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MAX binding protein

MNT, ROX, roX1
The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, c-Myc, MAX, ACID, V1a
Papers using MNT antibodies
The endocannabinoid 2-arachidonoyl-glycerol activates human neutrophils: critical role of its hydrolysis and de novo leukotriene B4 biosynthesis
Supplier
Moser Muriel, In PLoS ONE, 2010
... SYBR Green ROX qPCR Mastermix from Qiagen Inc., Mississauga, ON, Canada; ...
Gene-resolution analysis of DNA copy number variation using oligonucleotide expression microarrays.
Supplier
Huang Sui, In PLoS ONE, 2006
... For amplification of smaller amounts of RNA, SYBR Green and ROX (both Sigma-Aldrich) were added to the amplification reaction, which was performed in a 7900 HT Real-time instrument (Life Technologies) to monitor amplification yield ...
TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria
Supplier
Terrinoni Alessandro et al., In Biochemical and Biophysical Research Communications, 2004
... (Applied Biosystem, Foster City, CA, USA) using the Platinum SYBR Green qPCR SuperMix UDG without ROX (Invitrogen Life Technologies, Carlsbad, CA n°cat: 11733–046) ...
Comparison of diafiltration and tangential flow filtration for purification of nanoparticle suspensions
Supplier
Sobolev Alexander S et al., In International Journal of Nanomedicine, 2004
... The cells were lysed and the MNT were purified on Ni-NTA agarose (QIAGEN) according to the standard ...
Proprotein convertase cleavage liberates a fibrillogenic fragment of a resident glycoprotein to initiate melanosome biogenesis
Supplier
Marks Michael S. et al., In The Journal of Cell Biology, 2001
... MNT-1 human melanoma cells and furin-deficient LoVo adenocarcinoma cells (American Type Culture Collection) were maintained in DME containing 10% AIM-V medium (Life Technologies), 20% FBS, nonessential amino ...
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Papers on MNT
Rapid evolutionary turnover underlies conserved lncRNA-genome interactions.
New
Chang et al., Stanford, United States. In Genes Dev, Feb 2016
Analysis of the roX lncRNAs, which are essential for dosage compensation of the single X chromosome in Drosophila males, revealed 47 new roX orthologs in diverse Drosophilid species across ∼40 million years of evolution.
The Drosophila Helicase MLE Targets Hairpin Structures in Genomic Transcripts.
New
Lucchesi et al., Atlanta, United States. In Plos Genet, Jan 2016
The complex includes one of two long non-coding RNAs and MLE was shown to remodel the roX RNA hairpin structures in order to initiate assembly of the complex.
Novel Heterotypic Rox Sites for Combinatorial Dre Recombination Strategies.
New
Badea et al., In G3 (bethesda), Jan 2016
We describe several rox variant sites that are incompatible with roxP, but are able to efficiently recombine with themselves in either purified system or bacterial and eukaryotic tissue culture systems.
Nogo-B Receptor Modulates Pulmonary Artery Smooth Muscle Cell Function in Developing Lungs.
New
Teng et al., Milwaukee, United States. In Am J Respir Cell Mol Biol, Jan 2016
PASMC isolated eight days after surgery were assessed for the alteration of protein levels by immunoblots and ROS formation by dihydroethidium and Cell ROX deep red fluorescence.
Divergent actions of long noncoding RNAs on X-chromosome remodelling in mammals and Drosophila achieve the same end result: dosage compensation.
New
Lakhotia, Benares, India. In J Genet, Dec 2015
In contrast,Drosophila was soon shown to achieve dosage compensation through hypertranscription of single X in male whose chromatin remains more open.Identification of proteins that remodel chromatin either to cause one of the two X chromosomes in somatic cells of very early female mammalian embryos to become condensed and inactive or to remodel the single X in male Drosophila embryos to a more open state for hypertranscription provided important insights into the underlying cellular epigenetic processes.However, the most strikin g and unexpected discoveries were the identification of long noncoding RNAs (lncRNAs), X-inactive specific transcript (Xist) in mammals and roX1/2 in Drosophila, which were essential for achieving the contrasting chromatin organizations but leading to similar end result in terms of dosage compensation of X-linked genes in females and males.
Two emerging topics regarding long-range physical signaling in neurosystems: Membrane nanotubes and electromagnetic fields.
Review
New
Scholkmann, Zürich, Switzerland. In J Integr Neurosci, Jun 2015
This review paper looks at experimental results that showed electrical signals being propagated through MNTs, and that MNT-mediated electrical coupling between brain cells involves activation of low-voltage-gated calcium channels.
Recommended protocols for the liver micronucleus test: Report of the IWGT working group.
Review
New
Takasawa et al., Chiba, Japan. In Mutat Res Genet Toxicol Environ Mutagen, Jun 2015
The three methods can be combined with the micronucleus test (MNT) using bone marrow (BM) and/or peripheral blood (PB).
Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis.
Review
New
Eisenman et al., Hutchinson, United States. In Biochim Biophys Acta, May 2015
This network includes MXD1-4, MNT, MGA, MONDOA and MONDOB proteins.
Revealing long noncoding RNA architecture and functions using domain-specific chromatin isolation by RNA purification.
Impact
Chang et al., Stanford, United States. In Nat Biotechnol, 2014
dChIRP of roX1, a lncRNA essential for Drosophila melanogaster X-chromosome dosage compensation, reveals a 'three-fingered hand' ribonucleoprotein topology.
Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Impact
Schofield et al., Oxford, United Kingdom. In Nature, 2014
The functional assignments of ROXs open therapeutic possibilities via either ROX inhibition or targeting of differentially modified ribosomes.
Post-translational hydroxylation by 2OG/Fe(II)-dependent oxygenases as a novel regulatory mechanism in bacteria.
Review
Jia et al., Kingston, Canada. In Front Microbiol, 2013
Recently, an evolutionarily conserved class of ribosomal oxygenases (ROX) that catalyze the hydroxylation of specific residues in the ribosome has been identified in bacteria.
Growing with the wind. Ribosomal protein hydroxylation and cell growth.
Review
Wappner et al., Buenos Aires, Argentina. In Fly (austin), 2013
In this Extra View we comment on our recent work on Sudestada1 (Sud1), a Drosophila 2-oxoglutarate (2OG)-dependent dioxygenase that belongs to the Ribosomal Oxygenase (ROX) subfamily.
Autoregulation of the Drosophila Noncoding roX1 RNA Gene.
GeneRIF
Kelley et al., Houston, United States. In Plos Genet, 2011
the expression of roX1 gene is instead controlled through an autoregulatory loop; the production of roX1 and msl2, two key components of the MSL complex, are coordinated to meet the dosage compensation demands of the male cell.
OX40 engagement stabilizes Mxd4 and Mnt protein levels in antigen-stimulated T cells leading to an increase in cell survival.
GeneRIF
Weinberg et al., Portland, United States. In Eur J Immunol, 2011
Mxd4 and Mnt upregulation following OX40 engagement most likely increases T-cell survival
Imprinting of the Y chromosome influences dosage compensation in roX1 roX2 Drosophila melanogaster.
GeneRIF
Meller et al., Detroit, United States. In Genetics, 2009
Data suggest that the Y chromosome is likely to act through modulation of a process that is defective in roX1 roX2 mutants: X chromosome recognition or chromatin modification by the MSL complex.
Switch from Mnt-Max to Myc-Max induces p53 and cyclin D1 expression and apoptosis during cholestasis in mouse and human hepatocytes.
GeneRIF
Lu et al., Los Angeles, United States. In Hepatology, 2009
The switch from Mnt-Max to Myc-Max during bile duct ligation (cholestasis) and in hepatocytes treated with lithocholic acid is responsible for the induction in p53 and cyclin D1 expression and contributes to apoptosis.
Molecularly severe roX1 mutations contribute to dosage compensation in Drosophila.
GeneRIF
Meller et al., Detroit, United States. In Genesis, 2009
some molecularly severe roX1 mutations with no detectable transcript accumulation contribute dramatically to male rescue by autosomal roX1 transgenes
Max-independent functions of Myc in Drosophila melanogaster.
Impact
Gallant et al., Zürich, Switzerland. In Nat Genet, 2008
They are thought to exercise their effects upon binding to their partner protein Max, and their activities are largely antagonized by complexes of Max with Mnt or an Mxd family protein.
Extent of chromatin spreading determined by roX RNA recruitment of MSL proteins.
Impact
Meller et al., Houston, United States. In Science, 2002
The untranslated roX1 and roX2 RNAs are components of the Drosophila male-specific lethal (MSL) complex, which modifies histones to up-regulate transcription of the male X chromosome.
Chromodomains are protein-RNA interaction modules.
Impact
Becker et al., München, Germany. In Nature, 2000
MOF is part of a chromosome-associated complex comprising male-specific lethal (MSL) proteins and at least one non-coding roX RNA.
More papers using MNT antibodies
roX1 RNA paints the X chromosome of male Drosophila and is regulated by the dosage compensation system
Supplier
Lucchesi John C et al., In Epigenetics & Chromatin, 1996
... roX1 and roX2 RNAs were determined by quantitative reverse-transcriptase PCR in transgenic larvae ...
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