Innate immune function after breast, lung, and colorectal cancer surgery.
Anderson, United States. In J Surg Res, 23 Nov 2014
We also determined the plasma concentrations of interleukins (IL) 2 and 4, interferon-γ, granzyme B, perforin, soluble major histocompatibility complex class I-related chain A, and epinephrine, both before and 24 h after surgery.
The role of microRNAs in the control of innate immune response in cancer.
Halle, Germany. In J Natl Cancer Inst, Oct 2014
Ligands for receptors of natural killer (NK) cells and CD8(+) cytotoxic T lymphocytes (CTL), such as the inhibitory nonclassical HLA-G, the activating stress-induced major histocompatibility complex class I-related antigens MICA and MICB, and/or the UL16-binding proteins (ULBPs), are often aberrantly expressed upon viral infection and neoplastic transformation, thereby preventing virus-infected or malignant-transformed cells from elimination by immune effector cells.
Toward stable gene expression in CHO cells.
Singapore, Singapore. In Bioengineered, Sep 2014
The modified hCMV with one copy of IE inserted between the hCMV enhancer and core promoter in reverse orientation (MR1) was most effective at enhancing expression stability in CHO cells without comprising expression level when compared with the wild type hCMV.
Biology of CD1- and MR1-restricted T cells.
Oxford, United Kingdom. In Annu Rev Immunol, Dec 2013
In this review, we describe the most recent events in the field, with particular emphasis on (a) structural and functional aspects of lipid presentation by CD1 molecules, (b) the development of CD1d-restricted invariant natural killer T (iNKT) cells and transcription factors required for their differentiation, (c) the ability of iNKT cells to modulate innate and adaptive immune responses through their cross talk with lymphoid and myeloid cells, and (d) MR1-restricted and group I (CD1a, CD1b, and CD1c)-restricted T cells.
[MAIT cells in autoimmunity].
In Nihon Rinsho Meneki Gakkai Kaishi, Dec 2013
They are restricted by a nonpolymorphic MHC-related molecule-1 (MR1), and cells are selected in the thymus.
Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells.
Basel, Switzerland. In Nat Immunol, Sep 2013
Human T cells that express a T cell antigen receptor (TCR) containing γ-chain variable region 9 and δ-chain variable region 2 (Vγ9Vδ2) recognize phosphorylated prenyl metabolites as antigens in the presence of antigen-presenting cells but independently of major histocompatibility complex (MHC), the MHC class I-related molecule MR1 and antigen-presenting CD1 molecules.