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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 10 Nov 2014.

Major histocompatibility complex, class I-related

MR1, major histocompatibility complex class I-related
This gene is thought to play a role in the regulation of myofibrillogenesis. Mutations in this gene have been associated with the movement disorder paroxysmal non-kinesigenic dyskinesia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: MHC, CAN, MICA, HAD, IgM
Papers on MR1
Characterisation of non-classical MHC class I genes in the Tasmanian devil (Sarcophilus harrisii).
Belov et al., Sydney, Australia. In Immunogenetics, 31 Dec 2014
Here, we report characterisation of five non-classical class I genes in the Tasmanian devil, including Saha-UD, -UK, -UM, -MR1 and -CD1.
MAIT cells are depleted early but retain functional cytokine expression in HIV infection.
Kent et al., Melbourne, Australia. In Immunol Cell Biol, 28 Nov 2014
We studied longitudinal blood samples from 31 HIV-infected subjects for MAIT cell numbers, phenotype and function using both standard Vα7.2/CD161 surface markers and an MR1 tetramer.
MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets.
Klenerman et al., Saint Louis, United States. In Mucosal Immunol, 01 Nov 2014
UNLABELLED: Mucosal-associated invariant T (MAIT) cells are an innate-like T-cell population restricted by the non-polymorphic, major histocompatibility complex class I-related protein 1, MR1.
The role of microRNAs in the control of innate immune response in cancer.
Seliger et al., Halle, Germany. In J Natl Cancer Inst, 31 Oct 2014
Ligands for receptors of natural killer (NK) cells and CD8(+) cytotoxic T lymphocytes (CTL), such as the inhibitory nonclassical HLA-G, the activating stress-induced major histocompatibility complex class I-related antigens MICA and MICB, and/or the UL16-binding proteins (ULBPs), are often aberrantly expressed upon viral infection and neoplastic transformation, thereby preventing virus-infected or malignant-transformed cells from elimination by immune effector cells.
A prominent role for invariant T cells in the amphibian Xenopus laevis tadpoles.
Edholm et al., Rochester, United States. In Immunogenetics, 31 Oct 2014
These iT cells are typically restricted by nonclassical MHC class I molecules (e.g., CD1d and MR1) and undergo differentiation pathways distinct from conventional T cells.
Human T cells use CD1 and MR1 to recognize lipids and small molecules.
Moody et al., Boston, United States. In Curr Opin Chem Biol, 27 Oct 2014
Newer insights into αβ and γδ T cell activation by CD1 or MR1 proteins greatly expand the biochemical range of T cell antigens to include lipids and non-peptidic small molecules.
T-cell activation by transitory neo-antigens derived from distinct microbial pathways.
McCluskey et al., Melbourne, Australia. In Nature, Jun 2014
However, the genesis of these small organic molecules and their mode of presentation to MAIT cells by the major histocompatibility complex (MHC)-related protein MR1 (ref.
Modeling T cell receptor recognition of CD1-lipid and MR1-metabolite complexes.
Weng et al., Worcester, United States. In Bmc Bioinformatics, Dec 2013
BACKGROUND: T cell receptors (TCRs) can recognize diverse lipid and metabolite antigens presented by MHC-like molecules CD1 and MR1, and the molecular basis of many of these interactions has not been determined.
Biology of CD1- and MR1-restricted T cells.
Cerundolo et al., Oxford, United Kingdom. In Annu Rev Immunol, Dec 2013
In this review, we describe the most recent events in the field, with particular emphasis on (a) structural and functional aspects of lipid presentation by CD1 molecules, (b) the development of CD1d-restricted invariant natural killer T (iNKT) cells and transcription factors required for their differentiation, (c) the ability of iNKT cells to modulate innate and adaptive immune responses through their cross talk with lymphoid and myeloid cells, and (d) MR1-restricted and group I (CD1a, CD1b, and CD1c)-restricted T cells.
[MAIT cells in autoimmunity].
Miyake, In Nihon Rinsho Meneki Gakkai Kaishi, Dec 2013
They are restricted by a nonpolymorphic MHC-related molecule-1 (MR1), and cells are selected in the thymus.
Mucosal-associated invariant T-cells: new players in anti-bacterial immunity.
Willberg et al., Oxford, United Kingdom. In Front Immunol, Dec 2013
MR1 has recently been shown to present an unstable pyrimidine intermediate derived from a biosynthetic precursor of riboflavin; riboflavin biosynthesis occurs in many bacteria but not in human beings.
IL22 Regulates Human Urothelial Cell Sensory and Innate Functions through Modulation of the Acetylcholine Response, Immunoregulatory Cytokines and Antimicrobial Peptides: Assessment of an In Vitro Model.
Brubaker et al., Maywood, United States. In Plos One, Dec 2013
The cultured HUCs expressed muscarinic receptors (MR1 and MR2), carnitine acetyltransferase (CarAT), immunoregulatory cytokines IL7, IL15, and IL23, as well as the chemokine CCL20.
Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells.
De Libero et al., Basel, Switzerland. In Nat Immunol, Sep 2013
Human T cells that express a T cell antigen receptor (TCR) containing γ-chain variable region 9 and δ-chain variable region 2 (Vγ9Vδ2) recognize phosphorylated prenyl metabolites as antigens in the presence of antigen-presenting cells but independently of major histocompatibility complex (MHC), the MHC class I-related molecule MR1 and antigen-presenting CD1 molecules.
Co-dependents: MR1-restricted MAIT cells and their antimicrobial function.
Lewinsohn et al., Portland, United States. In Nat Rev Microbiol, 2013
The semi-invariant antigen recognition receptor of MAIT cells detects the non-polymorphic antigen-presenting molecule major histocompatibility complex class I-related protein 1 (MR1), which can bind microorganism-derived riboflavin metabolites.
MR1 presents microbial vitamin B metabolites to MAIT cells.
McCluskey et al., Melbourne, Australia. In Nature, 2012
Mucosal-associated invariant T (MAIT) cells are an abundant population of innate-like T cells in humans that are activated by an antigen(s) bound to the MHC class I-like molecule MR1.
Major histocompatibility complex class I molecules modulate embryonic neuritogenesis and neuronal polarization.
Kaufman et al., Los Angeles, United States. In J Neuroimmunol, 2012
The results of this study supported that MHCI appears to differentially modulate neuritogenesis and synaptogenesis.
Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor.
McCluskey et al., Melbourne, Australia. In J Exp Med, 2012
Mutagenesis of MR1 showed that only two residues, which were centrally positioned and on opposing sides of the antigen-binding cleft of MR1, were essential for MAIT cell activation
Dopamine dysregulation in a mouse model of paroxysmal nonkinesigenic dyskinesia.
Ptácek et al., San Francisco, United States. In J Clin Invest, 2012
These findings support the hypothesis that the PNKD protein functions to modulate striatal neuro-transmitter release in response to stress and other precipitating factors.
Paroxysmal non-kinesigenic dyskinesia due to a PNKD recurrent mutation: report of two Southern European families.
Macaya et al., Athens, Greece. In Eur J Paediatr Neurol, 2012
In this report we present two families with paroxysmal non-kinesigenic dyskinesia of Southern European origin carrying a PNKD protein recurrent mutation.
Human MR1 expression on the cell surface is acid sensitive, proteasome independent and increases after culturing at 26°C.
Martínez-Naves et al., Madrid, Spain. In Biochem Biophys Res Commun, 2011
Taken together these results strongly suggest that MR1 needs to bind proteasome-independent ligands in order to properly reach the cell surface.
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