Identification of a polyI:C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation.
In PLoS ONE, 2009
... pAb and anti-calreticulin pAb (Stressgen, Victoria, Canada), anti-p115 pAb (Calbiochem, Darmstadt, Germany), anti-LAMP-1 mAb (Biolegend), anti-MPR pAb (Abcam, Cambridge, UK), anti-human TLR8 ... Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking
In The Journal of Cell Biology, 2007
... Gruenberg, University of Geneva, Geneva, Switzerland), LC3 mouse mAb (MBL), LC3 rabbit pAb (Abgent), cation-dependent MPR chicken pAb (Millipore), human-specific IL2R-α mAb (American Type Culture Collection), ORP1L goat pAb (Imgenex), Rab5 mouse mAb (BD), ...
Calnuc function in endosomal sorting of lysosomal receptors.
Sherbrooke, Canada. In Traffic, Feb 2016
The objective of this study was to explore the role of Calnuc in the endocytic sorting of mannose-6-phosphate receptor (MPR) and Sortilin, two well-characterized lysosomal receptors that transit between the TGN and endosomes.
Genetics of primary ovarian insufficiency: new developments and opportunities.
Jinan, China. In Hum Reprod Update, Nov 2015
Based on candidate gene studies, single gene perturbations unequivocally having a deleterious effect in at least one population include Bone morphogenetic protein 15 (BMP15), Progesterone receptor membrane component 1 (PGRMC1), and Fragile X mental retardation 1 (FMR1) premutation on the X chromosome; Growth differentiation factor 9 (GDF9), Folliculogenesis specific bHLH transcription factor (FIGLA), Newborn ovary homeobox gene (NOBOX), Nuclear receptor subfamily 5, group A, member 1 (NR5A1) and Nanos homolog 3 (NANOS3) seem likely as well, but mostly being found in no more than 1-2% of a single population studied.
Endometrial miR-181a and miR-98 expression is altered during transition from normal into cancerous state and target PGR, PGRMC1, CYP19A1, DDX3X, and TIMP3.
Gainesville, United States. In J Clin Endocrinol Metab, 2012
miR-98 and miR-181a through their regulatory functions on PGRMC1, PGR, CYP19A1, TIMP3, and DDX3X expression may influence a wide range of endometrial cellular activities during normal menstrual cycle and transition into disease states.
A helping hand for cytochrome p450 enzymes.
Dallas, United States. In Cell Metab, 2007
In this issue of Cell Metabolism, Espenshade and colleagues (Hughes et al., 2007) show that the hemoprotein Dap1/PGRMC1 forms a stable complex with several members of the cytochrome P450 superfamily of enzymes and positively regulates their activities.
Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes.
Baltimore, United States. In Cell Metab, 2007
These findings demonstrate that PGRMC1 is required for P450 activity and suggest that interindividual variation in PGRMC1 function may impact multiple biochemical pathways and drug metabolism.