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TTK protein kinase

Mps1, TTK, Mps1p
This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: CAN, HAD, Adenylate Cyclase, V1a, Bub1
Papers on Mps1
The Chloride Anion Acts as a Second Messenger in Mammalian Cells - Modifying the Expression of Specific Genes.
Santa-Coloma et al., Buenos Aires, Argentina. In Cell Physiol Biochem, Feb 2016
We identified the gene RPS27, which encodes the multifunctional ribosomal protein RPS27, also known as metallopanstimulin-1 (MPS-1), and the gene GLRX5, encoding glutaredoxin-related protein 5, as chloride-dependent genes.
A Novel Marker for Purkinje Cells, Ribosomal Protein MPS1/S27: Expression of MPS1 in Human Cerebellum.
Fernandez-Pol, Chesterfield, United States. In Cancer Genomics Proteomics, Feb 2016
BACKGROUND: The ribosomal protein metallopanstimulin-1 (MPS1/S27) serves critical survival purposes in cell division, in normal and cancerous cells; for this reason, selective pressures of evolution have conserved the DNA sequences encoding MPS1/S27 in Archaea and Eukariotic cells.
Phosphoproteomic Profiling Reveals Epstein-Barr Virus Protein Kinase Integration of DNA Damage Response and Mitotic Signaling.
Hayward et al., Baltimore, United States. In Plos Pathog, Dec 2015
Furthermore, we demonstrated that BGLF4 binds to and directly phosphorylates the key cellular proteins PP1, MPS1 and CDC20 that lie upstream of SAC activation and APC/C inhibition.
Whole-genome duplication increases tumor cell sensitivity to MPS1 inhibition.
Abrieu et al., Montpellier, France. In Oncotarget, Dec 2015
Here, we report a novel strategy to preferentially kill tetraploid cells based on the abrogation of the spindle assembly checkpoint (SAC) via the targeting of TTK protein kinase (better known as monopolar spindle 1, MPS1).
Targeting Mitosis in Cancer: Emerging Strategies.
Mak et al., Toronto, Canada. In Mol Cell, Dec 2015
This reasoning stimulated our development of novel inhibitors targeting the critical regulators of genomic stability and the mitotic checkpoint: AURKA, PLK4, and Mps1/TTK.
Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylation.
Shieh et al., Taipei, Taiwan. In Nucleic Acids Res, Dec 2015
UNASSIGNED: Human Mps1 (hMps1) is a protein kinase essential for mitotic checkpoints and the DNA damage response.
CELL DIVISION CYCLE. Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling.
Kops et al., Amsterdam, Netherlands. In Science, Jul 2015
We show that the amino-terminal localization module of the SAC protein kinase MPS1 (monopolar spindle 1) directly interacts with the HEC1 (highly expressed in cancer 1) calponin homology domain in the NDC80 (nuclear division cycle 80) kinetochore complex in vitro, in a phosphorylation-dependent manner.
Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint.
Santocanale et al., Galway, Ireland. In Biol Open, 2014
However, mechanistically, the role of PLK1 in the SAC is not fully understood, with several recent reports indicating that it can cooperate with either one of the major checkpoint kinases, Aurora B or MPS1.
The structural mechanisms that underpin mitotic kinase activation.
Bayliss et al., Oxford, United Kingdom. In Biochem Soc Trans, 2013
These include members of the Cdk (cyclin-dependent kinase), Plk (Polo-like kinase), Aurora, Nek (NimA-related kinase) and Bub families, as well as Haspin, Greatwall and Mps1/TTK.
Tumour selective targeting of cell cycle kinases for cancer treatment.
Turner et al., London, United Kingdom. In Curr Opin Pharmacol, 2013
TP53 mutant cancer cell lines are sensitive to WEE1 and CHK1 inhibitors in combination with chemotherapy, while PTEN-deficient aneuploid cancer cell lines are sensitive to TTK inhibitors.
On the molecular mechanisms of mitotic kinase activation.
Yeoh et al., Leicester, United Kingdom. In Open Biol, 2012
These mitotic phosphorylation events are catalysed by several families of protein kinases, including Auroras, Cdks, Plks, Neks, Bubs, Haspin and Mps1/TTK.
MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components.
Watanabe et al., Tokyo, Japan. In Nat Cell Biol, 2012
MPS1 is an evolutionarily conserved protein kinase required for the SAC and chromosome bi-orientation.
Knockdown of metallopanstimulin-1 inhibits NF-κB signaling at different levels: the role of apoptosis induction of gastric cancer cells.
Gu et al., Shanghai, China. In Int J Cancer, 2012
a novel pathway, the MPS-1/NF-kappaB/Gadd45beta signal pathway, played an important role in MPS-1 knockdown-induced apoptosis of gastric cancer cells.
Spindle checkpoint-independent inhibition of mitotic chromosome segregation by Drosophila Mps1.
Lehner et al., Zürich, Switzerland. In Mol Biol Cell, 2012
Data indicate kinase activity seems to be required for Mps1 kinetochore localization.
Cnn1 inhibits the interactions between the KMN complexes of the yeast kinetochore.
De Wulf et al., Milano, Italy. In Nat Cell Biol, 2012
KMN-spindle attachment is regulated by the Aurora B(Ipl1) and MPS1(Mps1) kinases.
The CovS/CovR acid response regulator is required for intracellular survival of group B Streptococcus in macrophages.
May et al., Birmingham, United Kingdom. In Infect Immun, 2012
The GBS two-component system CovS/CovR, which is the major acid response regulator in this organism, is required for survival inside the phagosome of macrophages.
The MPS1 family of protein kinases.
Winey et al., Boulder, United States. In Annu Rev Biochem, 2011
MPS1 protein kinases are found widely, but not ubiquitously, in eukaryotes.
Two LXXLL motifs in the N terminus of Mps1 are required for Mps1 nuclear import during G(2)/M transition and sustained spindle checkpoint responses.
Xu et al., Boulder, United States. In Cell Cycle, 2011
our studies reveal a novel cell cycle-dependent nuclear translocation signal in the N terminus of Mps1 and suggest that timely nuclear entry could be important for sustaining spindle assembly checkpoint responses.
Tramtrack is genetically upstream of genes controlling tracheal tube size in Drosophila.
Llimargas et al., Barcelona, Spain. In Plos One, 2010
discovered multiple roles of Ttk in the development of the tracheal system on the morphogenetic level. Here, we sought to identify some of the underlying genetic components that are responsible for the tracheal phenotypes of Ttk mutants
The mouse Mps1p-like kinase regulates centrosome duplication.
Winey et al., Boulder, United States. In Cell, 2001
We demonstrate here that a mouse Mps1p ortholog (esk, which we designate mMps1p) regulates centrosome duplication.
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