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MOT1 Mot1p

MOT1, Mot1p, BTAF1, TAF-172
This gene encodes a TAF (TATA box-binding protein-associated factor), which associates with TBP (TATA box-binding protein) to form the B-TFIID complex that is required for transcription initiation of genes by RNA polymerase II. This TAF has DNA-dependent ATPase activity, which drives the dissociation of TBP from DNA, freeing the TBP to associate with other TATA boxes or TATA-less promoters. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: TBP, CAN, POLYMERASE, BRG1, ATPase
Papers on MOT1
Delimitation of the Earliness per se D1 (Eps-D1) flowering gene to a subtelomeric chromosomal deletion in bread wheat (Triticum aestivum).
New
Griffiths et al., Norwich, United Kingdom. In J Exp Bot, Jan 2016
The deletion spans the equivalent of the Triticum monoccocum Eps-A (m) 1 locus, and hence includes MODIFIER OF TRANSCRIPTION 1 (MOT1) and FTSH PROTEASE 4 (FTSH4), the candidates for Eps-A (m) 1.
The Multi-allelic Genetic Architecture of a Variance-Heterogeneity Locus for Molybdenum Concentration in Leaves Acts as a Source of Unexplained Additive Genetic Variance.
New
Carlborg et al., Uppsala, Sweden. In Plos Genet, Nov 2015
Two of the three polymorphisms underlying the genetic variance-heterogeneity are promoter variants for Molybdate transporter 1 (MOT1), and the third a variant located ~25 kb downstream of this gene.
Regulation of anti-sense transcription by Mot1p and NC2 via removal of TATA-binding protein (TBP) from the 3'-end of genes.
Timmers et al., Utrecht, Netherlands. In Nucleic Acids Res, 2015
The activity and dynamic nature of TATA-binding protein (TBP) crucial to RNA polymerase II-mediated transcription is under control of the Mot1p and NC2 complexes.
Development of a Cadaveric Model for Arthrocentesis.
Johnson et al., In J Vet Med Educ, 2014
No statistically significant difference was seen between HS and MO in most joints with the exception of MOT1 stifle and HST2 elbow.
Suppression of intragenic transcription requires the MOT1 and NC2 regulators of TATA-binding protein.
Timmers et al., Nashville, United States. In Nucleic Acids Res, 2014
In a comprehensive study of the yeast chromatin remodelers and the Mot1p-NC2 regulators of TATA-binding protein (TBP), we detected synthetic genetic interactions indicative of suppression of intragenic transcription.
Copper-deficiency in Brassica napus induces copper remobilization, molybdenum accumulation and modification of the expression of chloroplastic proteins.
Etienne et al., Caen, France. In Plos One, 2013
Cu deficiency also triggered an increase in Cu transporter expression in roots (COPT2) and leaves (HMA1), and more surprisingly, the induction of the MOT1 gene encoding a molybdenum transporter associated with a strong increase in molybdenum (Mo) uptake.
Physical and Genetic Interactions Between Uls1 and the Slx5-Slx8 SUMO-Targeted Ubiquitin Ligase.
Prelich et al., In G3 (bethesda), 2013
Mutations in SLX5, SLX8, and other SUMO pathway genes were previously identified in our lab as genomic suppressors of a point mutation (mot1-301) in the transcriptional regulator MOT1.
Two-step mechanism for modifier of transcription 1 (Mot1) enzyme-catalyzed displacement of TATA-binding protein (TBP) from DNA.
GeneRIF
Auble et al., Evanston, United States. In J Biol Chem, 2012
In the absence of ATP, ternary complex stability arises from both Mot1-DNA and Mot1-TBP interactions.
Inheritance beyond plain heritability: variance-controlling genes in Arabidopsis thaliana.
Carlborg et al., Uppsala, Sweden. In Plos Genet, 2011
Two well-studied systems, cellular control of molybdenum level by the ion-transporter MOT1 and flowering-time regulation by the FRI-FLC expression network, and a novel association for Leaf serration are used to illustrate the contribution of major individual loci, expression pathways, and gene-by-environment interactions to the genetic variance heterogeneity.
Allelic heterogeneity and trade-off shape natural variation for response to soil micronutrient.
Loudet et al., Versailles, France. In Plos Genet, 2011
Here, we have identified a new variant of a molybdenum (Mo) transporter, MOT1, which is causal for fitness changes under artificial conditions of both Mo-deficiency and Mo-toxicity and in which allelic variation among West-Asian populations is strictly correlated with the concentration of available Mo in native soils.
Structure and mechanism of the Swi2/Snf2 remodeller Mot1 in complex with its substrate TBP.
Impact
Hopfner et al., M√ľnchen, Germany. In Nature, 2011
Mot1 (modifier of transcription 1 in Saccharomyces cerevisiae, denoted BTAF1 in humans) is a Swi2/Snf2 enzyme that specifically displaces the TATA box binding protein (TBP) from the promoter DNA and regulates transcription globally by generating a highly dynamic TBP pool in the cell.
Genome-wide transcriptional dependence on conserved regions of Mot1.
GeneRIF
Pugh et al., United States. In Mol Cell Biol, 2011
findings suggest that the four conserved regions of Mot1 are essential for viability and required for proper regulation of most Mot1-regulated genes; loss of the ATPase domain, however, imparts some unexpected regulation on certain genes
Effects of molybdenum deficiency and defects in molybdate transporter MOT1 on transcript accumulation and nitrogen/sulphur metabolism in Arabidopsis thaliana.
GeneRIF
Fujiwara et al., Tokyo, Japan. In J Exp Bot, 2011
MOT1 has a role in maintaining primary metabolism of nitrogen, carbon, and sulfur under molybdenum deficiency.
RNA synthesis precision is regulated by preinitiation complex turnover.
GeneRIF
Auble et al., Charlottesville, United States. In Genome Res, 2010
Mot1 plays a broad role in establishing the precision and efficiency of RNA synthesis.
Chromatin interaction of TATA-binding protein is dynamically regulated in human cells.
GeneRIF
Timmers et al., Utrecht, Netherlands. In J Cell Sci, 2010
Results support a model for a BTAF1-mediated release of TBP-NC2 complexes from chromatin.
The general transcription machinery and general cofactors.
Review
Chiang et al., Cleveland, United States. In Crit Rev Biochem Mol Biol, 2006
In addition, other cofactors, such as TAF1, BTAF1, and negative cofactor 2 (NC2), can also modulate TBP or TFIID binding to the core promoter.
Roles for BTAF1 and Mot1p in dynamics of TATA-binding protein and regulation of RNA polymerase II transcription.
Review
Timmers et al., Utrecht, Netherlands. In Gene, 2003
Human BTAF1 (TAF(II)170/TAF-172) and its yeast ortholog, Mot1p, are evolutionarily conserved members of the SNF2-like family of ATPase proteins.
Evolution of the SNF2 family of proteins: subfamilies with distinct sequences and functions.
Review
Hanawalt et al., Stanford, United States. In Nucleic Acids Res, 1995
MOT1, SNF2 and BRM), maintenance of chromosome stability during mitosis (e.g.
Mutations in a putative global transcriptional regulator cause X-linked mental retardation with alpha-thalassemia (ATR-X syndrome).
Impact
Higgs et al., Oxford, United Kingdom. In Cell, 1995
We have shown that ATR-X results from diverse mutations of XH2, a member of a subgroup of the helicase superfamily that includes proteins involved in a wide range of cellular functions, including DNA recombination and repair (RAD16, RAD54, and ERCC6) and regulation of transcription (SW12/SNF2, MOT1, and brahma).
The TATA-binding protein and associated factors are components of pol III transcription factor TFIIIB.
Impact
Pugh et al., University Park, United States. In Cell, 1993
Here we show that classical pol III transcription involves a minimum of two novel TAFs: TAF-172 and TAF-L.
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