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Myelin-associated oligodendrocytic basic protein

may mediate late steps of myelin formation, possibly in myelin compaction and in the maintenance of the myelin sheath [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: MBP, PLP, CNP, MAG, CD45
Papers on MOBP
Involvement of MeCP2 in Regulation of Myelin-Related Gene Expression in Cultured Rat Oligodendrocytes.
Frost et al., Vadodara, India. In J Mol Neurosci, Oct 2015
MeCP2 knockdown in cultured oligodendrocytes by small interference RNA (siRNA) has shown increase in myelin genes (myelin basic protein (MBP), proteolipid protein (PLP), myelin oligodendrocyte glycoprotein (MOG), and myelin-associated oligodendrocyte basic protein (MOBP)), neurotrophin (brain-derived neurotrophic factor (BDNF)), and transcriptional regulator (YY1) transcripts level, which are involved in regulation of oligodendrocyte differentiation and myelination.
Modulation of Sox10, HIF-1α, Survivin, and YAP by Minocycline in the Treatment of Neurodevelopmental Handicaps following Hypoxic Insult.
Madri et al., Tokyo, Japan. In Am J Pathol, Sep 2015
Specifically, there was induction of genes, including Sox10, Hif1a, Hif2a, Birc5, Yap1, Epo, Bdnf, Notch1 (cleaved), Pcna, Mag, Mobp, Plp1, synapsin, Adgra2, Pecam1, and reduction in activation of caspase 3, all known to affect proliferation, apoptosis, synaptic transmission, and nerve transmission.
Oligodendrocyte morphometry and expression of myelin - Related mRNA in ventral prefrontal white matter in major depressive disorder.
Newton et al., United States. In J Psychiatr Res, Jun 2015
Using quantitative RT-PCR to measure oligodendrocyte-related mRNA for CNPase, PLP1, MBP, MOG, MOBP, Olig1 and Olig2, in MDD there was a significantly reduced expression of PLP1 mRNA (which positively correlated with smaller sizes) and increased expression of mRNA for CNPase, OLIG1 and MOG.
Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms.
Butler et al., Kansas City, United States. In Gene, May 2015
Gene level disturbances in cellular and molecular networks impacted by alcohol and alcoholism pathology include transketolase (TKT), transferrin (TF), and myelin (e.g., MBP, MOBP, and MOG).
Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy.
Dickson et al., Jacksonville, United States. In Nat Commun, 2014
We identify new CBD susceptibility loci and show that CBD and PSP share a genetic risk factor other than MAPT at 3p22 MOBP (myelin-associated oligodendrocyte basic protein).
Myelin oligodendrocyte basic protein and prognosis in behavioral-variant frontotemporal dementia.
Grossman et al., Mongolia. In Neurology, 2014
METHODS: Eighty-one patients with sporadic bvFTD were genotyped for tauopathy-associated SNPs at rs8070723 (microtubule-associated protein tau [MAPT]) and rs1768208 (myelin-associated oligodendrocyte basic protein [MOBP]).
Assessment of common variability and expression quantitative trait loci for genome-wide associations for progressive supranuclear palsy.
de Silva et al., Lubbock, United States. In Neurobiol Aging, 2014
A recent genome-wide association study (GWAS) revealed 3 novel risk loci on chromosomes 1, 2, and 3 that primarily implicate STX6, EIF2AK3, and MOBP, respectively.
Coordinated gene expression of neuroinflammatory and cell signaling markers in dorsolateral prefrontal cortex during human brain development and aging.
Rapoport et al., Bethesda, United States. In Plos One, 2013
During Development, changes were related to reported neuronal loss, dendritic growth and pruning, and microglial events; TLR4, IL1R1, NFKB1, MOBP, PLA2G4A, and PTGS2 expression increased in the first years of life, while expression of synaptic genes GAP43 and DBN1 decreased, before reaching plateaus.
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
Schellenberg et al., Marburg an der Lahn, Germany. In Nat Genet, 2011
We found significant previously unidentified signals (P < 5 × 10(-8)) associated with PSP risk at STX6, EIF2AK3 and MOBP.
Immune responses to JC virus in patients with multiple sclerosis treated with natalizumab: a cross-sectional and longitudinal study.
Du Pasquier et al., Lausanne, Switzerland. In Lancet Neurol, 2010
At the same timepoints, by use of proliferation and enzyme-linked immunospot assays, the cellular immune responses against JC virus, Epstein-Barr virus, cytomegalovirus, myelin oligodendrocyte glycoprotein, and myelin oligodendrocyte basic protein (MOBP) were assessed.
The myelin-associated oligodendrocytic basic protein (MOBP) as a relevant primary target autoantigen in multiple sclerosis.
Ben-Nun et al., Portugal. In Autoimmun Rev, 2010
The myelin-associated oligodendrocyte basic protein (MOBP), a relatively abundant CNS-specific myelin protein, which plays a role in stabilizing the myelin sheath in the CNS, has recently been implicated in the pathogenesis of MS.
Ethanol-responsive genes (Crtam, Zbtb16, and Mobp) located in the alcohol-QTL region of chromosome 9 are associated with alcohol preference in mice.
Singh et al., London, Canada. In Alcohol Clin Exp Res, 2009
Mobp is associated with the alcohol-preference genotype in the context of alcohol-preferring, compared to alcohol-avoiding mouse strains.
Expression of oligodendrocyte-associated genes in dorsolateral prefrontal cortex of patients with schizophrenia.
Lipska et al., Bethesda, United States. In Schizophr Res, 2008
MOBP mRNA levels were increased in the DLPFC white matter in patients with a history of substance abuse.
Oligodendroglial abnormalities in schizophrenia, mood disorders and substance abuse. Comorbidity, shared traits, or molecular phenocopies?
Sokolov, Baltimore, United States. In Int J Neuropsychopharmacol, 2007
Changes in oligodendroglia-related genes reported in SZ, BD and MDD appear to display considerable similarities (particularly decreased expression of MAG, ERBB, TF, PLP1, MOG, MOBP, MOG), while changes in cocaine abuse and alcoholism are more diverse.
Myelin-associated oligodendrocytic basic protein: a family of abundant CNS myelin proteins in search of a function.
Griffiths et al., Glasgow, United Kingdom. In Dev Neurosci, 2005
The myelin-associated oligodendrocytic basic protein (MOBP) family constitutes the third most abundant protein in CNS myelin.
Characterization of the murine splice variant Mobp155: developmental CNS expression pattern and subcellular localization of epitope-tagged protein.
Griffiths et al., Glasgow, United Kingdom. In Glia, 2005
Although the Mobp155 and Mobp170 isoforms encode a common predicted C-terminus they have different expression profiles and their products are targeted to mitochondria and the nucleus, respectively, in transiently transfected Cos7 cells.
Gene expression profiling in the brains of human cocaine abusers.
Albertson et al., Detroit, United States. In Addict Biol, 2005
A striking exception is a group of myelin-related genes, consisting of multiple transcripts representing myelin basic protein (MBP), proteolipid protein (PLP) and myelin-associated oligodendrocyte basic protein (MOBP), which as a group are substantially decreased in cocaine abusers compared to controls.
Gene expression profile of the nucleus accumbens of human cocaine abusers: evidence for dysregulation of myelin.
Bannon et al., Detroit, United States. In J Neurochem, 2004
Decreased expression of a number of myelin-related genes, including myelin basic protein (MBP), proteolipid protein (PLP), and myelin-associated oligodendrocyte basic protein (MOBP) was noted in nucleus accumbens of cocaine abusers
Phenotypic analysis of mice deficient in the major myelin protein MOBP, and evidence for a novel Mobp isoform.
McCallion et al., Glasgow, United Kingdom. In Glia, 2002
MOBP-deficient mice develop normally, generate intact compact CNS myelin, and demonstrate no obvious clinical phenotype; absence of MOBP is not simply compensated for by increased expression of the "classic" myelin basic protein (MBP).
Myelin-associated oligodendrocytic basic protein modulates the arrangement of radial growth of the axon and the radial component of myelin.
Yoshikawa, Fukushima, Japan. In Med Electron Microsc, 2001
Myelin-associated oligodendrocytic basic protein (MOBP) is abundantly expressed in central nervous system myelin, and shares several characteristics with myelin basic protein (MBP), in terms of regional distribution and function.
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