GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 08 Dec 2016.
Prostaglandin E synthase 2
mPGES-2, GBF1, PTGES2
The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. [provided by RefSeq, Jun 2009] (from
Lung GO et al., Boston, United States. In Am J Respir Crit Care Med, Feb 2016
Four genes (DNAH8, ALCAM, RARS and GBF1) also demonstrated an increase in rare non-synonymous, stop and/or splice mutations in cases compared to resistant smokers from the COPDGene study; however, these results were not statistically significant.
Sztul et al., Birmingham, United States. In Am J Physiol Cell Physiol, Jan 2016
We generated a GBF1 mutant (91/130) in which two residues required for oligomerization (K91 and E130 within the DCB domain) were replaced with A, and assessed the effects of these mutations on GBF1 localization and cellular functions.
Sabatini et al., Cambridge, United States. In Nat Cell Biol, 2013
ARF4 depletion preserves viability, Golgi integrity and cargo trafficking in the presence of BFA, and these effects depend on the guanine nucleotide exchange factor GBF1 and other ARF isoforms including ARF1 and ARF5.
Altan-Bonnet et al., Newark, United States. In Cell, 2010
Specific viral proteins modulate effector recruitment by Arf1 GTPase and its guanine nucleotide exchange factor GBF1, promoting preferential recruitment of phosphatidylinositol-4-kinase IIIbeta (PI4KIIIbeta) to membranes over coat proteins, yielding uncoated phosphatidylinositol-4-phosphate (PI4P) lipid-enriched organelles.