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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

ADP-ribosyltransferase 3

mono-ADP-ribosyltransferase, ART3
This gene encodes an arginine-specific ADP-ribosyltransferase. The encoded protein catalyzes a reversible reaction which modifies proteins by the addition or removal of ADP-ribose to an arginine residue to regulate the function of the modified protein. An ADP-ribosyltransferase pseudogene is located on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: CAN, V1a, ACID, POLYMERASE, Artemis
Papers on mono-ADP-ribosyltransferase
Evidence of a role for S. cerevisiae α-arrestin Art1 (Ldb19) in mating projection and zygote formations.
Loewen et al., Saskatoon, Canada. In Cell Biol Int, Jan 2016
Subsequent phenotypic observations linked this activity to more pronounced projection formation in an Art1 complemented noncuple α-arrestin knockout line, compared to the knockout-line alone, or either of the Art3 or Art6 complemented lines.
Structural Variability of C3larvin Toxin. Intrinsic Dynamics of the α/β fold of the C3-like Group of mono-ADP-Ribosyltransferase Toxins.
Merrill et al., Guelph, Canada. In J Biomol Struct Dyn, Dec 2015
UNASSIGNED: C3larvin toxin is a new member of the C3 class of the mono-ADP-ribosyltransferase (mART) toxin family.
An Interbacterial NAD(P)(+) Glycohydrolase Toxin Requires Elongation Factor Tu for Delivery to Target Cells.
Mougous et al., Seattle, United States. In Cell, Nov 2015
Structural analyses of Tse6 show that it resembles mono-ADP-ribosyltransferase proteins, such as diphtheria toxin, with the exception of a unique loop that both excludes proteinaceous ADP-ribose acceptors and contributes to hydrolysis.
Characterization of Vis Toxin, a Novel ADP-Ribosyltransferase from Vibrio splendidus.
Merrill et al., New York City, United States. In Biochemistry, Oct 2015
Vis toxin was identified by a bioinformatics strategy as a putative virulence factor produced by Vibrio splendidus with mono-ADP-ribosyltransferase activity.
Tubb3 regulation by the Erk and Akt signaling pathways: a mechanism involved in the effect of arginine ADP-ribosyltransferase 1 (Art1) on apoptosis of colon carcinoma CT26 cells.
Kuang et al., Chongqing, China. In Tumour Biol, Oct 2015
UNASSIGNED: The influence of the most important classical mono-ADP-ribosyltransferase, arginine ADP-ribosyltransferase 1 (Art1), on survival and apoptosis of colon carcinoma cells and the potential mechanisms have been partly discussed in our previous study but still need to be further studied.
Rho GTPase Recognition by C3 Exoenzyme Based on C3-RhoA Complex Structure.
Tsuge et al., Kyoto, Japan. In J Biol Chem, Sep 2015
C3 exoenzyme is a mono-ADP-ribosyltransferase (ART) that catalyzes transfer of an ADP-ribose moiety from NAD(+) to Rho GTPases.
The Father, Son and Cholix Toxin: The Third Member of the DT Group Mono-ADP-Ribosyltransferase Toxin Family.
Merrill et al., Guelph, Canada. In Toxins (basel), Aug 2015
It was identified as the third member of the diphtheria toxin group of mono-ADP-ribosyltransferase toxins along with P. aeruginosa exotoxin A and C. diphtheriae diphtheria toxin.
Loss of the Mono-ADP-ribosyltransferase, Tiparp, Increases Sensitivity to Dioxin-induced Steatohepatitis and Lethality.
Matthews et al., Toronto, Canada. In J Biol Chem, Aug 2015
The aryl hydrocarbon receptor (AHR) mediates the toxic effects of the environmental contaminant dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin; TCDD).
Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review.
Hassa et al., Zürich, Switzerland. In Mol Cancer, 2014
Several novel potential drug targets have been recently identified such as the BET bromodomain protein (BRD)-4, phosphoribosyl-pyrophosphate synthetase (PRPS)-2, macrodomain-containing mono-ADP-ribosyltransferase (ARTD)-9 (also known as PARP9), deltex-3-like E3 ubiquitin ligase (DTX3L) (also known as BBAP), NF-kappaB inducing kinase (NIK) and transforming growth factor beta receptor (TGFβR).This review highlights the new insights into the molecular basis of relapsed/refractory DLBCL and summarizes the most promising drug targets and experimental treatments for relapsed/refractory DLBCL, including the use of novel agents such as lenalidomide, ibrutinib, bortezomib, pidilizumab, epratuzumab, brentuximab-vedotin or CAR T cells, dual inhibitors, as well as mechanism-based combinatorial experimental therapies.
Sirtuin Functions in Female Fertility: Possible Role in Oxidative Stress and Aging.
Amicarelli et al., L'Aquila, Italy. In Oxid Med Cell Longev, 2014
Sirtuins (silent information regulator 2 (Sir2) proteins), NAD(+) dependent enzymes with deacetylase and/or mono-ADP-ribosyltransferase activity, are emerging as key antiaging molecules and regulators in many diseases.
Regulation of nucleocytoplasmic transport by ADP-ribosylation: the emerging role of karyopherin-β1 mono-ADP-ribosylation by ARTD15.
Di Girolamo, China. In Curr Top Microbiol Immunol, 2014
We have demonstrated that ARTD15/PARP16 is a novel mono-ADP-ribosyltransferase with a new intracellular location, as it is associated with the endoplasmic reticulum.
Function and regulation of the mono-ADP-ribosyltransferase ARTD10.
Lüscher et al., Aachen, Germany. In Curr Top Microbiol Immunol, 2014
Recent work describing the mono-ADP-ribosyltransferase ARTD10/PARP10 suggests that this enzyme affects apoptosis, NF-κB signaling, and DNA damage repair, at least in part dependent on its activity as mono-ADP-ribosyltransferase.
Association of polymorphisms in ART3 gene with male infertility in the Chinese population.
Ni et al., Wenzhou, China. In Int J Clin Exp Med, 2014
The ADP-ribosyltransferase 3 gene (ART3) has been reported to be associated with non-obstructive azoospermia (NOA) in the Japanese population.
NAD⁺-dependent enzymes at the endoplasmic reticulum.
Di Paola et al., Chieti, Italy. In Curr Top Med Chem, 2012
We have demonstrated that ARTD15/PARP16 is a novel mono-ADP-ribosyltransferase with a new intracellular location, as it is associated with the endoplasmic reticulum.
Genome-wide expression of azoospermia testes demonstrates a specific profile and implicates ART3 in genetic susceptibility.
Inoue et al., Niigata, Japan. In Plos Genet, 2008
genome-wide gene expression analyses were used to identify genes involved in the pathogenesis of non-obstructive azoospermia, and ART3 was subsequently identified as a susceptibility gene
A type III effector ADP-ribosylates RNA-binding proteins and quells plant immunity.
Alfano et al., Lincoln, United States. In Nature, 2007
Here we show that the type III effector HopU1 is a mono-ADP-ribosyltransferase (ADP-RT).
Genomic organization and expression of the human mono-ADP-ribosyltransferase ART3 gene.
Hauschildt et al., Leipzig, Germany. In Biochim Biophys Acta, 2006
ART3 expression appears to be governed by a combination of differential splicing and tissue-preferential use of two alternative promoters.
Expression of toxin-related human mono-ADP-ribosyltransferase 3 in human testes.
Hauschildt et al., Leipzig, Germany. In Asian J Androl, 2006
ART3 protein is expressed in testes in particular on spermatocytes, indicating that ART3 exerts a specific function only required at a particular stage of spermatogenesis.
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