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MYST histone acetyltransferase 1

MOF
This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: CAN, Histone, ACID, V1a, HAD
Papers on MOF
Aptamer-functionalized stir bar sorptive extraction coupled with gas chromatography-mass spectrometry for selective enrichment and determination of polychlorinated biphenyls in fish samples.
New
Cao et al., Ningbo, China. In Talanta, Apr 2016
This approach was based on the immobilization of aptamer which could recognize 2,3',5,5'-tetrachlorobiphenyl (PCB72) and 2',3',4',5,5'-pentachlorobiphenyl (PCB106) on one kind of metal-organic frameworks (Zn4O(BDC)3, MOF-5).
Enhancement of CO2 Adsorption and Catalytic Properties by Fe-Doping of [Ga2(OH)2(L)] (H4L = Biphenyl-3,3',5,5'-tetracarboxylic Acid), MFM-300(Ga2).
New
Schröder et al., Valencia, Spain. In Inorg Chem, Feb 2016
We thus report herein the highest CO2 uptake (2.86 mmol g(-1) at 273 K at 1 bar) for a Ga-based MOF.
A smart approach for in situ one step encapsulation and controlled delivery of chemotherapeutic drug using metal organic framework-drug composite in aqueous medium.
New
Adhikari et al., Indore, India. In Chemphyschem, Feb 2016
The in situ formation of MOF-drug composites demonstrates high drug loading capacity as compared to other conventional methods.
Atomistic Simulation of Protein Encapsulation in Metal-Organic Frameworks.
New
van der Spoel et al., In J Phys Chem B, Feb 2016
UNASSIGNED: Fabrication of metal-organic frameworks (MOFs) with large apertures triggers a brand-new research area for selective encapsulation of biomolecules within MOF nanopores.
Electrochemiluminescent immunosensing of prostate-specific antigen based on silver nanoparticles-doped Pb (II) metal-organic framework.
New
Du et al., Jinan, China. In Biosens Bioelectron, Jan 2016
UNASSIGNED: In this work, silver nanoparticles-doped Pb (II) metal-organic framework (Ag-MOF) was prepared and exploited as a luminescence probe for the development of label-free electrochemiluminescence (ECL) immunosensing scheme for prostate-specific antigen (PSA).
Liver plays a central role in asymmetric dimethylarginine-mediated organ injury.
Review
New
Vairetti et al., Pavia, Italy. In World J Gastroenterol, Jun 2015
High plasma ADMA levels are also relevant as they are associated with the onset of multi-organ failure (MOF).
The Functional Analysis of Histone Acetyltransferase MOF in Tumorigenesis.
Review
Jin et al., Changchun, China. In Int J Mol Sci, 2014
Human MOF (males absent on the first) is a member of the MYST (Moz-Ybf2/Sas3-Sas2-Tip60) family of histone acetyltransferases (HATs).
Influenza virus pathogenicity regulated by host cellular proteases, cytokines and metabolites, and its therapeutic options.
Review
Kido, Tokushima, Japan. In Proc Jpn Acad Ser B Phys Biol Sci, 2014
The knowledge gained within the last decade on the pandemic IAV(H1N1)2009 improved our understanding not only of the viral pathogenicity but also the host cellular factors involved in the pathogenicity of multiorgan failure (MOF), such as cellular trypsin-type hemagglutinin (HA0) processing proteases for viral multiplication, cytokine storm, metabolic disorders and energy crisis.
Protracted Oxidative Alterations in the Mechanism of Hematopoietic Acute Radiation Syndrome.
Review
Sharma et al., Bethesda, United States. In Antioxidants (basel), 2014
Multiple organ failure (MOF) leading to moribundity is a common sequela of the hemotapoietic form of ARS (hARS).
Ab initio carbon capture in open-site metal-organic frameworks.
Impact
Gagliardi et al., Minneapolis, United States. In Nat Chem, 2012
Common force fields typically underestimate by as much as two orders of magnitude the adsorption of CO(2) in open-site Mg-MOF-74, which has emerged as a promising MOF for CO(2) capture.
Chromatin and pluripotency: the MYSTerious connection.
Impact
Ivanova et al., New Haven, United States. In Cell Stem Cell, 2012
(2012) now show that Mof, a MYST family histone acetyltransferase, functions as a coactivator of Nanog-mediated transcription, maintains the expression of pluripotency-associated genes, and primes developmental genes for differentiation.
The histone acetyltransferase MOF is a key regulator of the embryonic stem cell core transcriptional network.
Impact
Dou et al., China. In Cell Stem Cell, 2012
Here we show that the histone acetyltransferase Mof plays an essential role in the maintenance of ESC self-renewal and pluripotency.
SIRT1 negatively regulates the activities, functions, and protein levels of hMOF and TIP60.
GeneRIF
Seto et al., Tampa, United States. In Mol Cell Biol, 2012
uncover novel pathways in which SIRT1 dynamically interacts with and regulates hMOF and TIP60 through deacetylation and provide additional mechanistic insights by which SIRT1 regulates DNA damage response
The MOF chromobarrel domain controls genome-wide H4K16 acetylation and spreading of the MSL complex.
GeneRIF
Akhtar et al., Freiburg, Germany. In Dev Cell, 2012
It was shown that the MOF chromobarrel domain is essential for H4K16 acetylation throughout the Drosophila genome and is required for spreading of the male-specific lethal complex on the X chromosome.
The role of MOF in the ionizing radiation response is conserved in Drosophila melanogaster.
GeneRIF
Pandita et al., Hyderābād, India. In Chromosoma, 2012
The role of MOF in the response to ionizing radiation is conserved between Drosophila and mammals.
Loss of the methyl lysine effector protein PHF20 impacts the expression of genes regulated by the lysine acetyltransferase MOF.
GeneRIF
Bedford et al., United States. In J Biol Chem, 2012
PHF20 is not required for maintaining the global H4K16 acetylation levels or locus specific histone acetylation but instead works downstream in transcriptional regulation of MOF target genes
FOXP3 orchestrates H4K16 acetylation and H3K4 trimethylation for activation of multiple genes by recruiting MOF and causing displacement of PLU-1.
GeneRIF
Liu et al., Ann Arbor, United States. In Mol Cell, 2012
RNAi-mediated silencing of MOF reduced both gene activation and tumor suppression by FOXP3, while both somatic mutations in clinical cancer samples and targeted mutation of FOXP3 in mouse prostate epithelial cells disrupted nuclear localization of MOF.
Medical management of the acute radiation syndrome.
Review
Martín et al., Madrid, Spain. In Rep Pract Oncol Radiother, 2010
Radiation induced multi-organ failure (MOF) describes the progressive dysfunction of two or more organ systems over time.
X-ray absorption spectroscopies: useful tools to understand metallorganic frameworks structure and reactivity.
Impact
Lamberti et al., Torino, Italy. In Chem Soc Rev, 2010
The large unit cells, the enormous flexibility and variation in structural motifs of MOFs represent a big challenge in the characterization of MOF materials, particularly in cases where single crystal diffraction data are not available.
Rational design, synthesis, purification, and activation of metal-organic framework materials.
Impact
Hupp et al., Evanston, United States. In Acc Chem Res, 2010
In particular, MOF materials, especially more complex ones, can be difficult to obtain in pure form and with the optimal degree of catenation, the interpenetration or interweaving of identical independent networks.
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