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Monoamine oxidase A

Monoamine Oxidase, MAO
enzyme involved in the oxidative deamination of biogenic and xenobiotic amines [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: MAO-B, CAN, HAD, ACID, V1a
Papers on Monoamine Oxidase
Enhanced osseointegration of hierarchical micro/nano-topographic titanium fabricated by micro-arc oxidation and electrochemical treatment.
Jiang et al., In Acs Appl Mater Interfaces, Feb 2016
Micro-arc oxidation (MAO) fabricated titanium oxide coatings with a porous topography have been proved to be a potent approach to enhance osteogenic capacity.
AChE inhibition-based multi-target-directed ligands, a novel pharmacological approach for the symptomatic and disease-modifying therapy of Alzheimer's disease.
Chen et al., Shanghai, China. In Curr Neuropharmacol, Feb 2016
Herein, we delineated the catalytic and non-catalytic functions of AChE, and summarized the works of our group and others in research and development of novel AChEI-based multi-target-directed ligands (MTDLs), such as dual binding site AChEIs and multi-target AChEIs inhibiting Aβ aggregation, regulating Aβ procession, antagonizing PAF receptor, scavenging oxygen radical, chelating metal ions, inhibiting MAO-B, blocking NMDA receptor and others.
Association of DNA methylation and monoamine oxidase a gene expression in the brains of different dog breeds.
Kim et al., Pusan, South Korea. In Gene, Feb 2016
UNASSIGNED: The monoamine oxidase A (MAOA) gene is an important candidate gene for human behavior that encodes an enzyme regulating the metabolism of key neurotransmitters.
A review of genetic alterations in the serotonin pathway and their correlation with psychotic diseases and response to atypical antipsychotics.
Mavreas et al., Ioánnina, Greece. In Schizophr Res, Jan 2016
All the serotonin elements - serotonin receptors, serotonin transporter, tryptophan hydroxylase and monoamine oxidase proteins - can show alterations in terms of mRNA or protein levels and protein sequence, in schizophrenia and bipolar disorder.
Hansch Analysis of Novel Acetamide Derivatives as Highly Potent and Specific MAO-A Inhibitors.
Goutam et al., Bhopāl, India. In Cent Nerv Syst Agents Med Chem, Jan 2016
Model also suggest that presence of comparatively less lipophilic group may increase MAO-A inhibitory activity and substituent that decrease the flexibility and increase rigidity of nucleus will enhance the activity.
Migraine Triggers and Oxidative Stress: A Narrative Review and Synthesis.
Borkum, United States. In Headache, Jan 2016
For some triggers, oxidants also arise as a byproduct of monoamine oxidase or cytochrome P450 processing, or from uncoupling of nitric oxide synthase.
Parkinson's disease: fewer treatment withdrawals with levodopa.
In Prescrire Int, Dec 2015
In mid-2015, interim results of a randomised trial conducted in the routine care setting, involving 1620 patients with newly diagnosed Parkinson's disease, showed that levodopa was slightly more effective in terms of mobility than dopamine agonists or MAO-B inhibitors, after a median follow-up of 3 years.
Safinamide for symptoms of Parkinson's disease.
Müller, Berlin, Germany. In Drugs Today (barc), Nov 2015
Ideal candidates for the balance of these neurotransmitter deficits are compounds like safinamide with broad mechanisms of action such as reversible monoamine oxidase type B inhibition, blockage of voltage-dependent sodium channels, modulation of calcium channels and of glutamate release.
Inhibition and oxygen activation in copper amine oxidases.
Dooley et al., Bozeman, United States. In Acc Chem Res, Jun 2015
Inhibition of these enzymes by antifungal or antiprotozoal agents, as well as classic monoamine oxidase (MAO) inhibitors, may contribute to the adverse side effects associated with drug treatment.
In Vitro and in Vivo Neuroprotective Effects of Walnut (Juglandis Semen) in Models of Parkinson's Disease.
Oh et al., Seoul, South Korea. In Int J Mol Sci, 2014
Monoamine oxidase (MAO) catalyzes the oxidative deamination of monoamines including dopamine (DA).
Anxiety and IBS revisited: ten years later.
Dumitrascu et al., Cluj-Napoca / Kolozsvár, Romania. In Clujul Med, 2014
Out of these 15 articles, 10 articles analyzed the correlation between anxiety-depression status in IBS patients using specific questionnaires, 2 articles analyzed genetic variables in IBS, 1 article analyzed serotonin and monoamine oxidase levels in IBS, 1 article analyzed serum levels of IL-1β and IL-10 in IBS, 1 article analyzed somatostatin and vasoactive intestinal peptide levels in IBS.
Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease (PD MED): a large, open-label, pragmatic randomised trial.
Clarke et al., In Lancet, 2014
BACKGROUND: Whether initial treatment for Parkinson's disease should consist of levodopa, dopamine agonists, or monoamine oxidase type B inhibitors (MAOBI) is uncertain.
GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease.
Lee et al., Taejŏn, South Korea. In Nat Med, 2014
Here, we show that reactive astrocytes aberrantly and abundantly produce the inhibitory gliotransmitter GABA by monoamine oxidase-B (Maob) and abnormally release GABA through the bestrophin 1 channel.
Pharmacological treatment of Parkinson disease: a review.
Lang et al., Hamilton, Canada. In Jama, 2014
RESULTS: Although levodopa is the most effective medication available for treating the motor symptoms of Parkinson disease, in certain instances (eg, mild symptoms, tremor as the only or most prominent symptom, aged <60 years) other medications (eg, monoamine oxidase type B inhibitors [MAOBIs], amantadine, anticholinergics, β-blockers, or dopamine agonists) may be initiated first to avoid levodopa-related motor complications.
Genetic mediators of neurocognitive outcomes in survivors of childhood acute lymphoblastic leukemia.
Pui et al., Memphis, United States. In J Clin Oncol, 2013
Polymorphisms in monoamine oxidase (T1460CA) were associated with increased attention variability (P = .03).
Apolipoprotein E influences melatonin biosynthesis by regulating NAT and MAOA expression in C6 cells.
Zhou et al., Hefei, China. In J Pineal Res, 2012
A higher level of melatonin was demonstrated in cultured ApoE4-C6 cells than in ApoE3-C6 cells. NAT was up-regulated in ApoE4-C6 cells compared with ApoE3-C6 cells, and MAOA and MAOB expression decreased in ApoE4-C6 cells.
²H kinetic isotope effects and pH dependence of catalysis as mechanistic probes of rat monoamine oxidase A: comparisons with the human enzyme.
Edmondson et al., Atlanta, United States. In Biochemistry, 2011
Rat MAO A exhibits functional properties similar but not identical with those of the human enzyme, providing additional support for C-H bond cleavage via a polar nucleophilic mechanism
Topological probes of monoamine oxidases A and B in rat liver mitochondria: inhibition by TEMPO-substituted pargyline analogues and inactivation by proteolysis.
Edmondson et al., Atlanta, United States. In Biochemistry, 2011
investigation of topological orientation of MAO-A (and MAO-B) in liver mitochondrial membranes
High-level expression and purification of rat monoamine oxidase A (MAO A) in Pichia pastoris: comparison with human MAO A.
Edmondson et al., Atlanta, United States. In Protein Expr Purif, 2010
Although approximately 90% identical in sequence to human MAO A, rat MAO A is a more efficient catalyst for amine neurotransmitter oxidation.
Gonadectomy and hormone replacement exert region- and enzyme isoform-specific effects on monoamine oxidase and catechol-O-methyltransferase activity in prefrontal cortex and neostriatum of adult male rats.
Kritzer et al., Stony Brook, United States. In Neuroscience, 2010
significant effects of hormone replacement and gonadectomy on catechol-O-methyltransferase and monoamine oxidase isoforms in both striatum and cortex
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