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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 23 Aug 2015.

Major histocompatibility complex, class I-related

MR1, major histocompatibility complex class I-related
This gene is thought to play a role in the regulation of myofibrillogenesis. Mutations in this gene have been associated with the movement disorder paroxysmal non-kinesigenic dyskinesia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: MHC, CAN, MICA, HAD, IgM
Papers on MR1
Donor Unrestricted T Cells: A Shared Human T Cell Response.
New
Moody et al., Utrecht, Netherlands. In J Immunol, 01 Oct 2015
However, other T cells can be considered "donor unrestricted" because their targets, CD1a, CD1b, CD1c, CD1d, or MR1, are expressed in a similar form among all humans.
Full-length coding sequences of three major histocompatibility complex class I-related chain A alleles, MICA*019, MICA*027 and MICA*045, identified by sequence-based typing in Chinese individuals.
New
Tao et al., Shenzhen, China. In Tissue Antigens, 07 Sep 2015
UNASSIGNED: Full-length coding sequences of three major histocompatibility complex class I-related chain A alleles, MICA*019, MICA*027 and MICA*045.
Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection.
New
Sandberg et al., Huddinge, Sweden. In Plos Pathog, 31 Aug 2015
MAIT cells recognize microbial riboflavin metabolites from a range of microbes presented by MR1 molecules.
MR1 presentation of vitamin B-based metabolite ligands.
Review
New
Rossjohn et al., Melbourne, Australia. In Curr Opin Immunol, Jun 2015
The major histocompatibility complex class I-related molecule MR1 can bind a novel class of antigens, namely a family of related small organic vitamin B metabolites.
The Role of Mucosal Associated Invariant T Cells in Antimicrobial Immunity.
New
Lewinsohn et al., Portland, United States. In Front Immunol, Dec 2014
Human MAIT cells are defined by the expression of the semi-invariant TCRα chain TRAV1-2/TRAJ12/20/33 and are restricted by the non-polymorphic major histocompatibility complex (MHC) class I-like molecule, MHC-related protein 1, MR1.
T cell antigen receptor recognition of antigen-presenting molecules.
New
Impact
McCluskey et al., Australia. In Annu Rev Immunol, Dec 2014
In addition, the CD1 family members and MR1 are MHC class I-like molecules that bind lipid-based Ags and vitamin B precursors, respectively.
Role of Innate T Cells in Anti-Bacterial Immunity.
Review
New
Williams et al., Southampton, United Kingdom. In Front Immunol, Dec 2014
These cells recognize foreign/self-lipid presented by non-classical MHC molecules, such as CD1d, MR1, and CD1a.
Adoptive T Cell Therapy Targeting CD1 and MR1.
Review
New
Hirano et al., Toronto, Canada. In Front Immunol, Dec 2014
CD1 and MR1 are class I-like monomorphic molecules and their restricted T cells possess unique T cell receptor specificity against entirely different classes of antigens.
MR1-Restricted Mucosal-Associated Invariant T Cells and Their Activation during Infectious Diseases.
Review
New
Cerundolo et al., Oxford, United Kingdom. In Front Immunol, Dec 2014
MR1-restricted mucosal-associated invariant T (MAIT) cells recognize vitamin B metabolites, which are generated by a broad range of bacteria, from Escherichia coli to Mycobacterium tuberculosis and BCG.
Regulation of Lipid Specific and Vitamin Specific Non-MHC Restricted T Cells by Antigen Presenting Cells and Their Therapeutic Potentials.
New
Cerundolo et al., Oxford, United Kingdom. In Front Immunol, Dec 2014
Furthermore, it has been demonstrated that small molecules derived from the microbial riboflavin biosynthetic pathway (vitamin B2) bind monomorphic MR1 molecules and activate mucosal-associated invariant T cells, another population of semi-invariant T cells.
T-cell activation by transitory neo-antigens derived from distinct microbial pathways.
New
Impact
McCluskey et al., Melbourne, Australia. In Nature, Jun 2014
However, the genesis of these small organic molecules and their mode of presentation to MAIT cells by the major histocompatibility complex (MHC)-related protein MR1 (ref.
Biology of CD1- and MR1-restricted T cells.
Review
Impact
Cerundolo et al., Oxford, United Kingdom. In Annu Rev Immunol, 2013
In this review, we describe the most recent events in the field, with particular emphasis on (a) structural and functional aspects of lipid presentation by CD1 molecules, (b) the development of CD1d-restricted invariant natural killer T (iNKT) cells and transcription factors required for their differentiation, (c) the ability of iNKT cells to modulate innate and adaptive immune responses through their cross talk with lymphoid and myeloid cells, and (d) MR1-restricted and group I (CD1a, CD1b, and CD1c)-restricted T cells.
Mucosal-associated invariant T-cells: new players in anti-bacterial immunity.
Review
Willberg et al., Oxford, United Kingdom. In Front Immunol, 2013
MR1 has recently been shown to present an unstable pyrimidine intermediate derived from a biosynthetic precursor of riboflavin; riboflavin biosynthesis occurs in many bacteria but not in human beings.
Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells.
Impact
De Libero et al., Basel, Switzerland. In Nat Immunol, 2013
Human T cells that express a T cell antigen receptor (TCR) containing γ-chain variable region 9 and δ-chain variable region 2 (Vγ9Vδ2) recognize phosphorylated prenyl metabolites as antigens in the presence of antigen-presenting cells but independently of major histocompatibility complex (MHC), the MHC class I-related molecule MR1 and antigen-presenting CD1 molecules.
Co-dependents: MR1-restricted MAIT cells and their antimicrobial function.
Review
Impact
Lewinsohn et al., Portland, United States. In Nat Rev Microbiol, 2013
The semi-invariant antigen recognition receptor of MAIT cells detects the non-polymorphic antigen-presenting molecule major histocompatibility complex class I-related protein 1 (MR1), which can bind microorganism-derived riboflavin metabolites.
Major histocompatibility complex class I molecules modulate embryonic neuritogenesis and neuronal polarization.
GeneRIF
Kaufman et al., Los Angeles, United States. In J Neuroimmunol, 2012
The results of this study supported that MHCI appears to differentially modulate neuritogenesis and synaptogenesis.
Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor.
GeneRIF
McCluskey et al., Melbourne, Australia. In J Exp Med, 2012
Mutagenesis of MR1 showed that only two residues, which were centrally positioned and on opposing sides of the antigen-binding cleft of MR1, were essential for MAIT cell activation
Dopamine dysregulation in a mouse model of paroxysmal nonkinesigenic dyskinesia.
GeneRIF
Ptácek et al., San Francisco, United States. In J Clin Invest, 2012
These findings support the hypothesis that the PNKD protein functions to modulate striatal neuro-transmitter release in response to stress and other precipitating factors.
Paroxysmal non-kinesigenic dyskinesia due to a PNKD recurrent mutation: report of two Southern European families.
GeneRIF
Macaya et al., Athens, Greece. In Eur J Paediatr Neurol, 2012
In this report we present two families with paroxysmal non-kinesigenic dyskinesia of Southern European origin carrying a PNKD protein recurrent mutation.
Human MR1 expression on the cell surface is acid sensitive, proteasome independent and increases after culturing at 26°C.
GeneRIF
Martínez-Naves et al., Madrid, Spain. In Biochem Biophys Res Commun, 2011
Taken together these results strongly suggest that MR1 needs to bind proteasome-independent ligands in order to properly reach the cell surface.
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