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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

MAS-related GPR, member D

MrgD, Mrgprd
seven transmembrane domain G-protein coupled receptor; most often found in sensory neurons [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: MAS, V1a, BLBP, CAN, TRPV1
Papers on MrgD
ACE2 and vasoactive peptides: novel players in cardiovascular/renal remodeling and hypertension.
Ocaranza et al., Santiago, Chile. In Ther Adv Cardiovasc Dis, Aug 2015
Alamandine produces the same effects as Ang-(1-7), such as vasodilation and prevention of fibrosis, by interacting with Mas-related GPCR, member D (MrgD).
Expression and clinical contribution of MRGD mRNA in non-small cell lung cancers.
Chen et al., Nanning, China. In J Buon, Jul 2015
PURPOSE: MAS-related G protein-coupled receptor, member D (MRGD) has been reported to be involved in tumorigenesis in vivo.
Incoherent feed-forward regulatory loops control segregation of C-mechanoreceptors, nociceptors, and pruriceptors.
Ma et al., Hangzhou, China. In J Neurosci, May 2015
We reported previously that the runt domain transcription factor Runx1 is required to coordinate the development of these unmyelinated cutaneous sensory neurons, including VGLUT3(+) low-threshold c-mechanoreceptors (CLTMs), MrgprD(+) polymodal nociceptors, MrgprA3(+) pruriceptors, MrgprB4(+) c-mechanoreceptors, and others.
Angiotensin type 2 receptor (AT2R) and receptor Mas: a complex liaison.
Steckelings et al., Berlin, Germany. In Clin Sci (lond), Feb 2015
Such mechanisms may comprise dimerization of the receptors or dimerization-independent mechanisms such as lack of specificity of the receptor ligands used in the experiments or involvement of the Ang-(1-7) metabolite alamandine and its receptor MrgD in the observed effects.
Chronic Compression of the Dorsal Root Ganglion Enhances Mechanically Evoked Pain Behavior and the Activity of Cutaneous Nociceptors in Mice.
LaMotte et al., Beijing, China. In Plos One, 2014
The incidence of a foot shaking evoked by indentation of the dorsum of foot with an aversive von Frey filament (tip diameter 200 μm, bending force 20 mN) was significantly higher in the foot ipsilateral to the CCD surgery as compared to the contralateral side on post-operative days 2 to 8. Mechanically-evoked action potentials were electrophysiologically recorded from the L3 DRG, in vivo, from cell bodies visually identified as expressing a transgenically labeled fluorescent marker (neurons expressing either the receptor MrgprA3 or MrgprD).
Role of non-classical renin-angiotensin system axis in renal fibrosis.
Liu et al., Nanjing, China. In Front Physiol, 2014
The new members have added new dimensions to RAS, including the ACE2/Ang(1-7)/Mas receptor axis, the prorenin/(pro)renin receptor(PRR)/intracelluar pathway axis, and the Angiotensin A (Ang A), alamandine-Mas-related G protein coupled receptor D(MrgD) axis.
Reduction of angiotensin A and alamandine vasoactivity in the rabbit model of atherogenesis: differential effects of alamandine and Ang(1-7).
Zulli et al., Melbourne, Australia. In Int J Exp Pathol, 2014
Alamandine binds to MrgD and is reported to induce vasodilation via stimulation of endothelial nitric oxide synthase (eNOS), but its role in atherogenic blood vessels is yet to be determined.
Alamandine: a new member of the angiotensin family.
Santos et al., Rio Grande, Brazil. In Curr Opin Nephrol Hypertens, 2014
PURPOSE OF REVIEW: In this article, we review the recent findings regarding a new derivative of angiotensin-(1-7) [Ang-(1-7)], alamandine, and its receptor, the Mas-related G-coupled receptor type D (MrgD) with a special emphasis on its role and how it can be formed.
Mas-related G protein-coupled receptor D is coupled to endogenous calcium-activated chloride channel in Xenopus oocytes.
Zheng et al., Guangzhou, China. In J Physiol Biochem, 2014
Mas-related G protein-coupled receptor D (MrgD) is expressed almost exclusively in nociceptive primary sensory neurons and the neurons located in stratum granulosum of skin.
Three functionally distinct classes of C-fibre nociceptors in primates.
Ringkamp et al., Baltimore, United States. In Nat Commun, 2013
Superficially applied capsaicin and intradermal injection of β-alanine, an MrgprD agonist, excite vigorously all QCs.
Expression and distribution patterns of Mas-related gene receptor subtypes A-H in the mouse intestine: inflammation-induced changes.
Timmermans et al., Antwerp, Belgium. In Histochem Cell Biol, 2013
Except for MrgD, E and F, whose changed expression has been revealed during inflammation in the mouse intestine in our earlier studies, information concerning the remaining cloned mouse Mrg subtypes in the gastrointestinal tract during (patho) physiological conditions is lacking.
The cellular code for mammalian thermosensation.
Hoon et al., Bethesda, United States. In J Neurosci, 2013
We also show that more extreme cold and heat activate additional populations of nociceptors, including cells expressing Mrgprd.
Mechanisms of itch evoked by β-alanine.
Dong et al., Baltimore, United States. In J Neurosci, 2012
Here we show that, in mice, β-alanine elicited itch-associated behavior that requires MrgprD, a G-protein-coupled receptor expressed by a subpopulation of primary sensory neurons.
Projection of non-peptidergic afferents to mouse tooth pulp.
Dong et al., Baltimore, United States. In J Dent Res, 2012
For clear visualization of the non-peptidergic afferents, we took advantage of a recently generated knock-in mouse model in which an axonal tracer, farnesylated green fluorescence protein (GFP), is expressed from the locus of a sensory neuron-specific gene, Mrgprd.
MRGD, a MAS-related G-protein coupled receptor, promotes tumorigenisis and is highly expressed in lung cancer.
Agatsuma et al., Tokyo, Japan. In Plos One, 2011
To elucidate the function of MAS-related GPCR, member D (MRGD) in cancers, we investigated the in vitro and in vivo oncogenic function of MRGD using murine fibroblast cell line NIH3T3 in which MRGD is stably expressed.
Mrgprd enhances excitability in specific populations of cutaneous murine polymodal nociceptors.
Koerber et al., Pittsburgh, United States. In J Neurosci, 2009
This study demonstrated that Mrgprd influences the excitability of polymodal nonpeptidergic nociceptors to mechanical and thermal stimuli.
Angiotensin metabolites can stimulate receptors of the Mas-related genes family.
Walther et al., Berlin, Germany. In Mol Cell Biochem, 2008
Mas, MrgD, and MRG mediated Ang IV-stimulated AA release that was highest for Mas. While Ang III activated Mas and MrgX2, Ang II stimulated AA release via Mas and MRG.
Cutaneous sensory neurons expressing the Mrgprd receptor sense extracellular ATP and are putative nociceptors.
McCleskey et al., Portland, United States. In J Neurophysiol, 2008
Mrgprd+ neurons are nociceptors in the outer epidermis and may respond indirectly to external stimuli by detecting ATP release in the skin
MrgD activation inhibits KCNQ/M-currents and contributes to enhanced neuronal excitability.
Pausch et al., Princeton, United States. In J Neurosci, 2007
We provide evidence for a novel interaction between MrgD and KCNQ/M-type potassium channels that contributes to an increase in excitability of DRG neurons and thus may enhance the signaling of primary afferent nociceptive neurons.
Interactions between the Mas-related receptors MrgD and MrgE alter signalling and trafficking of MrgD.
Milligan et al., Glasgow, United Kingdom. In Mol Pharmacol, 2006
Interactions between rMrgD and rMrgE modulate the function of rMrgD.
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