Local trauma in human patellar tendon leads to widespread changes in the tendon gene expression.
Nottingham, United Kingdom. In J Appl Physiol, Feb 2016
Results for DNA content were inconclusive, and no changes were detected in expression of Insulin-like growth factor-I, connective tissue growth factor, scleraxis, decorin, fibromodulin, tenascin-C, tenomodulin, VEGFa, CD68, IL-6, MMP12 and MMP13.
Comparative Characterization of Vaginal Cells Derived From Premenopausal Women With and Without Severe Pelvic Organ Prolapse.
Toronto, Canada. In Reprod Sci, Feb 2016
increased transcript levels of collagen VII, multiple matrix metalloproteinases (MMP3, MMP7, MMP10, MMP12, MMP13, and MMP14), integrins (ITGA1, ITGA4, ITGA6, ITGA8, ITGB1, ITGB2, and ITGB3), and cell adhesion molecules as compared to control-HVCs.
Smad4 Deficiency in Smooth Muscle Cells Initiates the Formation of Aortic Aneurysm.
Beijing, China. In Circ Res, Jan 2016
METHODS AND RESULTS: Conditional gene knockout strategy combined with histology and expression analysis showed that Smad4 or TGF-β receptor type II deficiency in SMCs led to the occurrence of aortic aneurysms along with an upregulation of Cathepsin S and Matrix metallopeptidase 12 (MMP12), which are proteases essential for elastin degradation.
MMP generated matrikines.
Birmingham, United States. In Matrix Biol, May 2015
Of the 20 MMPs identified, MMP-1, MMP-2, MMP-8, MMP-9, and MMP-12 have been implicated in regulating the matrikines Val-Gly-Val-Ala-Pro-Gly (elastin peptide) and proline-glycine-proline (PGP).
MMP12, lung function, and COPD in high-risk populations.
Boston, United States. In N Engl J Med, 2010
The minor allele of a SNP in MMP12 (rs2276109) is associated with a positive effect on lung function in children with asthma and in adults who smoke. This allele is also associated with a reduced risk of COPD in adult smokers.
Macrophage elastase kills bacteria within murine macrophages.
Pittsburgh, United States. In Nature, 2009
Mmp12(-/-) mice exhibit impaired bacterial clearance and increased mortality when challenged with both gram-negative and gram-positive bacteria at macrophage-rich portals of entry, such as the peritoneum and lung