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MAX-like protein X

Mlx, Max-like protein X
The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Mio, MAX, CAN, ACID, c-Myc
Papers on Mlx
The glucose-sensing transcription factor MLX promotes myogenesis via myokine signaling.
Demontis et al., Memphis, United States. In Genes Dev, Jan 2016
Here, we found that changes in glucose levels increase the activity of the glucose-responsive transcription factor MLX (Max-like protein X), which promotes and is necessary for myoblast fusion.
Mondo-Mlx Mediates Organismal Sugar Sensing through the Gli-Similar Transcription Factor Sugarbabe.
Hietakangas et al., Helsinki, Finland. In Cell Rep, Nov 2015
The ChREBP/Mondo-Mlx transcription factors are activated by sugars and are essential for sugar tolerance.
Mio acts in the Drosophila brain to control nutrient storage and feeding.
DiAngelo et al., Hempstead, United States. In Gene, Oct 2015
Mlx interactor (Mio), the Drosophila homolog of carbohydrate response element binding protein (ChREBP), functions as a transcription factor in the fat body of the fly to control triglyceride storage as well as feeding, suggesting that Mio may act in a nutrient-sensing pathway to coordinate food consumption and metabolism.
Latent KSHV Infected Endothelial Cells Are Glutamine Addicted and Require Glutaminolysis for Survival.
Lagunoff et al., Seattle, United States. In Plos Pathog, Jul 2015
KSHV also induces expression of the heterodimeric transcription factors c-Myc-Max and related heterodimer MondoA-Mlx.
The transcription factor Cabut coordinates energy metabolism and the circadian clock in response to sugar sensing.
Hietakangas et al., Jerusalem, Israel. In Embo J, Jul 2015
For example, sugar feeding promotes lipogenesis by activating glycolytic and lipogenic genes through the Mondo/ChREBP-Mlx transcription factor complex.
Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis.
Eisenman et al., Hutchinson, United States. In Biochim Biophys Acta, May 2015
Notably, MYC is part of a network of bHLHLZ proteins centered on the MYC heterodimeric partner MAX and its counterpart, the MAX-like protein MLX.
Warburg effect regulated by amphiregulin in the development of colorectal cancer.
Miyamoto et al., Fukuoka, Japan. In Cancer Med, Apr 2015
Max-like protein X (MLX) bound to ChoRE and enhanced the expression of AREG.
MondoA-Mlx transcriptional activity is limited by mTOR-MondoA interaction.
Ayer et al., Salt Lake City, United States. In Mol Cell Biol, 2015
MondoA and its obligate transcription partner Mlx are basic helix-loop-helix leucine zipper (bHLHZip) transcription factors that sense and execute a glucose-responsive transcriptional program.
Spectral heart rate variability in rats with cyclophosphamide-induced hemorrhagic cystitis treated with cyclooxygenase inhibitors.
Thor et al., Kraków, Poland. In Folia Med Cracov, 2014
The ANS activity was estimated through the spectral analysis of heart rate variability (HRV) in CP-HC rats divided into three study groups: 1-control, 2-treated with meloxicam (MLX) that preferentially blocks COX-2, and 3-treated with piroxicam (PRX) that inhibits COX1 and 2 activity.
MondoA deficiency enhances sprint performance in mice.
Chan et al., Houston, United States. In Biochem J, 2014
Studies in vitro suggest that the Max-like protein X (MondoA:Mlx) heterodimer senses the intracellular energy status and directly targets the promoter region of thioredoxin interacting protein (Txnip) and possibly glycolytic enzymes.
Recent advances in Takayasu arteritis.
Mimori et al., Kyoto, Japan. In Int J Rheum Dis, 2014
MLX and FCGR2A/3A were shown to be associated with TAK in Japanese and Turkish/American populations, respectively.
Is C771G polymorphism of MLX interacting protein-like (MLXIPL) gene a novel genetic risk factor for non-alcoholic fatty liver disease?
Samadikuchaksaraei et al., In Cell Mol Biol (noisy-le-grand), 2013
In a recent study, a genome-wide scan has identified C771G (His241Gln) polymorphism of MLX interacting protein like (MLXIPL) gene that is associated with the level of plasma triglycerides.
Glucose sensing by ChREBP/MondoA-Mlx transcription factors.
Hietakangas et al., Helsinki, Finland. In Semin Cell Dev Biol, 2012
The paralogous transcription factors ChREBP and MondoA, together with their common binding partner Mlx, have emerged as key mediators of intracellular glucose sensing.
Glucose controls nuclear accumulation, promoter binding, and transcriptional activity of the MondoA-Mlx heterodimer.
Ayer et al., Salt Lake City, United States. In Mol Cell Biol, 2010
Glucose is required at two additional steps to stimulate the transcription activation function of MondoA-Mlx complexes.
Hepatic overexpression of dominant negative Mlx improves metabolic profile in diabetes-prone C57BL/6J mice.
Horikawa et al., Maebashi, Japan. In Biochem Biophys Res Commun, 2009
Overexpression of dominant negative Mlx improves glucose intolerance by inhibiting expression not only of lipogenic enzymes but also other important genes such as Glucose-6-phosphatase and Elovl6.
Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression.
Ayer et al., Salt Lake City, United States. In Proc Natl Acad Sci U S A, 2008
These studies suggest a key role for MondoA:Mlx complexes in the adaptive transcriptional response to changes in extracellular glucose concentration and peripheral glucose uptake.
Docosahexaenoic acid (DHA) and hepatic gene transcription.
Christian et al., East Lansing, United States. In Chem Phys Lipids, 2008
Our studies have established that key transcription factors, like PPARalpha, SREBP-1, ChREBP and MLX, are regulated by n-3 PUFA, which in turn control levels of proteins involved in lipid and carbohydrate metabolism.
ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver.
Towle et al., Minneapolis, United States. In J Biol Chem, 2006
ChREBP.Mlx is the principal transcription factor regulating glucose-responsive genes in the liver and coordinately regulates a family of genes required for glucose utilization and energy storage
MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis.
Ayer et al., Salt Lake City, United States. In Mol Cell Biol, 2006
Endogenous MondoA and Mlx associate with mitochondria in primary skeletal muscle.
The Mlx network: evidence for a parallel Max-like transcriptional network that regulates energy metabolism.
Ayer et al., United States. In Curr Top Microbiol Immunol, 2005
At the center of this network is a Max-like protein called Mlx; hence we have called this network the Mlx network.
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