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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Aug 2015.

Monoamine oxidase A

Monoamine Oxidase, MAO
enzyme involved in the oxidative deamination of biogenic and xenobiotic amines [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: MAO-B, CAN, HAD, ACID, AGE
Papers on Monoamine Oxidase
Hologram quantitative structure-activity relationship and comparative molecular interaction field analysis of aminothiazole and thiazolesulfonamide as reversible LSD1 inhibitors.
New
Trossini et al., São Paulo, Brazil. In Future Med Chem, 31 Aug 2015
MAO and LSD-1 are both flavin adenine dinucleotide-dependent MAOs, and the MAO inhibitor, tranylcypromine, is currently undergoing clinical trials for cancer treatment because it acts as an irreversible LSD-1 inhibitor.
Monoamine Oxidase A gene polymorphisms and self reported aggressive behaviour in a Pakistani ethnic group.
New
Ayub et al., Napoli, Italy. In J Pak Med Assoc, 31 Aug 2015
It analysed 10 single nucleotide polymorphisms of monoamine oxidase A in unrelated males from the same ethnic background who were administered a Punjabi translation of the Buss and Perry aggression questionnaire.
The Separate and Combined Effects of Monoamine Oxidase A Inhibition and Nicotine on the Mismatch Negativity Event Related Potential.
New
Knott et al., Ottawa, Canada. In Pharmacol Biochem Behav, 27 Aug 2015
However, transient cognitive improvements via smoking in patients may also result from monoamine oxidase (MAO) inhibition, achieved through tobacco smoke.
Functional and genomic diversity of methylotrophic Rhodocyclaceae: description of Methyloversatilis discipulorum sp. nov.
New
Kalyuzhnaya et al., In Int J Syst Evol Microbiol, 31 Jul 2015
Similarly to M. thermotolerans, the three strains possess two-subunit methanol dehydrogenase (MxaFI), monoamine oxidase (MAO) and nitrogenase.
Inhibition and oxygen activation in copper amine oxidases.
New
Impact
Dooley et al., Bozeman, United States. In Acc Chem Res, Jun 2015
Inhibition of these enzymes by antifungal or antiprotozoal agents, as well as classic monoamine oxidase (MAO) inhibitors, may contribute to the adverse side effects associated with drug treatment.
Kynurenine pathway dysfunction in the pathophysiology and treatment of depression: Evidences from animal and human studies.
Review
New
Quevedo et al., Houston, United States. In J Psychiatr Res, Jun 2015
The medications currently available to treat depression, including serotonin re-uptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants (TCAs), fail to produce adequate remission of depressive symptoms for a large number of patients.
The Use of Transdermal Therapeutic Systems in Psychiatric Care: A Primer on Patches.
New
Stern et al., Houston, United States. In Psychosomatics, May 2015
Such medications include cholinesterase inhibitors for dementia, methylphenidate (MPH) for attention-deficit hyperactivity disorder, monoamine oxidase inhibitors (MAOIs) for depression, dopamine agonists for Parkinson disease and restless leg syndrome, and clonidine for attention-deficit hyperactivity disorder and impulse-control disorders.
Catecholamine-Based Treatment in AD Patients: Expectations and Delusions.
Review
New
Pierantozzi et al., Roma, Italy. In Front Aging Neurosci, Dec 2014
In reviewing the available literature, we consider the effects of levodopa, monoamine oxidase inhibitors, and noradrenaline (NE) modulators, showing disparate results.
Immunomodulatory effects mediated by serotonin.
Review
New
Pavón et al., Mexico. In J Immunol Res, Dec 2014
Three classes of genes regulating 5-HT function are constitutively expressed or induced in these cells: (a) membrane proteins that regulate the response to 5-HT, such as SERT, 5HTR-GPCR, and the 5HT3-ion channels; (b) downstream signaling transduction proteins; and (c) enzymes controlling 5-HT metabolism, such as IDO and MAO, which can generate biologically active catabolites, including melatonin, kynurenines, and kynurenamines.
New developments in the management of severe skin and deep skin structure infections - focus on tedizolid.
Review
New
Corey et al., Durham, United States. In Ther Clin Risk Manag, Dec 2014
Fourth, in patients who have been prescribed selective serotonin reuptake inhibitors or monoamine oxidase inhibitors, tedizolid may have fewer drug interactions than linezolid.
Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease (PD MED): a large, open-label, pragmatic randomised trial.
New
Impact
Clarke et al., In Lancet, Oct 2014
BACKGROUND: Whether initial treatment for Parkinson's disease should consist of levodopa, dopamine agonists, or monoamine oxidase type B inhibitors (MAOBI) is uncertain.
GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease.
New
Impact
Lee et al., Taejŏn, South Korea. In Nat Med, Aug 2014
Here, we show that reactive astrocytes aberrantly and abundantly produce the inhibitory gliotransmitter GABA by monoamine oxidase-B (Maob) and abnormally release GABA through the bestrophin 1 channel.
Rasagiline and rapid symptomatic motor effect in Parkinson's disease: review of literature.
Review
New
Zambito Marsala et al., Vicenza, Italy. In Neurol Ther, Jun 2014
Rasagiline is a monoamine oxidase type-B inhibitor used as monotherapy or in addition to levodopa in the treatment of Parkinson's disease.
Pharmacological treatment of Parkinson disease: a review.
Review
New
Impact
Lang et al., Hamilton, Canada. In Jama, May 2014
RESULTS: Although levodopa is the most effective medication available for treating the motor symptoms of Parkinson disease, in certain instances (eg, mild symptoms, tremor as the only or most prominent symptom, aged <60 years) other medications (eg, monoamine oxidase type B inhibitors [MAOBIs], amantadine, anticholinergics, β-blockers, or dopamine agonists) may be initiated first to avoid levodopa-related motor complications.
Genetic mediators of neurocognitive outcomes in survivors of childhood acute lymphoblastic leukemia.
Impact
Pui et al., Memphis, United States. In J Clin Oncol, 2013
Polymorphisms in monoamine oxidase (T1460CA) were associated with increased attention variability (P = .03).
Apolipoprotein E influences melatonin biosynthesis by regulating NAT and MAOA expression in C6 cells.
GeneRIF
Zhou et al., Hefei, China. In J Pineal Res, 2012
A higher level of melatonin was demonstrated in cultured ApoE4-C6 cells than in ApoE3-C6 cells. NAT was up-regulated in ApoE4-C6 cells compared with ApoE3-C6 cells, and MAOA and MAOB expression decreased in ApoE4-C6 cells.
²H kinetic isotope effects and pH dependence of catalysis as mechanistic probes of rat monoamine oxidase A: comparisons with the human enzyme.
GeneRIF
Edmondson et al., Atlanta, United States. In Biochemistry, 2011
Rat MAO A exhibits functional properties similar but not identical with those of the human enzyme, providing additional support for C-H bond cleavage via a polar nucleophilic mechanism
Topological probes of monoamine oxidases A and B in rat liver mitochondria: inhibition by TEMPO-substituted pargyline analogues and inactivation by proteolysis.
GeneRIF
Edmondson et al., Atlanta, United States. In Biochemistry, 2011
investigation of topological orientation of MAO-A (and MAO-B) in liver mitochondrial membranes
High-level expression and purification of rat monoamine oxidase A (MAO A) in Pichia pastoris: comparison with human MAO A.
GeneRIF
Edmondson et al., Atlanta, United States. In Protein Expr Purif, 2010
Although approximately 90% identical in sequence to human MAO A, rat MAO A is a more efficient catalyst for amine neurotransmitter oxidation.
Gonadectomy and hormone replacement exert region- and enzyme isoform-specific effects on monoamine oxidase and catechol-O-methyltransferase activity in prefrontal cortex and neostriatum of adult male rats.
GeneRIF
Kritzer et al., Stony Brook, United States. In Neuroscience, 2010
significant effects of hormone replacement and gonadectomy on catechol-O-methyltransferase and monoamine oxidase isoforms in both striatum and cortex
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