A7: Initial Assessment of Multi-biomarker Disease Activity Assay in JIA.
Seattle, United States. In Arthritis Rheumatol, 31 Mar 2014
The individual biomarker profiles for the control cohort and the children who met criteria for inactive disease appeared similar, but several individual biomarkers, including SAA, CRP, IL-6 and MMP-3 were elevated in the active disease group as compared to the children with CID and controls (Figure 2).
Immune-metabolic interaction in Drosophila.
London, United Kingdom. In Fly (austin), 14 Mar 2014
We have recently identified the transcription factor MEF2 as a critical switch between anabolic and immune function in the adult Drosophila fat body.
Hemorrhagic transformation after ischemic stroke in animals and humans.
Sacramento, United States. In J Cereb Blood Flow Metab, 28 Feb 2014
This contrasts to delayed HT (>18 to 24 hours after stroke) that relates to ischemia activation of brain proteases (MMP-2, MMP-3, MMP-9, and endogenous tissue plasminogen activator), neuroinflammation, and factors that promote vascular remodeling (vascular endothelial growth factor and high-moblity-group-box-1). Processes that mediate BBB repair and reduce HT risk are discussed, including transforming growth factor beta signaling in monocytes, Src kinase signaling, MMP inhibitors, and inhibitors of reactive oxygen species.
Exercise, GLUT4, and skeletal muscle glucose uptake.
Copenhagen, Denmark. In Physiol Rev, Jul 2013
AMPK and CaMKII are key signaling kinases that appear to regulate GLUT4 expression via the HDAC4/5-MEF2 axis and MEF2-GEF interactions resulting in nuclear export of HDAC4/5 in turn leading to histone hyperacetylation on the GLUT4 promoter and increased GLUT4 transcription.
JAK-STAT pathway and myogenic differentiation.
Suwŏn, South Korea. In Jakstat, May 2013
UNLABELLED: Myogenic differentiation plays an important role in muscle regeneration and is regulated by two transcription factor families, MRFs and MEF2, which induce differentiation of myoblasts through expression of the muscle-specific gene, myogenin.