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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 09 Dec 2014.

Matrix metallopeptidase 7

MMP-7, Matrix Metalloproteinase 7, Matrilysin
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MMP-9, MMP-2, CAN, HAD, matrix metalloproteinase
Papers using MMP-7 antibodies
A simple and fast densitometric method for the analysis of tyrosine hydroxylase immunoreactivity in the substantia nigra pars compacta and in the ventral tegmental area
Mohanraj Rajesh, In PLoS ONE, 2004
... Antibodies against SPARC (Santa Cruz Biotechnology, Santa Cruz, CA, USA), (p-)SAPK/JNK, (p-)ERK1/2, (p-)p-38, MMP-7 (Cell signaling technology, Danvers, MA,USA), VEGF, ...
Papers on MMP-7
Effect of budesonide transnasal nebulization in patients with eosinophilic chronic rhinosinusitis with nasal polyps.
Zhang et al., Beijing, China. In J Allergy Clin Immunol, 04 Jan 2015
Indices of remodeling, including albumin, MMP-2, MMP-7, MMP-8, and MMP-9, were significantly decreased, whereas collagen deposition and TIMP-1, TIMP-2, and TIMP-4 levels were significantly increased.
Alcohol Consumption, Wnt/β-Catenin Signaling, and Hepatocarcinogenesis.
Ronis et al., Little Rock, United States. In Adv Exp Med Biol, 31 Dec 2014
Analysis of EtOH-treated livers from a previously published rat model of chronic liver disease revealed increases in hepatocyte proliferation accompanied by a hepatic depletion of retinol and retinoic acid stores (p < 0.05), nuclear accumulation of β-catenin (p < 0.05), increased cytosolic expression p-GSK3β (p < 0.05), significant upregulation of soluble Wnts, Wnt2, and Wnt7a, and increased expression of several β-catenin targets involved in tumor promotion and progression, cyclin D1, c-myc, WISP1, and MMP7 (p < 0.05).
Prognostic impact of a compartment-specific angiogenic marker profile in patients with pancreatic cancer.
Koch et al., Heidelberg, Germany. In Oncotarget, 28 Dec 2014
ROC analysis of corresponding serum samples reveals MMP-7 and MMP-12 as strong classifiers for the diagnosis of patients with pancreatic cancer vs. healthy control donors.
CD151 in cancer progression and metastasis: a complex scenario.
Romanska et al., Gdańsk, Poland. In Lab Invest, Jan 2014
The molecular mechanism of CD151 in cancer is based on its ability to organize distribution and function of interacting proteins, ie, laminin-binding integrins (α3β1, α6β1 and α6β4), receptors for growth factors (HGFR, EGFR and TGF-β1R) and matrix metalloproteinases (MMP-7, MMP-2 and MMP-9), which indicates its importance in disease development.
Matrix metalloproteinase enzymes and their naturally derived inhibitors: novel targets in photocarcinoma therapy.
Saraf et al., Raipur, India. In Ageing Res Rev, Jan 2014
The important MMPs are MMP1, MMP2 and MMP7 which promote skin cancer when irradiated by UV rays.
Gene expression in the chicken caecum in response to infections with non-typhoid Salmonella.
Kyrova et al., Brno, Czech Republic. In Vet Res, Dec 2013
The highest induction in expression is observed for matrix metalloproteinase 7 (MMP7).
A Small Molecule Inhibitor of ETV1, YK-4-279, Prevents Prostate Cancer Growth and Metastasis in a Mouse Xenograft Model.
Uren et al., Baltimore, United States. In Plos One, Dec 2013
Expression of ETV1 target genes MMP7, FKBP10 and GLYATL2 were reduced in YK-4-279 treated animals.
Beyond the diagnosis of idiopathic pulmonary fibrosis; the growing role of systems biology and stratified medicine.
Maher, London, United Kingdom. In Curr Opin Pulm Med, Sep 2013
Proteomic studies have identified serum proteins, including matrix metalloproteinase 7 and CC chemokine ligand (CCL)-18, which associate with disease severity and predict prognosis.
Association between the MUC5B promoter polymorphism and survival in patients with idiopathic pulmonary fibrosis.
Schwartz et al., Denver, United States. In Jama, Jul 2013
The INSPIRE cohort was used to model the association of the MUC5B genotype with survival, accounting for the effect of matrix metalloproteinase 7 (MMP-7) blood concentration and other demographic and clinical covariates.
[Clinical prospects of tumor-associated proteases and their tissue inhibitors investigation in oncologic patient].
Kushlinskiĭ et al., In Vestn Ross Akad Med Nauk, 2012
Thus, results of 5-years monitoring have demonstrated that high preoperative serum MMP-7 and TIMP- levels were independent unfavorable prognosticfactors for CRC and univariate analysis revealed unfavorable prognostic role of high tumor MMP- 7 in patients with disseminated process.
Matrix metalloproteinases: inflammatory regulators of cell behaviors in vascular formation and remodeling.
Zhang et al., Hangzhou, China. In Mediators Inflamm, 2012
MMPs including MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, and MT1-MMP, are stimulated and activated by various stimuli in vascular tissues.
The forkhead box transcription factor FOXC1 promotes breast cancer invasion by inducing matrix metalloprotease 7 (MMP7) expression.
Keri et al., Cleveland, United States. In J Biol Chem, 2012
Findings identify MMP7 as a novel mechanism through which FOXC1 may regulate the basal-like breast cancer invasive phenotype and the propensity of these cancers to metastasize.
Is MMP-7 gene polymorphism a possible risk factor for chronic obstructive pulmonary disease in Turkish patients.
Eraltan et al., İstanbul, Turkey. In Genet Test Mol Biomarkers, 2012
These findings have suggested that MMP-7 polymorphism might be associated with the risk and progression of COPD in the Turkish population.
The transcription factor SOX18 regulates the expression of matrix metalloproteinase 7 and guidance molecules in human endothelial cells.
de Martin et al., Vienna, Austria. In Plos One, 2011
The identification of MMP7 as a direct SOX18 target gene as well as other potential candidates including guidance molecules provides a molecular basis for the proposed function of this transcription factor in the regulation of vessel formation.
Application of MMP-7 and MMP-10 in assisting the diagnosis of malignant pleural effusion.
Li et al., Shenyang, China. In Asian Pac J Cancer Prev, 2011
High MMP-7 is associated with malignant pleural effusion.
Expressions of MMPs and TIMP-1 in gastric ulcers may differentiate H. pylori-infected from NSAID-related ulcers.
Sheu et al., Tainan City, Taiwan. In Scientificworldjournal, 2011
H. pylori-infected gastric ulcers express higher MMP-7, MMP-9, and TIMP-1 than NSAID-related ulcers
Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression.
Hebrok et al., San Francisco, United States. In Cancer Cell, 2011
expression in pancreatic ductal adenocarcinoma cells and that MMP7 deletion limits tumor size and metastasis in mice
Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma.
Kheradmand et al., Houston, United States. In Nat Immunol, 2009
MMP7 coordinates allergic lung inflammation by activating interleukin 25 while simultaneously inhibiting retinoid-dependent development of regulatory T cells.
Considering the critical interface between tumor cells and stromal cells in the search for targets for anticancer therapy.
Declerck et al., Los Angeles, United States. In Cancer Cell, 2005
In this issue of Cancer Cell, a paper by Lynch et al. demonstrates how the careful study of changes that occur at the interface between tumor cells and stromal cells led to the discovery of a new function for matrix metalloproteinase-7 (MMP-7) in the formation of osteolytic lesions in prostate cancer.
MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL.
Futakuchi et al., Nashville, United States. In Cancer Cell, 2005
MMP-7, which was produced by osteoclasts at the tumor-bone interface, was capable of processing RANKL to a soluble form that promoted osteoclast activation.
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