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proteins. Page last changed on 14 Mar 2013.
Myosin, light chain 12B, regulatory
MLC20
The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [PubMed 11942626]).[supplied by OMIM, Mar 2008] (from
NCBI)
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Papers on
MLC20
Higher expression of phosphorylated myosin regulatory light chain in the common bile duct in pancreaticobiliary maljunction accompanied by bile duct dilatation in children: a post-mortem observational study.
New
Suzhou, China. In Pediatr Surg Int, 31 Mar 2013
OBJECTIVE: To examine the content of phosphorylated myosin regulatory light chain (P-MLC20) and myosin light-chain kinase (MLCK) in the common bile duct of pediatric patients with pancreaticobiliary maljunction (PBM) accompanied by bile duct dilatation (BDD), and investigate their potential role in PBM accompanied by BDD.
Dexamethasone induces rapid promotion of norepinephrine‑mediated vascular smooth muscle cell contraction.
New
China. In Mol Med Report, 28 Feb 2013
Myosin light chain (MLC20) phosphorylation of VSMCs was detected by western blot analysis to observe the effects of Dex on NE‑mediated contraction.
Hypoxia Differentially Reorganizes Contractile Proteins in Fetal and Adult Ovine Carotid Arteries.
New
Loma Linda, United States. In Am J Physiol Cell Physiol, 16 Feb 2013
Carotid arteries from these animals were denuded of endothelium and used fresh or after organ culture in 3 ng/ml VEGF, to determine in vitro myogenic contractility, artery stiffness, and the abundances (determined via immunoblots) of Smooth Muscle α-Actin (SMαA), Myosin Light Chain Kinase (MLCK) and 20 kDa Regulatory Myosin Light Chain (MLC20).
The Role of Serine-Threonine Phosphoprotein Phosphatases In Smooth Muscle Contractility.
New
Newcastle, South Africa. In Am J Physiol Cell Physiol, 16 Feb 2013
The degree of phosphorylation of Myosin Light Chain 20 (MLC20) is a major determinant of force generation in smooth muscle.
JunB mediates basal- and TGFβ1-induced smooth muscle cell contractility.
New
Boston, United States. In Plos One, Dec 2012
However, JunB silencing decreased levels of Rho kinase (ROCK) and myosin light chain (MLC20).
Aging impairs Ca2+ sensitization pathways in gallbladder smooth muscle.
New
Cáceres, Spain. In Age (dordr), Aug 2012
Aging reduced bethanechol- and cholecystokinin-evoked contractions, an effect associated with a reduction in MLC20 phosphorylation and in the effects of both Y-27632 and GF109203X.
Pennogenin Tetraglycoside induces rat myometrial contraction and MLC20 phosphorylation via PLC-IP(3) and RhoA/Rho kinase signaling pathways.
Beijing, China. In Plos One, 2011
METHODS: Here Tg was screened for effects on contractile activity in isolated uterine strips from estrogen-primed rats and on MLC20 phosphorylation and related signaling pathways in cultured rat myometrial cells as determined by Western blot.
MLCK-independent phosphorylation of MLC20 and its regulation by MAP kinase pathway in human bladder smooth muscle cells.
China. In Cytoskeleton (hoboken), 2011
Myosin light chain 20 (MLC20) is small ring around the neck region of heavy chain of myosins.
Vasorelaxant effect of Cinnamomi ramulus ethanol extract via rho-kinase signaling pathway.
Kyŏngju, South Korea. In Am J Chin Med, 2010
Furthermore, CRE dephosphorylated the subsequent downstream targets myosin phosphatase targeting subunit 1 (MYPT-1), protein kinase C potentiated phosphatase inhibitor protein-17 kDa (CPI-17) and myosin light chain 20 kDa (MLC20).
Reactive oxygen species are involved in regulating alpha1-adrenoceptor-activated vascular smooth muscle contraction.
Tainan City, Taiwan. In J Biomed Sci, 2009
METHODS: Using endothelium-denuded rat tail artery (RTA) strips, effects of anti-oxidants on isometric force, ROS production, phosphorylation of the 20-kDa myosin light chain (MLC20), and myosin phosphatase stimulated by alpha1-adrenoceptor agonist phenylephrine were examined.
Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.
GeneRIF
São Paulo, Brazil. In Eur Arch Psychiatry Clin Neurosci, 2009
Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
Role of non-kinase activity of myosin light-chain kinase in regulating smooth muscle contraction, a review dedicated to Dr. Setsuro Ebashi.
Review
Maebashi, Japan. In Biochem Biophys Res Commun, 2008
The kinase activity is mediated by the catalytic domain that phosphorylates the myosin light-chain of 20kDa (MLC20), activating smooth muscle myosin to interact with actin.
Drebrin attenuates the interaction between actin and myosin-V.
GeneRIF
Maebashi, Japan. In Biochem Biophys Res Commun, 2007
drebrin-A may affect spine dynamics, vesicle transport, and other myosin-V-driven motility in neurons through attenuating the interaction between actin and myosin-V
Sensitized airway smooth muscle plasticity and hyperreactivity: a review.
Review
Winnipeg, Canada. In Can J Physiol Pharmacol, 2007
Nevertheless, we did find that content and total activity of smooth muscle myosin light chain kinase (smMLCK) and the abundance of its message were greater; this would explain the increased MLC20 phosphorylation.
Signaling for contraction and relaxation in smooth muscle of the gut.
Review
Richmond, United States. In Annu Rev Physiol, 2005
Phosphorylation of Ser19 on the 20-kDa regulatory light chain of myosin II (MLC20) by Ca2+/calmodulin-dependent myosin light-chain kinase (MLCK) is essential for initiation of smooth muscle contraction.
Epigallocatechin-3-O-gallate disrupts stress fibers and the contractile ring by reducing myosin regulatory light chain phosphorylation mediated through the target molecule 67 kDa laminin receptor.
GeneRIF
Fukuoka, Japan. In Biochem Biophys Res Commun, 2005
These results suggest that EGCG inhibits the cell growth by reducing the MRLC phosphorylation and this effect is mediated by the 67LR.
Signal-transduction pathways that regulate smooth muscle function I. Signal transduction in phasic (esophageal) and tonic (gastroesophageal sphincter) smooth muscles.
Review
Providence, United States. In Am J Physiol Gastrointest Liver Physiol, 2005
The steps linking activation of PKC to myosin light chain (MLC20) phosphorylation and contraction, however, have not been clearly defined for LES, Eso, or other smooth muscles.
Insulin signaling in the vasculature.
Review
Mineola, United States. In Front Biosci, 2003
MBP activation prevents agonist induced MLC20 phosphorylation as well as VSMC contraction.
Dependence of metastatic cancer cell invasion on MLCK-catalyzed phosphorylation of myosin regulatory light chain.
GeneRIF
Bangkok, Thailand. In Prostate Cancer Prostatic Dis, 2002
role of myosin regulatory light chain phosphorylation by myosin light chain kinase (MLCK) in regulating the invasiveness of metastatic cancer cells
