The burgeoning family of unconventional T cells.
Melbourne, Australia. In Nat Immunol, 20 Nov 2015
These include CD1-restricted T cells, MR1-restricted mucosal associated invariant T cells (MAIT cells), MHC class Ib-reactive T cells, and γδ T cells.
CD1d- and MR1-Restricted T Cells in Sepsis.
London, Canada. In Front Immunol, Dec 2014
Recent studies have implicated unconventional, innate-like T lymphocytes, including CD1d- and MR1-restricted T cells as effectors and/or regulators of inflammatory responses during sepsis.
Assessment of Immunological Biomarkers in the First Year after Heart Transplantation.
Leipzig, Germany. In Dis Markers, Dec 2014
Activation markers CD25 and CD95, intracellular cytokines IL-2 and IFNγ, chemokines IP10 and MIG, and subsets of dendritic cells as well as antibodies against human leukocyte antigens (HLA) and major histocompatibility complex class I-related chain A (MICA) antigens were analyzed at different time points using flow cytometry and Luminex xMAP technology.
Biology of CD1- and MR1-restricted T cells.
Oxford, United Kingdom. In Annu Rev Immunol, 2013
In this review, we describe the most recent events in the field, with particular emphasis on (a) structural and functional aspects of lipid presentation by CD1 molecules, (b) the development of CD1d-restricted invariant natural killer T (iNKT) cells and transcription factors required for their differentiation, (c) the ability of iNKT cells to modulate innate and adaptive immune responses through their cross talk with lymphoid and myeloid cells, and (d) MR1-restricted and group I (CD1a, CD1b, and CD1c)-restricted T cells.