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MRF1 Mrf1p

MRF1, modulator recognition factor 1, Mrf1p
Members of the ARID protein family, including ARID5A, have diverse functions but all appear to play important roles in development, tissue-specific gene expression, and regulation of cell growth (Patsialou et al., 2005 [PubMed 15640446]).[supplied by OMIM, Mar 2008] (from NCBI)
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Top mentioned proteins: ACID, HAD, Mrf-2, CAN, Rhotekin
Papers on MRF1
Genome-wide association study supports the role of the immunological system and of the neurodevelopmental processes in response to haloperidol treatment.
Rujescu et al., Brescia, Italy. In Pharmacogenet Genomics, 2014
RESULTS: Two SNPs (rs7912580 and rs2412459) were associated with response in both samples, respectively, located in an intergenic region between the AT-rich interactive domain 5B (ARID5B, MRF1-like) gene and rhotekin 2 (RTKN2) gene, an intronic region located in the eukaryotic translation initiation factor 2α kinase 4 (EIF2AK4) gene (P=1.358e-06
Improving patient safety by detecting obstetric care-related adverse events: application of a new screening guide.
Aibar et al., Zaragoza, Spain. In Arch Gynecol Obstet, 2014
The aim of this study was to evaluate the usefulness of the MRF1-OBST screening guide in detecting adverse events in women who received obstetric care.
Neonatal genome-wide methylation patterns in relation to birth weight in the Norwegian Mother and Child Cohort.
London et al., In Am J Epidemiol, 2014
In multivariable-adjusted robust linear regression models, we identified differential methylation at 19 cytosine-guanine dinucleotides (CpGs) associated with either decreased (AT-rich interactive domain 5B (MRF1-like) (ARID5B), 2 CpGs) or increased (x-ray repair complementing defective repair in Chinese hamster cells 3 (XRCC3), 4 CpGs) birth weight.
Genetic inactivation of the allograft inflammatory factor-1 locus.
Sibinga et al., New York City, United States. In Genesis, 2013
Largely similar gene products arising from the same locus are known as ionized Ca(2+) binding adapter-1 (Iba1), microglial response factor-1 (MRF1), and daintain; Iba1 in particular has emerged as a histologic marker of microglia and their activation in pathologic CNS conditions, including the response to facial nerve axotomy and stroke, uveitis, and experimental autoimmune neuritis and encephalomyelitis.
Inhibitory effect of Shikonin on Candida albicans growth.
Cao et al., Shanghai, China. In Biol Pharm Bull, 2011
Our analyses also identified 9 differentially expressed genes, which were related to glycolysis-related genes (CDC19 and HXK2), fermentation-related genes (ALD5 and ADH1), antioxidant defense-related genes (SOD2 and SOD5), thioredoxin reductase-related gene (TRR1), mitochondrial respiratory electron transport chain-related gene (MRF1) and reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidoreductase-related gene (EBP1).
Mitochondrial release factor in yeast: interplay of functional domains.
Boguta et al., Warsaw, Poland. In Curr Genet, 2008
The MRF1 gene encodes the only class I release factor found in Saccharomyces cerevisiae mitochondria, mRF1.
The yeast translation release factors Mrf1p and Sup45p (eRF1) are methylated, respectively, by the methyltransferases Mtq1p and Mtq2p.
Sherman et al., Rochester, United States. In J Biol Chem, 2006
Mtq1p methylates Mrf1p A tryptic peptide of Mrf1p, GGQHVNTTDSAVR, containing the GGQ motif was found to be approximately 50% methylated at the glutamine residue in the normal strain but completely unmodified in the peptide from mtq1-Delta.
Modulator recognition factor 1, an AT-rich interaction domain family member, is a novel corepressor for estrogen receptor alpha.
Mendelsohn et al., Boston, United States. In Mol Endocrinol, 2005
Here we report the identification of modulator recognition factor 1 (MRF1) as an ERalpha-interacting corepressor protein.
Expression of mitochondrial release factor in relation to respiratory competence in yeast.
Boguta et al., Warsaw, Poland. In Curr Genet, 2005
mutation in MRF1 that inhibits translation is due to ribosome stalling at the stop codon, and the observed elevated level of release factor is a secondary effect of respiratory deficiency
The glutamine residue of the conserved GGQ motif in Saccharomyces cerevisiae release factor eRF1 is methylated by the product of the YDR140w gene.
Buckingham et al., Paris, France. In J Biol Chem, 2005
the natural substrate of the methyltransferase YDR140w is the ternary complex eRF1.eRF3.GTP
Translational readthrough of a termination codon in the yeast mitochondrial mRNA VAR1 as a result of mutation in the release factor mRF1.
Zagórski et al., Paris, France. In Acta Biochim Pol, 2004
Translation of he mitochondrially encoded polypeptides in strains with mutated mitochondrial release factor, mRF1, was found to result in the synthesis of a novel protein, V2.
Mutations in the yeast mrf1 gene encoding mitochondrial release factor inhibit translation on mitochondrial ribosomes.
Boguta et al., Warsaw, Poland. In J Biol Chem, 2004
Ten mutations isolated in a genetic screen for read-through of premature stop codons in mitochondrial genes were localized in the chromosomal gene encoding the mitochondrial release factor mRF1.
Mercury volatilization by R factor systems in Escherichia coli isolated from aquatic environments of India.
Ali et al., New Delhi, India. In Curr Microbiol, 2004
MRD14 isolated from the Dal Lake (Kashmir) could tolerate the highest concentration of HgCl(2), i.e., 55 microg/mL, and MRF1 from the flood water of the Yamuna River (Delhi) tolerated the lowest concentration, i.e., 25 microg/mL.
Structure-function analysis of enoyl thioester reductase involved in mitochondrial maintenance.
Hiltunen et al., Oulu, Finland. In J Mol Biol, 2003
Candida tropicalis enoyl thioester reductase Etr1p and the Saccharomyces cerevisiae homologue Mrf1p catalyse the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (FAS).
Functional characterization of yeast mitochondrial release factor 1.
Tate et al., Dunedin, New Zealand. In J Biol Chem, 2000
The yeast Saccharomyces cerevisiae mitochondrial release factor was expressed from the cloned MRF1 gene, purified from inclusion bodies, and refolded to give functional activity.
Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors.
Osumi et al., Himeji, Japan. In Gene, 1998
NRBF-1 has a significant homology to the yeast protein MRF1, a putative transcription factor regulating the expression of mitochondrial respiratory proteins.
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