Biology of CD1- and MR1-Restricted T Cells.
Oxford, United Kingdom. In Annu Rev Immunol, 21 Apr 2014
In this review, we describe the most recent events in the field, with particular emphasis on (a) structural and functional aspects of lipid presentation by CD1 molecules, (b) the development of CD1d-restricted invariant natural killer T (iNKT) cells and transcription factors required for their differentiation, (c) the ability of iNKT cells to modulate innate and adaptive immune responses through their cross talk with lymphoid and myeloid cells, and (d) MR1-restricted and group I (CD1a, CD1b, and CD1c)-restricted T cells.
Qualifying the lapped enamel surface: A profilometric, electron microscopic and microhardness study using human, bovine and ovine enamel.
Newcastle upon Tyne, United Kingdom. In Arch Oral Biol, 18 Mar 2014
Roughness average (Ra), bearing parameters (MR1, MR2, Rpk, Rk, Rvk), surface microhardness and scanning electron microscopy (SEM) were used to compare the different tissues.
MAITs, MR1 and vitamin B metabolites.
Australia. In Curr Opin Immunol, 28 Feb 2014
Recently the antigenic repertoire of αβT-cells has been expanded with the observation that mucosal-associated invariant T-cells (MAIT cells), an abundant population of innate-like T-cells, can recognise metabolites of vitamin B, when presented by the MHC-related protein, MR1.
MAIT cells in autoimmunity.
In Nihon Rinsho Meneki Gakkai Kaishi, Dec 2013
They are restricted by a nonpolymorphic MHC-related molecule-1 (MR1), and cells are selected in the thymus.
Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells.
Basel, Switzerland. In Nat Immunol, Sep 2013
Human T cells that express a T cell antigen receptor (TCR) containing γ-chain variable region 9 and δ-chain variable region 2 (Vγ9Vδ2) recognize phosphorylated prenyl metabolites as antigens in the presence of antigen-presenting cells but independently of major histocompatibility complex (MHC), the MHC class I-related molecule MR1 and antigen-presenting CD1 molecules.
[MAIT cells in autoimmunity].
In Nihon Rinsho Meneki Gakkai Kaishi, 2011
Mucosal associated invariant T (MAIT) cells are restricted by a nonpolymorphic MHC-related molecule-1 (MR1), and express an invariant TCRα chain: Vα7.2-Jα33 in humans and Vα19-Jα33 in mice.
Antimicrobial activity of mucosal-associated invariant T cells.
Paris, France. In Nat Immunol, 2010
Mucosal-associated invariant T lymphocytes (MAIT lymphocytes) are characterized by two evolutionarily conserved features: an invariant T cell antigen receptor (TCR) alpha-chain and restriction by the major histocompatibility complex (MHC)-related protein MR1.