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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ligand dependent nuclear receptor corepressor-like

This gene encodes a transcription factor that appears to function in spermatogenesis. Polymorphisms in this gene are associated with measures of skeletal frame size and adult height. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: mineralocorticoid receptor, HAD, AGE, MUC4, HMGA2
Papers on MLR-1
Rare truncating variations and risk of schizophrenia: Whole-exome sequencing in three families with affected siblings and a three-stage follow-up study in a Japanese population.
Someya et al., Niigata, Japan. In Psychiatry Res, Jan 2016
In the follow-up study, four variations (NWD1 W169X, LCORL R7fsX53, CAMK2B L497fsX497, and C9orf89 Q102X) had a higher mutant allele frequency in patients compared with controls, although these associations were not significant in the combined population, which comprised the first-, second- and third-stage populations.
NCAPG is differentially expressed during longissimus muscle development and is associated with growth traits in Chinese Qinchuan beef cattle.
Liu et al., China. In Genet Mol Biol, Dec 2015
In the present study, we validated this result and, using quantitative real-time PCR analysis, identified two adjacent genes, LCORL and DCAF16, that are more abundant in fetal muscle tissue; further analysis of tissue-specific expression patterns indicated high abundance of NCAPG in muscle.
PLAG1 and NCAPG-LCORL in livestock.
Takasuga, Fukushima, Japan. In Anim Sci J, Sep 2015
PLAG1 and/or NCAPG-LCORL, both of which are known as a locus for adult human height, have been detected for association with body weight/height in cattle and horses, and for selective sweep in dogs and pigs.
Composite Selection Signals for Complex Traits Exemplified Through Bovine Stature Using Multibreed Cohorts of European and African Bos taurus.
Raadsma et al., Sydney, Australia. In G3 (bethesda), Jul 2015
Of these 12 candidate gene regions, three contained known genes (i.e., NCAPG-LCORL, FBP2-PTCH1, and PLAG1-CHCHD7) related to bovine stature, and nine were not previously described in cattle (five in European and four in African cohorts).
Genomic signatures reveal new evidences for selection of important traits in domestic cattle.
Liu et al., College Park, United States. In Mol Biol Evol, Mar 2015
In addition to well-known genes such as KIT, MC1R, ASIP, GHR, LCORL, NCAPG, WIF1, and ABCA12, we found evidence for a variety of novel and less-known genes under selection in cattle, such as LAP3, SAR1B, LRIG3, FGF5, and NUDCD3.
A novel common variant in DCST2 is associated with length in early life and height in adulthood.
Early Growth Genetics (EGG) Consortium et al., Copenhagen, Denmark. In Hum Mol Genet, Mar 2015
We identified seven independent top single nucleotide polymorphisms (SNPs) (P < 1 × 10(-6)) for birth length, of which three were novel and four were in or near loci known to be associated with adult height (LCORL, PTCH1, GPR126 and HMGA2).
Genome-wide association study of body weight in Australian Merino sheep reveals an orthologous region on OAR6 to human and bovine genomic regions affecting height and weight.
Gondro et al., Armidale, Australia. In Genet Sel Evol, 2014
The region that surrounds this association signal on OAR6 contains three genes: leucine aminopeptidase 3 (LAP3), which is involved in the processing of the oxytocin precursor; NCAPG non-SMC condensin I complex, subunit G (NCAPG), which is associated with foetal growth and carcass size in cattle; and ligand dependent nuclear receptor corepressor-like (LCORL), which is associated with height in humans and cattle.
Loci associated with adult stature also affect calf birth survival in cattle.
Lund et al., Århus, Denmark. In Bmc Genet, 2014
The QTL peak included LCORL and NCAPG genes, which had been reported to influence fetal growth and adult stature in several species.
BIEC2-808543 SNP in the LCORL Gene is Associated with Body Conformation in the Yili Horse.
Liu et al., Ürümqi, China. In Anim Biotechnol, 2014
Recently, a SNP (BIEC2-808543) was demonstrated to be associated with equine body size in horses.
Splicing variants of NOL4 differentially regulate the transcription activity of Mlr1 and Mlr2 in cultured cells.
Kubo et al., Tokyo, Japan. In Zoolog Sci, 2014
Mlr1 (Mblk-1-related protein-1) and Mlr2 are mouse homologs of transcription factor Mblk-1 (Mushroom body large-type Kenyon cell-specific protein-1), which we originally identified from the honeybee brain.
Haplotype-based analysis of selective sweeps in sheep.
Kijas, Brisbane, Australia. In Genome, 2014
Further, five regions were identified centered on genes with strong evidence for positive selection (COL1A2, NCAPG, LCORL, and RXFP2).
Prognostic significance of metastatic lymph node ratio in patients with gastric cancer: an evaluation in north-East of iran.
Seilanian Toussi et al., Mashhad, Iran. In Iran J Cancer Prev, 2013
MLR has classified into 3 groups as follows: MLR0; 0, MLR1; >0-0.33 and MLR2; 0.34-1.
Genomic analysis establishes correlation between growth and laryngeal neuropathy in Thoroughbreds.
Robinson et al., East Lansing, United States. In Bmc Genomics, 2013
RESULTS: We found a significant association of RLN with the LCORL/NCAPG locus on ECA3 previously shown to affect body size in horses.
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
Early Growth Genetics (EGG) Consortium et al., Oxford, United Kingdom. In Nat Genet, 2013
Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height.
Identification and characterization of Mlr1,2: two mouse homologues of Mblk-1, a transcription factor from the honeybee brain(1).
Kubo et al., Tokyo, Japan. In Febs Lett, 2003
identification and characterization of Mlr2 a homolog of Mblk-1, a transcription factor from the honeybee brain; expressed predominantly in the spermatocytes of the testis
Conserved, extended MHC haplotypes.
Yunis et al., Boston, United States. In Exp Clin Immunogenet, 1991
Even for those who do not, extended haplotypes provide the means for identifying likely MLR-I-negative donor-recipients, and for identifying the genes involved in this function.
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