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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 23 Nov 2016.

Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3

MP1
This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: CAN, HAD, AGE, OCT, ACID
Papers on MP1
The interfacial properties of the peptide Polybia-MP1 and its interaction with DPPC are modulated by lateral electrostatic attractions.
New
Wilke et al., Ribeirão Preto, Brazil. In Biochim Biophys Acta, Feb 2016
Polybia-MP1 (IDWKKLLDAAKQIL-NH2), extracted from the Brazilian wasp Polybia paulista, exhibits a broad-spectrum bactericidal activity without being hemolytic and cytotoxic.
HYPERREFLECTIVE RETINAL SPOTS AND VISUAL FUNCTION AFTER ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR TREATMENT IN CENTER-INVOLVING DIABETIC MACULAR EDEMA.
New
Midena et al., Padova, Italy. In Retina, Jan 2016
Twenty diabetic patients underwent 3 consecutive intravitreal anti-vascular endothelial growth factor injections in the study eye (20 fellow eyes served as control), full ophthalmologic examination including spectral domain optical coherence tomography (Retinascan RS-3000; Nidek, Gamagori, Japan), and microperimetry (MP1; Nidek) at baseline (Visit-V1), 1 month after each injection (V2, V3, V4), and at 6 months (V5).
Separation of proteins by cation-exchange sequential injection chromatography using a polymeric monolithic column.
New
Masini, São Paulo, Brazil. In Anal Bioanal Chem, Jan 2016
Graphical Abstract Sequential injection chromatograph for cation-exchange separation of proteins in a iminodiacetatemodified polyglycidyl methacrylate-co-ethylene dimethacrylate, IDA-poly(GMA-co-EDMA), monolithic column, where MP1 = 20 mM KH2PO4/K2HPO4 (pH 7.0), HC = Holding coil, SP = Syringe Pump, RV = Relef Valve and D = UV-Detector.
Correlation of central visual function and ROP risk factors in prematures with and without acute ROP at the age of 6-13 years: the Giessen long-term ROP study.
New
Andrassi-Darida et al., Gießen, Germany. In Br J Ophthalmol, Jan 2016
VA was assessed with Early Treatment of Diabetic Retinopathy Study letters, LIS was measured at 0°, 2.8° and 8° in the visual field (Microperimeter MP1, Nidek Technologies), and spherical equivalent refraction assessed with a Nidek autorefractor (Nidek, Italy).
Intersession test-retest variability of conventional and novel parameters using the MP-1 microperimeter.
New
Chen et al., Perth, Australia. In Clin Ophthalmol, Dec 2015
PURPOSE: To investigate the intersession test-retest variability (TRV) of topography- and threshold-based parameters derived from the Nidek MP-1.
Specification of Dendritogenesis Site in Drosophila aCC Motoneuron by Membrane Enrichment of Pak1 through Dscam1.
New
Huang et al., San Francisco, United States. In Dev Cell, Nov 2015
We further discovered that Dscam1 localization in aCC occurs through an inter-neuronal contact that involves Dscam1 in the partner MP1 neuron.
Predicting Pathological Features at Radical Prostatectomy in Patients with Prostate Cancer Eligible for Active Surveillance by Multiparametric Magnetic Resonance Imaging.
Ferro et al., Milano, Italy. In Plos One, 2014
Mp-1.5 Tesla MRI examination staging with endorectal coil was performed at least 6-8 weeks after TRUS-guided biopsy.
Morphology and Function over a One-Year Follow Up Period after Intravitreal Dexamethasone Implant (Ozurdex) in Patients with Diabetic Macular Edema.
Carpineto et al., Verona, Italy. In Plos One, 2014
METHODS: Twenty-seven eyes in 27 treatment-naive patients affected by DME were treated with intravitreal Ozurdex® injections (IVOI) and followed up 12 months to evaluate morphological and functional changes by means of best-corrected visual acuity (BCVA), microperimetry (MP1), multifocal electroretinography (mfERG), pattern electroretinography (PERG) and spectral domain optical coherence tomography (SD-OCT).
Fundus-driven perimetry (microperimetry) compared to conventional static automated perimetry: similarities, differences, and clinical applications.
Review
Greenstein et al., Cardiff, United Kingdom. In Can J Ophthalmol, 2013
In this article, we review the technique, focusing on the MP-1 microperimeter (Nidek Instruments, Inc, Padua, Italy); we compare it with conventional static automated perimetry, emphasizing the importance of understanding the effects of the different stimulus conditions and data analyses on the interpretation of microperimetry data.
Preliminary study on combined pharmacological and laser treatment in optic pit serous maculopathy after literature review.
Review
Malagola et al., Roma, Italy. In Panminerva Med, 2012
In order to achieve this the latest generation of hi-tech diagnostic tests were used, such as Spectral-Domain Optical Coherence Tomography (SD-OCT), Visual Evoked Potentials (VEP), full-field Electroretinography (ERG), multifocal ERG (mfERG), Microperimetry (MP-1), Standard Automated Perimetry (SAP), Fluorescein Angiography (FA) and Indocyanine Green Angiography (ICG).
ERK1/2 MAP kinases: structure, function, and regulation.
Review
Roskoski, United States. In Pharmacol Res, 2012
A variety of scaffold proteins including KSR1/2, IQGAP1, MP1, β-Arrestin1/2 participate in the regulation of the ERK1/2 MAP kinase cascade.
A genome-wide RNAi screen in mouse embryonic stem cells identifies Mp1 as a key mediator of differentiation.
GeneRIF
van Lohuizen et al., Amsterdam, Netherlands. In J Exp Med, 2012
A genome-wide RNAi screen in mouse embryonic stem cells identifies Mp1 as a key mediator of differentiation.
Arabidopsis MSBP1 is activated by HY5 and HYH and is involved in photomorphogenesis and brassinosteroid sensitivity regulation.
GeneRIF
Xue et al., Shanghai, China. In Mol Plant, 2011
light triggers MSBP1 expression through direct binding to and activation by HY5 and HYH.
The MAP kinase ERK and its scaffold protein MP1 interact with the chromatin regulator Corto during Drosophila wing tissue development.
GeneRIF
Peronnet et al., Paris, France. In Bmc Dev Biol, 2010
Corto, rl and dMP1 interact during wing tissue differentiation; Corto, ERK(rl) and dMP1 form a complex in the nucleus and co-localize on several sites on polytene chromosomes
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
Impact
GeneRIF
Sabatini et al., Cambridge, United States. In Cell, 2010
A complex encoded by the MAPKSP1, ROBLD3, and c11orf59 genes interacts with the Rag GTPases, recruits them to lysosomes, and is essential for mTORC1 activation
The metalloendopeptidase gene Pitrm1 is regulated by hedgehog signaling in the developing mouse limb and is expressed in muscle progenitors.
GeneRIF
Wicking et al., Australia. In Dev Dyn, 2009
Pitrm1 is expressed in Pax3-expressing myoblast progenitors in the limb, the dermomyotome, and developing muscles of the face and torso.
Carcinogenic role of tumor necrosis factor-alpha inducing protein of Helicobacter pylori in human stomach.
Review
Fujiki et al., Saitama, Japan. In J Biochem Mol Biol, 2006
Based on our findings that TNF-alpha is an endogenous tumor promoter, we identified the TNFalpha inducing protein (Tipalpha) gene family, and confirmed Tipalpha and HP-MP1 as new carcinogenic proteins of H. pylori.Tipalpha protein is unique to H. pylori, and this paper shows the strong tumor promoting activity of Tipalpha gene family, in cooperation with Ras protein and its mechanisms of action in relation to NF-kappaB activation, and discusses the carcinogenic role of Tipalpha in stomach cancer.
Involvement of TNF-alpha changes in human cancer development, prevention and palliative care.
Review
Nakachi et al., Saitama, Japan. In Mech Ageing Dev, 2002
This paper presents three clinical examples of TNF-alpha up-regulation: by cord factors of Mycobacterium tuberculosis, such as trehalose 6-monomycolate, as an activator of protein kinase C and by a cord factor like fraction of Microsporum canis obtained in the air inside houses in Thailand, both of which are risk factors in human lung cancer development, and by Helicobacter pylori gene product, H. pylori membrane protein 1 (HP-MP1) in relation to human stomach cancer.
MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade.
Impact
Weber et al., Charlottesville, United States. In Science, 1998
A protein called MP1 (MEK Partner 1) was identified that bound specifically to MEK1 and ERK1 and facilitated their activation.
Genetic analysis of growth cone guidance in Drosophila: fasciclin II functions as a neuronal recognition molecule.
Impact
Goodman et al., Berkeley, United States. In Cell, 1991
In both grasshopper and Drosophila, fasciclin II is expressed on the MP1 fascicle and a subset of other axon pathways.
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