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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Motilin receptor

motilin receptor, GPR38
Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal (GI) tract. The protein encoded by this gene is a motilin receptor which is a member of the G-protein coupled receptor 1 family. This member is a multi-pass transmembrane protein, and is an important therapeutic target for the treatment of hypomotility disorders. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: ghrelin, HAD, ACID, V1a, CAN
Papers on motilin receptor
Ghrelin and motilin receptors as drug targets for gastrointestinal disorders.
Review
New
Furness et al., Melbourne, Australia. In Nat Rev Gastroenterol Hepatol, Jan 2016
In clinical trials, the motilin receptor agonist camicinal increased gastric emptying, but at lower doses reduced gastroparesis symptoms and improved appetite.
Neural mechanism of gastric motility regulation by electroacupuncture at RN12 and BL21: A paraventricular hypothalamic nucleus-dorsal vagal complex-vagus nerve-gastric channel pathway.
New
He et al., Hefei, China. In World J Gastroenterol, Jan 2016
The expression levels of c-fos, motilin (MTL) and gastrin (GAS) in the paraventricular hypothalamic nucleus (PVN) were assayed by immunohistochemistry, and the expression levels of motilin receptor (MTL-R) and gastrin receptor (GAS-R) in both the PVN and the gastric antrum were assayed by western blotting.
Ghrelin Is an Essential Factor for Motilin-Induced Gastric Contraction in Suncus murinus.
New
Sakai et al., Saitama, Japan. In Endocrinology, Dec 2015
Administration of the motilin receptor antagonist MA-2029 (0.1 mg/kg) and/or (d-Lys(3))-GHRP-6 (0.6 mg/kg) at the peak of phase III abolished the spontaneous gastric phase III contractions in vivo.
RQ-00201894: A motilin receptor agonist causing long-lasting facilitation of human gastric cholinergically-mediated contractions.
New
Sanger et al., Nagoya, Japan. In J Pharmacol Sci, Dec 2015
A reporter gene assay assessed motilin receptor function.
Emerging drugs for functional dyspepsia.
Review
New
Talley et al., Newcastle, Australia. In Expert Opin Emerg Drugs, Jun 2015
Novel agents such as the motilin receptor agonist camicinal and the muscarinic M1 and M2 receptor antagonist acotiamide appear promising; however, the need for a safe and efficacious treatment remains largely unmet.
The investigational drug camicinal for the treatment of gastroparesis.
Kuo et al., Chicago, United States. In Expert Opin Investig Drugs, 2015
Camicinal (GSK962040) is the most advanced, small-molecule, selective motilin receptor agonist with therapeutic potential to date.
Differential expression of motilin receptor in various parts of gastrointestinal tract in dogs.
Jin et al., Changchun, China. In Gastroenterol Res Pract, 2014
The presence of motilin receptor in the GI tract of different animal species has been verified.
Drugs acting at 5-HT4 , D2 , motilin, and ghrelin receptors differ markedly in how they affect neuromuscular functions in human isolated stomach.
Sanger et al., London, United Kingdom. In Neurogastroenterol Motil, 2014
The selective motilin receptor agonist camicinal provided considerably greater facilitation (478 (12-2080)% at 30 μM, n = 8).
Effects of intrathecal opioids combined with low-dose naloxone on motilin and its receptor in a rat model of postoperative pain.
Cao et al., Tianjin, China. In Life Sci, 2014
The expression of motilin in the hippocampus, stomach, duodenum, and plasma was determined by ELISA; and the expression of motilin receptor in the hippocampus was detected by Western blot assay.
Association between Motilin Receptor Gene Haplotypes and Growth Traits in Japanese Hinai-dori Crossbred Chickens.
Suzuki et al., Akita, Japan. In Asian-australas J Anim Sci, 2014
Motilin receptor (MLNR) is a candidate gene affecting growth traits in the region.
Ghrelin and motilin receptor agonists: time to introduce bias into drug design.
Review
Sanger, London, United Kingdom. In Neurogastroenterol Motil, 2014
Ghrelin and motilin receptor agonists increase gastric motility and are attractive drug targets.
The relationship between gastric motility and nausea: gastric prokinetic agents as treatments.
Review
Andrews et al., London, United Kingdom. In Eur J Pharmacol, 2013
Nevertheless, more selective 5-HT4 and motilin receptor agonists (erythromycin, directly stimulating gastric motility) inhibit vomiting in animals; low doses of erythromycin can also relieve symptoms in patients with gastroparesis.
Ghrelin receptor is activated by naringin and naringenin, constituents of a prokinetic agent Poncirus fructus.
Shim et al., Seoul, South Korea. In J Ethnopharmacol, 2013
The present study investigated whether PF-W has any effect on motilin receptor or ghrelin receptor, since these receptors enhance intestinal motility when activated.
Gastrointestinal dysmotility: evidence and clinical management.
Review
Deane et al., Adelaide, Australia. In Curr Opin Clin Nutr Metab Care, 2013
New treatment modalities for gastrointestinal dysfunction are being investigated and include small intestinal feeding, nonpharmacological options such as acupuncture, and drugs including novel motilin receptor agonists, and opioid antagonists.
Desensitization and internalization of the human motilin receptor is independent of the C-terminal tail.
GeneRIF
Depoortere et al., Leuven, Belgium. In Peptides, 2008
Desensitization and internalization of MLNR is independent of the C-terminal tail.
Motilin receptor expression in smooth muscle, myenteric plexus, and mucosa of human inflamed and noninflamed intestine.
GeneRIF
Lamers et al., Leiden, Netherlands. In Inflamm Bowel Dis, 2008
The motilin receptor is expressed in human colonic and ileal smooth muscle. Further, motilin receptor expression was also shown in the mucosa.
Mutational analysis of predicted intracellular loop domains of human motilin receptor.
GeneRIF
Onji et al., Japan. In Am J Physiol Gastrointest Liver Physiol, 2008
action by different chemical classes of agonists that are known to interact with distinct regions of the motilin receptor likely yield a common activation state of the cytosolic face of this receptor
Differential contributions of motilin receptor extracellular domains for peptide and non-peptidyl agonist binding and activity.
GeneRIF
Onji et al., Japan. In J Biol Chem, 2006
motilin receptor extracellular domains have roles in peptide and non-peptidyl agonist binding and activity
The motilin pharmacophore in CHO cells expressing the human motilin receptor.
GeneRIF
Peeters et al., Leuven, Belgium. In Biochem Biophys Res Commun, 2002
The motilin pharmacophore in CHO cells expressing the human motilin receptor
Receptor for motilin identified in the human gastrointestinal system.
Impact
Howard et al., Rahway, United States. In Science, 1999
The macrolide antibiotic erythromycin also interacted with the cloned motilin receptor, providing a molecular basis for its effects on the human GI tract.
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