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Myeloid cell nuclear differentiation antigen

MNDA
The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: 18 U, AIM2, IFI16, ACID, CAN
Papers on MNDA
Flow cytometry in the diagnosis of myelodysplastic syndromes and the value of myeloid nuclear differentiation antigen.
New
Kern et al., München, Germany. In Cytometry B Clin Cytom, Aug 2015
Myeloid nuclear differentiation antigen (MNDA) in myelomonocytic cells might be expressed more weakly in patients with MDS.
Novel copy-number variants in a population-based investigation of classic heterotaxy.
New
Mills et al., Bethesda, United States. In Genet Med, May 2015
We also identified a large, terminal deletion of 10q and a microdeletion at 1q23.1 involving the MNDA gene; both are rare variants suspected to be associated with heterotaxy.
The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.
Cristea et al., Princeton, United States. In Mol Syst Biol, 2015
The human PYHIN proteins, AIM2, IFI16, IFIX, and MNDA, are critical regulators of immune response, transcription, apoptosis, and cell cycle.
The emerging role of human PYHIN proteins in innate immunity: implications for health and disease.
Bowie et al., Dublin, Ireland. In Biochem Pharmacol, 2015
There are five human PYHIN proteins; Absent in melanoma 2 (AIM2), IFN-γ inducible protein 16 (IFI16), Myeloid cell nuclear differentiation antigen (MNDA), Pyrin and HIN domain family member 1 (PYHIN1) and the recently identified Pyrin domain only protein 3 (POP3).
Microarray and Proteomic Analyses of Myeloproliferative Neoplasms with a Highlight on the mTOR Signaling Pathway.
Schechter et al., Belgrade, Serbia. In Plos One, 2014
Using proteomic studies, significant up-regulation was observed for MAPK and PI3K/AKT signaling regulators that control myeloid cell apoptosis and proliferation: RAC2, MNDA, S100A8/9, CORO1A, and GNAI2.
Flow cytometry in the diagnosis of myelodysplastic syndromes (MDS) and the value of myeloid nuclear differentiation antigen (MNDA).
Kern et al., München, Germany. In Cytometry B Clin Cytom, 2014
Myeloid nuclear differentiation antigen (MNDA) in myelomonocytic cells might be expressed more weakly in patients with MDS.
Myeloid cell nuclear differentiation antigen is expressed in a subset of marginal zone lymphomas and is useful in the differential diagnosis with follicular lymphoma.
Freud et al., Stanford, United States. In Hum Pathol, 2014
Myeloid cell nuclear differentiation antigen (MNDA) is a nuclear protein that labels myelomonocytic cells as well as B lymphocytes that localize to the marginal zone areas of splenic white pulp.
Purification, characterization and docking studies of the HIN domain of human myeloid nuclear differentiation antigen (MNDA).
Wu et al., Beijing, China. In Biotechnol Lett, 2014
The HIN domain of myeloid nuclear differentiation antigen (MNDA) was expressed and purified as a monomer using E. coli JM109 as host.
Ancient and recent selective pressures shaped genetic diversity at AIM2-like nucleic acid sensors.
Sironi et al., Médéa, Algeria. In Genome Biol Evol, 2014
We performed an evolutionary analysis of ALR genes (MNDA, PYHIN1, IFI16, and AIM2) by analyzing inter- and intraspecies diversity.
Effects of the myeloid cell nuclear differentiation antigen on the proliferation, apoptosis and migration of osteosarcoma cells.
Li et al., Jinan, China. In Oncol Lett, 2014
The aim of this study was to evaluate the value of the myeloid cell nuclear differentiation antigen (MNDA), a member of the interferon-inducible p200 (IFI-200) family, as a therapeutic target for osteosarcoma by analyzing the baseline expression of MNDA in human osteosarcoma cells and determining the effect of MNDA overexpression on the proliferation and apoptosis profiles and migration/invasion ability in osteosarcoma cells.
Interferon-inducible p200-family proteins as novel sensors of cytoplasmic DNA: role in inflammation and autoimmunity.
Review
Srivastava et al., Cincinnati, United States. In J Interferon Cytokine Res, 2010
One family of IFN-inducible genes is the Ifi200 family, which includes the murine (eg, Ifi202a, Ifi202b, Ifi203, Ifi204, Mndal, and Aim2) and human (eg, IFI16, MNDA, IFIX, and AIM2) genes.
Significance of myeloid antigen expression in precursor T lymphoblastic lymphoma.
GeneRIF
Ling et al., Guangzhou, China. In Ai Zheng, 2010
Myeloid antigen expression is a predictor of a poor response to chemotherapy, and an adverse prognostic factor in adult T-lymphoblastic lymphoma, but not in children with T-LBL.
Identification of MNDA as a new marker for nodal marginal zone lymphoma.
GeneRIF
Piris et al., Madrid, Spain. In Leukemia, 2009
MNDA expression is a useful tool for the recognition of nodal marginal zone lymphoma
Interferon-inducible Ifi200-family genes in systemic lupus erythematosus.
Review
Panchanathan et al., Cincinnati, United States. In Immunol Lett, 2008
One family of ISGs is the Ifi200-family, which includes mouse (Ifi202a, Ifi202b, Ifi203, Ifi204, and Ifi205) and human (IFI16, MNDA, AIM2, and IFIX) genes.
Interferon-inducible IFI16 protein in human cancers and autoimmune diseases.
Review
Ho et al., Cincinnati, United States. In Front Biosci, 2007
The family includes structurally and functionally-related mouse (for example, p202, p203, and p204 proteins) and human (for example, MNDA, AIM2, and IFIX) proteins.
Dysregulated human myeloid nuclear differentiation antigen expression in myelodysplastic syndromes: evidence for a role in apoptosis.
GeneRIF
Head et al., Nashville, United States. In Cancer Res, 2006
MNDA has a role regulating programmed cell death in myeloid progenitor cells, and that its down-regulation in myelodysplastic syndromes is related to granulocyte-macrophage progenitor cell sensitivity to TRAIL-induced programmed cell death.
The HIN-200 family: more than interferon-inducible genes?
GeneRIF
Clarke et al., Australia. In Exp Cell Res, 2005
The importance of HIN-200 proteins in disease now is beginning to be understood as they appear to be involved in autoimmunity and may act as tumor suppressor proteins.
Variable expression of human myeloid specific nuclear antigen MNDA in monocyte lineage cells in atherosclerosis.
GeneRIF
Miranda et al., Nashville, United States. In J Cell Biochem, 2005
variation in MNDA expression appeared to change with phenotypic specialization of monocytes in atherosclerosis consistent with its association with inflammation and suspected roles in regulating gene expression or in mediating cell death
The interferon-inducible p200 family of proteins: a perspective on their roles in cell cycle regulation and differentiation.
Review
Keller et al., Frederick, United States. In Blood Cells Mol Dis, 2004
The members of this family of proteins are highly homologous to one another and consist of five murine proteins including p202, p203, p204 and p205 as well as three human homologues; IFI-16, myeloid cell nuclear differentiation antigen (MNDA) and absent in melanoma (AIM) 2. They possess at least one copy of a conserved 200 amino-acid motif which exists in two types; the a and b domains.
Differential induction of the 200-family proteins in Daudi Burkitt's lymphoma cells by interferon-alpha.
Review
Choubey et al., Maywood, United States. In J Biol Regul Homeost Agents, 2000
One family (the "200-family") of IFN-inducible proteins includes structurally related murine (p202a, p202b, p203, p204 and D3) and human (MNDA, IFI-16 and AIM2) proteins.
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