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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

MAS-related GPR, member X1

Top mentioned proteins: MAS, MrgX2, BLBP, CAN, beta-adaptin
Papers on MrgX1
Discovery and characterization of 2-(cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1.
Hopkins et al., Nashville, United States. In Chemmedchem, 2015
A large-scale screen has been carried out to isolate small-molecule allosteric agonists of MrgX1, the human homologue of MrgC11.
Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors.
Tsukamoto et al., Baltimore, United States. In Bioorg Med Chem, 2014
A series of Arg-Phe-NH2 peptidomimetics containing an Arg mimetic were synthesized and tested as agonists of human MrgX1, rat MrgC, and mouse MrgC11 receptors.
Activation of MrgC receptor inhibits N-type calcium channels in small-diameter primary sensory neurons in mice.
Guan et al., Baltimore, United States. In Pain, 2014
Because MrgC shares substantial genetic homogeneity with human MrgX1, our findings may suggest a rationale for developing intrathecally delivered MrgX1 receptor agonists to treat pathological pain in humans and provide critical insight regarding potential mechanisms that may underlie its analgesic effects.
MrgC agonism at central terminals of primary sensory neurons inhibits neuropathic pain.
Guan et al., Baltimore, United States. In Pain, 2014
The rodent Mas-related G-protein-coupled receptor subtype C (MrgC) shares substantial homogeneity with its human homologue, MrgX1, and is located specifically in small-diameter dorsal root ganglion neurons.
G protein coupled receptor specificity for C3a and compound 48/80-induced degranulation in human mast cells: roles of Mas-related genes MrgX1 and MrgX2.
Ali et al., Philadelphia, United States. In Eur J Pharmacol, 2011
We have previously shown that LAD2 cells express MrgX1 and MrgX2 but HMC-1 cells do not.
PMX-53 as a dual CD88 antagonist and an agonist for Mas-related gene 2 (MrgX2) in human mast cells.
Ali et al., Philadelphia, United States. In Mol Pharmacol, 2011
Human mast cells express the G protein coupled receptor (GPCR) for C5a (CD88).
Development of 2,4-diaminopyrimidine derivatives as novel SNSR4 antagonists.
Tomaszewski et al., Montréal, Canada. In Bioorg Med Chem Lett, 2011
2,4-Diaminopyrimidines derivatives were developed as a novel class of SNSR4 antagonists.
Taking qPCR to a higher level: Analysis of CNV reveals the power of high throughput qPCR to enhance quantitative resolution.
Livak et al., San Francisco, United States. In Methods, 2010
The quantitative capability of digital PCR is illustrated with an experiment distinguishing four and five copies of the human gene MRGPRX1.
Discovery of non-peptidergic MrgX1 and MrgX2 receptor agonists and exploration of an initial SAR using solid-phase synthesis.
Olsson et al., Malmö, Sweden. In Bioorg Med Chem Lett, 2009
A class of small molecules displaying comparable activities with peptide ligands BAM22 and corticostatin-14 at both the human and rhesus monkey MrgX1 and MrgX2 receptors, respectively, was discovered.
The discovery of a selective, small molecule agonist for the MAS-related gene X1 receptor.
Coates et al., Harlow, United Kingdom. In J Med Chem, 2009
The novel 7-transmembrane receptor MrgX1 is located predominantly in the dorsal root ganglion and has consequently been implicated in the perception of pain.
Simultaneous activation of the delta opioid receptor (deltaOR)/sensory neuron-specific receptor-4 (SNSR-4) hetero-oligomer by the mixed bivalent agonist bovine adrenal medulla peptide 22 activates SNSR-4 but inhibits deltaOR signaling.
Bouvier et al., Montréal, Canada. In Mol Pharmacol, 2006
Because sensory neuron-specific receptors (SNSRs) and the opioid receptors (OR) share a common ligand, the bovine adrenal medulla peptide (BAM) 22, and have opposite effects on pain modulation, we investigated the possible consequences of deltaOR/SNSR-4 hetero-oligomerization on the signaling properties of both receptor subtypes.
Characterization of the Mas-related gene family: structural and functional conservation of human and rhesus MrgX receptors.
Nash et al., San Diego, United States. In Br J Pharmacol, 2006
A subgroup of human Mrg receptors (MrgX1-X4) is not found in rodents and this has hampered efforts to define the physiological roles of these receptors.
Modulation of ion channels and synaptic transmission by a human sensory neuron-specific G-protein-coupled receptor, SNSR4/mrgX1, heterologously expressed in cultured rat neurons.
Ikeda et al., Bethesda, United States. In J Neurosci, 2004
To circumvent this problem, we expressed human SNSR4 (hSNSR4; also known as Hs.mrgX1) in rat superior cervical ganglion (SCG), dorsal root ganglion (DRG), and hippocampal neurons using nuclear injection or recombinant adenoviruses and examined modulation of ion channels and neurotransmission using whole-cell patch-clamp techniques.
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