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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Matrix metallopeptidase 19

MMP-19, Matrix metalloproteinase-19
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This protein is expressed in human epidermis and it has a role in cellular proliferation as well as migration and adhesion to type I collagen. Multiple transcript variants encoding distict isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: matrix metalloproteinase, MMP-9, MMP-2, MMP-3, MT1-MMP
Papers on MMP-19
Estrogen Receptor β controls MMP-19 expression in mouse ovaries during ovulation.
New
Inzunza et al., Stockholm, Sweden. In Reproduction, Jan 2016
Matrix metalloproteinases (MMPs) are modulators of the extracellular matrix, and the expression of one specific MMP, MMP-19, is normally increased in granulosa cells during their maturation until ovulation.
High-Level Expression and Prognostic Significance of Matrix Metalloprotease-19 and Matrix Metalloprotease-20 in Human Pancreatic Ductal Adenocarcinoma.
New
Tang et al., Hefei, China. In Pancreas, Jan 2016
This work aimed to determine the expression and prognostic significance of MMP-19 and MMP-20 in pancreatic ductal adenocarcinoma (PDAC).
Loss of NDRG2 promotes epithelial-mesenchymal transition of gallbladder carcinoma cells through MMP-19-mediated Slug expression.
New
Min et al., Taejŏn, South Korea. In J Hepatol, Dec 2015
Loss of NDRG2 induced the expression of matrix metalloproteinase-19 (MMP-19), which regulated the expression of Slug at the transcriptional level.
MMP-19 deficiency causes aggravation of colitis due to defects in innate immune cell function.
New
Sedlacek et al., Praha, Czech Republic. In Mucosal Immunol, Dec 2015
Here, we explore the role of MMP-19 in IBD pathology.
Matrix Metalloproteinases as Therapeutic Targets for Idiopathic Pulmonary Fibrosis.
Review
New
Owen et al., Albuquerque, United States. In Am J Respir Cell Mol Biol, Nov 2015
Two MMPs, MMP-13 and MMP-19, have antifibrotic activities in murine models of PF, and two MMPs, MMP-1 and MMP-10, have the potential to limit fibrotic responses to injury.
Expression of estrus modifies the gene expression profile in reproductive tissues on Day 19 of gestation in beef cows.
New
Cerri et al., Vancouver, Canada. In Theriogenology, Nov 2015
The majority of transcripts affected by estrous expression in the endometrium belong to the immune system and adhesion molecule family (MX1, MX2, MYL12A, MMP19, CXCL10, IGLL1, and SLPI; P ≤ 0.05), as well as those related with prostaglandin synthesis (OTR and COX-2; P ≤ 0.05).
Optimization of an ex vivo wound healing model in the adult human skin: Functional evaluation using photodynamic therapy.
New
Bayat et al., Manchester, United Kingdom. In Wound Repair Regen, Sep 2015
Proliferating nuclear antigen, p16, COLI, COLIII, MMP3, MMP19, and α-SMA were significantly more expressed (p < 0.05) in dermis surrounding the healing wound.
Matrix metalloproteinase (MMP)-19-deficient fibroblasts display a profibrotic phenotype.
New
Pardo et al., Mexico. In Am J Physiol Lung Cell Mol Physiol, Apr 2015
We have recently found that matrix metalloproteinase 19 (MMP-19)-deficient (Mmp19-/-) mice develop an exaggerated bleomycin-induced lung fibrosis, but the mechanisms are unclear.
Heterozygous triplication of upstream regulatory sequences leads to dysregulation of matrix metalloproteinase 19 in patients with cavitary optic disc anomaly.
New
Fingert et al., Iowa City, United States. In Hum Mutat, Mar 2015
Using comparative genomic hybridization and quantitative PCR analysis of this pedigree, we report identifying a 6-Kbp heterozygous triplication upstream of the matrix metalloproteinase 19 (MMP19) gene, present in all 17 affected family members and no normal members.
[Serum levels of matrix metalloproteinase 9 and 19 in the patients with pneumoconiosis].
Li et al., Zhengzhou, China. In Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, 2015
OBJECTIVE: To measure peripheral serum levels of matrix metalloproteinase 9 (MMP9) and matrix metalloproteinase 19 (MMP19) in patients with pneumoconiosis, and to investigate their feasibility as potential biomarkers for pneumoconiosis.
Proteinases and plaque rupture: unblocking the road to translation.
Review
Newby, Bristol, United Kingdom. In Curr Opin Lipidol, 2014
Novel targets, including MMP-8, MMP-10, MMP-14, MMP-19, MMP-25 and MMP-28, are also being considered.
FoxC1-dependent regulation of vascular endothelial growth factor signaling in corneal avascularity.
Review
Kume et al., Chicago, United States. In Trends Cardiovasc Med, 2013
The NC-specific Foxc1 deletion was also associated with elevated levels of both proangiogenic factors, such as the matrix metalloproteases (MMPs) MMP-3, MMP-9, and MMP-19 and the angiogenic inhibitor soluble vascular endothelial growth factor receptor 1 (sVEGFR-1).
Matrix metalloproteinases 15 and 19 are stromal regulators of colorectal cancer development from the early stages.
GeneRIF
Roncucci et al., Reggio nell'Emilia, Italy. In Int J Oncol, 2012
MMP-15 and MMP-19 are upregulated during colorectal tumorigenesis
An osteosarcoma zebrafish model implicates Mmp-19 and Ets-1 as well as reduced host immune response in angiogenesis and migration.
GeneRIF
Cleton-Jansen et al., Leiden, Netherlands. In J Pathol, 2012
An osteosarcoma zebrafish model implicates Mmp-19 and Ets-1 as well as reduced host immune response in angiogenesis and migration.
Matrix metalloproteinase-β19 expressed in cerebral amyloid angiopathy.
GeneRIF
Paetau et al., Helsinki, Finland. In Amyloid, 2011
vascular MMP-19 expression significantly associated with Cerebral amyloid angiopathy--associated intracerebral haemorrhage
Matrix metalloproteinase-19 inhibits growth of endothelial cells by generating angiostatin-like fragments from plasminogen.
GeneRIF
Sedlacek et al., Kiel, Germany. In Bmc Biochem, 2010
MMP-19 processes human plasminogen in a characteristic cleavage pattern to generate three angiostatin-like fragments
Matrix metalloproteinase-19 is highly expressed in astroglial tumors and promotes invasion of glioma cells.
GeneRIF
Mentlein et al., Kiel, Germany. In J Neuropathol Exp Neurol, 2010
Taken together, these results indicate that MMP19 is highly expressed in proliferating astrocytoma/glioma cells, and that its expression may facilitate their invasion through brain extracellular matrix components.
[The role of matrixmetalloproteinases in the tumor growth and metastasis].
Review
Gabrovski et al., In Khirurgiia (sofiia), 2009
There are more than 20 enzymes classified into 6 groups: Collagenases (MMP-1,-8,-13 and -18), Gelatinases (MMP-2 and MMP-9, Stromelysins (MMP-3,-7,-10,-11,-26,-27), Elastases (MMP-12), Membrane type specific MMPs (MMP-14,-15,-16,-17,-24 H -25) and other MMPs (MMP-19,-20,-28,-21,-22,-23).
Transcriptome studies of bovine endometrium reveal molecular profiles characteristic for specific stages of estrous cycle and early pregnancy.
Review
Wolf et al., München, Germany. In Exp Clin Endocrinol Diabetes, 2008
Transcriptome studies of endometrial samples recovered during the pre-attachment period identified many interferon-stimulated genes, genes that are possibly involved in embryo-maternal immune modulation ( C1S, C1R, C4, SERPING1, UTMP, CD81, IFITM1, BST2), as well as genes affecting cell adhesion ( AGRN, CD81, LGALS3BP, LGALS9, GPLD1, MFGE8, and TGM2) and remodeling of the endometrium ( CLDN4, MEP1B, LGMN, MMP19, TIMP2, TGM2, MET, and EPSTI1).
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