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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

MAS-related GPR, member D

MrgD, Mrgprd
seven transmembrane domain G-protein coupled receptor; most often found in sensory neurons [RGD, Feb 2006] (from NCBI)
Papers on MrgD
Mrgprd enhances excitability in specific populations of cutaneous murine polymodal nociceptors.
GeneRIF
Koerber et al., Pittsburgh, United States. In J Neurosci, 2009
This study demonstrated that Mrgprd influences the excitability of polymodal nonpeptidergic nociceptors to mechanical and thermal stimuli.
Angiotensin metabolites can stimulate receptors of the Mas-related genes family.
GeneRIF
Walther et al., Berlin, Germany. In Mol Cell Biochem, 2008
Mas, MrgD, and MRG mediated Ang IV-stimulated AA release that was highest for Mas. While Ang III activated Mas and MrgX2, Ang II stimulated AA release via Mas and MRG.
Cutaneous sensory neurons expressing the Mrgprd receptor sense extracellular ATP and are putative nociceptors.
GeneRIF
McCleskey et al., Portland, United States. In J Neurophysiol, 2008
Mrgprd+ neurons are nociceptors in the outer epidermis and may respond indirectly to external stimuli by detecting ATP release in the skin
MrgD activation inhibits KCNQ/M-currents and contributes to enhanced neuronal excitability.
GeneRIF
Pausch et al., Princeton, United States. In J Neurosci, 2007
We provide evidence for a novel interaction between MrgD and KCNQ/M-type potassium channels that contributes to an increase in excitability of DRG neurons and thus may enhance the signaling of primary afferent nociceptive neurons.
Interactions between the Mas-related receptors MrgD and MrgE alter signalling and trafficking of MrgD.
GeneRIF
Milligan et al., Glasgow, United Kingdom. In Mol Pharmacol, 2006
Interactions between rMrgD and rMrgE modulate the function of rMrgD.
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