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Opsin 4

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, Neuropeptide, ACID, V1a
Papers on MOP
Hetero-bimetallic metal-organic polyhedra.
Doonan et al., Adelaide, Australia. In Chem Commun (camb), Feb 2016
Careful activation produces co-ordinatively unsaturated 3d transition metal sites on the external MOP surfaces giving rise to H2 adsorption enthalpies in excess of -12 kJ mol(-1).
SNEV(P) (rp19/) (PSO) (4) deficiency increases PUVA induced senescence in mouse skin.
Grillari et al., Vienna, Austria. In Exp Dermatol, Jan 2016
We performed PUVA treatment as model system for potently inducing cellular senescence, consisting of 8-methoxypsoralen (8-MOP) in combination with UVA on mouse skin to induce DNA damage and premature skin aging.
Proteome profiling of the Rhodobacter capsulatus molybdenum response reveals a role of IscN in nitrogen fixation by Fe-nitrogenase.
Masepohl et al., Bochum, Germany. In J Bacteriol, Jan 2016
The levels of Mo-nitrogenase, NifHDK, and the Mo storage protein, Mop, increased with increasing Mo concentrations.
Selective modulation of the prostaglandin F2α pathway markedly impacts on endometriosis progression in a xenograft mouse model.
Horne et al., Québec, Canada. In Mol Hum Reprod, Dec 2015
STUDY FUNDING AND COMPETING INTERESTS: This work was supported by grant MOP-123259 to the late Dr Ali Akoum from the Canadian Institutes for Health Research.
Formation of Mitochondrial Outer Membrane Derived Protrusions and Vesicles in Arabidopsis thaliana.
Arimura et al., Tokyo, Japan. In Plos One, Dec 2015
Live imaging demonstrated that a plant MDV budded off from the tip of a MOP.
Intrathecal administration of nociceptin/orphanin FQ receptor agonists in rats: A strategy to relieve chemotherapy-induced neuropathic hypersensitivity.
Ghelardini et al., Florence, Italy. In Eur J Pharmacol, Dec 2015
In conclusion, intrathecal μ opioid peptide (MOP) and NOP receptor agonists relieved chemotherapy-induced neuropathic pain.
Simultaneous targeting of multiple opioid receptor types.
Lambert et al., Leicester, United Kingdom. In Curr Opin Support Palliat Care, Jun 2015
PURPOSE OF REVIEW: This article aims to discuss the multitarget concept for opioid receptor ligands framed on early observations that activating MOP (mu:μ) receptor whilst simultaneously blocking DOP (delta:δ) receptors reduces the onset of morphine tolerance.
Understanding opioid reward.
Margolis et al., San Francisco, United States. In Trends Neurosci, Apr 2015
Both rewarding and analgesic actions of opioids depend upon actions at the mu opioid (MOP) receptor.
Heteromers of μ-δ opioid receptors: new pharmacology and novel therapeutic possibilities.
Devi et al., New York City, United States. In Br J Pharmacol, 2015
UNLABELLED: Several studies suggest that heteromerization between μ (MOP) and δ (DOP) opioid receptors modulates the signalling properties of the individual receptors.
Functional plasticity of the N/OFQ-NOP receptor system determines analgesic properties of NOP receptor agonists.
Koch et al., Aachen, Germany. In Br J Pharmacol, 2014
Moreover, co-activation of NOP and μ-opioid peptide (MOP) receptors synergistically produced antinociception in NHPs.
Updating ECP action mechanisms.
Heshmati, Paris, France. In Transfus Apher Sci, 2014
Extracorporeal Photochemotherapy (ECP) consists in illumination of the patient's leukocytes in the presence of 8-Methoxy Psoralen (8-MOP) and its reinjection to the same patient.
Programmed elimination of cells by caspase-independent cell extrusion in C. elegans.
Horvitz et al., Cambridge, United States. In Nature, 2012
We describe a kinase pathway required for cell extrusion involving PAR-4, STRD-1 and MOP-25.1/-25.2, the C. elegans homologues of the mammalian tumour-suppressor kinase LKB1 and its binding partners STRADα and MO25α.
Melanopsin is highly resistant to light and chemical bleaching in vivo.
Van Gelder et al., Seattle, United States. In J Biol Chem, 2012
a model in which retinal is continuously covalently bound to melanopsin and may function through a reversible, bistable mechanism
Light-dependent phosphorylation of the carboxy tail of mouse melanopsin.
Robinson et al., Baltimore, United States. In Cell Mol Life Sci, 2012
heterologously expressed melanopsin is phosphorylated in a light-dependent manner, and this phosphorylation is involved in regulating the rate of G-protein activation and the lifetime of melanopsin's active state
Basic opioid pharmacology: an update.
Williams et al., Derby, United Kingdom. In Br J Pain, 2012
There are three classical opioid receptors (DOP, KOP and MOP), while the novel NOP receptor is considered to be a non-opioid branch of the opioid receptor family.
Melanopsin and mechanisms of non-visual ocular photoreception.
Van Gelder et al., Seattle, United States. In J Biol Chem, 2012
Melanopsin and mechanisms of non-visual ocular photoreception
Differential expression of melanopsin isoforms Opn4L and Opn4S during postnatal development of the mouse retina.
Foster et al., Oxford, United Kingdom. In Plos One, 2011
Opn4S mRNA was detected at relatively constant levels throughout postnatal development, with levels of Opn4S protein showing a marked increase between P0 and P3. Levels of Opn4L mRNA and protein were low at birth and markedlyd increased at P14 and P3.
Melanopsin signalling in mammalian iris and retina.
Yau et al., Baltimore, United States. In Nature, 2011
In mouse, this intrinsic pupillary light reflex requires the visual pigment melanopsin; it also requires PLCbeta4, a vertebrate homologue of the Drosophila NorpA phospholipase C which mediates rhabdomeric phototransduction.
Basic Opioid Pharmacology.
Williams, Derby, United Kingdom. In Rev Pain, 2008
Opioids can be classified according to their mode of synthesis into alkaloids, semi-synthetic and synthetic compounds.There are three classical receptors (DOP, KOP and MOP).
Crystal structure of the xanthine oxidase-related aldehyde oxido-reductase from D. gigas.
Huber et al., Portugal. In Science, 1995
The crystal structure of the aldehyde oxido-reductase (Mop) from the sulfate reducing anaerobic Gram-negative bacterium Desulfovibrio gigas has been determined at 2.25 A resolution by multiple isomorphous replacement and refined.
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