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Myeloid leukemia factor 1

MLF1, myeloid leukemia factor 1
This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010] (from NCBI)
Top mentioned proteins: B23, CAN, ALK, RAR, MLF1IP
Papers using MLF1 antibodies
Interactions with M-band titin and calpain 3 link myospryn (CMYA5) to tibial and limb-girdle muscular dystrophies
Udd Bjarne et al., In Nature genetics, 1994
... Non-pathogenic protein aggregates in skeletal muscle in MLF1 transgenic mice ...
Papers on MLF1
Myeloid leukemia factor 1 interfered with Bcl-XL to promote apoptosis and its function was regulated by 14-3-3.
Morris et al., Shijiazhuang, China. In J Physiol Biochem, Dec 2015
Myeloid leukemia factor 1 (MLF1) was involved in t(3;5) chromosomal rearrangement and aberrantly expressed in myelodysplastic syndromes/acute myeloid leukemia patients.
Distinctive genotypes in infants with T-cell acute lymphoblastic leukaemia.
Ford et al., Rio de Janeiro, Brazil. In Br J Haematol, Nov 2015
These losses result in the complete deletion of MLF1 and have not previously been described in T-ALL.
MLF1 interacting protein: a potential gene therapy target for human prostate cancer?
Shao et al., Xi'an, China. In Med Oncol, Feb 2015
Here, we investigated the role of one gene that has been previously associated with human prostate carcinoma cells-myelodysplasia/myeloid leukemia factor 1 interacting protein (MLF1IP)-in order to better ascertain its role in human prostate carcinogenesis.
Development of an NPM1/MLF1 D-FISH probe set for the detection of t(3;5)(q25;q35) identified in patients with acute myeloid leukemia.
Ketterling et al., Rochester, United States. In J Mol Diagn, 2014
The t(3;5)(q25;q35) NPM1/MLF1 fusion has an incidence of approximately 0.5% in acute myeloid leukemia (AML) and has an intermediate prognosis at diagnosis.
Drosophila myeloid leukemia factor acts with DREF to activate the JNK signaling pathway.
Yamaguchi et al., Kyoto, Japan. In Oncogenesis, 2013
Drosophila myelodysplasia/myeloid leukemia factor (dMLF), a homolog of human MLF1, oncogene was first identified by yeast two-hybrid screen using the DNA replication-related element-binding factor (DREF) as bait.
Draft Genome Sequence of the Obligately Alkaliphilic Sulfate-Reducing Bacterium Desulfonatronum thiodismutans Strain MLF1.
Bazylinski et al., Las Vegas, United States. In Genome Announc, 2013
Desulfonatronum thiodismutans strain MLF1, an alkaliphilic bacterium capable of sulfate reduction, was isolated from Mono Lake, California.
A single center analysis of nucleophosmin in acute myeloid leukemia: value of combining immunohistochemistry with molecular mutation analysis.
Huls et al., In Haematologica, 2013
In two of these cases we found the chromosomal translocation t(3;5)(q25;q35) encoding the NPM-MLF1 fusion protein.
The genomic landscape of small intestine neuroendocrine tumors.
Beutler et al., Rochester, United States. In J Clin Invest, 2013
197 protein-altering somatic SNVs affected a preponderance of cancer genes, including FGFR2, MEN1, HOOK3, EZH2, MLF1, CARD11, VHL, NONO, and SMAD1.
Investigation of tissue-specific expression and functions of MLF1-IP during development and in the immune system.
Luo et al., Montréal, Canada. In Plos One, 2012
Myeloid leukemia factor 1-interacting protein (MLF1-IP) has been found to exert functions in mitosis, although studies have been conducted only in cell lines up to now.
NPM-MLF1 synergizes with Npm haploinsufficiency to enhance myeloid progenitor activity.
Williams et al., In Leukemia, 2012
changes in the subcellular localization of NPM, due to alterations in the relative abundance of NPM and NPM-MLF1 proteins, may contribute to the enhanced myeloid progenitor activity of Npm +/- cells
Structural insights of the MLF1/14-3-3 interaction.
Ottmann et al., Dortmund, Germany. In Febs J, 2012
Data present the high-resolution crystal structure of this binding motif [MLF1(29-42)pSer34] in complex with 14-3-3epsilon and analyse the interaction with isothermal titration calorimetry.
Transcriptional program of ciliated epithelial cells reveals new cilium and centrosome components and links to human disease.
Stearns et al., Stanford, United States. In Plos One, 2011
We found that three genes associated with human disease states, Mdm1, Mlf1, and Dyx1c1, are upregulated during ciliogenesis and localize to centrioles and cilia.
Detection of t(3;5) and NPM1/MLF1 rearrangement in an elderly patient with acute myeloid leukemia: clinical and laboratory study with review of the literature.
Park et al., Seoul, South Korea. In Cancer Genet Cytogenet, 2010
MLF1 gene rearrangement is associated with acute myeloid leukemia.
Non-pathogenic protein aggregates in skeletal muscle in MLF1 transgenic mice.
Shelton et al., Los Angeles, United States. In J Neurol Sci, 2008
Over-expression of MLF1 has little impact on skeletal muscle function in mice; progressive formation of protein aggregates in muscle are not necessarily pathogenic; MLF1 and MRJ may function together to ameliorate the toxic effects of mutant proteins.
Shuttling imbalance of MLF1 results in p53 instability and increases susceptibility to oncogenic transformation.
Kato et al., Ikoma, Japan. In Mol Cell Biol, 2008
shuttling of MLF1 is critical for the regulation of cell proliferation and a disturbance in the shuttling balance increases the cell's susceptibility to oncogenic transformation
Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemias.
Martelli et al., Perugia, Italy. In Haematologica, 2007
The gene NPM1 that encodes for nucleophosmin (NPM1) is translocated or mutated in various lymphomas and leukemias, forming fusion proteins (NPM-ALK, NPM-RARalpha, NPM-MLF1) or NPM mutant products.
Nucleophosmin: a versatile molecule associated with hematological malignancies.
Urano et al., Nagoya, Japan. In Cancer Sci, 2006
The MLF1 and RARA genes are fused with NPM1 in myelodysplastic syndrome and acute myeloid leukemia (AML) with t(3;5) and acute promyelocytic leukemia with t(5;17), respectively.
Nucleophosmin regulates the stability and transcriptional activity of p53.
Pelicci et al., Milano, Italy. In Nat Cell Biol, 2002
The NPM gene is involved in several tumour-associated chromosome translocations, which have resulted in the formation of fusion proteins that retain the amino terminus of NPM, including NPM ALK, NPM RAR and NPM MLF1 (ref.
Chromosome and molecular abnormalities in myelodysplastic syndromes.
Fenaux, Lille, France. In Int J Hematol, 2001
These genes include MDS1-EVI1 in t(3;3) or t(3;21) translocations, TEL in t(5;12), HIP1 in t(5;7), MLF1 in t(3;5), and MEL1 in t(1;3).
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