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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Matrix metallopeptidase 3

MMP-3, Matrix Metalloproteinase 3, stromelysin-1, MEF2
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: matrix metalloproteinase, MMP-9, CAN, Interleukin-6, HAD
Papers using MMP-3 antibodies
Isolation and characterization of the cyanogen bromide peptides from the l(II) chain of chick cartilage collagen.
Buehler Markus J., In PLoS ONE, 1970
... mercuric acetate (APMA) for 1 hr at 37°C or by the recombinant active catalytic domain of MMP-3 (Merck-Calbiochem) at 1∶100 molar ratio ...
Papers on MMP-3
Oxidative stress, autophagy, epigenetic changes and regulation by miRNAs as potential therapeutic targets in osteoarthritis.
Largo et al., Madrid, Spain. In Biochem Pharmacol, Jan 2016
OA chondrocytes show a senescence secretory phenotype (SSP) consisting on the overproduction of cytokines (interleukins 1 and 6), growth factors (e.g., epidermal growth factor) and matrix metalloproteinases (MMP) (e.g., MMP-3, MMP-13).
Polyphosphate-induced matrix metalloproteinase-3-mediated differentiation in rat dental pulp fibroblast-like cells.
Nakata et al., Japan. In Biosci Trends, Dec 2015
In this study, matrix metalloproteinase (MMP)-3 small interfering RNA (siRNA) was transfected into purified rat dental pulp fibroblast-like cells (DPFCs) to investigate whether MMP-3 activity induced by Poly(P) is associated with cell differentiation into osteogenic cells.
Serum Fibroblast Growth Factor 23 (FGF23) in Patients with Rheumatoid Arthritis.
Narita et al., Niigata, Japan. In Intern Med, Dec 2015
The serum FGF23 level was significantly and positively correlated with the erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) levels, disease activity score-28 based on the ESR (DAS-28 ESR) and DAS-28 CRP (r=0.261,
Ezzat et al., In Endocr Pract, Dec 2015
CONCLUSION: Until there is a commercially available PRL assay that is not subject to interference by macroPRL, clinicians should consider the possibility of macroPRL, especially if the clinical presentation, imaging findings, and/or response to therapy reveal inconsistencies Abbreviations: DA = dopamine agonist GFC = gel filtration chromatography IgG = immunoglobulin G macroPRL = macroprolactin MMP3 = matrix metalloproteinase-3 NS = nonsignificant PEG = polyethylene glycol PRL = prolactin RA = rheumatoid arthritis SLE = systemic lupus erythematosus.
Biomarkers in saliva for the detection of oral squamous cell carcinoma and their potential use for early diagnosis: A systematic review.
Suarez Castillo et al., Bogotá, Colombia. In Acta Odontol Scand, Dec 2015
Salivary biomarkers for oral cancer most frequently found were mRNA and proteins for IL-8, CD44, MMP-1 and MMP-3.
MEF2 transcription factors: developmental regulators and emerging cancer genes.
Marra et al., Vancouver, Canada. In Oncotarget, Nov 2015
UNASSIGNED: The MEF2 transcription factors have roles in muscle, cardiac, skeletal, vascular, neural, blood and immune system cell development through their effects on cell differentiation, proliferation, apoptosis, migration, shape and metabolism.
Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies.
Amoli et al., Tehrān, Iran. In J Diabetes Res, 2014
We found significant association between CTLA-4, IL-18, VDR, TAP2, IL-12, and CD4 genes and T1DM, HNFα and MODY, haptoglobin, paraoxonase, leptin, TCF7L2, calreticulin, ERα, PPAR-γ2, CXCL5, calpain-10, IRS-1 and 2, GSTM1, KCNJ11, eNOS, VDR, INSR, ACE, apoA-I, apo E, adiponectin, PTPN1, CETP, AT1R, resistin, MMP-3, BChE K, AT2R, SUMO4, IL-10, VEGF, MTHFR, and GSTM1 with T2DM or its complications.
Inhibition by a retinoic acid receptor γ agonist of extracellular matrix remodeling mediated by human Tenon fibroblasts.
Sonoda et al., Ube, Japan. In Mol Vis, 2014
TGF-β1-induced MMP-1 and MMP-3 release, FAK phosphorylation, and fibronectin and type I collagen production in HTFs were also attenuated by R667.
Platelet-Rich Plasma Increases the Levels of Catabolic Molecules and Cellular Dedifferentiation in the Meniscus of a Rabbit Model.
Do et al., Seoul, South Korea. In Int J Mol Sci, 2014
The protein levels of MMP-1 and MMP-3 were higher in each PRP group, i.e., PRP(+) and IL(+)PRP(+), at each culture time.
Effect of Ginkgo biloba extract on matrix metalloproteinase-3 expression in a rat model of chondrocyte injury.
Guo et al., Beijing, China. In Genet Mol Res, 2014
A rat model with cartilage chondrocyte injury was established using interleukin-1β (IL-1β) to investigate the effect of Ginkgo biloba extract (EGb) on matrix metalloproteinase-3 (MMP-3) expression.
The Hippo transducer YAP1 transforms activated satellite cells and is a potent effector of embryonal rhabdomyosarcoma formation.
Camargo et al., Boston, United States. In Cancer Cell, 2014
YAP1-TEAD1 upregulate pro-proliferative and oncogenic genes and maintain the ERMS differentiation block by interfering with MYOD1 and MEF2 pro-differentiation activities.
Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription.
Lipton et al., Los Angeles, United States. In Cell, 2014
We report a pathway whereby basal and toxin-induced nitrosative/oxidative stress results in S-nitrosylation of transcription factor MEF2C in A53T hNs compared to corrected controls.
MEF2 is an in vivo immune-metabolic switch.
Dionne et al., London, United Kingdom. In Cell, 2013
We show that Mef2 is required in the fat body for anabolic function and the immune response.
A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway.
Werb et al., San Francisco, United States. In Cell Stem Cell, 2013
Here, we identify matrix metalloproteinase-3 (MMP3) as a regulator of Wnt signaling and mammary stem cell (MaSC) activity.
Exercise, GLUT4, and skeletal muscle glucose uptake.
Hargreaves et al., Copenhagen, Denmark. In Physiol Rev, 2013
AMPK and CaMKII are key signaling kinases that appear to regulate GLUT4 expression via the HDAC4/5-MEF2 axis and MEF2-GEF interactions resulting in nuclear export of HDAC4/5 in turn leading to histone hyperacetylation on the GLUT4 promoter and increased GLUT4 transcription.
Limited cleavage of tau with matrix-metalloproteinase MMP-9, but not MMP-3, enhances tau oligomer formation.
Giese et al., München, Germany. In Exp Neurol, 2012
In this study, we identify MMP-3 and MMP-9 as potential tau proteinases
miR-92b regulates Mef2 levels through a negative-feedback circuit during Drosophila muscle development.
Han et al., Ann Arbor, United States. In Development, 2012
The negative feedback circuit between miR-92b and Mef2 efficiently maintains the stable expression of both components that is required for homeostasis during Drosophila muscle development.
Zebrafish Mef2ca and Mef2cb are essential for both first and second heart field cardiomyocyte differentiation.
Hughes et al., London, United Kingdom. In Dev Biol, 2012
Mef2ca single mutants have delayed heart development, but form an apparently normal heart. Mef2cb single mutants have a functional heart and are viable adults.
Neurotoxin-induced selective ubiquitination and regulation of MEF2A isoform in neuronal stress response.
Mao et al., Atlanta, United States. In J Neurochem, 2012
MEF2A, but not MEF2C or MEF2D, is modified by ubiquitination in dopaminergic neuronal cell line SN4741 cells.
[Association of the MMP3, MMP9, ADAM33 and TIMP3 genes polymorphic markers with development and progression of chronic obstructive pulmonary disease].
Victorova et al., In Mol Biol (mosk), 2012
The MMP3 gene polymorphism may be an important risk factor for the development and progression of chronic obstructive pulmonary disease.
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