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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Progesterone receptor membrane component 1

This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: CAN, Igf2r, ACID, HAD, V1a
Papers using MPR antibodies
Identification of a polyI:C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation.
Gay Nick, In PLoS ONE, 2009
... pAb and anti-calreticulin pAb (Stressgen, Victoria, Canada), anti-p115 pAb (Calbiochem, Darmstadt, Germany), anti-LAMP-1 mAb (Biolegend), anti-MPR pAb (Abcam, Cambridge, UK), anti-human TLR8 ...
Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking
Carlin Cathleen R. et al., In The Journal of Cell Biology, 2007
... Gruenberg, University of Geneva, Geneva, Switzerland), LC3 mouse mAb (MBL), LC3 rabbit pAb (Abgent), cation-dependent MPR chicken pAb (Millipore), human-specific IL2R-α mAb (American Type Culture Collection), ORP1L goat pAb (Imgenex), Rab5 mouse mAb (BD), ...
Long-term safety and efficacy of enzyme replacement therapy for Fabry disease
Elleder Milan et al., In Virchows Archiv, 2003
... Mannoso-6-phosphate receptor (MPR, cation-independent) was detected using monoclonal antibody (2G11 clone, Abcam, Cambridge, UK), diluted 1:400 ...
Papers on MPR
Progesterone receptor membrane component 1 promotes survival of human breast cancer cells and the growth of xenograft tumors.
Pru et al., Farmington, United States. In Cancer Biol Ther, Feb 2016
Since P4 receptor membrane component 1 (PGRMC1) is expressed in breast cancer tumors and is known to mediate P4-induced cell survival, this study was designed to determine the expression of PGRMC1 in TNBC tumors and the involvement of PGRMC1 in regulating proliferation and survival of TNBC cells in vitro and the growth of TNBC tumors in vivo.
Differences in progesterone concentrations and mRNA expressions of progesterone receptors in bovine endometrial tissue between the uterine horns ipsilateral and contralateral to the corpus luteum.
Matsui et al., Gifu, Japan. In J Vet Med Sci, Feb 2016
The aim of the present study was to determine the endometrial tissue P4 concentrations and nuclear progesterone receptor (PGR), progesterone receptor membrane component 1 (PGRMC1) and PGRMC2 mRNA expressions in the cranial and middle part of the uterine horns during the luteal phase.
Calnuc function in endosomal sorting of lysosomal receptors.
Lavoie et al., Sherbrooke, Canada. In Traffic, Feb 2016
The objective of this study was to explore the role of Calnuc in the endocytic sorting of mannose-6-phosphate receptor (MPR) and Sortilin, two well-characterized lysosomal receptors that transit between the TGN and endosomes.
Rab35 GTPase Triggers Switch-like Recruitment of the Lowe Syndrome Lipid Phosphatase OCRL on Newborn Endosomes.
Echard et al., Paris, France. In Curr Biol, Feb 2016
Consistent with Rab35 and OCRL acting together, depletion of either Rab35 or OCRL leads to retention of internalized receptors such as the endogenous cation-independent mannose-6-phosphate receptor (CI-MPR) in peripheral clathrin-positive endosomes that display abnormal association with PtdIns(4,5)P2- and actin-binding proteins.
Expression and immunolocalization of membrane progesterone receptors in the bovine oviduct.
Kotwica et al., Olsztyn, Poland. In Domest Anim Endocrinol, Jan 2016
The aim of this study was to evaluate the expression of messenger RNAS (mRNAs) and proteins for progesterone receptor membrane component (PGRMC) 1 and 2 and membrane progestin receptors (mPR) α, β, and γ and to use immunohistochemistry to demonstrate their cell-specific localization in the bovine oviduct.
Genetics of primary ovarian insufficiency: new developments and opportunities.
Chen et al., Jinan, China. In Hum Reprod Update, Nov 2015
Based on candidate gene studies, single gene perturbations unequivocally having a deleterious effect in at least one population include Bone morphogenetic protein 15 (BMP15), Progesterone receptor membrane component 1 (PGRMC1), and Fragile X mental retardation 1 (FMR1) premutation on the X chromosome; Growth differentiation factor 9 (GDF9), Folliculogenesis specific bHLH transcription factor (FIGLA), Newborn ovary homeobox gene (NOBOX), Nuclear receptor subfamily 5, group A, member 1 (NR5A1) and Nanos homolog 3 (NANOS3) seem likely as well, but mostly being found in no more than 1-2% of a single population studied.
Potential applications for sigma receptor ligands in cancer diagnosis and therapy.
Dierckx et al., Groningen, Netherlands. In Biochim Biophys Acta, Oct 2015
The sigma-2 receptor was identified as the progesterone receptor membrane component 1 (PGRMC1).
Prosaposin: a protein with differential sorting and multiple functions.
Morales et al., In Histol Histopathol, Jun 2015
They are directed away from the cell surface by their binding to mannose-6-phosphate receptors (MPR).
Progesterone and allopregnanolone in the central nervous system: response to injury and implication for neuroprotection.
Schumacher et al., Le Kremlin-Bicêtre, France. In J Steroid Biochem Mol Biol, Feb 2015
Multiple receptors or associated proteins may contribute to the progesterone effects: classical nuclear receptors (PR), membrane progesterone receptor component 1 (PGRMC1), membrane progesterone receptors (mPR), and γ-aminobutyric acid type A (GABAA) receptors after conversion to allopregnanolone.
New aspects of progesterone interactions with the actin cytoskeleton and neurosteroidogenesis in the cerebellum and the neuronal growth cone.
Theiss et al., Bochum, Germany. In J Histochem Cytochem, 2014
Furthermore, new aspects of a progesterone-dependent regulation of neurosteroidogenesis mediated by the recently described progesterone binding protein PGRMC1 in the nervous system are discussed.
Salmonella inhibits retrograde trafficking of mannose-6-phosphate receptors and lysosome function.
Holden et al., London, United Kingdom. In Science, 2012
Sequestration of Rab9 by SifA-SKIP accounted for the effect of SifA on MPR transport and lysosome function.
Progesterone increases the release of brain-derived neurotrophic factor from glia via progesterone receptor membrane component 1 (Pgrmc1)-dependent ERK5 signaling.
Singh et al., Fort Worth, United States. In Endocrinology, 2012
Data describe that P4 elicits an increase in BDNF release from glia via a Pgrmc1-induced ERK5 signaling mechanism and identify Pgrmc1 as a potential therapeutic target for future hormone-based drug development.
Progesterone regulation of progesterone receptor membrane component 1 (PGRMC1) sumoylation and transcriptional activity in spontaneously immortalized granulosa cells.
Liu et al., Farmington, United States. In Endocrinology, 2012
The ability to suppress Tcf/Lef activity is part of the mechanism through which P4 activation of PGRMC1 regulates the gene cascades that control granulosa cell function with this action being dependent in part on the sumoylation status of PGRMC1.
Endometrial miR-181a and miR-98 expression is altered during transition from normal into cancerous state and target PGR, PGRMC1, CYP19A1, DDX3X, and TIMP3.
Chegini et al., Gainesville, United States. In J Clin Endocrinol Metab, 2012
miR-98 and miR-181a through their regulatory functions on PGRMC1, PGR, CYP19A1, TIMP3, and DDX3X expression may influence a wide range of endometrial cellular activities during normal menstrual cycle and transition into disease states.
The relationship between follicle development and progesterone receptor membrane component-1 expression in women undergoing in vitro fertilization.
Peluso et al., Farmington, United States. In Fertil Steril, 2012
In patients with elevated PGRMC1 mRNA levels, gonadotropin-induced follicle development is attenuated, although sufficient numbers of follicles develop to allow for embryo and subsequent pregnancy.
Differential responses of progesterone receptor membrane component-1 (Pgrmc1) and the classical progesterone receptor (Pgr) to 17β-estradiol and progesterone in hippocampal subregions that support synaptic remodeling and neurogenesis.
Finch et al., Los Angeles, United States. In Endocrinology, 2012
The effects of progesterone and estradiol onpgrmc1 and pgr expression in hippocampal neurons are reported.
A helping hand for cytochrome p450 enzymes.
Debose-Boyd, Dallas, United States. In Cell Metab, 2007
In this issue of Cell Metabolism, Espenshade and colleagues (Hughes et al., 2007) show that the hemoprotein Dap1/PGRMC1 forms a stable complex with several members of the cytochrome P450 superfamily of enzymes and positively regulates their activities.
Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes.
Espenshade et al., Baltimore, United States. In Cell Metab, 2007
These findings demonstrate that PGRMC1 is required for P450 activity and suggest that interindividual variation in PGRMC1 function may impact multiple biochemical pathways and drug metabolism.
Photo-leucine and photo-methionine allow identification of protein-protein interactions in living cells.
Thiele et al., Dresden, Germany. In Nat Methods, 2005
Applying this technology to membrane protein complexes, we discovered a previously unknown direct interaction of the progesterone-binding membrane protein PGRMC1 with Insig-1, a key regulator of cholesterol homeostasis.
Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor.
Kornfeld et al., Saint Louis, United States. In Science, 2001
Here, the VHS domain of GGA2 was shown to bind to the acidic cluster-dileucine motif in the cytoplasmic tail of the cation-independent mannose 6-phosphate receptor (CI-MPR).
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