia by the cell-fate determinant Musashi.
Impact
GeneRIF
Reya et al., Durham, United States. In Nature, 2010
Msi2 expression is not only highly upregulated during human chronic myeloid leukemia progression but is also an early indicator of poorer prognosis
Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia.
Impact
GeneRIF
Daley et al., Boston, United States. In Nat Med, 2010
Expression levels in human myeloid leukemia directly correlate with decreased survival in patients, defining MSI2 as a new prognostic marker and new target for therapy.
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