Divergent actions of long noncoding RNAs on X-chromosome remodelling in mammals and Drosophila achieve the same end result: dosage compensation.
Benares, India. In J Genet, Dec 2015
In contrast,Drosophila was soon shown to achieve dosage compensation through hypertranscription of single X in male whose chromatin remains more open.Identification of proteins that remodel chromatin either to cause one of the two X chromosomes in somatic cells of very early female mammalian embryos to become condensed and inactive or to remodel the single X in male Drosophila embryos to a more open state for hypertranscription provided important insights into the underlying cellular epigenetic processes.However, the most strikin g and unexpected discoveries were the identification of long noncoding RNAs (lncRNAs), X-inactive specific transcript (Xist) in mammals and roX1/2 in Drosophila, which were essential for achieving the contrasting chromatin organizations but leading to similar end result in terms of dosage compensation of X-linked genes in females and males.
Autoregulation of the Drosophila Noncoding roX1 RNA Gene.
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Houston, United States. In Plos Genet, 2011
the expression of roX1 gene is instead controlled through an autoregulatory loop; the production of roX1 and msl2, two key components of the MSL complex, are coordinated to meet the dosage compensation demands of the male cell.