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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Mortality factor 4 like 1

MRG15, MORF4L1, MORF-related gene on chromosome 15
Top mentioned proteins: Histone, BLBP, V1a, CAN, Ubiquitin
Papers on MRG15
Mortality factor 4 like 1 protein mediates epithelial cell death in a mouse model of pneumonia.
New
Mallampalli et al., Pittsburgh, United States. In Sci Transl Med, Nov 2015
We describe that mortality factor 4 like 1 (Morf4l1), a protein involved in chromatin remodeling, is constitutively expressed at low levels in the lung because of its continuous degradation mediated by an orphan ubiquitin E3 ligase subunit, Fbxl18.
Analysis of PALB2 in a cohort of Italian breast cancer patients: identification of a novel PALB2 truncating mutation.
New
Cioffi et al., Napoli, Italy. In Fam Cancer, Sep 2015
The c.1919C>A (p.S640X) mutation causes the lack of C-terminus region inducing alteration of MORF4L1-PALB2 association and the lack of interaction of PALB2 with RAD51 and BRCA2.
Structural Basis for Multi-specificity of MRG Domains.
New
Radhakrishnan et al., Evanston, United States. In Structure, Jul 2015
MRG15, a chromodomain-containing chromatin-binding protein, recruits diverse chromatin-associated complexes that regulate gene transcription, DNA repair, and RNA splicing.
Condensin II Regulates Interphase Chromatin Organization Through the Mrg-Binding Motif of Cap-H2.
New
Bosco et al., Somerset, United States. In G3 (bethesda), May 2015
Previous work in our laboratory has shown that the Cap-H2 subunit of condensin II physically and genetically interacts with the Drosophila homolog of human MORF4-related gene on chromosome 15 (MRG15).
Proteasome regulation of the chromodomain protein MRG-1 controls the balance between proliferative fate and differentiation in the C. elegans germ line.
New
Hansen et al., Calgary, Canada. In Development, Feb 2015
RFP-1 binds to MRG-1, a homologue of the mammalian chromodomain-containing protein MRG15 (MORF4L1), which has been implicated in promoting the proliferation of neural precursor cells.
PALB2: the hub of a network of tumor suppressors involved in DNA damage responses.
Review
Andreassen et al., Cincinnati, United States. In Biochim Biophys Acta, 2014
Further, an interaction with MRG15, which is related to chromatin regulation, may facilitate DNA repair in damaged chromatin.
Histone deacetylase 2 (HDAC2) protein-dependent deacetylation of mortality factor 4-like 1 (MORF4L1) protein enhances its homodimerization.
Zou et al., Chi-lung, Taiwan. In J Biol Chem, 2014
Histone acetyltransferase mortality factor 4-like 1 (MORF4L1) is a relatively new histone acetyltransferase component that exists as a homodimer to exert its epigenetic function.
Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer.
Tsichlis et al., Boston, United States. In Mol Cell, 2014
SETD2 trimethylates histone H3 at K36 during transcription, creating a docking site for MRG15 and PTB.
Characterization of native protein complexes and protein isoform variation using size-fractionation-based quantitative proteomics.
Lamond et al., Dundee, United Kingdom. In Mol Cell Proteomics, 2013
Specific proteins were detected interacting with multiple independent complexes, as typified by the separation of distinct complexes for the MRFAP1-MORF4L1-MRGBP interaction network.
Arabidopsis MRG domain proteins bridge two histone modifications to elevate expression of flowering genes.
Ito et al., Singapore, Singapore. In Nucleic Acids Res, 2013
The MRG15 family proteins function as 'reader' proteins by binding to H3K36me3 to control alternative splicing or prevent spurious intragenic transcription in animals.
Maintenance of interphase chromosome compaction and homolog pairing in Drosophila is regulated by the condensin cap-h2 and its partner Mrg15.
Bosco et al., Hannover, Germany. In Genetics, 2013
To better understand how Drosophila melanogaster condensin is regulated, we performed a yeast two-hybrid screen and identified the chromo-barrel domain protein Mrg15 to interact with the Cap-H2 condensin subunit.
Loss of the chromatin regulator MRG15 limits neural stem/progenitor cell proliferation via increased expression of the p21 Cdk inhibitor.
GeneRIF
Tominaga et al., San Antonio, United States. In Stem Cell Res, 2011
DNA damage foci, as indicated by immunostaining for gammaH2AX and 53BP1, are detectable in a sub-population of Mrg15 deficient NSC cultures under normal growing conditions and the majority of p21-positive cells are also positive for 53BP1 foci.
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.
Impact
Coronary Artery Disease (C4D) Genetics Consortium, In Nat Genet, 2011
Replication in an independent sample of 21,408 cases and 19,185 controls identified five loci newly associated with CAD (P < 5 × 10⁻⁸ in the combined discovery and replication analysis): LIPA on 10q23, PDGFD on 11q22, ADAMTS7-MORF4L1 on 15q25, a gene rich locus on 7q22 and KIAA1462 on 10p11.
Mutation analysis of the gene encoding the PALB2-binding protein MRG15 in BRCA1/2-negative breast cancer families.
GeneRIF
Foulkes et al., Montréal, Canada. In J Hum Genet, 2010
it seems unlikely that any constitutional changes in MRG15 confer an increased risk for breast cancer.
Exploring the link between MORF4L1 and risk of breast cancer.
GeneRIF
Pujana et al., l'Hospitalet de Llobregat, Spain. In Breast Cancer Res, 2010
While the present study expands on the role of MRG15 in the control of genomic stability, weak associations can not be ruled out for potential low-penetrance variants at MORF4L1 and breast cancer risk among BRCA2 mutation carriers
Conditional inactivation of MRG15 gene function limits survival during larval and adult stages of Drosophila melanogaster.
GeneRIF
Tower et al., Los Angeles, United States. In Exp Gerontol, 2010
Drosophila DmMRG15 gene function is required for female fertility, larval survival and adult life span, and provides reagents that should be useful for further dissecting the role of DmMRG15 in cell proliferation and aging.
Emerging role of the MORF/MRG gene family in various biological processes, including aging.
Review
Pereira-Smith et al., San Antonio, United States. In Ann N Y Acad Sci, 2010
Morf4 is a member of a family of seven genes, and Morf-related genes (Mrg) on chromosomes 15 (Mrg15) and X (MrgX) are also expressed.
MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks.
GeneRIF
Andreassen et al., Kōbe, Japan. In J Cell Sci, 2010
gene deficiency reduces DNA repair and increase sensitivity to DNA-crosslinking agents
The role of the MORF/MRG family of genes in cell growth, differentiation, DNA repair, and thereby aging.
Review
GeneRIF
Pereira-Smith et al., San Antonio, United States. In Ann N Y Acad Sci, 2007
MORF4 has a role in cellular aging, and MRG15 associates with both histone deacetylases and histone acetyl transferase complexes [review]
Identification of genes involved in cell senescence and immortalization: potential implications for tissue ageing.
Review
Pereira-Smith et al., Houston, United States. In Novartis Found Symp, 2000
It is a member of a family of seven genes and only MORF4 and the MORF-related genes MRG15 and MRGX are expressed.
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