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Monoamine oxidase A

Monoamine Oxidase, MAO
enzyme involved in the oxidative deamination of biogenic and xenobiotic amines [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: MAO-B, CAN, HAD, ACID, AGE
Papers on Monoamine Oxidase
Interactions between MAOA and SYP polymorphisms were associated with symptoms of attention-deficit/hyperactivity disorder in Chinese Han subjects.
New
Qian et al., Beijing, China. In Am J Med Genet B Neuropsychiatr Genet, 08 Jan 2015
UNLABELLED: As candidate genes of attention-deficit/hyperactivity disorder (ADHD), monoamine oxidase A (MAOA), and synaptophysin (SYP) are both on the X chromosome, and have been suggested to be associated with the predominantly inattentive subtype (ADHD-I).
Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Chemicals.
New
Guengerich et al., In Chem Res Toxicol, 08 Jan 2015
UNLABELLED: Analyzing the literature resources used in our previous reports, we calculated the fractions of the oxidoreductase enzymes FMO (microsomal flavin-containing monooxygenase), AKR (aldo-keto reductase), MAO (monoamine oxidase), and cytochrome P450 participating in metabolic reactions.
Four pioneers of L-dopa treatment: Arvid Carlsson, Oleh Hornykiewicz, George Cotzias, and Melvin Yahr.
New
Olanow et al., London, United Kingdom. In Mov Disord, 08 Jan 2015
They reported success and continued this treatment, usually combining it with the use of a monoamine oxidase inhibitor.
Radiosynthesis and ex vivo evaluation of [(18)F]-(S)-3-(6-(3-fluoropropoxy)benzo[d]isoxazol-3-yl)-5-(methoxymethyl)oxazolidin-2-one for imaging MAO-B with PET.
New
Vasdev et al., Toronto, Canada. In Bioorg Med Chem Lett, 24 Dec 2014
UNLABELLED: Carbon-11 labeled SL25.1188 ((S)-5-(methoxymethyl)-3-(6-(4,4,4-trifluorobutoxy)benzo[d]isoxazol-3-yl)oxazolidin-2-one) is a reversible radiotracer for monoamine oxidase B that was recently evaluated in healthy volunteers by positron emission tomography (PET).
Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease (PD MED): a large, open-label, pragmatic randomised trial.
New
Impact
Clarke et al., In Lancet, Oct 2014
BACKGROUND: Whether initial treatment for Parkinson's disease should consist of levodopa, dopamine agonists, or monoamine oxidase type B inhibitors (MAOBI) is uncertain.
GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease.
New
Impact
Lee et al., Taejŏn, South Korea. In Nat Med, Aug 2014
Here, we show that reactive astrocytes aberrantly and abundantly produce the inhibitory gliotransmitter GABA by monoamine oxidase-B (Maob) and abnormally release GABA through the bestrophin 1 channel.
Pharmacological treatment of Parkinson disease: a review.
Review
New
Impact
Lang et al., Hamilton, Canada. In Jama, May 2014
RESULTS: Although levodopa is the most effective medication available for treating the motor symptoms of Parkinson disease, in certain instances (eg, mild symptoms, tremor as the only or most prominent symptom, aged <60 years) other medications (eg, monoamine oxidase type B inhibitors [MAOBIs], amantadine, anticholinergics, β-blockers, or dopamine agonists) may be initiated first to avoid levodopa-related motor complications.
Antidepressants and the Risk of Hyponatremia: A Class-by-Class Review of Literature.
Review
New
Sabbe et al., Antwerp, Belgium. In Psychosomatics, May 2014
The risks associated with monoamine oxidase inhibitors, reboxetine, and bupropion could not be established owing to insufficient information.
The role of the monoamine oxidase A gene in moderating the response to adversity and associated antisocial behavior: a review.
Review
New
Gallardo-Pujol et al., Barcelona, Spain. In Psychol Res Behav Manag, Dec 2013
We focus on the most-studied polymorphism to date for antisocial responses to adversity: the monoamine oxidase A gene.
EMSAM (deprenyl patch): how a promising antidepressant was underutilized.
Review
New
Henderson et al., New York City, United States. In Neuropsychiatr Dis Treat, Dec 2013
The EMSAM patch is a unique monoamine oxidase inhibitor (MAOI) being the only antidepressant utilizing a transdermal delivery system.
[Enzymological characteristics of liver monoamine oxidase of the skipjack tuna Katsuwonus pelamis].
New
In Zh Evol Biokhim Fiziol, Nov 2013
There has been carried out a study of substrate and inhibitor specificity of the liver mitochondrial monoamine oxidase (MAO) of the striped-bellied tunny Katsuwonus pelamis.
Genetic mediators of neurocognitive outcomes in survivors of childhood acute lymphoblastic leukemia.
New
Impact
Pui et al., Memphis, United States. In J Clin Oncol, Jul 2013
Polymorphisms in monoamine oxidase (T1460CA) were associated with increased attention variability (P = .03).
Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction.
New
Impact
Tanabe et al., Ann Arbor, United States. In Nat Med, Mar 2013
We show here that lysine-specific demethylase 1 (LSD1) inhibition by RNAi in human erythroid cells or by the monoamine oxidase inhibitor tranylcypromine in human erythroid cells or β-type globin-transgenic mice enhances γ-globin expression.
Genetic factors in anxiety disorders.
Review
Maron et al., Würzburg, Germany. In Mod Trends Pharmacopsychiatri, 2012
Presently available clinical genetic studies point to a considerable heritability of anxiety disorders (30-67%), with multiple vulnerability genes such as 5-HT1A, 5-HTT, MAO-A, COMT, CCK-B, ADORA2A, CRHR1, FKBP5, ACE, RGS2/7 and NPSR1 suggested by molecular genetic association studies.
Apolipoprotein E influences melatonin biosynthesis by regulating NAT and MAOA expression in C6 cells.
GeneRIF
Zhou et al., Hefei, China. In J Pineal Res, 2012
A higher level of melatonin was demonstrated in cultured ApoE4-C6 cells than in ApoE3-C6 cells. NAT was up-regulated in ApoE4-C6 cells compared with ApoE3-C6 cells, and MAOA and MAOB expression decreased in ApoE4-C6 cells.
²H kinetic isotope effects and pH dependence of catalysis as mechanistic probes of rat monoamine oxidase A: comparisons with the human enzyme.
GeneRIF
Edmondson et al., Atlanta, United States. In Biochemistry, 2011
Rat MAO A exhibits functional properties similar but not identical with those of the human enzyme, providing additional support for C-H bond cleavage via a polar nucleophilic mechanism
Topological probes of monoamine oxidases A and B in rat liver mitochondria: inhibition by TEMPO-substituted pargyline analogues and inactivation by proteolysis.
GeneRIF
Edmondson et al., Atlanta, United States. In Biochemistry, 2011
investigation of topological orientation of MAO-A (and MAO-B) in liver mitochondrial membranes
Cell based therapies in Parkinson's Disease.
Review
Singhal et al., New Delhi, India. In Ann Neurosci, 2011
Other pharmacological measures like catechol-O-methyltrasferase (COMT) inhibitors like entacopone, telcapone and monoamine oxidase B (MAO-B) inhibitors like selegiline and rasagiline are also useful, while L-dopa remains the gold standard in the treatment of PD.
High-level expression and purification of rat monoamine oxidase A (MAO A) in Pichia pastoris: comparison with human MAO A.
GeneRIF
Edmondson et al., Atlanta, United States. In Protein Expr Purif, 2010
Although approximately 90% identical in sequence to human MAO A, rat MAO A is a more efficient catalyst for amine neurotransmitter oxidation.
Gonadectomy and hormone replacement exert region- and enzyme isoform-specific effects on monoamine oxidase and catechol-O-methyltransferase activity in prefrontal cortex and neostriatum of adult male rats.
GeneRIF
Kritzer et al., Stony Brook, United States. In Neuroscience, 2010
significant effects of hormone replacement and gonadectomy on catechol-O-methyltransferase and monoamine oxidase isoforms in both striatum and cortex
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