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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Prostaglandin E synthase 2

mPGES-2, GBF1, PTGES2
The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. [provided by RefSeq, Jun 2009] (from NCBI)
Top mentioned proteins: mPGES-1, cyclooxygenase, cPGES, p16, ARF1
Papers using mPGES-2 antibodies
Mitochondria supply membranes for autophagosome biogenesis during starvation.
Supplier
Meurs Eliane F., In PLoS ONE, 2009
... pGADT7-Sec7-GBF1 and pGADT7-DCB-GBF1 were constructed by insertion into EcoRI/BamHI sites and EcoRI/NcoI sites, respectively, of pGADT7 (Clontech).
Targeting of Arf-1 to the early Golgi by membrin, an ER-Golgi SNARE
Supplier
Donaldson Julie G. et al., In The Journal of Cell Biology, 2001
... Monoclonal anti-GM130 and anti-GBF1 antibodies were purchased from BD Biosciences.
Papers on mPGES-2
Exome Sequencing Analysis in Severe, Early-Onset Chronic Obstructive Pulmonary Disease.
New
Lung GO et al., Boston, United States. In Am J Respir Crit Care Med, Feb 2016
Four genes (DNAH8, ALCAM, RARS and GBF1) also demonstrated an increase in rare non-synonymous, stop and/or splice mutations in cases compared to resistant smokers from the COPDGene study; however, these results were not statistically significant.
Oligomerization of the Sec7 domain Arf guanine nucleotide exchange factor GBF1 is dispensable for Golgi localization and function but regulates degradation.
New
Sztul et al., Birmingham, United States. In Am J Physiol Cell Physiol, Jan 2016
We generated a GBF1 mutant (91/130) in which two residues required for oligomerization (K91 and E130 within the DCB domain) were replaced with A, and assessed the effects of these mutations on GBF1 localization and cellular functions.
The wheat TaGBF1 gene is involved in the blue-light response and salt tolerance.
New
Xia et al., Jinan, China. In Plant J, Dec 2015
Here we identified a wheat GBF1 gene that mediated both the blue light- and abiotic stress-responsive signaling pathways.
Prostaglandin E2 / cyclooxygenase pathway in human skeletal muscle: Influence of muscle fiber type and age.
New
Trappe et al., In J Appl Physiol, Dec 2015
PGE2/COX pathway proteins [COX enzymes (COX-1, COX-2), PGE2 synthases (cPGES, mPGES-1, mPGES-2), and PGE2 receptors (EP1, EP2, EP3, EP4)] were quantified via Western blot.
Regulating the large Sec7 ARF guanine nucleotide exchange factors: the when, where and how of activation.
Review
Sztul et al., Birmingham, United States. In Cell Mol Life Sci, 2014
One of these, the BIG/GBF1 family, includes three proteins that are each key regulators of the secretory pathway.
Curcumin inhibits the replication of enterovirus 71 in vitro.
Zhong et al., Harbin, China. In Acta Pharm Sin B, 2014
We further probed the antiviral mechanism of curcumin by examining the expression of GBF1 and PI4KB, both of which are required for the formation of viral replication complex.
A CREB3-ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens.
Impact
Sabatini et al., Cambridge, United States. In Nat Cell Biol, 2013
ARF4 depletion preserves viability, Golgi integrity and cargo trafficking in the presence of BFA, and these effects depend on the guanine nucleotide exchange factor GBF1 and other ARF isoforms including ARF1 and ARF5.
Z-box binding transcription factors (ZBFs): a new class of transcription factors in Arabidopsis seedling development.
Review
Chattopadhyay et al., Durgāpur, India. In Mol Plant, 2013
ZBFs include ZBF1, ZBF2, and ZBF3, which encode ZBF1/MYC2 (bHLH), ZBF2/GBF1 (bZIP), and ZBF3/CAM7 (Calmodulin) proteins, respectively.
The role of phosphatidylinositol 4-kinases and phosphatidylinositol 4-phosphate during viral replication.
Review
Neyts et al., Leuven, Belgium. In Biochem Pharmacol, 2013
Two recruitment strategies were reported: (i) binding and modulation of GBF1/Arf1 to enhance recruitment of PI4KIIIβ and (ii) interaction with ACBD3 for recruitment of PI4KIIIβ.
Molecular interactions of GBF1 with HY5 and HYH proteins during light-mediated seedling development in Arabidopsis thaliana.
GeneRIF
Chattopadhyay et al., New Delhi, India. In J Biol Chem, 2012
the functional interrelations of GBF1 with HY5 and HYH in Arabidopsis seedling development.
GBF1 bears a novel phosphatidylinositol-phosphate binding module, BP3K, to link PI3Kγ activity with Arf1 activation involved in GPCR-mediated neutrophil chemotaxis and superoxide production.
GeneRIF
Sabe et al., Kumamoto, Japan. In Mol Biol Cell, 2012
GBF1-mediated Arf1 activation is necessary to unify cell polarity during chemotaxis
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
GeneRIF
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
[Roles of COPI related proteins during virus replication].
Review
Zhang et al., Beijing, China. In Bing Du Xue Bao, 2012
Many viruses such as RNA viruses, DNA viruses and retroviruses, hijack or adapt COPI related proteins including coatomer, ARF1 and GBF1 for their own benefits.
Polarized cell growth in Arabidopsis requires endosomal recycling mediated by GBF1-related ARF exchange factors.
Impact
GeneRIF
Jürgens et al., Tübingen, Germany. In Nat Cell Biol, 2012
In Arabidopsis, GBF1-related exchange factors for the ARF GTPases (ARF GEFs) GNOM and GNL2 play essential roles in polar tip growth of root hairs and pollen, respectively.
ARF1 and GBF1 generate a PI4P-enriched environment supportive of hepatitis C virus replication.
GeneRIF
Chung et al., Beijing, China. In Plos One, 2011
the vesicular transport proteins ARF1 and GBF1 colocalized with PI4KIIIbeta and were both required for HCV replication
Phosphatidylserine-containing liposomes: potential pharmacological interventions against inflammatory and immune diseases through the production of prostaglandin E(2) after uptake by myeloid derived phagocytes.
Review
Nakanishi et al., Fukuoka, Japan. In Arch Immunol Ther Exp (warsz), 2011
PSLs are found to rather utilize COX-1/mPGES-2 system to produce PGE(2) secretion and then shift microglia and macrophages from pro- to anti-inflammatory phenotype by an autocrine action of PGE(2).
GBF1-Arf-COPI-ArfGAP-mediated Golgi-to-ER transport involved in regulation of lipid homeostasis.
GeneRIF
Nakayama et al., Kyoto, Japan. In Cell Struct Funct, 2010
The GBF1 participated in delivery of adipose triglyceride lipase (ATGL) onto the lipid droplets(LD) surface
Viral reorganization of the secretory pathway generates distinct organelles for RNA replication.
Impact
Altan-Bonnet et al., Newark, United States. In Cell, 2010
Specific viral proteins modulate effector recruitment by Arf1 GTPase and its guanine nucleotide exchange factor GBF1, promoting preferential recruitment of phosphatidylinositol-4-kinase IIIbeta (PI4KIIIbeta) to membranes over coat proteins, yielding uncoated phosphatidylinositol-4-phosphate (PI4P) lipid-enriched organelles.
Membrane prostaglandin E synthase-1: a novel therapeutic target.
Review
Impact
Jakobsson et al., Stockholm, Sweden. In Pharmacol Rev, 2007
cytosolic PGE synthase (cPGES) and two membrane-bound PGE synthases, mPGES-1 and mPGES-2.
Functional diversification of closely related ARF-GEFs in protein secretion and recycling.
Impact
Jürgens et al., Tübingen, Germany. In Nature, 2007
Mammalian GBF1 (ref.
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