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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 May 2015.

Matrix metallopeptidase 7

MMP-7, Matrix Metalloproteinase 7, Matrilysin
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MMP-9, MMP-2, CAN, HAD, matrix metalloproteinase
Papers using MMP-7 antibodies
A simple and fast densitometric method for the analysis of tyrosine hydroxylase immunoreactivity in the substantia nigra pars compacta and in the ventral tegmental area
Supplier
Mohanraj Rajesh, In PLoS ONE, 2004
... Antibodies against SPARC (Santa Cruz Biotechnology, Santa Cruz, CA, USA), (p-)SAPK/JNK, (p-)ERK1/2, (p-)p-38, MMP-7 (Cell signaling technology, Danvers, MA,USA), VEGF, ...
Papers on MMP-7
Autoantibody signatures combined with Epstein-Barr virus capsid antigen-IgA as a biomarker panel for the detection of nasopharyngeal carcinoma.
New
Xu et al., Shantou, China. In Cancer Prev Res (phila), 19 Jun 2015
In this study, serum levels of autoantibodies against a panel of six tumor-associated antigens (p53, NY-ESO-1, MMP-7, Hsp70, Prx VI and Bmi-1) and Epstein-Barr virus capsid antigen-IgA (VCA-IgA) were tested by ELISA in a training set (220 NPC patients and 150 controls) and validated in a validation set (90 NPC patients and 68 controls).
Gastrin stimulates MMP-1 expression in gastric epithelial cells: putative role in gastric epithelial cell migration.
New
Dockray et al., Liverpool, United Kingdom. In Am J Physiol Gastrointest Liver Physiol, 14 Jun 2015
In human subjects with increased serum gastrin due to PPI usage, MMP-1 transcript abundance was increased 2-fold; there was also increased MMP-7 transcript abundance but not MMP-3.
Changes in transcriptome of macrophages in atherosclerosis.
New
Orekhov et al., Moscow, Russia. In J Cell Mol Med, 13 Jun 2015
Compared to M0 macrophages, M4 cells have a unique transcriptome, with expression of surface markers such as S100A8, mannose receptor CD206 and matrix metalloproteinase 7. M4 macrophages did not express CD163, a scavenger receptor for haemoglobin/haptoglobin complex.
Prognostic significance of MMP-7 expression in colorectal cancer: a meta-analysis.
Review
New
Lv et al., Changchun, China. In Cancer Epidemiol, 30 Apr 2015
OBJECTIVE: Matrix metalloproteinase-7 (MMP-7) is a member of the family of matrix metalloproteinases (MMPs); it is associated with invasive tumor growth and distant metastasis in colorectal cancer (CRC).
Matrix Remodeling by MMPs during Wound Repair.
Review
New
Parks et al., Los Angeles, United States. In Matrix Biol, 11 Apr 2015
For wound closure, we discuss how two MMPs - MMP1 in human epidermis and MMP7 in mucosal epithelia - facilitate re-epithelialization by cleaving different ECM or ECM-associated proteins to affect similar integrin:matrix adhesion.
Alcohol consumption, Wnt/β-catenin signaling, and hepatocarcinogenesis.
Review
New
Ronis et al., Little Rock, United States. In Adv Exp Med Biol, Dec 2014
significant upregulation of soluble Wnts, Wnt2, and Wnt7a, and increased expression of several β-catenin targets involved in tumor promotion and progression, cyclin D1, c-myc, WISP1, and MMP7 (p<0.05).
Prognostic value of matrix metalloproteinases in oral squamous cell carcinoma.
New
Djonov et al., Bern, Switzerland. In Biotechnol Biotechnol Equip, Dec 2014
UNASSIGNED: The aim of this study was to investigate whether there is a correlation between the expressions of four matrix metalloproteinases (MMPs): MMP-2, MMP-7, MMP-9 and MMP-13, and the TNM (tumour-node-metastasis) stages of oral squamous cell carcinoma (OSCC); and to explore the implication of these MMPs in OSCC dissemination.
Gene expression in the chicken caecum in response to infections with non-typhoid Salmonella.
Review
Kyrova et al., Brno, Czech Republic. In Vet Res, 2013
The highest induction in expression is observed for matrix metalloproteinase 7 (MMP7).
A systematic review and meta-analysis of diagnostic and prognostic serum biomarkers of colorectal cancer.
Review
Gao et al., Luoyang, China. In Plos One, 2013
and MMP-7 with lowest (1.099, CI: 1.018-1.187))
Serum Matrix Metalloproteinase-7 is an independent prognostic biomarker in advanced bladder cancer.
Lamy et al., La Seyne-sur-Mer, France. In Clin Transl Med, 2013
MMP-7 is produced by stromal cells and by tumor cells and is overexpressed in a variety of epithelial and mesenchymal tumors.
Association between the MUC5B promoter polymorphism and survival in patients with idiopathic pulmonary fibrosis.
Impact
Schwartz et al., Denver, United States. In Jama, 2013
The INSPIRE cohort was used to model the association of the MUC5B genotype with survival, accounting for the effect of matrix metalloproteinase 7 (MMP-7) blood concentration and other demographic and clinical covariates.
The forkhead box transcription factor FOXC1 promotes breast cancer invasion by inducing matrix metalloprotease 7 (MMP7) expression.
GeneRIF
Keri et al., Cleveland, United States. In J Biol Chem, 2012
Findings identify MMP7 as a novel mechanism through which FOXC1 may regulate the basal-like breast cancer invasive phenotype and the propensity of these cancers to metastasize.
Is MMP-7 gene polymorphism a possible risk factor for chronic obstructive pulmonary disease in Turkish patients.
GeneRIF
Eraltan et al., İstanbul, Turkey. In Genet Test Mol Biomarkers, 2012
These findings have suggested that MMP-7 polymorphism might be associated with the risk and progression of COPD in the Turkish population.
The transcription factor SOX18 regulates the expression of matrix metalloproteinase 7 and guidance molecules in human endothelial cells.
GeneRIF
de Martin et al., Vienna, Austria. In Plos One, 2011
The identification of MMP7 as a direct SOX18 target gene as well as other potential candidates including guidance molecules provides a molecular basis for the proposed function of this transcription factor in the regulation of vessel formation.
Application of MMP-7 and MMP-10 in assisting the diagnosis of malignant pleural effusion.
GeneRIF
Li et al., Shenyang, China. In Asian Pac J Cancer Prev, 2011
High MMP-7 is associated with malignant pleural effusion.
Expressions of MMPs and TIMP-1 in gastric ulcers may differentiate H. pylori-infected from NSAID-related ulcers.
GeneRIF
Sheu et al., Tainan City, Taiwan. In Scientificworldjournal, 2011
H. pylori-infected gastric ulcers express higher MMP-7, MMP-9, and TIMP-1 than NSAID-related ulcers
Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression.
Impact
GeneRIF
Hebrok et al., San Francisco, United States. In Cancer Cell, 2011
expression in pancreatic ductal adenocarcinoma cells and that MMP7 deletion limits tumor size and metastasis in mice
Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma.
Impact
GeneRIF
Kheradmand et al., Houston, United States. In Nat Immunol, 2009
MMP7 coordinates allergic lung inflammation by activating interleukin 25 while simultaneously inhibiting retinoid-dependent development of regulatory T cells.
Considering the critical interface between tumor cells and stromal cells in the search for targets for anticancer therapy.
Impact
Declerck et al., Los Angeles, United States. In Cancer Cell, 2005
In this issue of Cancer Cell, a paper by Lynch et al. demonstrates how the careful study of changes that occur at the interface between tumor cells and stromal cells led to the discovery of a new function for matrix metalloproteinase-7 (MMP-7) in the formation of osteolytic lesions in prostate cancer.
MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL.
Impact
GeneRIF
Futakuchi et al., Nashville, United States. In Cancer Cell, 2005
MMP-7, which was produced by osteoclasts at the tumor-bone interface, was capable of processing RANKL to a soluble form that promoted osteoclast activation.
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