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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

MOG1 Mog1p

MOG1, Mog1p
This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010] (from NCBI)
Papers on MOG1
A novel nonsense variant in Nav1.5 cofactor MOG1 eliminates its sodium current increasing effect and may increase the risk of arrhythmias.
Svendsen et al., Copenhagen, Denmark. In Can J Cardiol, 2011
Our screening of Nav1.5 cofactor MOG1 uncovered a novel nonsense variant that appeared to be present at a higher frequency among these patients with atrial fibrillation and Brugada syndrome than control subjects.
MOG1: a new susceptibility gene for Brugada syndrome.
Guicheney et al., Paris, France. In Circ Cardiovasc Genet, 2011
Results suggest that dominant-negative mutations in MOG1 can impair the trafficking of Na(v)1.5 to the membrane, leading to I(Na) reduction and clinical manifestation of Brugada syndrome.
Identification of a new co-factor, MOG1, required for the full function of cardiac sodium channel Nav 1.5.
Wang et al., Cleveland, United States. In J Biol Chem, 2008
in cardiomyocytes, MOG1 is mostly localized in the cell membrane and co-localized with Nav1.5, indicating that MOG1 is a critical regulator of sodium channel function in the heart
Role for the Ran binding protein, Mog1p, in Saccharomyces cerevisiae SLN1-SKN7 signal transduction.
Fassler et al., Iowa City, United States. In Eukaryot Cell, 2004
Mog1p may play a role in SLN1-SKN7 signal transduction, Skn7 binding and activation of osmotic response genes
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