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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 28 Mar 2014.

Major histocompatibility complex, class I-related

MR1, major histocompatibility complex class I-related
This gene is thought to play a role in the regulation of myofibrillogenesis. Mutations in this gene have been associated with the movement disorder paroxysmal non-kinesigenic dyskinesia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: CAN, MHC, MICA, HAD, IgM
Papers on MR1
Biology of CD1- and MR1-Restricted T Cells.
New
Impact
Cerundolo et al., Oxford, United Kingdom. In Annu Rev Immunol, 21 Apr 2014
In this review, we describe the most recent events in the field, with particular emphasis on (a) structural and functional aspects of lipid presentation by CD1 molecules, (b) the development of CD1d-restricted invariant natural killer T (iNKT) cells and transcription factors required for their differentiation, (c) the ability of iNKT cells to modulate innate and adaptive immune responses through their cross talk with lymphoid and myeloid cells, and (d) MR1-restricted and group I (CD1a, CD1b, and CD1c)-restricted T cells.
[Effect of donor and recipient anti-MICA antibodies on early renal graft function following transplantation].
New
Yu et al., Guangzhou, China. In Nan Fang Yi Ke Da Xue Xue Bao, 20 Apr 2014
OBJECTIVE: To investigate the effects of donor and recipient anti-major histocompatibility complex class I-related chain A (MICA) antibodies on early renal graft function in renal transplant recipients.
Draft Genome Sequence of the Endophytic Bacterium Enterobacter spp. MR1, Isolated from Drought Tolerant Plant (Butea monosperma).
New
Golakiya et al., Jūnāgadh, India. In Indian J Microbiol, 31 Mar 2014
MR1 an endophytic plant growth promoting bacterium was isolated from the roots of Butea monosperma, a drought tolerant plant.
Qualifying the lapped enamel surface: A profilometric, electron microscopic and microhardness study using human, bovine and ovine enamel.
New
Waterhouse et al., Newcastle upon Tyne, United Kingdom. In Arch Oral Biol, 18 Mar 2014
Roughness average (Ra), bearing parameters (MR1, MR2, Rpk, Rk, Rvk), surface microhardness and scanning electron microscopy (SEM) were used to compare the different tissues.
MAITs, MR1 and vitamin B metabolites.
Review
New
Rossjohn et al., Australia. In Curr Opin Immunol, 28 Feb 2014
Recently the antigenic repertoire of αβT-cells has been expanded with the observation that mucosal-associated invariant T-cells (MAIT cells), an abundant population of innate-like T-cells, can recognise metabolites of vitamin B, when presented by the MHC-related protein, MR1.
B cells modulate mucosal associated invariant T cell immune responses.
New
Sztein et al., Baltimore, United States. In Front Immunol, 07 Feb 2014
These responses were restricted by the non-classical MHC-related molecule 1 (MR1) and involved the endocytic pathway.
MAIT cells in autoimmunity.
New
Miyake, In Nihon Rinsho Meneki Gakkai Kaishi, Dec 2013
They are restricted by a nonpolymorphic MHC-related molecule-1 (MR1), and cells are selected in the thymus.
Acquisition of innate-like microbial reactivity in mucosal tissues during human fetal MAIT-cell development.
New
Sandberg et al., Huddinge, Sweden. In Nat Commun, Dec 2013
Innate-like, evolutionarily conserved MR1-restricted mucosa-associated invariant T (MAIT) cells represent a large antimicrobial T-cell subset in humans.
Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells.
New
Impact
De Libero et al., Basel, Switzerland. In Nat Immunol, Sep 2013
Human T cells that express a T cell antigen receptor (TCR) containing γ-chain variable region 9 and δ-chain variable region 2 (Vγ9Vδ2) recognize phosphorylated prenyl metabolites as antigens in the presence of antigen-presenting cells but independently of major histocompatibility complex (MHC), the MHC class I-related molecule MR1 and antigen-presenting CD1 molecules.
MAIT cells, surveyors of a new class of antigen: development and functions.
Review
New
Lantz et al., Paris, France. In Curr Opin Immunol, Apr 2013
Mucosal associated invariant T (MAIT) cells are evolutionarily conserved T cells that are restricted by the non-classical MHC-1b molecule, MR1.
Co-dependents: MR1-restricted MAIT cells and their antimicrobial function.
Review
Impact
Lewinsohn et al., Portland, United States. In Nat Rev Microbiol, 2013
The semi-invariant antigen recognition receptor of MAIT cells detects the non-polymorphic antigen-presenting molecule major histocompatibility complex class I-related protein 1 (MR1), which can bind microorganism-derived riboflavin metabolites.
MR1 presents microbial vitamin B metabolites to MAIT cells.
Impact
McCluskey et al., Melbourne, Australia. In Nature, 2012
Mucosal-associated invariant T (MAIT) cells are an abundant population of innate-like T cells in humans that are activated by an antigen(s) bound to the MHC class I-like molecule MR1.
Major histocompatibility complex class I molecules modulate embryonic neuritogenesis and neuronal polarization.
GeneRIF
Kaufman et al., Los Angeles, United States. In J Neuroimmunol, 2012
The results of this study supported that MHCI appears to differentially modulate neuritogenesis and synaptogenesis.
Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor.
GeneRIF
McCluskey et al., Melbourne, Australia. In J Exp Med, 2012
Mutagenesis of MR1 showed that only two residues, which were centrally positioned and on opposing sides of the antigen-binding cleft of MR1, were essential for MAIT cell activation
Dopamine dysregulation in a mouse model of paroxysmal nonkinesigenic dyskinesia.
GeneRIF
Ptácek et al., San Francisco, United States. In J Clin Invest, 2012
These findings support the hypothesis that the PNKD protein functions to modulate striatal neuro-transmitter release in response to stress and other precipitating factors.
Paroxysmal non-kinesigenic dyskinesia due to a PNKD recurrent mutation: report of two Southern European families.
GeneRIF
Macaya et al., Athens, Greece. In Eur J Paediatr Neurol, 2012
In this report we present two families with paroxysmal non-kinesigenic dyskinesia of Southern European origin carrying a PNKD protein recurrent mutation.
[MAIT cells in autoimmunity].
Review
Miyake, In Nihon Rinsho Meneki Gakkai Kaishi, 2011
Mucosal associated invariant T (MAIT) cells are restricted by a nonpolymorphic MHC-related molecule-1 (MR1), and express an invariant TCRα chain: Vα7.2-Jα33 in humans and Vα19-Jα33 in mice.
Human MR1 expression on the cell surface is acid sensitive, proteasome independent and increases after culturing at 26°C.
GeneRIF
Martínez-Naves et al., Madrid, Spain. In Biochem Biophys Res Commun, 2011
Taken together these results strongly suggest that MR1 needs to bind proteasome-independent ligands in order to properly reach the cell surface.
The effect of MICA antigens on transplant outcomes: a systematic review.
Review
Li et al., Chengdu, China. In J Evid Based Med, 2011
BACKGROUND AND OBJECTIVE: Human major histocompatibility complex class I-related gene A (MICA) is reportedly associated with poor transplant outcomes and a high risk of acute and chronic rejection in solid organ transplantation.
Antimicrobial activity of mucosal-associated invariant T cells.
Impact
Lantz et al., Paris, France. In Nat Immunol, 2010
Mucosal-associated invariant T lymphocytes (MAIT lymphocytes) are characterized by two evolutionarily conserved features: an invariant T cell antigen receptor (TCR) alpha-chain and restriction by the major histocompatibility complex (MHC)-related protein MR1.
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