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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

MOB kinase activator 1B

MOB1A, MOB1B
The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: MOB, YAP, NDR, MSP, MST2
Papers on MOB1A
Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice.
New
Suzuki et al., Fukuoka, Japan. In Proc Natl Acad Sci U S A, Feb 2016
Mob1a/1b double deficiency in mouse liver (LMob1DKO) results in hyperplasia of oval cells and immature cholangiocytes accompanied by inflammatory cell infiltration and fibrosis.
The Hippo/STE20 homolog SIK1 interacts with MOB1 to regulate cell proliferation and cell expansion in Arabidopsis.
New
Gong et al., Tianjin, China. In J Exp Bot, Jan 2016
A yeast two-hybrid screen identified Mob1/Mats homologs MOB1A and MOB1B as SIK1-interacting partners.
Genetic variants in Hippo pathway genes YAP1, TEAD1 and TEAD4 are associated with melanoma-specific survival.
New
Wei et al., Nanjing, China. In Int J Cancer, Sep 2015
We used the genotyping data of 1,115 common single nucleotide polymorphisms (SNPs) in the 12 pathway core genes (i.e., MST1, MST2, SAV1, LATS1, LATS2, MOB1A, MOB1B, YAP1, TEAD1, TEAD2, TEAD3 and TEAD4) from the dataset of our previously published CM genome-wide association study and comprehensively analyzed their associations with CM-specific survival (CSS) in 858 CM patients by using the Kaplan-Meier analyses and Cox proportional hazards regression models.
Lats1 Deletion Causes Increased Germ Cell Apoptosis and Follicular Cysts in Mouse Ovaries.
New
Diaz et al., Syracuse, United States. In Biol Reprod, Jul 2015
LATS1, LATS2, and MOB1B were localized to both germ and somatic cells of primordial to antral follicles.
The Arabidopsis thaliana Mob1A gene is required for organ growth and correct tissue patterning of the root tip.
Palme et al., Freiburg, Germany. In Ann Bot, 2013
Therefore, this study set out to investigate the role of two Arabidopsis thaliana Mob1-like genes, namely Mob1A and Mob1B, in plant development.
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.
Gingras et al., Toronto, Canada. In Sci Signal, 2013
Phosphatase inhibition produced temporally distinct changes in proteins that interacted with MOB1A and MOB1B (Mps one binder kinase activator-like 1A and 1B) and promoted interactions with upstream Hippo pathway proteins, such as MST1 and MST2, and with the trimeric protein phosphatase 6 complex (PP6).
Regulation and functions of mammalian LATS/NDR kinases: looking beyond canonical Hippo signalling.
Hergovich, London, United Kingdom. In Cell Biosci, 2012
In mammals, the counterparts of the Hippo/Mats/Warts/Yorkie cascade, namely MST1/2, MOB1A/B, LATS1/2 and YAP/TAZ, function in a similar fashion.
Function and cancer genomics of FAT family genes (review).
Review
Katoh, Tokyo, Japan. In Int J Oncol, 2012
Copy number aberration, translocation and point mutation of FAT1, FAT2, FAT3, FAT4, FRMD1, FRMD6, NF2, WWC1, WWC2, SAV1, STK3, STK4, MOB1A, MOB1B, LATS1, LATS2, YAP1 and WWTR1/TAZ genes should be comprehensively investigated in various types of human cancers to elucidate the mutation landscape of the FAT‑Hippo signaling cascades.
Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice.
Suzuki et al., Fukuoka, Japan. In J Clin Invest, 2012
Mps one binder 1a (MOB1A) and MOB1B are key components of the Hippo signaling pathway and are mutated or inactivated in many human cancers.
Human Mob1 proteins are required for cytokinesis by controlling microtubule stability.
Tavares et al., Portugal. In J Cell Sci, 2012
Here we report that human Mob1A and Mob1B proteins are involved in the regulation of abscission of the intercellular bridge.
Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases.
Hergovich et al., Basel, Switzerland. In Mol Cell Biol, 2010
The human MOB protein family consists of six distinct members (human MOB1A [hMOB1A], -1B, -2, -3A, -3B, and -3C), with hMOB1A/B the best studied due to their putative tumor-suppressive functions through the regulation of NDR/LATS kinases.
Roles of mammalian sterile 20-like kinase 2-dependent phosphorylations of Mps one binder 1B in the activation of nuclear Dbf2-related kinases.
Hata et al., Tokyo, Japan. In Genes Cells, 2009
We previously reported that Thr74 of MOB1B is phosphorylated by MST2.
Defective in mitotic arrest 1/ring finger 8 is a checkpoint protein that antagonizes the human mitotic exit network.
Halazonetis et al., Genève, Switzerland. In Mol Cancer Res, 2007
A molecular pathway homologous to the S. cerevisiae mitotic exit network (MEN) and S. pombe septation initiation network has recently been described in higher eukaryotes and involves the tumor suppressor kinase LATS1 and its subunit MOB1A.
Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3.
Hemmings et al., Basel, Switzerland. In Mol Cell Biol, 2005
MOB1A (Mps one binder 1A) protein further increased the activity, leading to a fully active kinase.
Human LATS1 is a mitotic exit network kinase.
Halazonetis et al., Philadelphia, United States. In Cancer Res, 2005
We report here that human LATS1 interacts with MOB1A, a protein whose homologue in budding yeast associates with kinases involved in mitotic exit.
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