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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Oct 2014.

Matrix metallopeptidase 7

MMP-7, Matrix Metalloproteinase 7, Matrilysin
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MMP-9, MMP-2, CAN, HAD, matrix metalloproteinase
Papers using MMP-7 antibodies
A simple and fast densitometric method for the analysis of tyrosine hydroxylase immunoreactivity in the substantia nigra pars compacta and in the ventral tegmental area
Supplier
Mohanraj Rajesh, In PLoS ONE, 2004
... Antibodies against SPARC (Santa Cruz Biotechnology, Santa Cruz, CA, USA), (p-)SAPK/JNK, (p-)ERK1/2, (p-)p-38, MMP-7 (Cell signaling technology, Danvers, MA,USA), VEGF, ...
Papers on MMP-7
Analysis of the expression of nine secreted matrix metalloproteinases and their endogenous inhibitors in the brain of mice subjected to ischaemic stroke.
New
Copin et al., Genève, Switzerland. In Thromb Haemost, Aug 2014
Herein, we compared the global changes in MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP12 and MMP13, and their endogenous inhibitors TIMP1 and TIMP2, both at the mRNA and protein levels, during the hyperacute (6 h), acute (24 h) and subacute (72 h) stages following transient focal cerebral ischaemia and treatment with recombinant tissue plasminogen activator (rtPA).
Genome-wide association study identifies new disease loci for isolated clubfoot.
New
Gurnett et al., Saint Louis, United States. In J Med Genet, May 2014
Additional suggestive SNPs were identified near FOXN3, SORCS1 and MMP7/TMEM123 that also confirmed on replication.
SPARC expression is negatively correlated with clinicopathological factors of gastric cancer and inhibits malignancy of gastric cancer cells.
New
Liu et al., Beijing, China. In Oncol Rep, May 2014
SPARC suppressed the invasion and migration of GC by reducing MMP-7, MMP-9, N-cadherin, Sp1 and p-ERK1/2 expression.
FRZB knockdown upregulates β-catenin activity and enhances cell aggressiveness in gastric cancer.
New
Zang et al., Shanghai, China. In Oncol Rep, May 2014
FRZB knockdown increased cell migration and invasion and increased the expression of Wnt/β‑catenin downstream targets such as MMP7 and cyclin D1.
Matrix metalloproteinase enzymes and their naturally derived inhibitors: novel targets in photocarcinoma therapy.
Review
New
Saraf et al., Raipur, India. In Ageing Res Rev, Jan 2014
The important MMPs are MMP1, MMP2 and MMP7 which promote skin cancer when irradiated by UV rays.
Type IV collagen α1-chain noncollagenous domain blocks MMP-2 activation both in-vitro and in-vivo.
New
Pawar et al., Menlo Park, United States. In Sci Rep, Dec 2013
In-vivo studies using α1-integrin null-mice treated with higher doses of α1(IV)NC1 showed integrin independent inhibition of tumor growth and active-MMP-2, without affecting MMP-9, MMP-7 and angiostatin.
Beyond the diagnosis of idiopathic pulmonary fibrosis; the growing role of systems biology and stratified medicine.
Review
New
Maher, London, United Kingdom. In Curr Opin Pulm Med, Sep 2013
Proteomic studies have identified serum proteins, including matrix metalloproteinase 7 and CC chemokine ligand (CCL)-18, which associate with disease severity and predict prognosis.
Association between promoters polymorphisms of matrix metalloproteinases and risk of digestive cancers: a meta-analysis.
Review
New
Daru et al., Shanghai, China. In J Cancer Res Clin Oncol, Sep 2013
For MMP7 -181 A/G, significant association was observed under two genetic models in the overall (dominant: OR = 1.26, 95 % CI = 1.10-1.43,
Association between the MUC5B promoter polymorphism and survival in patients with idiopathic pulmonary fibrosis.
New
Impact
Schwartz et al., Denver, United States. In Jama, Jul 2013
The INSPIRE cohort was used to model the association of the MUC5B genotype with survival, accounting for the effect of matrix metalloproteinase 7 (MMP-7) blood concentration and other demographic and clinical covariates.
[Clinical prospects of tumor-associated proteases and their tissue inhibitors investigation in oncologic patient].
Review
Kushlinskiĭ et al., In Vestn Ross Akad Med Nauk, 2012
Thus, results of 5-years monitoring have demonstrated that high preoperative serum MMP-7 and TIMP- levels were independent unfavorable prognosticfactors for CRC and univariate analysis revealed unfavorable prognostic role of high tumor MMP- 7 in patients with disseminated process.
Matrix metalloproteinases: inflammatory regulators of cell behaviors in vascular formation and remodeling.
Review
Zhang et al., Hangzhou, China. In Mediators Inflamm, 2012
MMPs including MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, and MT1-MMP, are stimulated and activated by various stimuli in vascular tissues.
The forkhead box transcription factor FOXC1 promotes breast cancer invasion by inducing matrix metalloprotease 7 (MMP7) expression.
GeneRIF
Keri et al., Cleveland, United States. In J Biol Chem, 2012
Findings identify MMP7 as a novel mechanism through which FOXC1 may regulate the basal-like breast cancer invasive phenotype and the propensity of these cancers to metastasize.
Is MMP-7 gene polymorphism a possible risk factor for chronic obstructive pulmonary disease in Turkish patients.
GeneRIF
Eraltan et al., İstanbul, Turkey. In Genet Test Mol Biomarkers, 2012
These findings have suggested that MMP-7 polymorphism might be associated with the risk and progression of COPD in the Turkish population.
The transcription factor SOX18 regulates the expression of matrix metalloproteinase 7 and guidance molecules in human endothelial cells.
GeneRIF
de Martin et al., Vienna, Austria. In Plos One, 2011
The identification of MMP7 as a direct SOX18 target gene as well as other potential candidates including guidance molecules provides a molecular basis for the proposed function of this transcription factor in the regulation of vessel formation.
Application of MMP-7 and MMP-10 in assisting the diagnosis of malignant pleural effusion.
GeneRIF
Li et al., Shenyang, China. In Asian Pac J Cancer Prev, 2011
High MMP-7 is associated with malignant pleural effusion.
Expressions of MMPs and TIMP-1 in gastric ulcers may differentiate H. pylori-infected from NSAID-related ulcers.
GeneRIF
Sheu et al., Tainan City, Taiwan. In Scientificworldjournal, 2011
H. pylori-infected gastric ulcers express higher MMP-7, MMP-9, and TIMP-1 than NSAID-related ulcers
Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression.
Impact
GeneRIF
Hebrok et al., San Francisco, United States. In Cancer Cell, 2011
expression in pancreatic ductal adenocarcinoma cells and that MMP7 deletion limits tumor size and metastasis in mice
Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma.
Impact
GeneRIF
Kheradmand et al., Houston, United States. In Nat Immunol, 2009
MMP7 coordinates allergic lung inflammation by activating interleukin 25 while simultaneously inhibiting retinoid-dependent development of regulatory T cells.
Considering the critical interface between tumor cells and stromal cells in the search for targets for anticancer therapy.
Impact
Declerck et al., Los Angeles, United States. In Cancer Cell, 2005
In this issue of Cancer Cell, a paper by Lynch et al. demonstrates how the careful study of changes that occur at the interface between tumor cells and stromal cells led to the discovery of a new function for matrix metalloproteinase-7 (MMP-7) in the formation of osteolytic lesions in prostate cancer.
MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL.
Impact
GeneRIF
Futakuchi et al., Nashville, United States. In Cancer Cell, 2005
MMP-7, which was produced by osteoclasts at the tumor-bone interface, was capable of processing RANKL to a soluble form that promoted osteoclast activation.
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