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Dual specificity phosphatase 9

MPK4, DUSP9, MKP-4
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases, is expressed only in placenta, kidney, and fetal liver, and is localized to the cytoplasm and nucleus. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MAPK, ACID, ERK3, MEKK1, CAN
Papers on MPK4
Protein-protein interactions in plant mitogen-activated protein kinase cascades.
Review
New
Harmon et al., Gainesville, United States. In J Exp Bot, Jan 2016
This review surveys various technologies used for characterizing MAPK-substrate interactions and presents case studies of MPK4 and MPK6, highlighting the multiple functions of MAPKs.
Early perception of stink bug damage in developing seeds of field-grown soybean induces chemical defences, and decreases bug attack.
New
Zavala et al., Buenos Aires, Argentina. In Pest Manag Sci, Dec 2015
RESULTS: This study demonstrated that mitogen-activated protein kinases (MPK) 3, MPK4 and MPK6 are expressed and activated in developing seeds of field-grown soybean, and regulates a defensive response after stink bug damage.
Mitogen-Dependent Regulation of DUSP1 Governs ERK and p38 Signaling During Early 3T3-L1 Adipocyte Differentiation.
New
Morrison et al., Baton Rouge, United States. In J Cell Physiol, Dec 2015
In support of this, qRT-PCR identified several MAPK-specific DUSPs induced during early (DUSP2, -4, -5, & -6), mid (DUSP4 & -16) and late (DUSP9) stages of adipocyte differentiation.
Functional analysis of NtMPK2 uncovers its positive role in response to Pseudomonas syringae pv. tomato DC3000 in tobacco.
New
Xia et al., Chongqing, China. In Plant Mol Biol, Nov 2015
Extensive studies on Arabidopsis MPK4 have implicated that the MAP kinase is involved in multilayered plant defense pathways.
Selective Expression of the MAPK Phosphatase Dusp9/MKP-4 in Mouse Plasmacytoid Dendritic Cells and Regulation of IFN-β Production.
New
Lang et al., Erlangen, Germany. In J Immunol, Sep 2015
In this study, we identified the MAPK phosphatase Dusp9/MKP-4 by transcriptome analysis as selectively expressed in pDCs, but not cDCs.
Epigenetic silencing of DUSP9 induces the proliferation of human gastric cancer by activating JNK signaling.
New
Zhi et al., Guangzhou, China. In Oncol Rep, Jul 2015
Dual-specificity phosphatase 9 (DUSP9) is a strong negative regulator of transcription factor activating kinases (ERK, JNK and p38) in the mitogen-activated protein kinase (MAPK) pathways.
The mRNA decay factor PAT1 functions in a pathway including MAP kinase 4 and immune receptor SUMM2.
New
Petersen et al., Copenhagen, Denmark. In Embo J, Apr 2015
For example, Arabidopsis MAP kinase 4 (MPK4) regulates the expression of a subset of defense genes via at least one WRKY transcription factor.
Phosphorylation of trihelix transcriptional repressor ASR3 by MAP KINASE4 negatively regulates Arabidopsis immunity.
New
Shan et al., Wuhan, China. In Plant Cell, Mar 2015
MAMP treatments induce rapid phosphorylation of ASR3 at threonine 189 via MPK4, a mitogen-activated protein kinase that negatively regulates PTI responses downstream of multiple MAMP receptors.
BMP4 Signaling Acts via dual-specificity phosphatase 9 to control ERK activity in mouse embryonic stem cells.
Impact
GeneRIF
Chen et al., Beijing, China. In Cell Stem Cell, 2012
these findings identify DUSP9 as a critical mediator of BMP signaling to control appropriate ERK activity critical for ESC fate determination.
Phosphorylation of the kinase interaction motif in mitogen-activated protein (MAP) kinase phosphatase-4 mediates cross-talk between protein kinase A and MAP kinase signaling pathways.
GeneRIF
Keyse et al., Dundee, United Kingdom. In J Biol Chem, 2011
DUSP9/MKP-4 is a bona fide target of PKA signaling and attenuation of DUSP9/MKP-4 function can mediate cross-talk between the PKA pathway and MAPK signaling through both ERK1/2 and p38alpha in vivo
Exploring binding sites other than the catalytic core in the crystal structure of the catalytic domain of MKP-4.
GeneRIF
Kim et al., Taejŏn, South Korea. In Acta Crystallogr D Biol Crystallogr, 2011
2.7 A resolution crystal structure of the catalytic domain of MKP-4 (MKP-4C) is presented
Decreased expression of dual-specificity phosphatase 9 is associated with poor prognosis in clear cell renal cell carcinoma.
GeneRIF
Zhou et al., Shenzhen, China. In Bmc Cancer, 2010
decreased expression of DUSP-9 is associated with poor prognosis in ccRCC.
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
Impact
GIANT Consortium et al., Cambridge, United States. In Nat Genet, 2010
These include a second independent signal at the KCNQ1 locus; the first report, to our knowledge, of an X-chromosomal association (near DUSP9); and a further instance of overlap between loci implicated in monogenic and multifactorial forms of diabetes (at HNF1A).
MAPK cascade signalling networks in plant defence.
Review
Hirt et al., Vienna, Austria. In Curr Opin Plant Biol, 2009
Here, we describe the most recent insights into MAPK-mediated pathogen defence response regulation with a particular focus on the cascades involving MPK3, MPK4 and MPK6.
Dual-specificity MAP kinase phosphatases (MKPs) and cancer.
Review
Keyse, Dundee, United Kingdom. In Cancer Metastasis Rev, 2008
The second group contains three closely related ERK-specific and cytoplasmic MKPs encoded by DUSP6/MKP-3, DUSP7/MKP-X and DUSP9/MKP-4.
Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance.
GeneRIF
Kahn et al., Boston, United States. In Proc Natl Acad Sci U S A, 2008
Dusp9 has a protective effect against the development of insulin resistance through its ability to dephosphorylate and inactivate crucial mediators of stress-induced insulin resistance, such as ERK and JNK
Salicylic acid in plant defence--the players and protagonists.
Review
Grant et al., Edinburgh, United Kingdom. In Curr Opin Plant Biol, 2007
We review progress towards characterising key players (NPR1, MPK4) and processes (methylation, amino acid conjugation, S-nitrosylation) contributing to SA-signalling and perception pathways.
Arabidopsis map kinase 4 negatively regulates systemic acquired resistance.
Impact
Mundy et al., Copenhagen, Denmark. In Cell, 2001
Transposon inactivation of Arabidopsis MAP kinase 4 produced the mpk4 mutant exhibiting constitutive systemic acquired resistance (SAR) including elevated salicylic acid (SA) levels, increased resistance to virulent pathogens, and constitutive pathogenesis-related gene expression shown by Northern and microarray hybridizations.
Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase.
Impact
Arkinstall et al., Genève, Switzerland. In Science, 1998
Another homologous but nonselective phosphatase, MKP-4, bound and was activated by ERK2, JNK/SAPK, and p38 MAP kinases.
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