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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 30 Sep 2015.

Major histocompatibility complex, class I-related

MR1, major histocompatibility complex class I-related
This gene is thought to play a role in the regulation of myofibrillogenesis. Mutations in this gene have been associated with the movement disorder paroxysmal non-kinesigenic dyskinesia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: MHC, CAN, MICA, HAD, IgM
Papers on MR1
Lipid and small-molecule display by CD1 and MR1.
Moody et al., Boston, United States. In Nat Rev Immunol, 31 Oct 2015
The antigen-presenting molecules CD1 and MHC class I-related protein (MR1) display lipids and small molecules to T cells.
T-cell receptor repertoire of human peripheral CD161(hi)TRAV1-2(+) MAIT cells revealed by next generation sequencing and single cell analysis.
Dornmair et al., München, Germany. In Hum Immunol, 14 Oct 2015
They are involved in the defence against microbes as they recognize small organic molecules of microbial origin that are presented by the non-classical MHC molecule 1 (MR1).
Donor Unrestricted T Cells: A Shared Human T Cell Response.
Moody et al., Utrecht, Netherlands. In J Immunol, 01 Oct 2015
However, other T cells can be considered "donor unrestricted" because their targets, CD1a, CD1b, CD1c, CD1d, or MR1, are expressed in a similar form among all humans.
The T cell antigen receptor: the Swiss army knife of the immune system.
Sewell et al., Cardiff, United Kingdom. In Clin Exp Immunol, Jul 2015
These 'unconventional' T cells bear TCRs that are capable of recognizing lipid ligands presented in the context of the MHC-like CD1 protein family or bacterial metabolites bound to the MHC-related protein 1 (MR1).
MR1 presentation of vitamin B-based metabolite ligands.
Rossjohn et al., Melbourne, Australia. In Curr Opin Immunol, Jun 2015
The major histocompatibility complex class I-related molecule MR1 can bind a novel class of antigens, namely a family of related small organic vitamin B metabolites.
CD1d- and MR1-Restricted T Cells in Sepsis.
Haeryfar et al., London, Canada. In Front Immunol, Dec 2014
Recent studies have implicated unconventional, innate-like T lymphocytes, including CD1d- and MR1-restricted T cells as effectors and/or regulators of inflammatory responses during sepsis.
T cell antigen receptor recognition of antigen-presenting molecules.
McCluskey et al., Australia. In Annu Rev Immunol, Dec 2014
In addition, the CD1 family members and MR1 are MHC class I-like molecules that bind lipid-based Ags and vitamin B precursors, respectively.
Role of Innate T Cells in Anti-Bacterial Immunity.
Williams et al., Southampton, United Kingdom. In Front Immunol, Dec 2014
These cells recognize foreign/self-lipid presented by non-classical MHC molecules, such as CD1d, MR1, and CD1a.
Adoptive T Cell Therapy Targeting CD1 and MR1.
Hirano et al., Toronto, Canada. In Front Immunol, Dec 2014
CD1 and MR1 are class I-like monomorphic molecules and their restricted T cells possess unique T cell receptor specificity against entirely different classes of antigens.
MR1-Restricted Mucosal-Associated Invariant T Cells and Their Activation during Infectious Diseases.
Cerundolo et al., Oxford, United Kingdom. In Front Immunol, Dec 2014
MR1-restricted mucosal-associated invariant T (MAIT) cells recognize vitamin B metabolites, which are generated by a broad range of bacteria, from Escherichia coli to Mycobacterium tuberculosis and BCG.
Autoantibody Profiles in Collagen Disease Patients with Interstitial Lung Disease (ILD): Antibodies to Major Histocompatibility Complex Class I-Related Chain A (MICA) as Markers of ILD.
Tohma et al., Sagamihara, Japan. In Biomark Insights, Dec 2014
The average anti-major histocompatibility complex class I-related chain A (MICA) Ab levels were higher in RA patients with CVD-ILD than in those without (P = 0.0013).
T-cell activation by transitory neo-antigens derived from distinct microbial pathways.
McCluskey et al., Melbourne, Australia. In Nature, Jun 2014
However, the genesis of these small organic molecules and their mode of presentation to MAIT cells by the major histocompatibility complex (MHC)-related protein MR1 (ref.
Biology of CD1- and MR1-restricted T cells.
Cerundolo et al., Oxford, United Kingdom. In Annu Rev Immunol, 2013
In this review, we describe the most recent events in the field, with particular emphasis on (a) structural and functional aspects of lipid presentation by CD1 molecules, (b) the development of CD1d-restricted invariant natural killer T (iNKT) cells and transcription factors required for their differentiation, (c) the ability of iNKT cells to modulate innate and adaptive immune responses through their cross talk with lymphoid and myeloid cells, and (d) MR1-restricted and group I (CD1a, CD1b, and CD1c)-restricted T cells.
Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells.
De Libero et al., Basel, Switzerland. In Nat Immunol, 2013
Human T cells that express a T cell antigen receptor (TCR) containing γ-chain variable region 9 and δ-chain variable region 2 (Vγ9Vδ2) recognize phosphorylated prenyl metabolites as antigens in the presence of antigen-presenting cells but independently of major histocompatibility complex (MHC), the MHC class I-related molecule MR1 and antigen-presenting CD1 molecules.
Major histocompatibility complex class I molecules modulate embryonic neuritogenesis and neuronal polarization.
Kaufman et al., Los Angeles, United States. In J Neuroimmunol, 2012
The results of this study supported that MHCI appears to differentially modulate neuritogenesis and synaptogenesis.
Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor.
McCluskey et al., Melbourne, Australia. In J Exp Med, 2012
Mutagenesis of MR1 showed that only two residues, which were centrally positioned and on opposing sides of the antigen-binding cleft of MR1, were essential for MAIT cell activation
Dopamine dysregulation in a mouse model of paroxysmal nonkinesigenic dyskinesia.
Ptácek et al., San Francisco, United States. In J Clin Invest, 2012
These findings support the hypothesis that the PNKD protein functions to modulate striatal neuro-transmitter release in response to stress and other precipitating factors.
Paroxysmal non-kinesigenic dyskinesia due to a PNKD recurrent mutation: report of two Southern European families.
Macaya et al., Athens, Greece. In Eur J Paediatr Neurol, 2012
In this report we present two families with paroxysmal non-kinesigenic dyskinesia of Southern European origin carrying a PNKD protein recurrent mutation.
Human MR1 expression on the cell surface is acid sensitive, proteasome independent and increases after culturing at 26°C.
Martínez-Naves et al., Madrid, Spain. In Biochem Biophys Res Commun, 2011
Taken together these results strongly suggest that MR1 needs to bind proteasome-independent ligands in order to properly reach the cell surface.
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