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Mitogen-activated protein kinase kinase kinase 11

MLK3, RhoE, mixed lineage kinase 3, Rnd3
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using MLK3 antibodies
Collagen I–mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1
Johnson Keith R. et al., In The Journal of Cell Biology, 2002
... Anti-DDR1 rabbit pAb (C-20), anti-Rap1 rabbit pAb, and anti-MLK3 rabbit pAb were obtained from Santa Cruz Biotechnology, Inc ...
Papers on MLK3
Mixed lineage kinase 3 is required for matrix metalloproteinase expression and invasion in ovarian cancer cells.
Chadee et al., Toledo, United States. In Exp Cell Res, 2012
The findings establish MLK3 as an important regulator of MMP expression and invasion in ovarian cancer cells.
Neuronal polarization is impaired in mice lacking RhoE expression.
Guasch et al., Valencia, Spain. In J Neurochem, 2012
These findings support our previous report revealing the important role of RhoE in the normal development of the nervous system
Mixed-lineage kinase 3 phosphorylates prolyl-isomerase Pin1 to regulate its nuclear translocation and cellular function.
Rana et al., Maywood, United States. In Proc Natl Acad Sci U S A, 2012
These findings collectively suggest that the MLK3-Pin1 signaling cascade plays a critical role in regulating the cell cycle, centrosome numbers, and oncogenesis.
HBx activates FasL and mediates HepG2 cell apoptosis through MLK3-MKK7-JNKs signal module.
Zheng et al., Xuzhou, China. In World J Gastroenterol, 2012
Data show that HBx can induce HepG2 cell apoptosis via a novel active MLK3-MKK7-JNKs signaling module to upregulate FasL protein expression.
Rnd1 and Rnd3 targeting to lipid raft is required for p190 RhoGAP activation.
Negishi et al., Kyoto, Japan. In Mol Biol Cell, 2012
role of the N-terminal region in signaling; Rnd1 and Rnd3 have a KERRA (Lys-Glu-Arg-Arg-Ala) sequence of amino acids in their N-terminus, which functions as the lipid raft-targeting determinant; the sequence mediates lipid raft targeting of p190 RhoGAP correlated with its activation
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