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ADAM metallopeptidase domain 8

ms2, ADAM8
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009] (from NCBI)
Top mentioned proteins: HAD, CAN, AGE, ACID, metalloprotease
Papers on ms2
Magnetic Separation-Assistant Fluorescence Resonance Energy Transfer Inhibition for Highly Sensitive Probing of Nucleolin.
New
Wang et al., Tianjin, China. In Anal Chem, Jan 2016
Compared to nonseparation FRET inhibition, the separation of free Cy5.5-AS1411 from Cy5.5-AS1411-Fe3O4@PPY solution (the first magnetic separation, MS-1) had as high as 25-fold enhancement of the sensitivity, whereas further separation of the nucleolin-inducing far-between Fe3O4@PPY from the FRET inhibition solution (the second magnetic separation, MS-2) could further enhance the sensitivity to 35-fold.
Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform Localizes to Circulating Microvesicles.
New
Rabe et al., Kiel, Germany. In J Biol Chem, Nov 2015
Here, by quantification of serum sIL-6R in protease-deficient mice as well as human patients we also excluded ADAM10, ADAM8, neutrophil elastase, cathepsin G, and proteinase 3 from contributing to circulating sIL-6R.
Oral Contraceptives Attenuate Cardiac Autonomic Responses to Musical Auditory Stimulation: Pilot Study.
New
Valenti et al., In Altern Ther Health Med, Sep 2015
and (4) the LF (ms2) from 954.8 ± 457 ms2 to 686.2 ± 491 ms2 (P = .0024).
The Effect of ADAM8 on the Proliferation and Apoptosis of Hepatocytes and Hepatoma Carcinoma Cells.
New
Lu et al., Luoyang, China. In J Biochem Mol Toxicol, Sep 2015
UNASSIGNED: This study was undertaken to evaluate the effect of ADAM8 on the proliferation and apoptosis of hepatocytes and hepatoma carcinoma cells during hepatocellular carcinoma (HCC) progression.
[The DIEP Flap as Method of Choice in Breast Reconstruction - Results and Protocol for Succesful Reconstruction].
New
Munder et al., Düsseldorf, Germany. In Handchir Mikrochir Plast Chir, Aug 2015
MATERIALS AND METHODS: All patients who received an autologous breast reconstruction between January 2010 and January 2014 using free DIEP or free MS-2-TRAM flaps were included in the study.
Comparative analysis of gingival crevicular fluid a disintegrin and metalloproteinase 8 levels in health and periodontal disease: A clinic-biochemical study.
New
Mohandas et al., India. In J Pharm Bioallied Sci, Aug 2015
AIM AND BACKGROUND: A disintegrin and metalloproteinase 8 (ADAM8) is a marker belonging to the class of ADAM family of metalloproteinase which is found to be involved in inflammation and bone resorption in periodontal disease by acting as osteoclast stimulating factor.
ADAM-family metalloproteinases in lung inflammation: potential therapeutic targets.
Review
New
Ludwig et al., Aachen, Germany. In Am J Physiol Lung Cell Mol Physiol, Mar 2015
ADAM8, ADAM9, ADAM15, and ADAM33 are upregulated during acute or chronic lung inflammation, and recent functional or genetic analyses have linked them to disease development.
EpCAM-Independent Enrichment of Circulating Tumor Cells in Metastatic Breast Cancer.
Disseminated Cancer Cell Network (DCC Net) Duesseldorf et al., Düsseldorf, Germany. In Plos One, 2014
The expression of respective proteins (Trop2, CD49f, c-Met, CK8, CD44, ADAM8, CD146, TEM8, CD47) was verified by immunofluorescence on EpCAMpos (e.g.
PrP overdrive: does inhibition of α-cleavage contribute to PrP(C) toxicity and prion disease?
Review
Millhauser et al., Boston, United States. In Prion, 2014
In biophysical studies, we recently characterized the action of relevant members of the ADAM (A Disintegrin And Metalloproteinase) enzyme family (ADAM8, 10, and 17) and found that they all produce α-cleavage, but at 3 distinct cleavage sites, with proteolytic efficiency modulated by the physiologic metals copper and zinc.
Alemtuzumab in the treatment of multiple sclerosis.
Review
Fernandez, Málaga, Spain. In J Inflamm Res, 2013
Approval was granted on the strength of two pivotal studies, Comparison of Alemtuzumab and Rebif® Efficacy in Multiple Sclerosis (CARE-MS)-1 in the first-line setting and CARE-MS-2 in patients who had failed first-line therapy.
ADAM8 in asthma. Friend or foe to airway inflammation?
Review
Deng et al., Chongqing, China. In Am J Respir Cell Mol Biol, 2013
Recruitment of leukocytes from the vasculature into airway sites is essential for induction of airway inflammation, a process thought to be mediated by a disintegrin and metalloprotease 8 (ADAM8).
α-Cleavage of cellular prion protein.
Review
Kong et al., Cleveland, United States. In Prion, 2012
We demonstrated that, in muscle cells, ADAM8 is the primary protease for the α-cleavage of PrP (C) , but another unidentified protease(s) must also play a minor role.
Upregulation of a disintegrin and metalloprotease 8 influences tumor metastasis and prognosis in patients with osteosarcoma.
GeneRIF
Zhang et al., Changsha, China. In Pathol Oncol Res, 2012
Upregulation of a disintegrin and metalloprotease 8 influences tumor metastasis with osteosarcoma.
Cellular prion protein regulates its own α-cleavage through ADAM8 in skeletal muscle.
GeneRIF
Kong et al., Cleveland, United States. In J Biol Chem, 2012
overexpression of PrP(C) led to up-regulation of ADAM8, suggesting that PrP(C) may regulate its own alpha-cleavage through modulating ADAM8 activity.
The metalloprotease ADAM8 is associated with and regulates the function of the adhesion receptor PSGL-1 through ERM proteins.
GeneRIF
Urzainqui et al., Santa Cruz de Tenerife, Spain. In Eur J Immunol, 2011
ADAM8 is both associated with PSGL-1 through the ezrin-radixin-moesin actin-binding proteins and able to cause the proteolytic cleavage of this adhesion receptor.
A disintegrin and metalloprotease -8 and -15 and susceptibility for ascending aortic dissection.
GeneRIF
Mennander et al., Tampere, Finland. In Scand J Clin Lab Invest, 2011
gene expressions for ADAM8 and ADAM15 were notably lower in ascending aorta as compared with aortic dissection
Increased expression of a disintegrin and metalloprotease 8 in allergic rhinitis.
GeneRIF
Lee et al., Seoul, South Korea. In Am J Rhinol Allergy, 2011
increased expression in allergic rhinitis
ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23.
Impact
Blobel et al., New York City, United States. In Nat Immunol, 2006
Here we used loss-of-function and gain-of-function experiments with cells lacking or overexpressing candidate CD23-releasing enzymes (ADAM8, ADAM9, ADAM10, ADAM12, ADAM15, ADAM17, ADAM19 and ADAM33), ADAM-knockout mice and a selective inhibitor to identify ADAM10 as the main CD23-releasing enzyme in vivo.
A modified nucleotide in tRNA as a possible regulator of aerobiosis: synthesis of cis-2-methyl-thioribosylzeatin in the tRNA of Salmonella.
Impact
Ames et al., In Cell, 1984
The bacteria do not methylthiolate (ms2-) the i6A under these conditions.
Viral hepatitis, type B. Studies on natural history and prevention re-examined.
Impact
Deinhardt et al., In N Engl J Med, 1979
Administration of heat-inactivated hepatitis B virus, MS-2 strain, to 29 children induced an inapparent infection in three, characterized by a transient appearance of HBsAg and HBeAg, and the persistence of anti-HBc, anti-HBe and anti-HBs for more than two years.
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