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Monoamine oxidase A

Monoamine Oxidase, MAO
enzyme involved in the oxidative deamination of biogenic and xenobiotic amines [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: MAO-B, CAN, HAD, ACID, AGE
Papers on Monoamine Oxidase
A rapid thin-layer chromatography bioautographic method for detecting the monoamine oxidase inhibitors in plants.
New
Yu et al., Lanzhou, China. In Nat Prod Res, 28 Apr 2014
UNLABELLED: It is well known that the isolation of monoamine oxidase (MAO) inhibitors from natural sources is an important strategy for drug development in the treatment of depression, Parkinson's disease and Alzheimer's disease.
Testing for association of the monoamine oxidase A promoter polymorphism with brain structure volumes in both autism and the fragile X syndrome.
New
Piven et al., In J Neurodev Disord, 26 Apr 2014
We have previously shown that the monoamine oxidase A (MAOA) promoter polymorphism is associated with cerebral cortical volumes in children with autism, and we now sought to determine whether the association was also present in children with FXS.
[Drug treatment of early-stage (de novo and "honeymoon") Parkinson disease.]
New
Defebvre et al., Créteil, France. In Rev Neurol (paris), 24 Apr 2014
Like monoamine oxidase inhibitors B (MAOI-B), synthetic dopamine agonists exhibit several advantages: easy-to-use treatment with a once-daily administration, delayed L-Dopa initiation, significant efficacy on motor symptoms (although lower than that of L-Dopa).
Divalent Metal Ions Enhance DOPAL-induced Oligomerization of Alpha-Synuclein.
New
Goldstein et al., Bethesda, United States. In Neurosci Lett, 23 Apr 2014
Co-incubation with Cu2+ amplified (p=0.01), while monoamine oxidase inhibition prevented, L-DOPA-related dimerization of alpha-synuclein (p=0.01).
Evidence of MAOA genotype involvement in spatial ability in males.
New
Ernst et al., Gent, Belgium. In Behav Brain Res, 23 Apr 2014
UNLABELLED: Although the Monoamine Oxidase-A (MAOA) gene has been linked to spatial learning and memory in animal models, convincing evidence in humans is lacking.
Update on the pharmacology of selective inhibitors of MAO-A and MAO-B; focus on modulation of CNS monoamine neurotransmitter release.
Review
New
Finberg, Haifa, Israel. In Pharmacol Ther, 04 Apr 2014
UNLABELLED: Inhibitors of monoamine oxidase (MAO) were initially used in medicine following the discovery of their antidepressant action.
Serotonergic pharmacology in animal models: from behavioral disorders to dyskinesia.
Review
New
Véronique et al., Bron, France. In Neuropharmacology, 01 Mar 2014
We review existing rodent and non-human primate (NHP) animal models in which selective 5-HT or dual 5-HT-norepinephrine (NE) transporter inhibitors, as well as specific 5-HT receptors agonists and antagonists, monoamine oxidase A inhibitors (IMAO-A) and MDMA (Ecstasy) have been used.
Monoamine oxidases as sources of oxidants in the heart.
Review
New
Di Lisa et al., Padova, Italy. In J Mol Cell Cardiol, 09 Feb 2014
Among these, monoamine oxidase (MAO) has been described as a prominent source.
Gene-sex interactions in schizophrenia: focus on dopamine neurotransmission.
Review
New
Bortolato et al., Lawrence, United States. In Front Behav Neurosci, Dec 2013
These G×S interactions have been particularly documented for catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO), the main enzymes catalyzing DA metabolism.
Genetic mediators of neurocognitive outcomes in survivors of childhood acute lymphoblastic leukemia.
New
Impact
Pui et al., Memphis, United States. In J Clin Oncol, Jul 2013
Polymorphisms in monoamine oxidase (T1460CA) were associated with increased attention variability (P = .03).
Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction.
New
Impact
Tanabe et al., Ann Arbor, United States. In Nat Med, Mar 2013
We show here that lysine-specific demethylase 1 (LSD1) inhibition by RNAi in human erythroid cells or by the monoamine oxidase inhibitor tranylcypromine in human erythroid cells or β-type globin-transgenic mice enhances γ-globin expression.
[Tobacco--once a medicinal plant. Does it contain substances with medicinal properties?].
Review
Budzianowski, Laizhou, China. In Przegl Lek, 2012
In turn, studies of the brains of smokers using positron emission tomography showed significantly decreased level of monoamine oxidase B--an enzyme which degrades dopamine--the neurotransmitter which the significant insufficiency of about 80-85%, is responsible for the symptoms of Parkinson's disease.
Apolipoprotein E influences melatonin biosynthesis by regulating NAT and MAOA expression in C6 cells.
GeneRIF
Zhou et al., Hefei, China. In J Pineal Res, 2012
A higher level of melatonin was demonstrated in cultured ApoE4-C6 cells than in ApoE3-C6 cells. NAT was up-regulated in ApoE4-C6 cells compared with ApoE3-C6 cells, and MAOA and MAOB expression decreased in ApoE4-C6 cells.
SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive.
Impact
Guarente et al., Cambridge, United States. In Cell, 2012
Here we used mice with increased or decreased brain SIRT1 to show that this sirtuin regulates anxiety and exploratory drive by activating transcription of the gene encoding the monoamine oxidase A (MAO-A) to reduce serotonin levels in the brain.
²H kinetic isotope effects and pH dependence of catalysis as mechanistic probes of rat monoamine oxidase A: comparisons with the human enzyme.
GeneRIF
Edmondson et al., Atlanta, United States. In Biochemistry, 2011
Rat MAO A exhibits functional properties similar but not identical with those of the human enzyme, providing additional support for C-H bond cleavage via a polar nucleophilic mechanism
Topological probes of monoamine oxidases A and B in rat liver mitochondria: inhibition by TEMPO-substituted pargyline analogues and inactivation by proteolysis.
GeneRIF
Edmondson et al., Atlanta, United States. In Biochemistry, 2011
investigation of topological orientation of MAO-A (and MAO-B) in liver mitochondrial membranes
High-level expression and purification of rat monoamine oxidase A (MAO A) in Pichia pastoris: comparison with human MAO A.
GeneRIF
Edmondson et al., Atlanta, United States. In Protein Expr Purif, 2010
Although approximately 90% identical in sequence to human MAO A, rat MAO A is a more efficient catalyst for amine neurotransmitter oxidation.
Gonadectomy and hormone replacement exert region- and enzyme isoform-specific effects on monoamine oxidase and catechol-O-methyltransferase activity in prefrontal cortex and neostriatum of adult male rats.
GeneRIF
Kritzer et al., Stony Brook, United States. In Neuroscience, 2010
significant effects of hormone replacement and gonadectomy on catechol-O-methyltransferase and monoamine oxidase isoforms in both striatum and cortex
Inhibition of the histone demethylase LSD1 blocks alpha-herpesvirus lytic replication and reactivation from latency.
Impact
Kristie et al., Bethesda, United States. In Nat Med, 2009
Depletion of LSD1 or inhibition of its activity with monoamine oxidase inhibitors (MAOIs) results in the accumulation of repressive chromatin and a block to viral gene expression.
International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature.
Review
Impact
Davenport et al., Cambridge, United Kingdom. In Pharmacol Rev, 2009
Concomitant ingestion of these foodstuffs with monoamine oxidase inhibitors may result in the hypertensive crisis known as the "beer, wine, and cheese effect" attributed to their sympathomimetic action.
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