Mio acts in the Drosophila brain to control nutrient storage and feeding.
Hempstead, United States. In Gene, Oct 2015
Mlx interactor (Mio), the Drosophila homolog of carbohydrate response element binding protein (ChREBP), functions as a transcription factor in the fat body of the fly to control triglyceride storage as well as feeding, suggesting that Mio may act in a nutrient-sensing pathway to coordinate food consumption and metabolism.
MondoA deficiency enhances sprint performance in mice.
Houston, United States. In Biochem J, 2014
Studies in vitro suggest that the Max-like protein X (MondoA:Mlx) heterodimer senses the intracellular energy status and directly targets the promoter region of thioredoxin interacting protein (Txnip) and possibly glycolytic enzymes.
Recent advances in Takayasu arteritis.
Kyoto, Japan. In Int J Rheum Dis, 2014
MLX and FCGR2A/3A were shown to be associated with TAK in Japanese and Turkish/American populations, respectively.
Docosahexaenoic acid (DHA) and hepatic gene transcription.
East Lansing, United States. In Chem Phys Lipids, 2008
Our studies have established that key transcription factors, like PPARalpha, SREBP-1, ChREBP and MLX, are regulated by n-3 PUFA, which in turn control levels of proteins involved in lipid and carbohydrate metabolism.