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Pannexin 1

The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, AGE, HAD, Cho, ACID
Papers on MRSI
Metabolic voxel-based analysis of the complete human brain using fast 3D-MRSI: Proof of concept in multiple sclerosis.
Ranjeva et al., Marseille, France. In J Magn Reson Imaging, Feb 2016
PURPOSE: To detect local metabolic abnormalities over the complete human brain in multiple sclerosis (MS) patients, we used optimized fast volumic echo planar spectroscopic imaging (3D-EPSI).
In vivo (1) H MRS and (31) P MRSI of the response to cyclocreatine in transgenic mouse liver expressing creatine kinase.
Branch et al., United States. In Nmr Biomed, Dec 2015
Published findings support the use of in vivo (31) P MRSI of creatine kinase (CK)-expressing hepatocytes to monitor proliferation of implanted hepatocytes.
Magnetic Resonance Spectroscopy of siRNA-Based Cancer Therapy.
Bhujwalla et al., Baltimore, United States. In Methods Mol Biol, Dec 2015
Here we describe the use of siRNA to downregulate choline kinase, a critical enzyme in choline phospholipid metabolism of cancer cells and tumors, and the use of (1)H MRS of cells and (1)H magnetic resonance spectroscopic imaging (MRSI) of tumors to assess the efficacy of the downregulation.
Early glial activation precedes neurodegeneration in the cerebral cortex after SIV infection: a 3D, multivoxel proton magnetic resonance spectroscopy study.
Gonen et al., New York City, United States. In Hiv Med, Jul 2015
OBJECTIVES: As ∼40% of HIV-infected individuals experience neurocognitive decline, we investigated whether proton magnetic resonance spectroscopic imaging ((1) H-MRSI) detects early metabolic abnormalities in the cerebral cortex of a simian immunodeficiency virus (SIV)-infected rhesus monkey model of neuroAIDS.
Assessment of glutamate in striatal subregions in obsessive-compulsive disorder with proton magnetic resonance spectroscopy.
Shungu et al., New York City, United States. In Psychiatry Res, May 2015
Therefore, in this study, a proton MRS imaging (1H MRSI) technique with relatively high spatial resolution at 3.0 T was used to measure minimally contaminated glutamate levels in three striatal subregions (i.e., dorsal caudate, dorsal putamen, and ventral striatum) in 15 unmedicated adults with OCD and 16 matched healthy control subjects.
Liver regeneration and energetic changes in rats following hepatic radiation therapy and hepatocyte transplantation by ³¹P MRSI.
Guha et al., Seattle, United States. In Liver Int, Apr 2015
METHODS: To study the metabolic changes that occur in RILD with and without HT, (31)P MRSI data were acquired in rats treated with partial hepatectomy (PH) alone, PH with hepatic irradiation (PHRT) or PHRT with HT (PHRT+HT).
Hypo-metabolism of the rostral anterior cingulate cortex associated with working memory impairment in 18 cases of schizophrenia.
Gonen et al., New York City, United States. In Brain Imaging Behav, Apr 2015
This retrospective study of 18 schizophrenia cases and 10 matched controls used proton magnetic resonance spectroscopic imaging ((1)H-MRSI, TR/TE = 1800/35 ms, 0.5 cm(3) spatial resolution) to test whether the Work-Mem Index of the Wechsler Adult Intelligence Scale, third edition is associated with differences in the rostral to caudal ACC ratios of N-acetylaspartate (NAA) and creatine (Cr).
In vivo ³¹P magnetic resonance spectroscopic imaging (MRSI) for metabolic profiling of human breast cancer xenografts.
Heerschap et al., Trondheim, Norway. In J Magn Reson Imaging, Mar 2015
We explored 3D (31) P magnetic resonance spectroscopic imaging (MRSI) at high magnetic field for in vivo assessment of individual phospholipids in two patient-derived breast cancer xenografts representing good and poor prognosis (luminal- and basal-like tumors).
Metabolic imaging of pancreatic ductal adenocarcinoma detects altered choline metabolism.
Bhujwalla et al., Baltimore, United States. In Clin Cancer Res, Feb 2015
EXPERIMENTAL DESIGN: We investigated the metabolism of a panel of PDAC cell lines in culture and noninvasively in vivo with (1)H magnetic resonance spectroscopic imaging (MRSI) to identify noninvasive biomarkers and uncover potential metabolic targets.
Twelve-year monitoring of a patient with megalencephalic leukoencephalopathy with subcortical cysts.
De Stefano et al., Siena, Italy. In Neurol Sci, 2014
We describe here clinical findings and volumetric MRI and (1)H-MR spectroscopic imaging ((1)H-MRSI) data of a 12-year follow-up on a patient with MLC.
Use of high-resolution volumetric MR spectroscopic imaging in assessing treatment response of glioblastoma to an HDAC inhibitor.
Olson et al., Atlanta, United States. In Ajr Am J Roentgenol, 2014
This article describes the use of MR spectroscopic imaging (MRSI) to predict early clinical and behavioral response to a therapy and an effort to develop high-resolution, volumetric MRSI to improve its clinical application.
Loss of pannexin 1 attenuates melanoma progression by reversion to a melanocytic phenotype.
Laird et al., London, Canada. In J Biol Chem, 2012
while Panx1 is present in skin melanocytes it is up-regulated during melanoma tumor progression, and tumorigenesis can be inhibited by the knockdown of Panx1 raising the possibility that Panx1 may be a viable target for the treatment of melanoma.
Multi-echo acquisition.
Posse, Albuquerque, United States. In Neuroimage, 2012
The rapid development of fMRI was paralleled early on by the adaptation of MR spectroscopic imaging (MRSI) methods to quantify water relaxation changes during brain activation.
Pannexin 1 forms an anion-selective channel.
Surprenant et al., Manchester, United Kingdom. In Pflugers Arch, 2012
Panx1 assembles into a membrane anion channel with a relatively low single-channel conductance.
Pannexin 1, an ATP release channel, is activated by caspase cleavage of its pore-associated C-terminal autoinhibitory region.
Bayliss et al., Charlottesville, United States. In J Biol Chem, 2012
mechanism of PANX1 channel regulation
The P2X7 receptor and Pannexin-1 are both required for the promotion of multinucleated macrophages by the inflammatory cytokine GM-CSF.
Di Virgilio et al., Ottawa, Canada. In J Immunol, 2011
both P2X(7) and Panx-1 are required for GM-CSF promotion of multinucleated macrophages fusion
Germline mutations in MSR1, ASCC1, and CTHRC1 in patients with Barrett esophagus and esophageal adenocarcinoma.
Eng et al., Cleveland, United States. In Jama, 2011
MSR1 was significantly associated with the presence of Barrett esophagus/esophageal adenocarcinoma in derivation and validation samples
13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression.
Goga et al., San Francisco, United States. In Cell Metab, 2011
Here, we use a switchable model of Myc-driven liver cancer, along with hyperpolarized (13)C-pyruvate magnetic resonance spectroscopic imaging (MRSI) to visualize glycolysis in de novo tumor formation and regression.
Nuclear medicine in the rehabilitative treatment evaluation in stroke recovery. Role of diaschisis resolution and cerebral reorganization.
Mountz, Pittsburgh, United States. In Eura Medicophys, 2007
The status of the peri-infarction region can be characterized in terms of components of diaschisis and ischemia using proton magnetic resonance spectroscopy imaging ((1)H MRSI) and rest/stress rCBF assessment of cerebral vascular reserve.
[The role of magnetic resonance spectroscopic imaging in patients with Parkinson's disease].
Furuya et al., Kyoto, Japan. In Nihon Rinsho, 1997
Proton magnetic resonance spectroscopic imaging(MRSI) is the multi-voxel method, from which we can obtain many spectra from many voxel at the same time.
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