Biology of CD1- and MR1-Restricted T Cells.
Oxford, United Kingdom. In Annu Rev Immunol, 03 Mar 2014
In this review, we describe the most recent events in the field, with particular emphasis on (a) structural and functional aspects of lipid presentation by CD1 molecules, (b) the development of CD1d-restricted invariant natural killer T (iNKT) cells and transcription factors required for their differentiation, (c) the ability of iNKT cells to modulate innate and adaptive immune responses through their cross talk with lymphoid and myeloid cells, and (d) MR1-restricted and group I (CD1a, CD1b, and CD1c)-restricted T cells.
humMR1, a highly specific humanized single chain antibody for targeting EGFRvIII.
Tabrīz, Iran. In Int Immunopharmacol, 28 Feb 2014
CDR loops of MR1, a phage display-derived murine single chain antibody developed against this mutant receptor, were grafted on human frameworks that had been selected based on similarity to MR1 in terms of two distinct parameters, variable domain protein sequence and CDR canonical structures.
MAITs, MR1 and vitamin B metabolites.
Australia. In Curr Opin Immunol, 28 Feb 2014
Recently the antigenic repertoire of αβT-cells has been expanded with the observation that mucosal-associated invariant T-cells (MAIT cells), an abundant population of innate-like T-cells, can recognise metabolites of vitamin B, when presented by the MHC-related protein, MR1.
Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells.
Basel, Switzerland. In Nat Immunol, Sep 2013
Human T cells that express a T cell antigen receptor (TCR) containing γ-chain variable region 9 and δ-chain variable region 2 (Vγ9Vδ2) recognize phosphorylated prenyl metabolites as antigens in the presence of antigen-presenting cells but independently of major histocompatibility complex (MHC), the MHC class I-related molecule MR1 and antigen-presenting CD1 molecules.
[MAIT cells in autoimmunity].
In Nihon Rinsho Meneki Gakkai Kaishi, 2011
Mucosal associated invariant T (MAIT) cells are restricted by a nonpolymorphic MHC-related molecule-1 (MR1), and express an invariant TCRα chain: Vα7.2-Jα33 in humans and Vα19-Jα33 in mice.
Antimicrobial activity of mucosal-associated invariant T cells.
Paris, France. In Nat Immunol, 2010
Mucosal-associated invariant T lymphocytes (MAIT lymphocytes) are characterized by two evolutionarily conserved features: an invariant T cell antigen receptor (TCR) alpha-chain and restriction by the major histocompatibility complex (MHC)-related protein MR1.