The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.
Princeton, United States. In Mol Syst Biol, 2015
The human PYHIN proteins, AIM2, IFI16, IFIX, and MNDA, are critical regulators of immune response, transcription, apoptosis, and cell cycle.
Interferon-inducible p200-family proteins as novel sensors of cytoplasmic DNA: role in inflammation and autoimmunity.
Cincinnati, United States. In J Interferon Cytokine Res, 2010
One family of IFN-inducible genes is the Ifi200 family, which includes the murine (eg, Ifi202a, Ifi202b, Ifi203, Ifi204, Mndal, and Aim2) and human (eg, IFI16, MNDA, IFIX, and AIM2) genes.
Interferon-inducible Ifi200-family genes in systemic lupus erythematosus.
Cincinnati, United States. In Immunol Lett, 2008
One family of ISGs is the Ifi200-family, which includes mouse (Ifi202a, Ifi202b, Ifi203, Ifi204, and Ifi205) and human (IFI16, MNDA, AIM2, and IFIX) genes.