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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

MOB2 Mob2p

MOB2, Mob2p
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Top mentioned proteins: NDR, ACE2, MOB, CAN, V1a
Papers on MOB2
Regulation of DNA damage responses and cell cycle progression by hMOB2.
New
Hergovich et al., London, United Kingdom. In Cell Signal, Feb 2015
Biochemically, human MOB2 (hMOB2) can inhibit NDR kinases by competing with hMOB1 for binding to NDRs.
The N-terminal region of the Neurospora NDR kinase COT1 regulates morphology via its interactions with MOB2A/B.
Yarden et al., Jerusalem, Israel. In Mol Microbiol, 2013
To study the interactions between COT1 and MOB2 proteins, we mutated several conserved residues and a novel phosphorylation site within the COT1 NTR.
Strong parent-of-origin effects in the association of KCNQ1 variants with type 2 diabetes in American Indians.
Baier et al., Phoenix, United States. In Diabetes, 2013
Parent-of-origin effects were observed in an Icelandic population for several genetic variants associated with type 2 diabetes, including those in KLF14 (rs4731702), MOB2 (rs2334499), and KCNQ1 (rs2237892, rs231362).
Growth-inhibitory effects of MOB2 on human hepatic carcinoma cell line SMMC-7721.
Tan et al., Beijing, China. In World J Gastroenterol, 2013
AIM: To investigate the growth-inhibiting and apoptosis-inducing effects of the gene MOB2 on human hepatic carcinoma cell line SMMC-7721.
Hydrophobic motif phosphorylation coordinates activity and polar localization of the Neurospora crassa nuclear Dbf2-related kinase COT1.
Seiler et al., Göttingen, Germany. In Mol Cell Biol, 2012
We demonstrate that the Neurospora crassa NDR kinase COT1 forms inactive dimers via a conserved N-terminal extension, which is also required for the interaction of the kinase with MOB2 to generate heterocomplexes with basal activity.
MOB control: reviewing a conserved family of kinase regulators.
Review
Hergovich, London, United Kingdom. In Cell Signal, 2011
Initially, yeast genetics revealed essential roles for Mob1p and Mob2p in the regulation of mitotic exit and cell morphogenesis.
Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases.
GeneRIF
Hergovich et al., Basel, Switzerland. In Mol Cell Biol, 2010
Data indicate that human MOB2 is a negative regulator of human NDR kinases in biochemical and biological settings.
Generation and analysis of expressed sequence tags from a cDNA library of the fruiting body of Ganoderma lucidum.
Chen et al., Beijing, China. In Chin Med, 2009
Several candidate genes, such as hydrophobin, MOB2, profilin and PHO84 were detected for the first time in G. lucidum.
Function of Drosophila mob2 in photoreceptor morphogenesis.
Fan et al., China. In Cell Tissue Res, 2009
In a screen to isolate genes involved in determining stalk and rhabdomere formation, this study has identified the Drosophila mob2 (Dmob2) gene.
Two NDR kinase-MOB complexes function as distinct modules during septum formation and tip extension in Neurospora crassa.
Seiler et al., Göttingen, Germany. In Mol Microbiol, 2009
The two MOB2-type proteins interact with both COT1 isoforms and control polar tip extension and branching by regulating COT1 activity.
MST2- and Furry-mediated activation of NDR1 kinase is critical for precise alignment of mitotic chromosomes.
Mizuno et al., Sendai, Japan. In Curr Biol, 2009
We also provide evidence that Fry binds to microtubules, localizes on the spindle, acts as a scaffold that binds to both NDR1 and MOB2, and synergistically activates NDR1 with MOB2.
Conserved elements of the RAM signaling pathway establish cell polarity in the basidiomycete Cryptococcus neoformans in a divergent fashion from other fungi.
Idnurm et al., Durham, United States. In Mol Biol Cell, 2006
A targeted deletion of a fifth component of RAM (MOB2) conferred identical phenotypes to kic1, cbk1, sog2, or tao3 mutations.
Roles of the RAM signaling network in cell cycle progression in Saccharomyces cerevisiae.
Polymenis et al., College Station, United States. In Curr Genet, 2006
The Saccharomyces cerevisiae Hym1p, Mob2p, Tao3p, Cbk1p, Sog2p and Kic1p proteins are thought to function together in the RAM signaling network, which controls polarized growth, cell separation and cell integrity.
The fission yeast MO25 protein functions in polar growth and cell separation.
Brunner et al., Heidelberg, Germany. In Eur J Cell Biol, 2005
Both functions of Pmo25p appear to be mediated by the Orb6p-Mob2p kinase complex.
ACE2, CBK1, and BUD4 in budding and cell separation.
Stillman et al., Salt Lake City, United States. In Eukaryot Cell, 2005
Mutations in the RAM network genes, including CBK1, MOB2, KIC1, HYM1, and TAO3, cause defects in bud site selection, asymmetric apical growth, and mating projections.
Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases.
GeneRIF
Silver et al., Boston, United States. In J Biol Chem, 2004
Binds to and stimulates the kinase activity of the related human serine-threonine kinases NDR1 and NDR2.
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