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ATP-binding cassette, sub-family C

MRP3, ABCC3, multidrug resistance-associated protein 3
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: ACID, CAN, CD45, MDR1, HAD
Papers on MRP3
[Prognostic significance of Pgp, MRP1, and MRP3 in ovarian cancer patients].
New
Špaček et al., In Ceska Gynekol, 31 Dec 2016
OBJECTIVE: To evaluate the correlation of resistance proteins Pgp (P-glycoprotein), MRP1 (Multidrug Related Protein, Multidrug Resistance-Associated Protein) and MRP3 with clinical - pathological factors and to find the clinical outcome of these data in ovarian cancer patients.
MRP3 as a novel resistance factor for sorafenib in hepatocellular carcinoma.
New
Takayama et al., Tokushima, Japan. In Oncotarget, Feb 2016
Our data clearly demonstrate that the efflux transporter MRP3 plays an important role in resistance to sorafenib in HCC cells.
Oral morphine pharmacokinetic in obesity: the role of P-glycoprotein, MRP2, MRP3, UGT2B7 and CYP3A4 jejunal contents and obesity-associated biomarkers.
New
Decleves et al., In Mol Pharm, Feb 2016
OBJECTIVE: To study the influence of the jejunal expression levels of P-gp, MRP2, MRP3, UGT2B7, CYP3A4, the influence of the ABCB1 c.3435C>T polymorphism and of several obesity-associated biomarkers, on oral morphine and glucuronides pharmacokinetics in a population of morbid obese subjects.
Overexpression of ABCC3 promotes cell proliferation, drug resistance, and aerobic glycolysis and is associated with poor prognosis in urinary bladder cancer patients.
New
Liu et al., Haizhou, China. In Tumour Biol, Feb 2016
ATP-binding cassette, subfamily C, member 3 (ABCC3), a member of the ABC transporter family, is highly expressed in tumor cells, where it actively effluxes a broad spectrum of metabolites.
Diclofenac and its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro.
New
Rodrigues et al., Bristol, United Kingdom. In Drug Metab Dispos, Jan 2016
DF was identified as a substrate of organic anion transporter 2 only (OAT2, Km = 46.8
The role of ATP-binding cassette transporter genes in the progression of prostate cancer.
New
Ozen et al., Erzurum, Turkey. In Prostate, Jan 2016
In this study, we aimed to profile expressions of nine ABC transporters, ABCA5, ABCB1, ABCB6, ABCC1, ABCC2, ABCC3, ABCC5, ABCC10, and ABCF2, in recurrent, non-recurrent PCa and normal prostate tissues.
A germline predictive signature of response to platinum chemotherapy in esophageal cancer.
New
Saggioro et al., Padova, Italy. In Transl Res, Jan 2016
The predictive power of 5 DMET SNPs mapping in ABCC2, ABCC3, CYP2A6, PPARG, and SLC7A8 genes was greater than that of clinical factors alone (area under the curve [AUC] = 0.74 vs 0.62).
Silencing pancreatic adenocarcinoma upregulated factor (PAUF) increases the sensitivity of pancreatic cancer cells to gemcitabine.
New
Jiang et al., Beijing, China. In Tumour Biol, Jan 2016
Gene array showed that PAUF function in gemcitabine sensitivity might involve MRP2, MRP3, MDR1, PIK3R1, and NFkB2 genes.
Evaluation of Ketoconazole and its Alternative Clinical CYP3A4/5 Inhibitors as Inhibitors of Drug Transporters: The In Vitro Effects of Ketoconazole, Ritonavir, Clarithromycin and Itraconazole on 13 Clinically-Relevant Drug Transporters.
New
Buckley et al., In Drug Metab Dispos, Jan 2016
In this study, the inhibitory effects of ketoconazole, clarithromycin, ritonavir and itraconazole (and its CYP3A4-inhibitory metabolites, hydroxy-, keto- and N-desalkyl itraconazole) towards 13 drug transporters (OATP1B1, OATP1B3, OAT1, OAT3, OCT1, OCT2, MATE1, MATE2-K, P-gp, BCRP, MRP2, MRP3 and BSEP) were systematically assessed in transporter-expressing HEK-293 cell lines or membrane vesicles.
New insights in the biology of ABC transporters ABCC2 and ABCC3: impact on drug disposition.
Review
New
Jonker et al., Groningen, Netherlands. In Expert Opin Drug Metab Toxicol, Feb 2015
AREAS COVERED: ABCC2 and ABCC3 (also known as MRP2 and MRP3) mediate the transport of various conjugated organic anions, including many drugs, toxicants and endogenous compounds.
Ginseng alleviates cyclophosphamide-induced hepatotoxicity via reversing disordered homeostasis of glutathione and bile acid.
Li et al., Nanjing, China. In Sci Rep, 2014
In addition, NRF 2, one of regulatory elements on the expression of GCLC, GCLM, GS, GST, NTCP and MRP3, was up-regulated when ginseng was co-administrated.
Polymorphisms of the drug transporters ABCB1, ABCG2, ABCC2 and ABCC3 and their impact on drug bioavailability and clinical relevance.
Review
Cascorbi et al., Kiel, Germany. In Expert Opin Drug Metab Toxicol, 2014
AREAS COVERED: Here the influence of polymorphisms of the prominent ABC transporters P-glycoprotein (MDR1, ABCB1), breast cancer resistance protein (BCRP, ABCG2) and the multidrug resistance-associated protein (MRP) 2 (ABCC2) as well as MRP3 (ABCC3) on the pharmacokinetic of drugs and associated consequences on therapy response and clinical outcome is discussed.
The roles of MRP2, MRP3, OATP1B1, and OATP1B3 in conjugated hyperbilirubinemia.
Review
Keppler, Heidelberg, Germany. In Drug Metab Dispos, 2014
Under pathophysiological conditions such as cholestatic liver injury and MRP2 inhibition, the basolateral efflux pump multidrug resistance protein 3 (MRP3 or ABCC3) is responsible for the occurrence of conjugated hyperbilirubinemia.
New insights in bilirubin metabolism and their clinical implications.
Review
Jirsa et al., Praha, Czech Republic. In World J Gastroenterol, 2013
The data show that a substantial fraction of bilirubin conjugates is primarily secreted by MRP3 at the sinusoidal membrane into the blood, from where they are subsequently reuptaken by sinusoidal membrane-bound organic anion transporting polypeptides OATP1B1 and OATP1B3.
Interplay between metabolism and transport of resveratrol.
Review
Jaeger et al., Vienna, Austria. In Ann N Y Acad Sci, 2013
However, a high rate of biotransformation, in concert with the action of the efflux transporters MRP2, MRP3, and ABCG2, reduces intracellular resveratrol concentrations, and may thereby decrease its pharmacological activity.
Elevated hepatic multidrug resistance-associated protein 3/ATP-binding cassette subfamily C 3 expression in human obstructive cholestasis is mediated through tumor necrosis factor alpha and c-Jun NH2-terminal kinase/stress-activated protein kinase-signaling pathway.
GeneRIF
Chen et al., Chongqing, China. In Hepatology, 2012
up-regulation of hepatic MRP3/ABCC3 expression in human obstructive cholestasis is likely triggered by TNFalpha, mediated by activation of JNK/SAPK and SP1.
Oral availability of cefadroxil depends on ABCC3 and ABCC4.
GeneRIF
Oude Elferink et al., Amsterdam, Netherlands. In Drug Metab Dispos, 2012
Transport of cefadroxil by ABCC3 and ABCC4 was saturable with K(m) values of 2.5 +/- 0.7 and 0.25 +/- 0.07 mM, respectively.
Aberrant regulation of the MRP3 gene in non-small cell lung carcinoma.
GeneRIF
Forman et al., Merced, United States. In J Thorac Oncol, 2012
We demonstrate direct involvement between nuclear factor erythroid-2-related factor 2 and the MRP3 promoter, which leads to the up-regulation of the MRP3 gene.
Efflux protein expression in human stem cell-derived retinal pigment epithelial cells.
GeneRIF
Skottman et al., Tampere, Finland. In Plos One, 2011
Findings show that the gene expression of ATP-dependent efflux transporters MRP1, -3, -4, -5, and p-gp fluctuated during stem cell-derived retinal pigment epithelial cells (hESC-RPE) maturation.
Effect of ABCB1 and ABCC3 polymorphisms on osteosarcoma survival after chemotherapy: a pharmacogenetic study.
GeneRIF
Gonzalez-Neira et al., Madrid, Spain. In Plos One, 2010
effect of ABCB1 and ABCC3 polymorphisms on osteosarcoma survival after chemotherapy
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