Cortistatin and pituitary hormone secretion in rat.
Warsaw, Poland. In J Physiol Pharmacol, 2009
CST binds with high affinity to all somatostatin receptors, and contrary to somatostatin, is also able to bind with MrgX2 and GH secretagogue receptor of ghrelin (GHS-R1) receptors.
The role of cortistatin in the human immune system.
Rotterdam, Netherlands. In Mol Cell Endocrinol, 2008
The activities specific to CST may be partially attributable to its binding to the growth hormone secretagogue (GHS)-receptor (GHS-R) and the orphan G-protein-coupled receptor MrgX2.
Endocrine actions of cortistatin: in vivo studies.
Torino, Italy. In Mol Cell Endocrinol, 2008
However, CST actions, tissue expression patterns and regulation do not fully overlap with those of SST, and, moreover, CST, but not SST, also binds and activates proadrenomedullin N-terminal peptide receptor (MrgX2) and shows binding affinity to ghrelin receptor (GHS-R1a).