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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

Major histocompatibility complex, class I-related

MR1, major histocompatibility complex class I-related
This gene is thought to play a role in the regulation of myofibrillogenesis. Mutations in this gene have been associated with the movement disorder paroxysmal non-kinesigenic dyskinesia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: MHC, CAN, MICA, HAD, IgM
Papers on MR1
Immune sensing of microbial glycolipids and related conjugates by T cells and the pattern recognition receptors MCL and Mincle.
New
Williams et al., Melbourne, Australia. In Carbohydr Res, 29 Feb 2016
The antigen-presenting molecule MR1 captures vitamin B metabolites and presents them to mucosal associated invariant T cells.
What Makes MAITs Wait?
New
Impact
Exley, Manchester, United Kingdom. In Immunity, 19 Feb 2016
UNASSIGNED: Mucosal-associated invariant T (MAIT) cells recognize microbial non-peptidic antigens presented by non-classical MHC MR1.
Bacteria Exposed Biliary Epithelium and Liver B Cells Activate Intrahepatic Mait Cells in an MR1-Dependent Manner.
New
Oo et al., Birmingham, United Kingdom. In J Hepatol, 29 Jan 2016
BACKGROUND: Mucosal-Associated Invariant T (MAIT) cells are innate-like T cells characterised by the invariant TCR-chain, Vα7.2-Jα33, and are restricted by MR1, which presents bacterial vitamin B metabolites.
Clinical significance of tumor expression of major histocompatibility complex class I-related chains A and B (MICA/B) in gastric cancer patients.
New
Molina et al., Santiago, Chile. In Oncol Rep, 23 Jan 2016
UNASSIGNED: Gastric cancer (GC) is the third most common cause of cancer death worldwide.
Recognition of Vitamin B Precursors and Byproducts by Mucosal Associated Invariant T Cells.
New
McCluskey et al., Australia. In J Biol Chem, 18 Jan 2016
The major histocompatibility class I-like antigen-presenting molecule, MR1, captures these pyrimidine intermediates, but only after their condensation with small molecules derived from glycolysis and other metabolic pathways to form short-lived antigens.
Assessment of changes in expression and presentation of NKG2D under influence of MICA serum factor in different stages of breast cancer.
New
Khodadadi et al., Ahvāz, Iran. In Tumour Biol, 11 Jan 2016
In this study, we correlated the serum level of major histocompatibility complex class I-related chain A (sMICA) with expression and presentation of NKG2D receptors on NK cells among patients with breast cancer.
Deciphering the aggregation mechanism of bacteria (Shewanella oneidensis MR1) in the presence of polyethyleneimine: Effects of the exopolymeric superstructure and polymer molecular weight.
New
Duval et al., Vandœuvre-lès-Nancy, France. In Colloids Surf B Biointerfaces, 08 Jan 2016
The selected strain, Schewanella oneidensis MR-1, produces a lipopolysaccharide (LPS) of various lengths depending on the growth conditions.
Abnormal expression levels of sMICA and NKG2D are correlated with poor prognosis in pancreatic cancer.
New
Zhu et al., Hefei, China. In Ther Clin Risk Manag, 31 Dec 2015
Soluble major histocompatibility complex class I-related chain A molecules (sMICA) and natural-killer group 2 member D (NKG2D) not only correlate with tumorigenesis and progression, but also with tumor invasion and metastasis.
Mucosal-associated invariant T cell-rich congenic mouse strain allows functional evaluation.
New
Lantz et al., In J Clin Invest, 02 Dec 2015
Despite strong evolutionary conservation of the invariant TCR-α chain and restricting molecule MR1, this population is rare in laboratory mouse strains (≈0.1% in lymphoid organs), and lack of an appropriate mouse model has hampered the study of MAIT biology.
The burgeoning family of unconventional T cells.
New
Impact
Moody et al., Melbourne, Australia. In Nat Immunol, Nov 2015
These include CD1-restricted T cells, MR1-restricted mucosal associated invariant T cells (MAIT cells), MHC class Ib-reactive T cells, and γδ T cells.
Lipid and small-molecule display by CD1 and MR1.
New
Impact
Moody et al., Boston, United States. In Nat Rev Immunol, Oct 2015
The antigen-presenting molecules CD1 and MHC class I-related protein (MR1) display lipids and small molecules to T cells.
Assessment of Immunological Biomarkers in the First Year after Heart Transplantation.
Barten et al., Leipzig, Germany. In Dis Markers, 2014
METHODS: Activation markers CD25 and CD95, intracellular cytokines IL-2 and IFNγ, chemokines IP10 and MIG, and subsets of dendritic cells as well as antibodies against human leukocyte antigens (HLA) and major histocompatibility complex class I-related chain A (MICA) antigens were analyzed at different time points using flow cytometry and Luminex xMAP technology.
T cell antigen receptor recognition of antigen-presenting molecules.
Impact
McCluskey et al., Australia. In Annu Rev Immunol, 2014
In addition, the CD1 family members and MR1 are MHC class I-like molecules that bind lipid-based Ags and vitamin B precursors, respectively.
Serum soluble major histocompatibility complex class I-related chain A/B expression in patients with alcoholic liver disease in Hainan Li community.
Yu et al., Changsha, China. In Int J Clin Exp Med, 2014
BACKGROUND/AIMS: To study the expression and clinical significance of serum soluble major histocompatibility complex class I-related chain A/B (sMICA/B), and its correlation with percentage of CD4(+), CD8(+), and NK cells, Liver fibrosis screening test, and liver enzymes in alcoholic liver disease (ALD).
T-cell activation by transitory neo-antigens derived from distinct microbial pathways.
Impact
McCluskey et al., Melbourne, Australia. In Nature, 2014
However, the genesis of these small organic molecules and their mode of presentation to MAIT cells by the major histocompatibility complex (MHC)-related protein MR1 (ref.
Major histocompatibility complex class I molecules modulate embryonic neuritogenesis and neuronal polarization.
GeneRIF
Kaufman et al., Los Angeles, United States. In J Neuroimmunol, 2012
The results of this study supported that MHCI appears to differentially modulate neuritogenesis and synaptogenesis.
Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor.
GeneRIF
McCluskey et al., Melbourne, Australia. In J Exp Med, 2012
Mutagenesis of MR1 showed that only two residues, which were centrally positioned and on opposing sides of the antigen-binding cleft of MR1, were essential for MAIT cell activation
Dopamine dysregulation in a mouse model of paroxysmal nonkinesigenic dyskinesia.
GeneRIF
Ptácek et al., San Francisco, United States. In J Clin Invest, 2012
These findings support the hypothesis that the PNKD protein functions to modulate striatal neuro-transmitter release in response to stress and other precipitating factors.
Paroxysmal non-kinesigenic dyskinesia due to a PNKD recurrent mutation: report of two Southern European families.
GeneRIF
Macaya et al., Athens, Greece. In Eur J Paediatr Neurol, 2012
In this report we present two families with paroxysmal non-kinesigenic dyskinesia of Southern European origin carrying a PNKD protein recurrent mutation.
Human MR1 expression on the cell surface is acid sensitive, proteasome independent and increases after culturing at 26°C.
GeneRIF
Martínez-Naves et al., Madrid, Spain. In Biochem Biophys Res Commun, 2011
Taken together these results strongly suggest that MR1 needs to bind proteasome-independent ligands in order to properly reach the cell surface.
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