GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Matrix metallopeptidase 12
MMP-12, Matrix Metalloproteinase 12, macrophage metalloelastase, macrophage elastase
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008] (from
NCBI)
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Top mentioned proteins:
MMP-9, MMP-2, CAN, HAD, MMP-3
Papers using
MMP-12
antibodies
Inflammation and breast cancer: metalloproteinases as common effectors of inflammation and extracellular matrix breakdown in breast cancer
Supplier
In Cancer Microenvironment, 2007
... Forest University for immunohistochemical staining with the following markers: MMP1 (1906-1), MMP3 (1908-1), MMP9 (1939-1), MMP12 (1906-1; all Epitomics, Inc., Burlingame, CA), and ...
Th2-predominant inflammation and blockade of IFN-gamma signaling induce aneurysms in allografted aortas
Supplier
In PLoS ONE, 2003
... (AB8221), TIMP-3 (MAB3318) and GAPDH (MAB374) (Millipore, Watford, UK), MMP-10 (MAB9101)and CD206 (AF2534) from R&D, MMP-12 from Abcam (ab38935, Cambridge, UK), COX-2 ...
Controlling the false discovery rate in behavior genetics research
Supplier
In BMC Genomics, 2000
... Anti-MMP12 (Biomol, Plymouth Meeting, PA) ...
Papers on
MMP-12
Local trauma in human patellar tendon leads to widespread changes in the tendon gene expression.
New
Nottingham, United Kingdom. In J Appl Physiol, Feb 2016
Results for DNA content were inconclusive, and no changes were detected in expression of Insulin-like growth factor-I, connective tissue growth factor, scleraxis, decorin, fibromodulin, tenascin-C, tenomodulin, VEGFa, CD68, IL-6, MMP12 and MMP13.
Comparative Characterization of Vaginal Cells Derived From Premenopausal Women With and Without Severe Pelvic Organ Prolapse.
New
Toronto, Canada. In Reprod Sci, Feb 2016
increased transcript levels of collagen VII, multiple matrix metalloproteinases (MMP3, MMP7, MMP10, MMP12, MMP13, and MMP14), integrins (ITGA1, ITGA4, ITGA6, ITGA8, ITGB1, ITGB2, and ITGB3), and cell adhesion molecules as compared to control-HVCs.
New insights into the substrate specificity of macrophage elastase MMP-12.
New
In Biol Chem, Feb 2016
UNASSIGNED: Macrophage elastase, or MMP-12, is mainly produced by alveolar macrophages and is believed to play a major role in the development of chronic obstructive pulmonary disease (COPD).
Smad4 Deficiency in Smooth Muscle Cells Initiates the Formation of Aortic Aneurysm.
New
Beijing, China. In Circ Res, Jan 2016
METHODS AND RESULTS: Conditional gene knockout strategy combined with histology and expression analysis showed that Smad4 or TGF-β receptor type II deficiency in SMCs led to the occurrence of aortic aneurysms along with an upregulation of Cathepsin S and Matrix metallopeptidase 12 (MMP12), which are proteases essential for elastin degradation.
Pulmonary C Fibers Modulate MMP-12 Production via PAR2 and Are Involved in the Long-Term Airway Inflammation and Airway Hyperresponsiveness Induced by Respiratory Syncytial Virus Infection.
New
Chongqing, China. In J Virol, Jan 2016
MMP408 and FSLLRY-NH2 were the selective antagonists for MMP-12 and PAR2, respectively, to investigate the roles of MMP-12 and PAR2 in PCFs - mediating airway diseases.
Identification of Commonly Dysregulated Genes in Non-small-cell Lung Cancer by Integrated Analysis of Microarray Data and qRT-PCR Validation.
Review
New
Shijiazhuang, China. In Lung, Aug 2015
Our data suggested that some of the DEGs, including MMP12, COL11A1, THBS2, FAP, and CAV1, may participate in the pathology of NSCLC and could be applied as potential markers or therapeutic targets for NSCLC.
MMP generated matrikines.
Review
New
Birmingham, United States. In Matrix Biol, May 2015
Of the 20 MMPs identified, MMP-1, MMP-2, MMP-8, MMP-9, and MMP-12 have been implicated in regulating the matrikines Val-Gly-Val-Ala-Pro-Gly (elastin peptide) and proline-glycine-proline (PGP).
Matrix metalloproteinase interactions with collagen and elastin.
Review
New
Columbia, United States. In Matrix Biol, May 2015
Elastolysis is also facilitated by the collagen binding domain in the cases of MMP-2 and MMP-9, and remote exosites of the catalytic domain in the case of MMP-12.
Stanford-A acute aortic dissection, inflammation, and metalloproteinases: a review.
Review
Roma, Italy. In Ann Med, 2014
Among MMPs, MMP-12 is considered a specific marker of aortic wall disease, whatever the genetic predisposition may be.
Association between MMP-12-82A/G polymorphism and cancer risk: a meta-analysis.
Review
Harbin, China. In Int J Clin Exp Med, 2014
BACKGROUND: Numerous studies have focused on the association between MMP-12-82A>G polymorphism and cancer risk, but produced inconsistent results.
A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity.
Impact
Vancouver, Canada. In Nat Med, 2014
Interferon-α (IFN-α) is essential for antiviral immunity, but in the absence of matrix metalloproteinase-12 (MMP-12) or IκBα (encoded by NFKBIA) we show that IFN-α is retained in the cytosol of virus-infected cells and is not secreted.
Regulation of the catabolic cascade in osteoarthritis by the zinc-ZIP8-MTF1 axis.
Impact
Kwangju, South Korea. In Cell, 2014
ZIP8-mediated Zn2+ influx upregulated the expression of matrix-degrading enzymes (MMP3, MMP9, MMP12, MMP13, and ADAMTS5) in chondrocytes.
Experimental Pneumocystis lung infection promotes M2a alveolar macrophage-derived MMP12 production.
GeneRIF
Birmingham, United States. In Am J Physiol Lung Cell Mol Physiol, 2012
Pneumocystis murina exposure induced Mmp12 mRNA expression in whole lungs and alveolar macrophages in mice.
Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis.
GeneRIF
Edinburgh, United Kingdom. In Hepatology, 2012
Macrophage-derived MMP-12 regulates elastin degradation even in progressive experimental liver fibrosis.
Probing water-protein contacts in a MMP-12/CGS27023A complex by nuclear magnetic resonance spectroscopy.
GeneRIF
Switzerland. In J Biomol Nmr, 2012
Studied the catalytic domain of MMP-12 in complex with the known inhibitor CGS27023A. A 3D (15)N-edited/(14)N,(12)C-filtered ROESY experiment was used to monitor and distinguish protein amide protons in fast exchange with bulk water.
Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: relationship to disease severity.
GeneRIF
Glasgow, United Kingdom. In J Allergy Clin Immunol, 2012
Sputum MMP-12 concentrations and activity in patients with chronic obstructive pulmonary disease are associated with the extent of emphysema
Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12).
GeneRIF
New York City, United States. In Plos One, 2011
Our results establish microglia as a significant source of progranulin(PGRN), and MMP-12 as modulators of PGRN
Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction.
Impact
Kwangju, South Korea. In Nat Med, 2010
HIF-2alpha directly induces the expression in chondrocytes of genes encoding catabolic factors, including matrix metalloproteinases (MMP1, MMP3, MMP9, MMP12 and MMP13), aggrecanase-1 (ADAMTS4), nitric oxide synthase-2 (NOS2) and prostaglandin-endoperoxide synthase-2 (PTGS2).
MMP12, lung function, and COPD in high-risk populations.
Impact
GeneRIF
Boston, United States. In N Engl J Med, 2010
The minor allele of a SNP in MMP12 (rs2276109) is associated with a positive effect on lung function in children with asthma and in adults who smoke. This allele is also associated with a reduced risk of COPD in adult smokers.
Macrophage elastase kills bacteria within murine macrophages.
Impact
GeneRIF
Pittsburgh, United States. In Nature, 2009
Mmp12(-/-) mice exhibit impaired bacterial clearance and increased mortality when challenged with both gram-negative and gram-positive bacteria at macrophage-rich portals of entry, such as the peritoneum and lung
