[Significance of chromosome 7 abnormalities in myeloid malignancies].
Shanghai, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2014
Genes (EZH2, MLL5, DOCK4, SAMD9L/SAMD9) located in commonly deleted segments of 7q have been cloned and characterized along with the advance of molecular biology.This review summaries the current advancement about myeloid malignancies associated with monosomy7/del(7q).
Common Viral Integration Sites Identified in Avian Leukosis Virus-Induced B-Cell Lymphomas.
Baltimore, United States. In Mbio, 2014
In addition to the four genes implicated previously, we identify other genes as common integration sites, including TNFRSF1A, MEF2C, CTDSPL, TAB2, RUNX1, MLL5, CXorf57, and BACH2.
Regulation of histone H3K4 methylation in brain development and disease.
New York City, United States. In Philos Trans R Soc Lond B Biol Sci, 2014
Importantly, the reported alterations for some of the diseased brain specimens included a widespread broadening of H3K4 methylation profiles at gene promoters, a process that could be regulated by the UpSET(KMT2E/MLL5)-histone deacetylase complex.
Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemia.
Hannover, Germany. In J Clin Oncol, 2011
The prognostic impact of DNMT3A mutations was evaluated in the context of other clinical prognostic markers and genetic risk factors (cytogenetic risk group; mutations in NPM1, FLT3, CEBPA, IDH1, IDH2, MLL1, NRAS, WT1, and WT1 SNPrs16754; expression levels of BAALC, ERG, EVI1, MLL5, MN1, and WT1).