Inhibition of Notch signalling ameliorates experimental inflammatory arthritis.
Suwŏn, South Korea. In Ann Rheum Dis, 19 Dec 2013
Pharmacological inhibition of γ-secretase and antisense-mediated knockdown of Notch attenuates the severity of inflammatory arthritis, including arthritis indices, paw thickness, tissue damage and neutrophil infiltration, and reduces the levels of active NF-κB, ICAM-1, proinflammatory cytokines and matrix metalloproteinase-3 activity in the mouse model of RA.
Biomarkers in vasculitis.
Boston, United States. In Curr Opin Rheumatol, 18 Dec 2013
More conventional hypothesis-based studies have indicated that the following circulating proteins have potential to improve upon clinically available tests: pentraxin-3 in giant cell arteritis and Takayasu's arteritis; von Willebrand factor antigen in childhood central nervous system vasculitis; eotaxin-3 and other markers related to eosinophils or Th2 immune responses in eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome); and MMP-3, TIMP-1, and CXCL13 in ANCA-associated vasculitis.
Exercise, GLUT4, and skeletal muscle glucose uptake.
Copenhagen, Denmark. In Physiol Rev, Jul 2013
AMPK and CaMKII are key signaling kinases that appear to regulate GLUT4 expression via the HDAC4/5-MEF2 axis and MEF2-GEF interactions resulting in nuclear export of HDAC4/5 in turn leading to histone hyperacetylation on the GLUT4 promoter and increased GLUT4 transcription.
Epac in cardiac calcium signaling.
Châtenay-Malabry, France. In J Mol Cell Cardiol, May 2013
The pathway identified involved phospholipase C (PLC) and Ca(2+)/calmodulin kinase II (CaMKII).
JAK-STAT pathway and myogenic differentiation.
Suwŏn, South Korea. In Jakstat, May 2013
UNLABELLED: Myogenic differentiation plays an important role in muscle regeneration and is regulated by two transcription factor families, MRFs and MEF2, which induce differentiation of myoblasts through expression of the muscle-specific gene, myogenin.