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Matrix metallopeptidase 9

MMP-9, Matrix Metalloproteinase 9, gelatinase
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MMP-2, CAN, lipocalin, HAD, V1a
Papers using MMP-9 antibodies
Plasmodium falciparum-infected erythrocytes decrease the integrity of human blood-brain barrier endothelial cell monolayers
Arese Paolo et al., In Malaria Journal, 2006
... recombinant human (rh)IL-1beta, blocking anti-human (h)IL-1beta antibodies and Merck's inhibitor I, (N-hydroxy-1-(4-methoxyphenyl)sulfonyl-4-(4-biphenylcarbonyl)piperazine-2-carboxamide), a specific inhibitor of MMP-9/MMP-13 activity, were from Merck, Darmstadt, Germany; ELISA kit ...
Hepatobiliary excretion of berberine.
Navarro Alfons, In PLoS ONE, 2003
... ERK 1/2 and AKT, the total and phosphorylated protein antibodies, MMP-9 antibody and horseradish peroxidase (HRP)-labeled anti-rabbit secondary antibody were purchased from Cell Signaling Technology (Boston, MA) ...
Rab3D and annexin A2 play a role in regulated secretion of vWF, but not tPA, from endothelial cells
Bassham Diane, In PLoS ONE, 2003
... from BD Transduction Laboratories™ (San Jose, CA, USA), mouse anti-PDI from Assay Designs, rabbit polyclonal anti-MMP-9 from Enzo® Life Sciences (Plymouth, PA), polyclonal rabbit anti-GFP antibody from Abcam (Cambridge, UK), and rabbit ...
Hyaluronan–CD44 interaction hampers migration of osteoclast-like cells by down-regulating MMP-9
Gattei Valter et al., In The Journal of Cell Biology, 1998
... Antibodies against MMP-9 were obtained from Santa Cruz Biotechnology, Inc ...
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Papers on MMP-9
Prognostic significance of CD44v6, p63, Podoplanin, and MMP-9 in oral squamous cell carcinomas.
Warnakulasuryia et al., Portugal. In Oral Dis, Feb 2016
OBJECTIVES: To analyse the expression of the CD44v6, p63, podoplanin and MMP-9, and their prognostic significance in patients with oral squamous cell carcinomas (OSCC).
Differences in GFR and Tissue Oxygenation, and Interactions between Stenotic and Contralateral Kidneys in Unilateral Atherosclerotic Renovascular Disease.
Textor et al., Rochester, United States. In Clin J Am Soc Nephrol, Feb 2016
Tissue oxygenation (using R(2)* as a measure of deoxyhemoglobin) was determined by blood oxygen level-dependent magnetic resonance imaging at 3 T. Renal vein neutrophil gelatinase-associated lipocalin (NGAL), monocyte chemoattractant protein-1 (MCP-1), and plasma renin activity were measured.
High level of αB-crystallin contributes to the progression of osteosarcoma.
Cheng et al., Nanchang, China. In Oncotarget, Feb 2016
In this study, we showed that Cryab expression was elevated in OS tissues and cell lines, and down-regulation of Cryab in MG-63 and U-2OS cells led to a decline in the cells' aggressiveness, and reduced secretion of matrix metalloproteinase-9 (MMP-9) in vitro, and lower metastasis potential in vivo.
Niclosamide suppresses migration of hepatocellular carcinoma cells and downregulates matrix metalloproteinase-9 expression.
Ishige et al., Yotsukaidō, Japan. In Oncol Lett, Dec 2015
Expression levels of cyclin D1 and matrix metalloproteinase 9 (MMP9) were analyzed by performing revers transcription-quantitative polymerase chain reaction.
Matrix Metalloproteinases and Their Inhibitors in Chronic Obstructive Pulmonary Disease.
Petrek et al., Olomouc, Czech Republic. In Arch Immunol Ther Exp (warsz), Dec 2015
In COPD, the MMP/TIMP network, mainly MMP-9, has been repeatedly observed to be dysregulated at both the local (lung) and systemic levels.
The Role of Matrix Metalloproteinase-9 (MMP-9) as a Prognostic Factor in Epithelial and Lymphatic Neoplasia.
- et al., In Chirurgia (bucur), Nov 2015
Matrix metalloproteinase 9 is a zinc-dependent extracellular matrix remodeling endopeptidase directly involved in the local invasion mechanisms and in metastasis.
Association of Matrix Metalloproteinase-9 Gene -1562C/T Polymorphism with Essential Hypertension: A Systematic Review and Meta-Analysis Article.
Zhang et al., Shanghai, China. In Iran J Public Health, Nov 2015
BACKGROUND: Matrix metalloproteinase-9 (MMP-9) gene -1562C/T polymorphism could regulate its expression level and thus affected people's predisposition to essential hypertension.
Acute Kidney Injury in Patients with Cirrhosis.
Singal et al., Birmingham, United States. In J Clin Transl Hepatol, Oct 2015
In this regard, novel serum and/or urinary biomarkers such as neutrophil gelatinase-associated lipocalin, interleukins-6 and 18, kidney injury molecule-1, fatty acid binding protein, and endothelin-1 are emerging with a potential for accurately differentiating common causes of AKI.
Role of interleukin 33/ST2 axis in the immune-mediated pathogenesis of age-related macular degeneration.
Dick et al., Bristol, United Kingdom. In Lancet, Mar 2015
Interleukin-33 treatment impaired fibroblast migration and gel contraction alongside suppression of MMP-2 and MMP-9 expression.
An Overview of Matrix Metalloproteinase 9 Polymorphism and Gastric Cancer Risk.
Swarnakar et al., Calcutta, India. In Asian Pac J Cancer Prev, 2014
Several genetic polymorphisms have been identified that show allele specific effects on MMP9 regulation and are associated with gastric cancer, the fourth most common malignancy in the world.
Oestradiol Treatment Counteracts the Effect of Fructose-Rich Diet on Matrix Metalloproteinase 9 Expression and NFκB Activation.
Stankovic et al., Belgrade, Serbia. In Folia Biol (praha), 2014
Among other matrix metalloproteinases, MMP-9 has an important role in adverse cardiac remodelling and might have a role in the development of cardiovascular disorders associated with metabolic syndrome.
Crosstalk between sentinel and helper macrophages permits neutrophil migration into infected uroepithelium.
Engel et al., Bonn, Germany. In Cell, 2014
This chemokine activated matrix metalloproteinase-9 in neutrophils, allowing their entry into the uroepithelium to combat the bacteria.
Safety and tolerability of an intratumorally injected DNAzyme, Dz13, in patients with nodular basal-cell carcinoma: a phase 1 first-in-human trial (DISCOVER).
Khachigian et al., Sydney, Australia. In Lancet, 2013
Proportions of cells positive for caspases 3, 8, and 9 and P53 were increased, but those of cells positive for Bcl-2 and MMP-9 were decreased.
Limited cleavage of tau with matrix-metalloproteinase MMP-9, but not MMP-3, enhances tau oligomer formation.
Giese et al., München, Germany. In Exp Neurol, 2012
In this study, we identify MMP-3 and MMP-9 as potential tau proteinases
Matrix metalloproteinase-9 genetic polymorphisms and the risk for advanced pelvic organ prolapse.
Shah et al., Durham, United States. In Obstet Gynecol, 2012
Two MMP9 gene single nucleotide polymorphisms were associated with advanced pelvic organ prolapse: 1) rs3918253 (adjusted odds ratio [OR] 0.64, 95% confidence interval [CI] 0.41-1.0, P=.05); and 2) rs3918256 (adjusted OR 0.64, 95% CI 0.41-1.01, P=.05).
[Association of the MMP3, MMP9, ADAM33 and TIMP3 genes polymorphic markers with development and progression of chronic obstructive pulmonary disease].
Victorova et al., In Mol Biol (mosk), 2012
The MMP9 gene polymorphism may be an important risk factor for the development and progression of chronic obstructive pulmonary disease.
Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance.
Egeblad et al., United States. In Cancer Cell, 2012
We observed associations between vascular leakage and response to doxorubicin, including improved response in matrix metalloproteinase-9 null mice that had increased vascular leakage.
[Role of matrix metalloproteinase-9 in the pathogenesis of osteoporosis in patients with chronic obstructive pulmonary disease].
Nevzorova et al., In Ter Arkh, 2011
Elevated MMP-9 levels may play an important role in bone resorption in COPD.
Oxidation of CaMKII determines the cardiotoxic effects of aldosterone.
Anderson et al., Iowa City, United States. In Nat Med, 2011
Aldosterone induces CaMKII oxidation by recruiting NADPH oxidase, and this oxidized and activated CaMKII promotes matrix metalloproteinase 9 (MMP9) expression in cardiomyocytes.
cAMP-mediated upregulation of gelatinases in primary cultures of isolated rat hepatocytes.
Sudhakaran et al., Thiruvananthapuram, India. In Indian J Biochem Biophys, 2004
analysis of cAMP dependent regulation of MMP-9 in hepatocytes
More papers using MMP-9 antibodies
Cytoplasmically “sequestered” wild type p53 protein is resistant to Mdm2-mediated degradation
Bischof P. et al., In Human Reproduction (Oxford, England), 1998
... Sheep polyclonal MMP-9 antibody was from The Binding Site (Birmingham, UK) ...
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