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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 15 May 2015.

Major histocompatibility complex, class I-related

MR1, major histocompatibility complex class I-related
This gene is thought to play a role in the regulation of myofibrillogenesis. Mutations in this gene have been associated with the movement disorder paroxysmal non-kinesigenic dyskinesia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: MHC, CAN, MICA, HAD, IgM
Papers on MR1
Engineering NK Cells Modified With an EGFRvIII-specific Chimeric Antigen Receptor to Overexpress CXCR4 Improves Immunotherapy of CXCL12/SDF-1α-secreting Glioblastoma.
New
Temme et al., Hamburg, Germany. In J Immunother, 30 Jun 2015
On the basis of the DNAX-activation protein 12 (DAP12), a signaling adapter molecule involved in signal transduction of activating NK cell receptors, we constructed an epidermal growth factor variant III (EGFRvIII)-CAR, designated MR1.1-DAP12 which confers specific cytotoxicity of NK cell towards EGFRvIII glioblastoma cells in vitro and to established subcutaneous U87-MG tumor xenografts.
In Vitro and In Vivo Analysis of the Gram-Negative Bacteria-Derived Riboflavin Precursor Derivatives Activating Mouse MAIT Cells.
New
Lantz et al., Paris, France. In J Immunol, 15 Jun 2015
Mucosal-associated invariant T (MAIT) cells recognize microbial compounds presented by the MHC-related 1 (MR1) protein.
Mucosal-associated invariant T cells are numerically and functionally deficient in patients with mycobacterial infection and reflect disease activity.
New
Park et al., Kwangju, South Korea. In Tuberculosis (edinb), 31 May 2015
MAIT cells in TB patients failed to produce interferon-γ irrespective of the mode of stimulation, whereas NTM patients displayed a defect in MR1-dependent signaling pathway.
ART for head and neck patients: On the difference between VMAT and IMPT.
New
Georg et al., Vienna, Austria. In Acta Oncol, 08 May 2015
MATERIAL AND METHODS: For six H&N patients two repeated computed tomography (CT) and magnetic resonance (MR) (CT1/MR1 at week 2 and CT2/MR2 at week 4) scans were acquired additionally to the initial planning CT/MR.
T cell antigen receptor recognition of antigen-presenting molecules.
New
Impact
McCluskey et al., Australia. In Annu Rev Immunol, 21 Apr 2015
In addition, the CD1 family members and MR1 are MHC class I-like molecules that bind lipid-based Ags and vitamin B precursors, respectively.
MR1 presentation of vitamin B-based metabolite ligands.
Review
New
Rossjohn et al., Melbourne, Australia. In Curr Opin Immunol, Feb 2015
UNASSIGNED: The major histocompatibility complex class I-related molecule MR1 can bind a novel class of antigens, namely a family of related small organic vitamin B metabolites.
MAIT cells and pathogen defense.
Review
New
Cowley, Rockville, United States. In Cell Mol Life Sci, Dec 2014
These cells possess an evolutionarily conserved invariant T cell receptor α chain restricted by the nonpolymorphic class Ib major histocompatibility (MHC) molecule, MHC class I-related protein (MR1).
Attrition of TCR Vα7.2+ CD161++ MAIT Cells in HIV-Tuberculosis Co-Infection Is Associated with Elevated Levels of PD-1 Expression.
New
Shankar et al., Kuala Lumpur, Malaysia. In Plos One, Dec 2014
Mucosal-associated invariant T (MAIT) cells are evolutionarily conserved antimicrobial MR1-restricted CD8+ T cells co-expressing the semi-invariant TCR Vα7.2, and are numerous in the blood and mucosal tissues of humans.
Harnessing the antibacterial and immunological properties of mucosal-associated invariant T cells in the development of novel oral vaccines against enteric infections.
Review
New
Lavelle et al., Dublin, Ireland. In Biochem Pharmacol, Dec 2014
Mucosal-associated invariant T (MAIT) cells are a recently discovered population of unconventional T cells characterized by an evolutionarily conserved αβ T cell receptor (TCR) that recognizes antigens presented by major histocompatibility complex (MHC) class I-related (MR1) molecule.
The role of microRNAs in the control of innate immune response in cancer.
Review
New
Seliger et al., Halle, Germany. In J Natl Cancer Inst, Oct 2014
Ligands for receptors of natural killer (NK) cells and CD8(+) cytotoxic T lymphocytes (CTL), such as the inhibitory nonclassical HLA-G, the activating stress-induced major histocompatibility complex class I-related antigens MICA and MICB, and/or the UL16-binding proteins (ULBPs), are often aberrantly expressed upon viral infection and neoplastic transformation, thereby preventing virus-infected or malignant-transformed cells from elimination by immune effector cells.
T-cell activation by transitory neo-antigens derived from distinct microbial pathways.
New
Impact
McCluskey et al., Melbourne, Australia. In Nature, Jun 2014
However, the genesis of these small organic molecules and their mode of presentation to MAIT cells by the major histocompatibility complex (MHC)-related protein MR1 (ref.
Biology of CD1- and MR1-restricted T cells.
Review
Impact
Cerundolo et al., Oxford, United Kingdom. In Annu Rev Immunol, 2013
In this review, we describe the most recent events in the field, with particular emphasis on (a) structural and functional aspects of lipid presentation by CD1 molecules, (b) the development of CD1d-restricted invariant natural killer T (iNKT) cells and transcription factors required for their differentiation, (c) the ability of iNKT cells to modulate innate and adaptive immune responses through their cross talk with lymphoid and myeloid cells, and (d) MR1-restricted and group I (CD1a, CD1b, and CD1c)-restricted T cells.
Mucosal-associated invariant T-cells: new players in anti-bacterial immunity.
Review
Willberg et al., Oxford, United Kingdom. In Front Immunol, 2013
MR1 has recently been shown to present an unstable pyrimidine intermediate derived from a biosynthetic precursor of riboflavin; riboflavin biosynthesis occurs in many bacteria but not in human beings.
Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells.
Impact
De Libero et al., Basel, Switzerland. In Nat Immunol, 2013
Human T cells that express a T cell antigen receptor (TCR) containing γ-chain variable region 9 and δ-chain variable region 2 (Vγ9Vδ2) recognize phosphorylated prenyl metabolites as antigens in the presence of antigen-presenting cells but independently of major histocompatibility complex (MHC), the MHC class I-related molecule MR1 and antigen-presenting CD1 molecules.
Co-dependents: MR1-restricted MAIT cells and their antimicrobial function.
Review
Impact
Lewinsohn et al., Portland, United States. In Nat Rev Microbiol, 2013
The semi-invariant antigen recognition receptor of MAIT cells detects the non-polymorphic antigen-presenting molecule major histocompatibility complex class I-related protein 1 (MR1), which can bind microorganism-derived riboflavin metabolites.
Major histocompatibility complex class I molecules modulate embryonic neuritogenesis and neuronal polarization.
GeneRIF
Kaufman et al., Los Angeles, United States. In J Neuroimmunol, 2012
The results of this study supported that MHCI appears to differentially modulate neuritogenesis and synaptogenesis.
Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor.
GeneRIF
McCluskey et al., Melbourne, Australia. In J Exp Med, 2012
Mutagenesis of MR1 showed that only two residues, which were centrally positioned and on opposing sides of the antigen-binding cleft of MR1, were essential for MAIT cell activation
Dopamine dysregulation in a mouse model of paroxysmal nonkinesigenic dyskinesia.
GeneRIF
Ptácek et al., San Francisco, United States. In J Clin Invest, 2012
These findings support the hypothesis that the PNKD protein functions to modulate striatal neuro-transmitter release in response to stress and other precipitating factors.
Paroxysmal non-kinesigenic dyskinesia due to a PNKD recurrent mutation: report of two Southern European families.
GeneRIF
Macaya et al., Athens, Greece. In Eur J Paediatr Neurol, 2012
In this report we present two families with paroxysmal non-kinesigenic dyskinesia of Southern European origin carrying a PNKD protein recurrent mutation.
Human MR1 expression on the cell surface is acid sensitive, proteasome independent and increases after culturing at 26°C.
GeneRIF
Martínez-Naves et al., Madrid, Spain. In Biochem Biophys Res Commun, 2011
Taken together these results strongly suggest that MR1 needs to bind proteasome-independent ligands in order to properly reach the cell surface.
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