gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Matrix metallopeptidase 26

MMP-26, matrix metalloproteinase-26, matrilysin-2, endometase
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein degrades type IV collagen, fibronectin, fibrinogen, casein, vitronectin, alpha 1-antitrypsin, alpha 2-macroglobulin, and insulin-like growth factor-binding protein 1, and activates MMP9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MMP-7, MMP-9, POLYMERASE, TIMP-4, matrix metalloproteinase
Papers using MMP-26 antibodies
Mislocalization and unconventional functions of cellular MMPs in cancer
Sang Qing-Xiang Amy et al., In Journal of Cancer, 2005
... MMP-26 Specific siRNA containing vector- The construction of the siRNA-expression plasmids was based on siSTRIKE™ U6 Hairpin Cloning Systems (Promega Corporation).
Papers on MMP-26
Evidence for a Proapoptotic Role of Matrix Metalloproteinase-26 in Human Prostate Cancer Cells and Tissues.
Sang et al., Tallahassee, United States. In J Cancer, Dec 2015
For example, human MMP-26/endometase/matrilysin-2 was reported to be either protective or pro-tumorigenic.
Regulation of chondrosarcoma invasion by MMP26.
Xu et al., Kunming, China. In Tumour Biol, 2015
Here, we show that matrix metalloproteinase-26 (MMP26) level is significantly higher in the resected CS than in the adjacent healthy chondral tissue from the patients.
Maturation of growth differentiation factor 15 in human placental trophoblast cells depends on the interaction with Matrix Metalloproteinase-26.
Wang et al., Beijing, China. In J Clin Endocrinol Metab, 2014
CONTEXT: Matrix Metalloproteinase-26 (MMP-26) is the smallest member of matrix metalloproteinase (MMP) family that functions mainly in the extracellular milieu to cleave the extracellular matrix proteins.
Matrilysin-2 expression in colorectal cancer is associated with overall survival of patients.
Li et al., Chengdu, China. In Tumour Biol, 2014
Matrilysin-2 (MMP-26) has been proved to play an important role during invasion and metastasis of some human solid tumor.
Activation of matrix metalloproteinase-26 by HOXA10 promotes embryo adhesion in vitro.
Sun et al., Nanjing, China. In Biochem Biophys Res Commun, 2014
Here, we report that matrix metalloproteinase-26 (MMP-26) is a novel downstream target gene of homeobox a 10 (HOXA10) in human endometrial cells.
Efficient soluble expression of secreted matrix metalloproteinase 26 in Brevibacillus choshinensis.
Fang et al., Changchun, China. In Protein Expr Purif, 2013
Matrix metalloproteinase 26 (MMP-26) is a novel member of the matrix metalloproteinase family with minimal domain constitution and unknown physiological function.
[Expression and significance of MMP-26, TIMP-4 and MMP-9 in diffuse large B-cell lymphoma cells].
Chen et al., Zunyi, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2013
The aim of this study was to investigate the expression of matrix metalloproteinase 26 (MMP-26), tissue inhibitor of metalloproteinase-4 (TIMP-4) and matrix metalloproteinase 9 (MMP-9) in patients with diffuse large B cell lymphoma (DLBCL) and their correlations with pathogenesis and development of DLBCL.
Estrogen and estrogen receptor induce matrix metalloproteinase-26 expression in endometrial carcinoma cells.
Isaka et al., Tokyo, Japan. In Oncol Rep, 2013
The human matrix metalloproteinase (MMP)-26, also called matrilysin-2 or endometase, has been isolated as a matrilysin (MMP-7) homolog.
GM-CSF enhances tumor invasion by elevated MMP-2, -9, and -26 expression.
Mueller et al., Heidelberg, Germany. In Cancer Med, 2013
Here, expression of MMP-26 protein was predominantly located in pre- and early-invasive areas suggesting MMP-26 expression as an early event in promoting GM-CSF dependent tumor invasion.
The Anti-inflammatory Role of Endometase/Matrilysin-2 in Human Prostate Cancer Cells.
Sang et al., Tallahassee, United States. In J Cancer, 2012
Human endometase/matrilysin-2/matrix metalloproteinase-26 (MMP-26) is an endopeptidase mostly produced by human carcinoma cells.
Roles of matrix metalloproteinase-26 in the growth, invasion and angiogenesis of breast cancer.
Li et al., Changchun, China. In Oncol Lett, 2012
Matrix metalloproteinase-26 (MMP-26) is a novel member of the MMP family and plays a significant role in the progression of estrogen-dependent malignancies.
Matrix metalloproteinases in the restorative proctocolectomy pouch of pediatric ulcerative colitis.
Kolho et al., Helsinki, Finland. In World J Gastroenterol, 2012
Most pouch samples showed expression of epithelial (e) and stromal (s) MMP-3 (e, n = 22; s, n = 20), MMP-7 (e, n = 28; s, n = 27), MMP-12 (e, n = 20; s, n =24), TIMP-2 (e, n = 23; s, n = 23) and MMP-3 (e, n = 23; s, n = 28) but MMP-8 (e, n = 0; s, n = 1), MMP-9 (e, n = 0; s, n = 9) and MMP-26 (e, n = 0; s, n = 3) and TIMP-1 (n = 0, both) were lacking.
Localization and hormonal regulation of endometrial matrix metalloproteinase-26 in the rhesus macaque.
Slayden et al., Botucatu, Brazil. In Hum Reprod, 2012
BACKGROUND: The current understanding of hormonal regulation of matrix metalloproteinase-26 (MMP-26) in the primate endometrium is incomplete.
[Screening for genes associated with cardiac fibrosis induced by aldosterone].
Ren et al., Beijing, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2012
The expression of CCL7, MMP-26 and IL31RA was tested by RT-PCR and western blot, the results is identical with those by gene chips.
Matrix metalloproteinase-26, a novel MMP, is constitutively expressed in the human intervertebral disc in vivo and in vitro.
Hanley et al., Charlotte, United States. In Exp Mol Pathol, 2012
Molecular analyses showed significant downregulation of expression of MMP-26 (p=0.03), and significant 9.8-fold upregulation of TGF-beta (p=0.01) in more degenerated discs vs. healthier discs.
Non-small cell lung cancer invasion and metastasis promoted by MMP-26.
Zheng et al., Changchun, China. In Mol Med Report, 2011
MMP-26 plays an important role in local invasion at least in part through coordination with MMP-9.
Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip.
Freitas et al., Teresina, Brazil. In Arch Oral Biol, 2011
direct association observed between morphological scores of malignancy and MMP immunoreactivity, with the association being significant for MMP-26. present results demonstrate important role of MMPs in development of SCCs of lower lip and tongue.
Matrilysins may not predict the metastatic potential in squamous cell carcinoma of the tongue.
de Almeida Freitas et al., Brasília, Brazil. In Acta Odontol Scand, 2010
role of these proteins in the process of invasion and metastasis cannot be ruled out since their presence is more marked along the tumor invasion front compared to more central areas of squamous cell carcinoma of the tongue
GnRH I and II up-regulate MMP-26 expression through the JNK pathway in human cytotrophoblasts.
Wang et al., Beijing, China. In Reprod Biol Endocrinol, 2009
GnRH I and II could up-regulate MMP-26 expression through the JNK signaling pathway in human trophoblast-like/trophoblast cells.
Mislocalization and unconventional functions of cellular MMPs in cancer.
Strongin, Los Angeles, United States. In Cancer Metastasis Rev, 2006
This review is focused on two, entirely different MMPs, one of which is membrane-tethered and another of which is soluble (MT1-MMP and MMP-26, respectively) from twenty four known human MMPs.
share on facebooktweetadd +1mail to friends