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MutS homolog 4

MSH4, Msh4p
This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: MSH5, proopiomelanocortin, MLH1, CAN, ACID
Papers on MSH4
Cattle Sex-Specific Recombination and Genetic Control from a Large Pedigree Analysis.
New
Wiggans et al., Saint Paul, United States. In Plos Genet, Nov 2015
Two novel loci, NEK9 and REC114, were associated with recombination rate in both sexes, whereas three loci, MSH4, SMC3 and CEP55, affected recombination rate in females only.
Synthesis and bioactivity of MSH4 oligomers prepared by an A2 + B2 strategy.
New
Mash et al., Tucson, United States. In Tetrahedron Lett, Jul 2015
UNASSIGNED: Oligomers incorporating the tetrapeptide MSH4, the minimum active sequence of melanocyte stimulating hormone, were synthesized by an A2 + B2 strategy involving microwave-assisted copper-catalyzed azide-alkyne cycloaddition.
Variation in crossover frequencies perturb crossover assurance without affecting meiotic chromosome segregation in Saccharomyces cerevisiae.
New
Nishant et al., Thiruvananthapuram, India. In Genetics, Feb 2015
In Saccharomyces cerevisiae and mammals, Msh4 and Msh5 proteins stabilize Holliday junctions and its progenitors to facilitate crossing over.
Crossover formation during rice meiosis relies on interaction of OsMSH4 and OsMSH5.
Cheng et al., Beijing, China. In Genetics, 2014
MSH4 encodes a MutS protein that plays a specialized role in meiosis.
TP53, MSH4, and LATS1 germline mutations in a family with clustering of nervous system tumors.
Ohgaki et al., Lyon, France. In Am J Pathol, 2014
Missense mutations in the MSH4 DNA repair gene (c.2480T>A;
MBD4 cooperates with DNMT1 to mediate methyl-DNA repression and protects mammalian cells from oxidative stress.
Defossez et al., Paris, France. In Epigenetics, 2014
We identified two new binding sites for MBD4 and DNMT1 at methylated CpG islands of CDKN1A/p21 and MSH4, where they synergistically mediate transcriptional repression.
Variation in genome-wide levels of meiotic recombination is established at the onset of prophase in mammalian males.
Hassold et al., Madison, United States. In Plos Genet, 2014
We utilized immunofluorescence to analyze the number and distribution of proteins that function at different stages in the recombination pathway: RAD51 and DMC1, strand invasion proteins acting shortly after double-strand break (DSB) formation, MSH4, part of the complex stabilizing double Holliday junctions, and the Bloom helicase BLM, thought to have anti-crossover activity.
[Detecting testis- and epididymis-specific methylated promoters in human cell-free seminal DNA by MeDIP-qPCR].
Xiong et al., Wuhan, China. In Zhonghua Nan Ke Xue, 2013
RESULTS: The methylation levels of the promoters PRAME, PEG10, MORC1, GML, HOXA5, DNMT3L, SNURF, MSH4, DAZ1 and CLPB were 14.93, 2.64, 0.69, 2.66, 17.50, 21.10, 5.98, 2.28, 13.50 and 3.86%, respectively, in the NZ group, obviously lower than 121.25, 73.62, 16.25, 42.90, 76.74, 112.40, 59.79, 25.85, 91.90 and 64.53% in the PV group.
RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis.
Impact
Hunter et al., Davis, United States. In Nat Genet, 2013
RNF212 acts at these sites to stabilize meiosis-specific recombination factors, including the MutSγ complex (MSH4-MSH5).
Mutation analysis of three genes in patients with maturation arrest of spermatogenesis and couples with recurrent miscarriages.
GeneRIF
Lissens et al., Brussels, Belgium. In Reprod Biomed Online, 2011
mutation analysis of SYCP3, DNMT3L and MSH4 in patients with maturation arrest of spermatogenesis and couples with recurrent miscarriages
Genetic analysis of baker's yeast Msh4-Msh5 reveals a threshold crossover level for meiotic viability.
GeneRIF
Alani et al., Ithaca, United States. In Plos Genet, 2010
Msh4 and msh5 mutants displayed reduced crossing over in meiosis but maintained wild-type spore viability.
Temperature-dependent modulation of chromosome segregation in msh4 mutants of budding yeast.
GeneRIF
Hoffmann et al., Burgess Hill, United Kingdom. In Plos One, 2008
analysis of temperature-dependent modulation of chromosome segregation in msh4 mutants of budding yeast
[Genetics and male infertility].
Review
Lissens et al., Brussels, Belgium. In Verh K Acad Geneeskd Belg, 2008
We also studied five autosomal genes: SYCP3, MSH4, DNMT3L, STRA8 and ETV5.
hMSH4-hMSH5 adenosine nucleotide processing and interactions with homologous recombination machinery.
GeneRIF
Fishel et al., Philadelphia, United States. In J Biol Chem, 2008
Data have identified the interaction region between the individual subunits of hMSH4-hMSH5 that are likely involved in clamp formation and show that each subunit of the heterodimer binds ATP.
Genetic investigation of four meiotic genes in women with premature ovarian failure.
GeneRIF
Fellous et al., Jouy-le-Moutier, France. In Eur J Endocrinol, 2008
Data show that there is no association between MSH4 gene mutation and premature ovarian failure.
[NIe(4),Asp(5),d-Phe(7), (67)Ga/(68)Ga-1,4,7,10-tetraazacyclododecane-N,N’,N’’,N’’’-1,4,7,10-tetraacetic acid-Lys(11)]-α-MSH4-11
Review
Cheng, Bethesda, United States. In Unknown Journal, 2007
[NIe(4),Asp(5),d-Phe(7), (67)Ga/(68)Ga-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid- Lys(11)]-α-MSH4-11 ((67)Ga/(68)Ga-NAPamide) is a radioligand developed as a molecular imaging probe for primary and metastatic melanoma (1).
Genetics of meiotic prophase I in plants.
Review
Impact
Cande et al., Berkeley, United States. In Annu Rev Plant Biol, 2005
In the past two years, a number of components involved in this pathway, including Structure Maintenance of Chromosomes (SMC), MRE11, the RAD51 homologs, BRCA2, MSH4, MER3, and ZIP1, have been characterized in plants; in addition, several genes that encode components unique to plants, such as POOR HOMOLOGOUS SYNAPSIS 1 and AMEIOTIC 1, have been cloned.
[Homologs of MutS and MutL during mammalian meiosis].
Review
Paquis-Flucklinger et al., Nice, France. In Med Sci (paris), 2003
During mammalian meiosis, it is likely that chromosome synapsis requires the presence of a MSH4-MSH5 heterodimer.
[Human infertility: meiotic genes as potential candidates].
Review
Fellous et al., Jouy-le-Moutier, France. In Gynecol Obstet Fertil, 2002
For this purpose, the exons of these 5 genes (DMC1, SPO11, MSH4, MSH5, CCNA1) were all amplified by PCR with specific primers and each amplified-exon was sequenced.
Mutation of a meiosis-specific MutS homolog decreases crossing over but not mismatch correction.
Impact
Roeder et al., New Haven, United States. In Cell, 1995
MSH4 is a novel meiosis-specific gene required for wild-type levels of spore viability in S. cerevisiae.
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