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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Membrane-spanning 4-domains, subfamily A, member 12

MS4A12
The protein encoded by this gene is a cell surface protein found primarily in the apical membrane of colonocytes. Silencing of this gene in colon cancer cells inhibits the proliferation, cell motility, and chemotactic invasion of cells. This gene is part of a cluster of similar genes found on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009] (from NCBI)
Top mentioned proteins: CD20, CDX2, Cdx1, IgE, FCER1B
Papers on MS4A12
Global gene expression in pseudomyxoma peritonei, with parallel development of two immortalized cell lines.
New
Renehan et al., Manchester, United Kingdom. In Oncotarget, Jun 2015
The array analysis identified 27 up-regulated and 34 down-regulated genes: candidate up-regulated genes included SLC16A4, DSC3, Aldolase B, EPHX4, and ARHGAP24; candidate down-regulated genes were MS4A12, TMIGD1 and Caspase-5.
Predictive gene signatures: molecular markers distinguishing colon adenomatous polyp and carcinoma.
Carey et al., Dundee, United Kingdom. In Plos One, 2013
The hCellMarkerPlex incorporates twenty-one gene markers: epithelial (EZR, KRT18, NOX1, SLC9A2), proliferation (PCNA, CCND1, MS4A12), differentiation (B4GANLT2, CDX1, CDX2), apoptotic (CASP3, NOX1, NTN1), fibroblast (FSP1, COL1A1), structural (ACTG2, CNN1, DES), gene transcription (HDAC1), stem cell (LGR5), endothelial (VWF) and mucin production (MUC2).
Single-cell dissection of transcriptional heterogeneity in human colon tumors.
Impact
Quake et al., Stanford, United States. In Nat Biotechnol, 2011
We develop two-gene classifier systems (KRT20 versus CA1, MS4A12, CD177, SLC26A3) that predict clinical outcomes with hazard ratios superior to those of pathological grade and comparable to those of microarray-derived multigene expression signatures.
Selective activation of tumor growth-promoting Ca2+ channel MS4A12 in colon cancer by caudal type homeobox transcription factor CDX2.
GeneRIF
Sahin et al., Mainz, Germany. In Mol Cancer, 2008
RNA interference of CDX1 and CDX2 and chromatin immunoprecipitation in colon cancer cells revealed that MS4A12 transcript and protein expression is essentially dependent on the presence of endogenous CDX2.
MS4A12 is a colon-selective store-operated calcium channel promoting malignant cell processes.
GeneRIF
Türeci et al., Mainz, Germany. In Cancer Res, 2008
MS4A12 is a colon-selective store-operated calcium channel promoting malignant cell processes.
Structural organization of the human MS4A gene cluster on Chromosome 11q12.
Tedder et al., Durham, United States. In Immunogenetics, 2001
Recently, 16 novel human and mouse genes were identified that encode new members of this nascent protein family that we have named the membrane-spanning 4A gene family, with at least 12 subgroups (MS4A1-MS4A12).
Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse.
Tedder et al., Durham, United States. In Genomics, 2001
This family was therefore named the membrane-spanning 4A gene family, with at least 12 subgroups (MS4A1 through MS4A12) currently representing at least 21 distinct human and mouse proteins.
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