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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

MAS-related GPR, member X2

MrgX2, G protein-coupled receptor MrgX2
Top mentioned proteins: MAS, somatostatin, MAST, V1a, Neuropeptide
Papers on MrgX2
Modulation of host defense peptide-mediated human mast cell activation by LPS.
Ali et al., Philadelphia, United States. In Innate Immun, Jan 2016
Surprisingly, we found that CHRG01 and FK-13 caused Ca(2+) mobilization and degranulation in human mast cells via a novel G protein-coupled receptor known as Mas-related gene-X2 (MrgX2).
Activation of human mast cells by retrocyclin and protegrin highlight their immunomodulatory and antimicrobial properties.
Ali et al., Philadelphia, United States. In Oncotarget, Nov 2015
However, RC-100 and PG-1 induced degranulation in rat basophilic leukemia (RBL-2H3) cells stably expressing Mas related G protein coupled receptor X2 (MrgX2).
The Origin, Expression, Function and Future Research Focus of a G Protein-coupled Receptor, Mas-related Gene X2 (MrgX2).
Sha et al., Shenzhen, China. In Prog Histochem Cytochem, Jul 2015
MrgX2 is a member of the MrgX family.
Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria.
Okayama et al., Tokyo, Japan. In J Allergy Clin Immunol, 2014
Mas-related gene X2 (MrgX2) has been identified as a receptor for basic neuropeptides, such as SP and vasoactive intestinal peptide.
β-Defensins activate human mast cells via Mas-related gene X2.
Ali et al., Philadelphia, United States. In J Immunol, 2013
Whereas human mast cells endogenously express G protein-coupled receptor, Mas-related gene X2 (MrgX2), rat basophilic leukemia, RBL-2H3 cells, and murine BMMCs do not.
Somatostatin and somatostatin analogues reduce PDGF-induced endometrial cell proliferation and motility.
Granata et al., Torino, Italy. In Hum Reprod, 2012
Cortistatin (CST), which displays high structural and functional homology with SST, binds all ssts, as well as MrgX2.
Mas-related gene X2 (MrgX2) is a novel G protein-coupled receptor for the antimicrobial peptide LL-37 in human mast cells: resistance to receptor phosphorylation, desensitization, and internalization.
Ali et al., Philadelphia, United States. In J Biol Chem, 2012
identified MrgX2 as a novel G protein-coupled receptor for the antibacterial peptide LL-37 and demonstrated that unlike most G protein-coupled receptors it is resistant to agonist-induced receptor phosphorylation, desensitization, and internalization.
G protein coupled receptor specificity for C3a and compound 48/80-induced degranulation in human mast cells: roles of Mas-related genes MrgX1 and MrgX2.
Ali et al., Philadelphia, United States. In Eur J Pharmacol, 2011
We have previously shown that LAD2 cells express MrgX1 and MrgX2 but HMC-1 cells do not.
PMX-53 as a dual CD88 antagonist and an agonist for Mas-related gene 2 (MrgX2) in human mast cells.
Ali et al., Philadelphia, United States. In Mol Pharmacol, 2011
Previous studies indicated that C5a could cause mast cell degranulation, at least in part, via a mechanism similar to that proposed for basic neuropeptides such as substance P, possibly involving Mas-related gene 2 (MrgX2).
Cortistatin modulates calcitonin gene-related peptide release from neuronal tissues of rat. Comparison with somatostatin.
Tringali et al., Roma, Italy. In Peptides, 2011
Gene expression of CST and its putative receptor MrgX2 in dorsal root ganglia (DRG) neurons in man suggests the involvement of CST in pain transmission.
Cortistatin and pituitary hormone secretion in rat.
Martynska et al., Warsaw, Poland. In J Physiol Pharmacol, 2009
CST binds with high affinity to all somatostatin receptors, and contrary to somatostatin, is also able to bind with MrgX2 and GH secretagogue receptor of ghrelin (GHS-R1) receptors.
Angiotensin metabolites can stimulate receptors of the Mas-related genes family.
Walther et al., Berlin, Germany. In Mol Cell Biochem, 2008
Mas, MrgD, and MRG mediated Ang IV-stimulated AA release that was highest for Mas. While Ang III activated Mas and MrgX2, Ang II stimulated AA release via Mas and MRG.
Targeting human mast cells expressing g-protein-coupled receptors in allergic diseases.
Ra et al., Tokyo, Japan. In Allergol Int, 2008
Human MCs are activated and secrete histamine in response to neuropeptides, such as substance P and somatostatin, mediated by a GPCR, MRGX2.
The role of cortistatin in the human immune system.
Hofland et al., Rotterdam, Netherlands. In Mol Cell Endocrinol, 2008
The activities specific to CST may be partially attributable to its binding to the growth hormone secretagogue (GHS)-receptor (GHS-R) and the orphan G-protein-coupled receptor MrgX2.
Endocrine actions of cortistatin: in vivo studies.
Ghigo et al., Torino, Italy. In Mol Cell Endocrinol, 2008
However, CST actions, tissue expression patterns and regulation do not fully overlap with those of SST, and, moreover, CST, but not SST, also binds and activates proadrenomedullin N-terminal peptide receptor (MrgX2) and shows binding affinity to ghrelin receptor (GHS-R1a).
Somatostatin, cortistatin and their receptors in tumours.
Papotti et al., Torino, Italy. In Mol Cell Endocrinol, 2008
CST binds all SS receptors, and, differently from SS, also the ghrelin receptor GHSR1a and the CST specific receptor MrgX2.
Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception.
Su et al., Kunming, China. In Gene, 2005
MRGX2 amino acid substitutions may alter the interactions between MRGX2 protein and its ligand, thus, potentially led to adaptive changes of the pain-perception-related nervous system during human evolution.
MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion.
Fidock et al., United Kingdom. In J Biol Chem, 2003
cortistatin-14 shown to be a high affinity ligand for G protein coupled receptor MrgX2 which is expressed in dorsal root ganglion
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