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Myogenic factor 6

MRF4, Myf6, herculin
The protein encoded by this gene is a probable basic helix-loop-helix (bHLH) DNA binding protein involved in muscle differentiation. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of autosomal dominant centronuclear myopathy (ADCNM). [provided by RefSeq, May 2010] (from NCBI)
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Top mentioned proteins: MyoD, Myogenin, Myf5, CAN, FasT
Papers on MRF4
Molecular cloning, characterisation and functional analysis of the duck Forkhead box O3 (FOXO3) gene.
New
Li et al., China. In Br Poult Sci, Feb 2016
MRF4, MyoD, MyoG, Myf5 and PAX7 mRNA expression in the pEGFP-N1-FOXO3 group was lowest.
Effects of Dietary Supplementation of β-hydroxy-β-methylbutyrate on Sow Performance and mRNA Expression of Myogenic Markers in Skeletal Muscle of Neonatal Piglets.
New
Wu et al., China. In Reprod Domest Anim, Jan 2016
Furthermore, maternal HMB treatment increased the mRNA levels of the myogenic genes, including muscle regulatory factor-4 (MRF4, p < 0.05), myogenic differentiation factor (MyoD) and insulin-like growth factor-1 (IGF-1, p < 0.01).
MicroRNA, miR-374b, directly targets Myf6 and negatively regulates C2C12 myoblasts differentiation.
New
Zuo et al., Wuhan, China. In Biochem Biophys Res Commun, Dec 2015
Myogenesis is a complex process including myoblast proliferation, differentiation and myotube formation and is controlled by myogenic regulatory factors (MRFs), MyoD, MyoG, Myf5 and Myf6 (also known as MRF4).
Molecular characterization of Myf5 and comparative expression patterns of myogenic regulatory factors in Siniperca chuatsi.
New
Zhang et al., Changsha, China. In Gene Expr Patterns, Dec 2015
Whereas the highest expressional level of the MRF4 was observed at the muscular effect stage.
Ectopic expression of Msx2 in mammalian myotubes recapitulates aspects of amphibian muscle dedifferentiation.
New
Paro et al., Basel, Switzerland. In Stem Cell Res, Nov 2015
We found that MSX2, but not MSX1, leads to cellularization of myotubes and downregulates the expression of myotube markers, such as MHC, MRF4 and myogenin.
Network Analysis for the Identification of Differentially Expressed Hub Genes Using Myogenin Knock-down Muscle Satellite Cells.
Choi et al., Kyŏngsan, South Korea. In Plos One, 2014
Muscle, a multinucleate syncytium formed by the fusion of mononuclear myoblasts, arises from quiescent progenitors (satellite cells) via activation of muscle-specific transcription factors (MyoD, Myf5, myogenin: MYOG, and MRF4).
Postmitotic Expression of SOD1(G93A) Gene Affects the Identity of Myogenic Cells and Inhibits Myoblasts Differentiation.
Musarò et al., Roma, Italy. In Mediators Inflamm, 2014
Transfected SOD1(G93A) gene expression in postmitotic skeletal myocytes downregulated the expression of relevant markers of committed and differentiated myoblasts such as MyoD, Myogenin, MRF4, and the muscle specific miRNA expression.
[Interactions of proliferation and differentiation signaling pathways in myogenesis].
Review
Grzelkowska-Kowalczyk et al., Warsaw, Poland. In Postepy Hig Med Dosw (online), 2013
Myoblast specialization, differentiation and fusion require the activity of myogenic regulatory factors, which include MyoD, myogenin, Myf5 and MRF4.
Differential modulation of cell cycle progression distinguishes members of the myogenic regulatory factor family of transcription factors.
Review
Dilworth et al., Ottawa, Canada. In Febs J, 2013
The muscle-specific basic helix-loop-helix proteins MyoD, Myf5, myogenin (Myog) and MRF4 constitute the myogenic regulatory factor (MRF) family of transcription factors that drive muscle gene expression during myogenesis.
How is myogenesis initiated in chordates?
Review
Jedrzejowska et al., Wrocław, Poland. In Folia Biol (krakow), 2011
Expression of transcriptor factors MyoD, Myf5, myogenin and MRF4 forms the basis of myogenesis.
Loss of synaptic vesicles from neuromuscular junctions in aged MRF4-null mice.
GeneRIF
Kraner et al., Dayton, United States. In Neuroreport, 2011
Intrinsic muscle factor MRF4 plays an important role in maintenance of neuromuscular junctions.
Many routes to the same destination: lessons from skeletal muscle development.
Review
Sweetman et al., Loughborough, United Kingdom. In Reproduction, 2011
Recent findings show that a core transcriptional network, initiated by the myogenic regulatory factors (MRFs; MYF5, MYOD, myogenin and MRF4), is activated by separate populations of cells in embryos in response to various signalling pathways.
Polymorphisms of MRF4 and H-FABP genes association with growth traits in Qinchuan cattle and related hybrids.
GeneRIF
Chen et al., China. In Mol Biol Rep, 2011
MRF4 and H-FABP genes are associated with growth traits in Qinchuan cattle and related hybrids [MRF4]
Myogenic regulatory factors transactivate the Tceal7 gene and modulate muscle differentiation.
GeneRIF
Garry et al., Minneapolis, United States. In Biochem J, 2010
Data demonstrated that Myf6 is Tceal7 upstream transactivators using transcriptional assays.
Myogenic regulatory factors regulate M-cadherin expression by targeting its proximal promoter elements.
GeneRIF
Chen et al., Taiwan. In Biochem J, 2010
MRF4 targets the proximal region of M-cadherin promoter and bind the E4-box.
Evidence for a myotomal Hox/Myf cascade governing nonautonomous control of rib specification within global vertebral domains.
GeneRIF
Mallo et al., Portugal. In Dev Cell, 2010
Hox genes produce global patterns in the axial skeleton; Myf5 and Myf6 have roles in rib formation
The molecular regulation of muscle stem cell function.
Review
Kuang et al., Ottawa, Canada. In Cold Spring Harb Symp Quant Biol, 2007
Extensive genetic analysis has revealed that Myf5 and MyoD are required for myogenic determination, whereas myogenin and MRF4 have roles in terminal differentiation.
Dedifferentiation of mammalian myotubes induced by msx1.
Impact
Keating et al., Salt Lake City, United States. In Cell, 2001
Ectopic expression of msx1 in C2C12 myotubes reduced the nuclear muscle proteins MyoD, myogenin, MRF4, and p21 to undetectable levels in 20%-50% of the myotubes.
Mox2 is a component of the genetic hierarchy controlling limb muscle development.
Impact
Pachnis et al., London, United Kingdom. In Nature, 1999
Among the genes known to be important for muscle development in mammalian embryos are those encoding the basic helix-loop-helix (bHLH) myogenic regulatory factors (MRFs; MyoD, Myf5, myogenin and MRF4) and Pax3, a paired-type homeobox gene that is critical for the development of limb musculature.
Functional redundancy of the muscle-specific transcription factors Myf5 and myogenin.
Impact
Jaenisch et al., Cambridge, United States. In Nature, 1996
The myogenic basic helix-loop-helix transcription factors, Myf5, MyoD, myogenin and MRF4, play key roles in skeletal muscle development.
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