Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.
Madrid, Spain. In Eur J Med Chem, 27 Feb 2014
UNLABELLED: The design, synthesis, and pharmacological evaluation of donepezil-indolyl based amines 7-10, amides 12-16, and carboxylic acid derivatives 5 and 11, as multipotent ASS234 analogs, able to inhibit simultaneously cholinesterase (ChE) and monoamine oxidase (MAO) enzymes for the potential treatment of Alzheimer's disease (AD), is reported.
Montréal, Canada. In Can J Hosp Pharm, Jul 2013
Methylene blue would seem to have monoamine oxidase A inhibitory properties.
New trends in the neurobiology and pharmacology of affective disorders.
Kraków, Poland. In Pharmacol Rep, 2012
Since the early 1950s, when the first antidepressants were introduced, i.e., the non-selective MAO inhibitors and tricyclic drugs, a number of hypotheses describing ethiopathogenesis of depression and antidepressant drug action have been formulated.